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Volumn 13, Issue 30, 2007, Pages 3065-3072

Salivary defensins and their importance in oral health and disease

Author keywords

Antimicrobial peptide; Clinical application; Defensin; Disease; Gingival fluid; Oral; Saliva; Salivary gland

Indexed keywords

ALPHA DEFENSIN; BETA DEFENSIN; BETA DEFENSIN 2; BETA DEFENSIN 3; DEFENSIN; LENTIVIRUS VECTOR; MESSENGER RNA; POLYPEPTIDE ANTIBIOTIC AGENT;

EID: 34548690015     PISSN: 13816128     EISSN: None     Source Type: Journal    
DOI: 10.2174/138161207782110417     Document Type: Review
Times cited : (53)

References (122)
  • 2
    • 0034533621 scopus 로고    scopus 로고
    • Epithelial structural protein of the skin and oral cavity: Function in health and disease
    • Presland RB, Dale BA. Epithelial structural protein of the skin and oral cavity: Function in health and disease. Crit Rev Oral Biol Med 2000; 11: 383-408.
    • (2000) Crit Rev Oral Biol Med , vol.11 , pp. 383-408
    • Presland, R.B.1    Dale, B.A.2
  • 3
    • 0023286455 scopus 로고
    • The functions of saliva
    • Mandel ID. The functions of saliva. J Dent Res 1987; 66: 623-7.
    • (1987) J Dent Res , vol.66 , pp. 623-627
    • Mandel, I.D.1
  • 4
    • 0036119654 scopus 로고    scopus 로고
    • Saliva-the defender of the oral cavity
    • Amerongen AV, Veerman EC. Saliva-the defender of the oral cavity. Oral Dis 2002; 8: 12-22.
    • (2002) Oral Dis , vol.8 , pp. 12-22
    • Amerongen, A.V.1    Veerman, E.C.2
  • 5
    • 29144521244 scopus 로고    scopus 로고
    • Human antimicrobial peptides: Defensins, cathelicidins and histatins
    • De Smet K, Contreras R. Human antimicrobial peptides: Defensins, cathelicidins and histatins. Biotechnol Lett 2005; 27: 1337-47.
    • (2005) Biotechnol Lett , vol.27 , pp. 1337-1347
    • De Smet, K.1    Contreras, R.2
  • 7
    • 0036891933 scopus 로고    scopus 로고
    • Cathelicidin antimicrobial peptides are expressed in salivary glands and saliva
    • Murakami M. Ohtake T, Dorchner RA, Gallo RL. Cathelicidin antimicrobial peptides are expressed in salivary glands and saliva. Dent Res 2002; 81: 845-50.
    • (2002) Dent Res , vol.81 , pp. 845-850
    • Murakami, M.1    Ohtake, T.2    Dorchner, R.A.3    Gallo, R.L.4
  • 10
    • 0035937107 scopus 로고    scopus 로고
    • Isolation and characterization of human beta-defensin-3, a novel human inductible peptide antibiotics
    • Harder J, Bartels J, Christophers E, Schroder JM. Isolation and characterization of human beta-defensin-3, a novel human inductible peptide antibiotics. J Biol Chem 2001; 276: 5707-13.
    • (2001) J Biol Chem , vol.276 , pp. 5707-5713
    • Harder, J.1    Bartels, J.2    Christophers, E.3    Schroder, J.M.4
  • 13
    • 33748094122 scopus 로고    scopus 로고
    • Antimicrobial peptides: An essential component of the skin defensive barrier
    • Braff MH, Gallo RL. Antimicrobial peptides: An essential component of the skin defensive barrier. Curr Top. Microbiol Immunol. 2006; 306: 91-110.
    • (2006) Curr Top. Microbiol Immunol , vol.306 , pp. 91-110
    • Braff, M.H.1    Gallo, R.L.2
  • 14
    • 33745698864 scopus 로고    scopus 로고
    • Defensins in innate antiviral immunity
    • Klotman ME, Chang TL. Defensins in innate antiviral immunity. Nat Rev Immunol 2006; 6: 447-56.
    • (2006) Nat Rev Immunol , vol.6 , pp. 447-456
    • Klotman, M.E.1    Chang, T.L.2
  • 16
    • 20644462344 scopus 로고    scopus 로고
    • Mammalian defensins in the antimicrobial immune response
    • Selsted ME, Ouellette AJ. Mammalian defensins in the antimicrobial immune response. Nat Immunol 2005; 6: 551-7.
    • (2005) Nat Immunol , vol.6 , pp. 551-557
    • Selsted, M.E.1    Ouellette, A.J.2
  • 17
    • 0033664277 scopus 로고    scopus 로고
    • Leukocyte antimicrobial peptides: Multifunctional effector molecules of innate immunity
    • Risso A. Leukocyte antimicrobial peptides: Multifunctional effector molecules of innate immunity. J Leukocyte Biol 2000; 68: 785-92.
