Directed library of anilinogeranyl analogues of farnesyl diphosphate via mixed solid- and solution-phase synthesis

Organic Letters

Volumn 7, Issue 11, 2005, Pages 2109-2112

  Subramanian, Thangaiah ^a   Wang, Zhongwen ^a,b   Troutman, Jerry M ^a   Andres, Douglas A ^a,b   Spielmann, H Peter ^a,b  

^a UNIVERSITY OF KENTUCKY   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANILINE DERIVATIVE; FARNESYL DIPHOSPHATE; PHOSPHORUS DERIVATIVE; PYROPHOSPHATE;

AMINATION; ARTICLE; BROMINATION; SOLID PHASE SYNTHESIS; SYNTHESIS;

ALCOHOLS; ANILINE COMPOUNDS; COMBINATORIAL CHEMISTRY TECHNIQUES; MOLECULAR STRUCTURE; POLYISOPRENYL PHOSPHATES; TERPENES;

EID: 20444442345     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol050386o     Document Type: Article

References (25)

1. Scheffzek, K.; Ahmadian, M. R.; Wittinghofer, A. Trends Biochem. Sci. 1998, 23, 257-262.
2. Zhang, F. L.; Casey, P. J. Annu. Rev. Biochem. 1996, 65, 241-269.
3. Malumbres, M.; Barbacid, M. Nat. Rev. Cancer 2003, 3, 459-465.
4. Glomset, J. A.; Farnsworth, C. C. Annu. Rev. Cell Biol. 1994, 10, 181-205.
5. Reiss, Y.; Goldstein, J. L.; Seabra, M. C.; Casey, P. J.; Brown, M. S. Cell 1990, 62, 81-88.
6. Clarke, S. Annu. Rev. Biochem. 1992, 61, 355-386.
7. Cox, A. D.; Der, C. J. Cancer Biol. Ther. 2002, 1, 599-606.
8. Cox, A. D. Drugs 2001, 61, 723-732.
9. Sebti, S. M.; Hamilton, A. D. Oncogene 2000, 19, 6584-6593.
10. Turek, T. C.; Gaon, I.; Distefano, M. D.; Strickland. C. L. J. Org. Chem. 2001, 66, 3253-3264.
11. Kale, T. A.; Hsieh, S. A.; Rose, M. W.; Distefano, M. D. Curr. Top. Med. Chem. 2003, 3, 1043-1074.
12. Gibbs, B. S.; Zahn, T. J.; Mu, Y.; Sebolt-Leopold, J. S.; Gibbs, R. A. J. Med. Chem. 1999, 42, 3800-3808.
13. Chehade, K. A.; Andres, D. A.; Morimoto, H.; Spielmann, H. P. J. Org. Chem. 2000, 65, 3027-3033.
14. Micali, E.; Chehade, K. A.; Isaacs, R. J.; Andres, D. A.; Spielmann, H. P. Biochemistry 2001, 40, 12254-12265.
15. Chehade, K. A.; Kiegiel, K.; Isaacs, R. J.; Pickett, J. S.; Bowers, K. E.; Fierke, C. A.; Andres, D. A.; Spielmann, H. P. J. Am. Chem. Soc. 2002, 124, 8206-8219.
16. Rawat, D. S.; Gibbs, R. A. Org. Lett. 2002, 4, 3027-3030.
17. Maltais, R.; Tremblay, M. R.; Poirier, D. J. Comb. Chem. 2000, 2, 604-614.
18. Maltais, R.; Luu-The, V.; Poirier, D. Bioorg. Med. Chem. 2001, 9, 3101-3111.
19. Haque, T. S.; Tadesse, S.; Marcinkeviciene, J.; Rogers, M. J.; Sizemore, C.; Kopcho, L. M.; Amsler, K.; Ecret, L. D.; Zhan, D. L.; Hobbs, F.; Slee, A.; Trainor, G. L.; Stern, A. M.; Copeland, R. A.; Combs, A. P. J. Med. Chem. 2002, 45, 4669-4678.
20. Maltais, R.; Luu-The, V.; Poirier, D. J. Med. Chem. 2002, 45, 640-653.
21. Lepre, C. A.; Peng, J.; Fejzo, J.; Abdul-Manan, N.; Pocas, J.; Jacobs, M.; Xie, X.; Moore, J. M. Comb. Chem. High Throughput Screening 2002, 5, 583-590.
22. Thompson, L. A.; Ellman, J. A. Chem. Rev. 1996, 96, 555-600.
23. Ma, S.; Duan, D.; Wang, Y. J. Comb. Chem. 2002, 4, 239-247.
24. Mu, Y.; Gibbs, R. A.; Eubanks, L. M.; Poulter, C. D. J. Org. Chem. 1996, 61, 8010-8015.
25. Davisson, V. J.; Woodside, A. B.; Neal, T. R.; Stremler, K. E.; Muehlbacher, M.; Poulter, C. D. J. Org. Chem. 1986, 51, 4768-4779.