Inhibition of hyperalgesia by ablation of lamina I spinal neurons expressing the substance P receptor

Science

Volumn 278, Issue 5336, 1997, Pages 275-279

  Mantyh, Patrick W ^a,b   Rogers, Scott D ^a,b   Honore, Prisca ^a,b   Allen, Brian J ^a,b   Ghilardi, Joseph R ^a,b   Li, Jun ^b   Daughters, Randy S ^b   Lappi, Douglas A ^c   Wiley, Ronald G ^a   Simone, Donald A ^b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

^c Advanced Targeting Systems   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SAPORIN; SUBSTANCE P; SUBSTANCE P RECEPTOR;

ARTICLE; CYTOTOXICITY; ETIOLOGY; HYPERALGESIA; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RECEPTOR BINDING; SPINAL CORD NERVE CELL;

ANIMALS; CAPSAICIN; CELL MEMBRANE; CELLS, CULTURED; FLUORESCENT ANTIBODY TECHNIQUE; HYPERALGESIA; IMMUNOTOXINS; INJECTIONS, SPINAL; N-GLYCOSYL HYDROLASES; NEURONS; PAIN; PAIN MEASUREMENT; PLANT PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, NEUROKININ-1; SIGNAL TRANSDUCTION; SPINAL CORD; SUBSTANCE P;

EID: 0030764290     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.278.5336.275     Document Type: Article

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58. We thank S. Vigna for antibody to SPR and J. Maggio for antibody to SP and A. Georgopoulos, M. Nichols, and S. Vigna for helpful suggestions and critical reading of the manuscript. Supported by NIH grants NS23970, NS31223, and MH56368, a Veterans Administration Merit Review, and the Association Française pour la Recherche en Thérapeutique.