    • (2000) J Leukocyte Biol , vol.68 , pp. 785-792
    • Risso, A.1
  • 19
    • 0029819784 scopus 로고    scopus 로고
    • Paneth cell defensins: Endogeneous peptide components of intestinal host defense
    • Ouellette AJ, Selested ME. Paneth cell defensins: Endogeneous peptide components of intestinal host defense. FASEB J 1996; 10: 1280-9.
    • (1996) FASEB J , vol.10 , pp. 1280-1289
    • Ouellette, A.J.1    Selested, M.E.2
  • 20
    • 0032875134 scopus 로고    scopus 로고
    • Innate mechanism of epithelial host defense: Spotlight on intestine
    • Hecht G. Innate mechanism of epithelial host defense: Spotlight on intestine. Am J Physiol 1999; 277: 351-8.
    • (1999) Am J Physiol , vol.277 , pp. 351-358
    • Hecht, G.1
  • 21
    • 0033848233 scopus 로고    scopus 로고
    • Determination of defensin HNP-1, HNP-2, and HNP-3 in human saliva by using LC/MS
    • Goebel C, Mackay LG, Vickers ER, Mather LE. Determination of defensin HNP-1, HNP-2, and HNP-3 in human saliva by using LC/MS. Peptides 20000; 21: 757-65.
    • Peptides , vol.2000 , Issue.21 , pp. 757-765
    • Goebel, C.1    Mackay, L.G.2    Vickers, E.R.3    Mather, L.E.4
  • 22
    • 0142228796 scopus 로고    scopus 로고
    • Decreased excretion of antimicrobial proteins and peptides in saliva of patients with oral candidiasis
    • Tanida T, Okamoto T, Okamoto A, Wang H, Hamada T, Ueta E, et al. Decreased excretion of antimicrobial proteins and peptides in saliva of patients with oral candidiasis. J Oral Pathol Med 2003; 32: 586-94.
    • (2003) J Oral Pathol Med , vol.32 , pp. 586-594
    • Tanida, T.1    Okamoto, T.2    Okamoto, A.3    Wang, H.4    Hamada, T.5    Ueta, E.6
  • 23
  • 24
    • 0032407465 scopus 로고    scopus 로고
    • Defensin-1, a peptide detected in the saliva of oral squamous cell carcinoma patients
    • Mizukawa N, Sugiyama K, Fukunaga J, Ueno T, Mishima K, Takagi S, et al. Defensin-1, a peptide detected in the saliva of oral squamous cell carcinoma patients, Anticancer Res 1998; 18: 4645-9.
    • (1998) Anticancer Res , vol.18 , pp. 4645-4649
    • Mizukawa, N.1    Sugiyama, K.2    Fukunaga, J.3    Ueno, T.4    Mishima, K.5    Takagi, S.6
  • 26
    • 0032589454 scopus 로고    scopus 로고
    • Defensin-1, an antimicrobial peptide present in the saliva of patients with oral disease
    • Mizukawa N, Sugiyama K, Ueno T, Mishima K, Takagi S, Sugahara T. Defensin-1, an antimicrobial peptide present in the saliva of patients with oral disease. Oral Dis 1999; 5: 139-42.
    • (1999) Oral Dis , vol.5 , pp. 139-142
    • Mizukawa, N.1    Sugiyama, K.2    Ueno, T.3    Mishima, K.4    Takagi, S.5    Sugahara, T.6
  • 29
    • 10644233169 scopus 로고    scopus 로고
    • Detection of individual human neutrophil alpha-defensins (human neutrophil peptides 1, 2 and 3) in unfractionated gingival crevicular fluid-a MALDI-MS approach
    • Lundy FT, Orr DF, Shaw C, Lamey PJ, Linden GJ. Detection of individual human neutrophil alpha-defensins (human neutrophil peptides 1, 2 and 3) in unfractionated gingival crevicular fluid-a MALDI-MS approach. Mol Immunol 2005; 42: 575-9.
    • (2005) Mol Immunol , vol.42 , pp. 575-579
    • Lundy, F.T.1    Orr, D.F.2    Shaw, C.3    Lamey, P.J.4    Linden, G.J.5
  • 31
    • 0032313341 scopus 로고    scopus 로고
    • Epithelial anitimicrobial peptides: Review and significant for oral applications
    • Weinberg A, Krisanaprakornkit S, Dale BA: Epithelial anitimicrobial peptides: Review and significant for oral applications. Crit Rev Oral Biol Med 1998; 9: 399-414.
    • (1998) Crit Rev Oral Biol Med , vol.9 , pp. 399-414
    • Weinberg, A.1    Krisanaprakornkit, S.2    Dale, B.A.3
  • 32
    • 0038634160 scopus 로고    scopus 로고
    • Schroder JM, Harder J. Human beta-defensin-2. In J Biochem Cell Biol 1999; 31: 645-51.
    • Schroder JM, Harder J. Human beta-defensin-2. In J Biochem Cell Biol 1999; 31: 645-51.
