Mitogen-activated protein kinases as potential targets for pain killers

Current Opinion in Investigational Drugs

Volumn 5, Issue 1, 2004, Pages 71-75

  Ji, Ru Rong ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Analgesics; ERK; Inflammatory pain; Neural plasticity; Neuropathic pain; p38 MAPK

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANALGESIC AGENT; INTERLEUKIN 1BETA; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE P38; MORPHINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NEUROKININ; NIFEDIPINE; NPC 037282; PRODYNORPHIN; PROSTAGLANDIN E2; SYNAPTOPHYSIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANALGESIA; ANALGESIC ACTIVITY; ARTICLE; CENTRAL NERVOUS SYSTEM; DRUG EFFICACY; DRUG STRUCTURE; DRUG TARGETING; ENZYME ACTIVATION; ENZYME INHIBITION; GLIA; HUMAN; INFLAMMATION; NERVE CELL PLASTICITY; NERVE INJURY; NEUROPATHIC PAIN; NOCICEPTION; NONHUMAN; PAIN; PERIPHERAL NERVOUS SYSTEM; PROTEIN FUNCTION; PROTEIN PROCESSING; SENSORY NERVE CELL; SPINAL CORD DORSAL HORN; SPINAL CORD NERVE CELL; TISSUE INJURY; TRANSCRIPTION REGULATION; TRANSLATION REGULATION;

