Farnesylated proteins as anticancer drug targets: From laboratory to the clinic

Current Medicinal Chemistry - Anti-Cancer Agents

Volumn 4, Issue 2, 2004, Pages 123-138

  Russo, Patrizia ^a   Loprevite, Maura ^a   Cesario, Alfredo ^b   Ardizzoni, Andrea ^a,c  

^a UNIVERSITY OF GENOA   (Italy)

^b CATHOLIC UNIVERSITY   (Italy)

^c Azienda Ospedaliera   (Italy)

Author keywords

Cell cycle; Cytotoxicity; Farnesylated proteins; Farnesyltransferase; Farnesyltransferase inhibitors; Phase I, II, III studies; Ras

Indexed keywords

3 BENZYL 7 CYANO 2,3,4,5 TETRAHYDRO 1 (1H IMIDAZOL 4 YLMETHYL) 4 (2 THIENYLSULFONYL) 1H 1,4 BENZODIAZEPINE; ANTINEOPLASTIC AGENT; CISPLATIN; FLUOROURACIL; GEMCITABINE; GUANOSINE TRIPHOSPHATE; L 778123; LAMIN A; LAMIN B; LONAFARNIB; MELPHALAN; OLOMOUCINE; PACLITAXEL; PROTEIN FARNESYLTRANSFERASE INHIBITOR; PROTEIN KINASE C; RAF PROTEIN; RAS PROTEIN; RHO FACTOR; ROSCOVITINE; RPR 115135; TIPIFARNIB; TYROSINE KINASE RECEPTOR; UNCLASSIFIED DRUG;

ACUTE GRANULOCYTIC LEUKEMIA; ANOREXIA; ANTINEOPLASTIC ACTIVITY; BONE MARROW SUPPRESSION; BREAST CANCER; CARDIOTOXICITY; CHRONIC MYELOID LEUKEMIA; CLINICAL TRIAL; COLON CANCER; COLORECTAL CANCER; CONTINUOUS INFUSION; DEHYDRATION; DIARRHEA; DRUG ACCUMULATION; DRUG ANTAGONISM; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG DOSE REGIMEN; DRUG ELIMINATION; DRUG ERUPTION; DRUG HALF LIFE; DRUG POTENTIATION; DRUG PROTEIN BINDING; DRUG SYNTHESIS; DRUG TARGETING; DRUG TOLERABILITY; DYSPNEA; ENZYME INHIBITION; FATIGUE; FEBRILE NEUTROPENIA; GASTROINTESTINAL TOXICITY; GENE MUTATION; GLIOBLASTOMA; HEAD AND NECK CANCER; HUMAN; HYPERBILIRUBINEMIA; HYPOTENSION; LETHARGY; LIVER DYSFUNCTION; LUNG NON SMALL CELL CANCER; MYELODYSPLASTIC SYNDROME; NAUSEA; NEUROTOXICITY; NEUTROPENIA; NONHUMAN; PANCREAS CANCER; PARESTHESIA; PERIPHERAL NEUROPATHY; PROTEIN PROCESSING; QT PROLONGATION; RETINA DISEASE; REVIEW; SENSORY NEUROPATHY; SEPSIS; SOLID TUMOR; SOMNOLENCE; STOMATITIS; STRUCTURE ACTIVITY RELATION; TACHYCARDIA; THROMBOCYTOPENIA; VOMITING;

ALKYL AND ARYL TRANSFERASES; ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CLINICAL TRIALS; FARNESYLTRANSTRANSFERASE; HUMANS; MUTATION; NEOPLASMS; PROTEIN ISOPRENYLATION; RAS PROTEINS;

EID: 1642524281     PISSN: 15680118     EISSN: None     Source Type: Journal    
DOI: 10.2174/1568011043482098     Document Type: Review

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