  • 33
    • 0034929327 scopus 로고    scopus 로고
    • Defensin antimicrobial peptides in the oral cavity
    • Dale BA, Krishnaprakornkit S. Defensin antimicrobial peptides in the oral cavity. J Oral Pathol Med 2001; 30: 321-7.
    • (2001) J Oral Pathol Med , vol.30 , pp. 321-327
    • Dale, B.A.1    Krishnaprakornkit, S.2
  • 34
    • 0001475281 scopus 로고    scopus 로고
    • Garcia J-RC, Jaumann F, Schulz S, Krause A, Rodriguez-JF, Forssmann U, et al. Identification of a novel multifunctional β-defensin (human β-defensin 3) with specific antimicrobial activity. Cell Tissue Res 2001; 306: 257-64.
    • Garcia J-RC, Jaumann F, Schulz S, Krause A, Rodriguez-JF, Forssmann U, et al. Identification of a novel multifunctional β-defensin (human β-defensin 3) with specific antimicrobial activity. Cell Tissue Res 2001; 306: 257-64.
  • 35
    • 0034125829 scopus 로고    scopus 로고
    • Mucoid pseudomonas aeruginosa, TNF-α, and IL-1β, but not IL-6 induces human β-defensin-2 in respiratory epithelia
    • Harder J, Mayer-Hoffert U. Teran LM, Schwichtenberg L, Bartels J, Maune S, et al. Mucoid pseudomonas aeruginosa, TNF-α, and IL-1β, but not IL-6 induces human β-defensin-2 in respiratory epithelia. Am J Respir Cell Mol Biol 2000; 22: 714-21.
    • (2000) Am J Respir Cell Mol Biol , vol.22 , pp. 714-721
    • Harder, J.1    Mayer-Hoffert, U.2    Teran, L.M.3    Schwichtenberg, L.4    Bartels, J.5    Maune, S.6
  • 36
    • 0033043785 scopus 로고    scopus 로고
    • Mouse β-defensin 3 is an inducible antimicrobial peptide expressed in the epithelia of multiple organs
    • Bals R, Wang X, Meegalla. RL, Wattler S, Weiner DJ Nehls MC, Wilson JM. Mouse β-defensin 3 is an inducible antimicrobial peptide expressed in the epithelia of multiple organs. Infect Immun 1999; 67: 3524-47.
    • (1999) Infect Immun , vol.67 , pp. 3524-3547
    • Bals, R.1    Wang, X.2    Meegalla, R.L.3    Wattler, S.4    Weiner, D.J.5    Nehls, M.C.6    Wilson, J.M.7
  • 37
    • 0034703072 scopus 로고    scopus 로고
    • CD14-dependent lipopolysaccharide-induced β-defensin-2 expression in human tracheobronchial epithelium
    • Becker MN, Diamond G, Verghese MW, Randell SH. CD14-dependent lipopolysaccharide-induced β-defensin-2 expression in human tracheobronchial epithelium. J Biol Chem 2000; 275: 29731-6.
    • (2000) J Biol Chem , vol.275 , pp. 29731-29736
    • Becker, M.N.1    Diamond, G.2    Verghese, M.W.3    Randell, S.H.4
  • 39
    • 0031913244 scopus 로고    scopus 로고
    • Mouse β-defensin 1 is a salt-sensitive antimicrobial peptide present in epithelia of the lung and urogenital tract
    • Bals R, Goldman MJ, Wilson JM. Mouse β-defensin 1 is a salt-sensitive antimicrobial peptide present in epithelia of the lung and urogenital tract. Infect Immun 1998; 66: 1225-32.
    • (1998) Infect Immun , vol.66 , pp. 1225-1232
    • Bals, R.1    Goldman, M.J.2    Wilson, J.M.3
  • 40
    • 0035430147 scopus 로고    scopus 로고
    • Human β-defensin 4: A novel inducible peptide with a specific salt-sensitive spectrum of antimicrobial activity
    • Garcia J-RC, Krause A, Schulz S, Rodriguez-J F, Kluver E, Adermann K, et al. Human β-defensin 4: A novel inducible peptide with a specific salt-sensitive spectrum of antimicrobial activity. FASEB J 2001; 15: 1819-21.
    • (2001) FASEB J , vol.15 , pp. 1819-1821
    • Garcia, J.-R.C.1    Krause, A.2    Schulz, S.3    Rodriguez-J, F.4    Kluver, E.5    Adermann, K.6
  • 43
    • 0344483901 scopus 로고    scopus 로고
    • Production β-defensin antimicrobial peptides by the oral mucosa and salivary glands
    • Mathews M, Jia HP, Guthmiller JM, Losh G, Graham S, Johnson GK, et al. Production β-defensin antimicrobial peptides by the oral mucosa and salivary glands. Infect Immun 1999; 67: 2740-5.