ANALGESICS; ANIMALS; DRUG DELIVERY SYSTEMS; DRUG DESIGN; ENZYME ACTIVATION; ENZYME INHIBITORS; HUMANS; INFLAMMATION; MITOGEN-ACTIVATED PROTEIN KINASES; PAIN; PERIPHERAL NERVOUS SYSTEM DISEASES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 2342441834     PISSN: 14724472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Julius D, Basbaum AI: Molecular mechanisms of nociception. Nature (2001) 413(6852):203-210.
2. Woolf CJ, Salter MW: Neuronal plasticity: Increasing the gain in pain. Science (2000) 288(5472):1765-1769.
3. Woolf CJ, Mannion RJ: Neuropathic pain: Aetiology, symptoms, mechanisms, and management. Lancet (1999) 353(9168):1959-1964.
4. Koltzenburg M: Painful neuropathies. Curr Opin Neurol (1998) 11(5):515-521.
5. Ji RR, Woolf CJ: Neuronal plasticity and signal transduction in nociceptive neurons: Implications for the initiation and maintenance of pathological pain. Neurobiol Dis (2001) 8(1):1-10.
6. Widmann C, Gibson S, Jarpe MB, Johnson GL: Mitogen-activated protein kinase: Conservation of a three-kinase module from yeast to human. Physiol Rev (1999) 79(1):143-180.
7. Atkins CM, Selcher JC, Petraitis JJ, Trzaskos JM, Sweatt JD: The MAPK cascade is required for mammalian associative learning. Nat Neurosci (1998) 1(7):602-609.
8. Ji RR, Baba H, Brenner GJ, Woolf CJ: Nociceptive-specific activation of ERK in spinal neurons contributes to pain hypersensitivity. Nat Neurosci (1999) 2(12):1114-1119.
9. Karim F, Wang CC, Gereau RW: Metabotropic glutamate receptor subtypes 1 and 5 are activators of extracellular signal-regulated kinase signaling required for inflammatory pain in mice. J Neurosci (2001) 21(11):3771-3779.
10. Hunt SP, Pini A, Evan G: Induction of c-fos-like protein in spinal cord neurons following sensory stimulation. Nature (1987) 328(6131):632-634.
11. Menetrey D, Gannon A, Levine JD, Basbaum AI: Expression of c-fos protein in interneurons and projection neurons of the rat spinal cord in response to noxious somatic, articular, and visceral stimulation. J Comp Neurol (1989) 285(2):177-195.
12. Presley RW, Menetrey D, Levine JD, Basbaum AI: Systemic morphine suppresses noxious stimulus-evoked fos protein-like immunoreactivity in the rat spinal cord. J Neurosci (1990) 10(1):323-335.
13. Traub RJ, Pechman P, Iadarola MJ, Gebhart GF: Fos-like proteins in the lumbosacral spinal cord following noxious and non-noxious colorectal distention in the rat. Pain (1992) 49(3):393-403.
14. Ji RR, Befort K, Brenner GJ, Woolf CJ: ERK MAP kinase activation in superficial spinal cord neurons induces prodynorphin and NK-1 upregulation and contributes to persistent inflammatory pain hypersensitivity. J Neurosci (2002) 22(2):478-485.
15. Dubner R, Ruda MA: Activity-dependent neuronal plasticity following tissue injury and inflammation. Trends Neurosci (1992) 15(3):96-103.
16. Iadarola MJ, Brady LS, Draisci G, Dubner R: Enhancement of dynorphin gene expression in spinal cord following experimental inflammation: Stimulus specificity, behavioral parameters and opioid receptor binding. Pain (1988) 35(3):313-326.
17. Abbadie C, Brown JL, Mantyh PW, Basbaum AI: Spinal cord substance P receptor immunoreactivity increases in both inflammatory and nerve injury models of persistent pain. Neuroscience (1996) 70(1):201-209.
18. Obata K, Yamanaka H, Dai Y, Tachibana T, Fukuoka T, Tokunaga A, Yoshikawa H, Noguchi K: Differential activation of extracellular signal-regulated protein kinase in primary afferent neurons regulates brain-derived neurotrophic factor expression after peripheral inflammation and nerve injury. J Neurosci (2003) 23(10):4117-4126.
19. Mannion RJ, Costigan M, Decosterd I, Amaya F, Ma QP, Holstege JC, Ji RR, Acheson A, Lindsay RM, Wilkinson GA, Woolf CJ: Neurotrophins: Peripherally and centrally acting modulators of tactile stimulus-induced inflammatory pain hypersensitivity. Proc Natl Acad Sci USA (1999) 96(16):9385-9390.
20. Ji RR, Samad TA, Jin SX, Schmoll R, Woolf CJ: p38 MAPK activation by NGF in primary sensory neurons after inflammation increases TRPV1 levels and maintains heat hyperalgesia. Neuron (2002) 36(1):57-68.
21. Caterina MJ, Leffler A, Malmberg AB, Martin WJ, Trafton J, Petersen-Zeitz KR, Koltzenburg M, Basbaum AI, Julius D: Impaired noniception and pain sensation in mice lacking the capsaicin receptor. Science (2000) 288(5464):306-313.
22. Davis JB, Gray J, Gunthorpe MJ, Hatcher JP, Davey PT, Overend P, Harries MH, Latcham J, Clapham C, Atkinson K, Hughes SA et al: Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia. Nature (2000) 405(6783):183-187.
23. Carlton SM, Coggeshall RE: Peripheral capsaicin receptors increase in the inflamed rat hindpaw: A possible mechanism for peripheral sensitization. Neurosci Lett (2001) 310(1):53-56.
24. Meller ST, Dykstra C, Grzybycki D, Murphy S, Gebhart GF: The possible role of glia in nociceptive processing and hyperalgesia in the spinal cord of the rat. Neuropharmacology (1994) 33(11):1471-1478.
25. DeLeo JA, Yezierski RP: The role of neuroinflammation and neuroimmune activation in persistent pain. Pain (2001) 90(1-2):1-6.
26. Watkins LR, Milligan ED, Maier SF: Glial activation: A driving force for pathological pain. Trends Neurosci (2001) 24(8):450-455.
27. Winkelstein BA, Rutkowski MD, Sweitzer SM, Pahl JL, DeLeo JA: Nerve injury proximal or distal to the DRG induces similar spinal glial activation and selective cytokine expression but differential behavioral responses to pharmacologic treatment. J Comp Neurol (2001) 439(2):127-139.
28. Jin SX, Zhuang ZY, Woolf CJ, Ji RR: p38 mitogen-activated protein kinase is activated after a spinal nerve ligation in spinal cord microglia and dorsal root ganglion neurons and contributes to the generation of neuropathic pain. J Neurosci (2003) 23(10):4017-4022.
29. Kim SH, Chung JM: An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat. Pain (1992) 50(3):355-363.
30. Schafers M, Svensson CI, Sommer C, Sorkin LS: Tumor necrosis factor-α induces mechanical allodynia after spinal nerve ligation by activation of p38 MAPK in primary sensory neurons. J Neurosci (2003) 23(7):2517-2521.
31. Medicherla S, Sweitzer SM, Scott B, Feng Y, Liu Y, Yeomans DC, Protter A: Antinociceptive action of a p38α MAPK inhibitor, NPC-037282, in a diabetic neuropathy model. Soc Neurosci Abstr (2002) 32:Abs 757.6.
32. Geisser ME, Casey KL, Brucksch CB, Ribbens CM, Appleton BB, Crofford LJ: Perception of noxious and innocuous heat stimulation among healthy women and women with fibromyalgia: Association with mood, somatic focus, and catastrophizing. Pain (2003) 102(3):243-250.
33. Henriksson KG: Fibromyalgia - from syndrome to disease. Overview of pathogenetic mechanisms. J Rehabil Med (2003) 41(Suppl):89-94.