    • (1999) Infect Immun , vol.67 , pp. 2740-2745
    • Mathews, M.1    Jia, H.P.2    Guthmiller, J.M.3    Losh, G.4    Graham, S.5    Johnson, G.K.6
  • 46
    • 0037406465 scopus 로고    scopus 로고
    • Upregulated expression of human β defensin-1 and -3 mRNA during differestiation of keratinocyte immortalized cell lines, HaCaT and PHK16-0b
    • Abiko Y, Nishimura M, Kusano K, Yamazaki M, Arakawa T, Takuma T, et al. Upregulated expression of human β defensin-1 and -3 mRNA during differestiation of keratinocyte immortalized cell lines, HaCaT and PHK16-0b. J Dermatol Sci 2003; 31: 225-8.
    • (2003) J Dermatol Sci , vol.31 , pp. 225-228
    • Abiko, Y.1    Nishimura, M.2    Kusano, K.3    Yamazaki, M.4    Arakawa, T.5    Takuma, T.6
  • 47
    • 0347540289 scopus 로고    scopus 로고
    • Periodontal epithelium: A newly recognized role in health and disease
    • Dale BA. Periodontal epithelium: A newly recognized role in health and disease. Periodontol 2000 2002; 30: 70-8.
    • (2002) Periodontol 2000 , vol.30 , pp. 70-78
    • Dale, B.A.1
  • 48
    • 4143097141 scopus 로고    scopus 로고
    • Differential gene induction of human beta-defensins (hBD-1, -2, -3, and -4) in keratinocytes is inhibited by retinoic acid
    • Harder J, Mayer-Hoffert U, Wehkamp K, SchwichtenbergL, AchroderJM. Differential gene induction of human beta-defensins (hBD-1, -2, -3, and -4) in keratinocytes is inhibited by retinoic acid. J Invest Dermatol 2004; 123: 522-9.
    • (2004) J Invest Dermatol , vol.123 , pp. 522-529
    • Harder, J.1    Mayer-Hoffert, U.2    Wehkamp, K.3    SchwichtenbergL4    AchroderJM5
  • 49
    • 0035084604 scopus 로고    scopus 로고
    • Differential expression of human beta-defensin 2 in keratinized and non-keratinized oral epithelial lesions; immunohistochemistry and in situ hybridization
    • Abiko Y, Suraweera AK, Nishimura M, Arakawa T, Takuma T, Mizoguchi I, et al. Differential expression of human beta-defensin 2 in keratinized and non-keratinized oral epithelial lesions; immunohistochemistry and in situ hybridization. Virchow Arch 2001; 438: 248-53.
    • (2001) Virchow Arch , vol.438 , pp. 248-253
    • Abiko, Y.1    Suraweera, A.K.2    Nishimura, M.3    Arakawa, T.4    Takuma, T.5    Mizoguchi, I.6
  • 50
    • 0030569343 scopus 로고    scopus 로고
    • Widespread expression of beta-defensin hBD-1 in human secretory glands and epithelial cells
    • Zao C, Wang I, Lehrer RI. Widespread expression of beta-defensin hBD-1 in human secretory glands and epithelial cells. FEBS Lett 1996; 396: 319-22.
    • (1996) FEBS Lett , vol.396 , pp. 319-322
    • Zao, C.1    Wang, I.2    Lehrer, R.I.3
  • 53
    • 4143094791 scopus 로고    scopus 로고
    • Correlated expression of human beta defensin-1, -2 and -3 mRNAs in gingival tissues of young children
    • Saitoh M, Abiko Y, Shimabukuro S, Kusano K, Nishimura M, Arakawa T, et al. Correlated expression of human beta defensin-1, -2 and -3 mRNAs in gingival tissues of young children. Arch Oral Biol 2004; 49: 799-803.
    • (2004) Arch Oral Biol , vol.49 , pp. 799-803
    • Saitoh, M.1    Abiko, Y.2    Shimabukuro, S.3    Kusano, K.4    Nishimura, M.5    Arakawa, T.6
  • 54
    • 0034441731 scopus 로고    scopus 로고
    • Expression of the antimicrobial peptide, human beta-defensin 1, in duct cells of minor salivary glands and detection in saliva
    • Sahasrabudhe KS, Kimball JR, Morton TH, Weinberg A, Dale BA. Expression of the antimicrobial peptide, human beta-defensin 1, in duct cells of minor salivary glands and detection in saliva. J Dent Res 2000; 79: 1669-74.
    • (2000) J Dent Res , vol.79 , pp. 1669-1674
    • Sahasrabudhe, K.S.1    Kimball, J.R.2    Morton, T.H.3    Weinberg, A.4    Dale, B.A.5
  • 55
    • 0742266231 scopus 로고    scopus 로고
    • Presence of human β-defensin 2 peptide in keratinization in salivary gland tumor
    • Abiko Y, Nishimura M, Kusano K, Kaku T. Presence of human β-defensin 2 peptide in keratinization in salivary gland tumor. Oral Med Pathol 2000; 5: 95-7.
    • (2000) Oral Med Pathol , vol.5 , pp. 95-97
    • Abiko, Y.1    Nishimura, M.2    Kusano, K.3    Kaku, T.4
  • 56
    • 0036390959 scopus 로고    scopus 로고
    • Upregulation of human beta-defensin 2 peptide expression in oral lichen planus, leukoplakia and candidiasis; an immunohistochemical study
    • Abiko Y, Jinbu Y, Noguchi T, Nishimura M, Kusano K, Amaratunga P, et al. Upregulation of human beta-defensin 2 peptide expression in oral lichen planus, leukoplakia and candidiasis; an immunohistochemical study. Pathol Res Pract 2002; 198: 537-42.
    • (2002) Pathol Res Pract , vol.198 , pp. 537-542
    • Abiko, Y.1    Jinbu, Y.2    Noguchi, T.3    Nishimura, M.4    Kusano, K.5    Amaratunga, P.6
  • 58
    • 0036040263 scopus 로고    scopus 로고
    • Expression of beta-defensin 1 and 2 mRNA by human monocytes, macrophages and dendritic cells
    • Duits LA, Revensbergen B, Rademaker M, Hiemstra PS, Nibbering PH. Expression of beta-defensin 1 and 2 mRNA by human monocytes, macrophages and dendritic cells. Immunology 2002; 106: 517-25.
    • (2002) Immunology , vol.106 , pp. 517-525
    • Duits, L.A.1    Revensbergen, B.2    Rademaker, M.3    Hiemstra, P.S.4    Nibbering, P.H.5
  • 59
    • 0036120646 scopus 로고    scopus 로고
    • Clinical applications of antimicrobial host proteins lactoperoxidase, lysozyme and lactoferrin in xerostomia: Efficacy and safety
    • Tenovuo J. Clinical applications of antimicrobial host proteins lactoperoxidase, lysozyme and lactoferrin in xerostomia: Efficacy and safety. Oral Dis 2002; 8: 23-9.
    • (2002) Oral Dis , vol.8 , pp. 23-29
    • Tenovuo, J.1
  • 60
    • 21244433198 scopus 로고    scopus 로고
    • Susceptibilities of periodontopathogenic and cariogenic bacteria to antibacterial peptides, {beta}-defensins and LL37, produced by human epithelial cells
    • Ouhara K, Komatsuzawa H, Yamada S, Shiba H, Fujiwara T, Ohara M, et al. Susceptibilities of periodontopathogenic and cariogenic bacteria to antibacterial peptides, {beta}-defensins and LL37, produced by human epithelial cells. Antimicrob Agents Chemother 2005; 55: 888-96.
    • (2005) Antimicrob Agents Chemother , vol.55 , pp. 888-896
    • Ouhara, K.1    Komatsuzawa, H.2    Yamada, S.3    Shiba, H.4    Fujiwara, T.5    Ohara, M.6
  • 61
    • 24344438507 scopus 로고    scopus 로고
    • Differential induction of human beta-defensin expression by periodontal commensals and pathogens in periodontal pocket epithelial cells
    • Vankeerberghen A, Nuytten H, Dierickx K, Quirynen M, Cassiman JJ, Cuppens H. Differential induction of human beta-defensin expression by periodontal commensals and pathogens in periodontal pocket epithelial cells. J Periodontol 2005; 76: 1293-303.
    • (2005) J Periodontol , vol.76 , pp. 1293-1303
    • Vankeerberghen, A.1    Nuytten, H.2    Dierickx, K.3    Quirynen, M.4    Cassiman, J.J.5    Cuppens, H.6
  • 62
    • 0033995146 scopus 로고    scopus 로고
    • Synergistic actions of antibacterial neutrophil defensins and cathelicidins
    • Nagaoka I, Hirota S, Yomogida S, Ohwada A, Hirata M. Synergistic actions of antibacterial neutrophil defensins and cathelicidins. Inflamm Res 2000; 49: 73-9.
    • (2000) Inflamm Res , vol.49 , pp. 73-79
    • Nagaoka, I.1    Hirota, S.2    Yomogida, S.3    Ohwada, A.4    Hirata, M.5
  • 63
    • 0021994946 scopus 로고
    • Electron microprobe analysis of human labial gland secretory granules in cystic fibrosis
    • Izutsu K, Johnson D, Schubert M, Wang E, Ramsey B, Tamarin A, et al. Electron microprobe analysis of human labial gland secretory granules in cystic fibrosis. J Clin Invest 1985; 75: 1951-6.
    • (1985) J Clin Invest , vol.75 , pp. 1951-1956
    • Izutsu, K.1    Johnson, D.2    Schubert, M.3    Wang, E.4    Ramsey, B.5    Tamarin, A.6
  • 64
    • 0033136135 scopus 로고    scopus 로고
    • The flow rate and composition of human labial gland saliva
    • Ferguson DB. The flow rate and composition of human labial gland saliva, Arch Oral Biol 1999; 44(Suppl 1): S11-4.
    • (1999) Arch Oral Biol , vol.44 , Issue.SUPPL. 1
    • Ferguson, D.B.1
  • 66
    • 0030949875 scopus 로고    scopus 로고
    • Human beta-defensin-1 is a salt-sensitive antibiotic in lung that is inactivated in cystic fibrosis
    • Goldman MJ, Anderson GM, Stolzenberg ED, Kari UP, Zasloff M, Wilson JM. Human beta-defensin-1 is a salt-sensitive antibiotic in lung that is inactivated in cystic fibrosis. Cell 1997; 88: 553-60.
    • (1997) Cell , vol.88 , pp. 553-560
    • Goldman, M.J.1    Anderson, G.M.2    Stolzenberg, E.D.3    Kari, U.P.4    Zasloff, M.5    Wilson, J.M.6
  • 68
    • 14744281431 scopus 로고    scopus 로고
    • Susceptibility of Streptococcus mutans and Actinobacillus actino-mycetemcomitans to bactericidal activity of human beta-defensin 3 in biological fluids
    • Maisetta G, Batoni G, Esin S, Raco, G, Bottai D, Favilli F, et al. Susceptibility of Streptococcus mutans and Actinobacillus actino-mycetemcomitans to bactericidal activity of human beta-defensin 3 in biological fluids. Antimicrob Agents Chemother 2005; 49: 1245-8.
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 1245-1248
    • Maisetta, G.1    Batoni, G.2    Esin, S.3    Raco, G.4    Bottai, D.5    Favilli, F.6
  • 69
    • 0034441731 scopus 로고    scopus 로고
    • Expression of the antimicrobial peptide, human beta-defenlin 1, in duct cells of minor salivary gland and detection in saliva
    • Sahasrabudhe KS, Kimball JR, Morton TH, Weinberg A, Dale BA. Expression of the antimicrobial peptide, human beta-defenlin 1, in duct cells of minor salivary gland and detection in saliva. J Dent Res 2000; 79: 1669-74.
    • (2000) J Dent Res , vol.79 , pp. 1669-1674
    • Sahasrabudhe, K.S.1    Kimball, J.R.2    Morton, T.H.3    Weinberg, A.4    Dale, B.A.5
  • 70
    • 0031089153 scopus 로고    scopus 로고
    • Human salivary mucin MG1 selectively forms heterotypic complexes with amylase, proline-rich proteins, statherin, and histatins
    • Iontcheva I, Oppenheim FG, Troxler RF. Human salivary mucin MG1 selectively forms heterotypic complexes with amylase, proline-rich proteins, statherin, and histatins. J Dent Res 1997; 76: 734-43.
    • (1997) J Dent Res , vol.76 , pp. 734-743
    • Iontcheva, I.1    Oppenheim, F.G.2    Troxler, R.F.3
  • 71
    • 0026094266 scopus 로고
    • Interaction of a salivary mucin-secretory immunoglobulin A complex with mucosal pathogens
    • Biesbrock AR, Reddy MS, Levine MJ. Interaction of a salivary mucin-secretory immunoglobulin A complex with mucosal pathogens. Infect Immun 1991; 59: 3492-7.
    • (1991) Infect Immun , vol.59 , pp. 3492-3497
    • Biesbrock, A.R.1    Reddy, M.S.2    Levine, M.J.3
  • 72
    • 0033214433 scopus 로고    scopus 로고
    • Regulation of intestinal alpha-defensin activation by the metalloproteinase matrilysin in innate host defense
    • Wilson CL, Ouellette AJ, Satchell DP, Ayabe T, Lopez-Boado YS, Stratman JL, et al. Regulation of intestinal alpha-defensin activation by the metalloproteinase matrilysin in innate host defense. Science 1999; 286: 113-7.
    • (1999) Science , vol.286 , pp. 113-117
    • Wilson, C.L.1    Ouellette, A.J.2    Satchell, D.P.3    Ayabe, T.4    Lopez-Boado, Y.S.5    Stratman, J.L.6
  • 74
    • 0242721348 scopus 로고    scopus 로고
    • Expression and distribution of osteopontin and matrix metalloproteinase (MMP)-3 and -7 in mouse salivary glands
    • Muramatsu T, Ohta K, Asaka M, Kizaki H, Shimono M. Expression and distribution of osteopontin and matrix metalloproteinase (MMP)-3 and -7 in mouse salivary glands. Eur J Morphol 2002; 40: 209-12.
    • (2002) Eur J Morphol , vol.40 , pp. 209-212
    • Muramatsu, T.1    Ohta, K.2    Asaka, M.3    Kizaki, H.4    Shimono, M.5
  • 75
    • 26844567701 scopus 로고    scopus 로고
    • Synergistic effect of antibacterial agents human beta-defensins, cathelicidin LL-37 and lysozyme against Staphylococcus aureus and Escherichia coli
    • Chen X, Niyonsaba F, Ushio H, Okuda D. Nagaoka I, Ikeda S, et al. Synergistic effect of antibacterial agents human beta-defensins, cathelicidin LL-37 and lysozyme against Staphylococcus aureus and Escherichia coli. J Dermatol Sci 2005; 40: 123-32.
    • (2005) J Dermatol Sci , vol.40 , pp. 123-132
    • Chen, X.1    Niyonsaba, F.2    Ushio, H.3    Okuda, D.4    Nagaoka, I.5    Ikeda, S.6
  • 77
    • 0033981142 scopus 로고    scopus 로고
    • Transcriptional regulation of β-defensin gene expression in tracheal epithelial cells
    • Diamond G, Kaiser V, Rhodes J, Russell JP, Revins CL. Transcriptional regulation of β-defensin gene expression in tracheal epithelial cells. Infect Immun 2000; 68: 113-9.
    • (2000) Infect Immun , vol.68 , pp. 113-119
    • Diamond, G.1    Kaiser, V.2    Rhodes, J.3    Russell, J.P.4    Revins, C.L.5
  • 79
    • 0036136328 scopus 로고    scopus 로고
    • Regulation of human beta-defensin-2 in gingival cells: The involvement of mitogen-activated protein kinase pathways but not the NF-kappa B transcription factor family
    • Krisanaprakomkit S, Kimball JR, Dale BA. Regulation of human beta-defensin-2 in gingival cells: The involvement of mitogen-activated protein kinase pathways but not the NF-kappa B transcription factor family. J Immunol, 2002; 168: 316-24.
    • (2002) J Immunol , vol.168 , pp. 316-324
    • Krisanaprakomkit, S.1    Kimball, J.R.2    Dale, B.A.3
  • 80
    • 0036178642 scopus 로고    scopus 로고
    • Human beta-defensin-2 production in keratinocyte is regulated by interleukin-1, bacteria and the state of differentiation
    • Liu AY, Destoumieux D, Wong AV, Park CH, Valore EV, Liu L, et al. Human beta-defensin-2 production in keratinocyte is regulated by interleukin-1, bacteria and the state of differentiation. J Invest Dermatol 2002; 118: 275-81.
    • (2002) J Invest Dermatol , vol.118 , pp. 275-281
    • Liu, A.Y.1    Destoumieux, D.2    Wong, A.V.3    Park, C.H.4    Valore, E.V.5    Liu, L.6
  • 81
    • 18444367057 scopus 로고    scopus 로고
    • Activation of a Src-dependent Raf-MEK1/2-ERK signaling pathway is required for IL-1 alpha-induced upregulation of beta-defensin 2 in human middle ear epithelial cells. BBA-Mol
    • Moon SK, Lee HY, Li JD, Nagura M, Kang SH, Chun YM, et al. Activation of a Src-dependent Raf-MEK1/2-ERK signaling pathway is required for IL-1 alpha-induced upregulation of beta-defensin 2 in human middle ear epithelial cells. BBA-Mol Cell Res 2002; 1590: 41-51.
    • (2002) Cell Res , vol.1590 , pp. 41-51
    • Moon, S.K.1    Lee, H.Y.2    Li, J.D.3    Nagura, M.4    Kang, S.H.5    Chun, Y.M.6
  • 82
    • 0037040913 scopus 로고    scopus 로고
    • The solution of structures of the human beta-defensins lead to a better understanding of the potent bactericidal activity of HBD3 against Staphylococcus aureus
    • Schibli DJ, Hunter HN, Aseyev V, Starner TD, Wiencek JM, McCray PB, et al. The solution of structures of the human beta-defensins lead to a better understanding of the potent bactericidal activity of HBD3 against Staphylococcus aureus. J Biol Chem 2002; 277: 8279-89.
    • (2002) J Biol Chem , vol.277 , pp. 8279-8289
    • Schibli, D.J.1    Hunter, H.N.2    Aseyev, V.3    Starner, T.D.4    Wiencek, J.M.5    McCray, P.B.6
  • 83
    • 0036142740 scopus 로고    scopus 로고
    • NF-kappa B-mediated transcriptional regulation of human beta-defensin-2 gene following lipopolysac-charide stimulation
    • Tsutsumi-Ishii Y, Nagaoka I. NF-kappa B-mediated transcriptional regulation of human beta-defensin-2 gene following lipopolysac-charide stimulation. J Leukocyte Biol 2002; 71: 154-62.
    • (2002) J Leukocyte Biol , vol.71 , pp. 154-162
    • Tsutsumi-Ishii, Y.1    Nagaoka, I.2
  • 84
    • 14744281431 scopus 로고    scopus 로고
    • Susceptibility of Streptococcus mutans and Actinobacillus actino-mycetemcomitans to bactericidal activity of human beta-defensin 3 in biological fluids
    • Maisetta G, Batoni G, Esin S, Raco G, Bottai D, Favilli F, et al. Susceptibility of Streptococcus mutans and Actinobacillus actino-mycetemcomitans to bactericidal activity of human beta-defensin 3 in biological fluids. Antimicrob Agents Chemother 2005; 49: 1245-8.
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 1245-1248
    • Maisetta, G.1    Batoni, G.2    Esin, S.3    Raco, G.4    Bottai, D.5    Favilli, F.6
  • 85
    • 0242642285 scopus 로고    scopus 로고
    • Selective induction of human beta-defensin mRNAs by Actinobacillus actinomycetemcomitans in primary and immortalized oral epithelial cells
    • Feucht EC, DeSanti CL, Weinberg A. Selective induction of human beta-defensin mRNAs by Actinobacillus actinomycetemcomitans in primary and immortalized oral epithelial cells. Oral Microbiol Immun 2003; 18: 359-63.
    • (2003) Oral Microbiol Immun , vol.18 , pp. 359-363
    • Feucht, E.C.1    DeSanti, C.L.2    Weinberg, A.3
  • 88
    • 33747157233 scopus 로고    scopus 로고
    • Lipopolysaccharide induced-in vivo increases in beta-defensins of the rat parotid gland
    • Darnell M, Aras HC, Magnusson B, Ekstrom J. Lipopolysaccharide induced-in vivo increases in beta-defensins of the rat parotid gland. Arch Oral Biol 2006; 51: 769-74.
    • (2006) Arch Oral Biol , vol.51 , pp. 769-774
    • Darnell, M.1    Aras, H.C.2    Magnusson, B.3    Ekstrom, J.4
  • 89
    • 0037219471 scopus 로고    scopus 로고
    • Differential expression of alpha- and beta-defensins in human peripheral blood
    • Fang XM, Shu Q, Chen QX, Book M, Sahl HG, Hoeft A, et al. Differential expression of alpha- and beta-defensins in human peripheral blood. Eur J Clin Invest 2003; 33: 82-7.
    • (2003) Eur J Clin Invest , vol.33 , pp. 82-87
    • Fang, X.M.1    Shu, Q.2    Chen, Q.X.3    Book, M.4    Sahl, H.G.5    Hoeft, A.6
  • 90
    • 0034584313 scopus 로고    scopus 로고
    • Xerostomia and hyposalivation
    • Nederfors T. Xerostomia and hyposalivation. Adv Dent Res 2000; 14: 48-56.
    • (2000) Adv Dent Res , vol.14 , pp. 48-56
    • Nederfors, T.1
  • 91
    • 36348937023 scopus 로고    scopus 로고
    • Shigeyama Y, Anzai T, Ishizaka A, Yoshida A, Kurino H, Takehara N. Evaluation of Chromogranin A in dry mouse patients. J Dent. Hlth 2006; 56: 596.
    • Shigeyama Y, Anzai T, Ishizaka A, Yoshida A, Kurino H, Takehara N. Evaluation of Chromogranin A in dry mouse patients. J Dent. Hlth 2006; 56: 596.
  • 92
    • 13844301902 scopus 로고    scopus 로고
    • Stress responses and innate immunity: Aging as a contributory factor
    • Butcher SK, Lord JM. Stress responses and innate immunity: Aging as a contributory factor. Aging Cell 2004; 3: 151-60.
    • (2004) Aging Cell , vol.3 , pp. 151-160
    • Butcher, S.K.1    Lord, J.M.2
  • 93
    • 0034020351 scopus 로고    scopus 로고
    • Inducible expression of human beta-defensin 2 by Fusobacterium nucleatum in oral Epithelial cells: Multiple signaling pathway and role of commensal bacteria in innate Immunity and the epithelial barrier
    • Krisanaprakornkit S, Kimball JR, Weinberg A, Darveau RP, Bainbridge BW, Dale BA. Inducible expression of human beta-defensin 2 by Fusobacterium nucleatum in oral Epithelial cells: Multiple signaling pathway and role of commensal bacteria in innate Immunity and the epithelial barrier. Infect Immun 2000; 68: 2907-15.
    • (2000) Infect Immun , vol.68 , pp. 2907-2915
    • Krisanaprakornkit, S.1    Kimball, J.R.2    Weinberg, A.3    Darveau, R.P.4    Bainbridge, B.W.5    Dale, B.A.6
  • 94
    • 17644399137 scopus 로고    scopus 로고
    • Differential gene expression of human beta-defensins (hBD-1, -2, -3) in inflammatory gingival diseases
    • Dommisch H, Acil Y, Dunsche A, Winter J, Jepsen S. Differential gene expression of human beta-defensins (hBD-1, -2, -3) in inflammatory gingival diseases. Oral Microbiol Immun 2005; 20: 186-90.
    • (2005) Oral Microbiol Immun , vol.20 , pp. 186-190
    • Dommisch, H.1    Acil, Y.2    Dunsche, A.3    Winter, J.4    Jepsen, S.5
  • 96
    • 0037231945 scopus 로고    scopus 로고
    • Single-nucleotide polymorphisms (SNPs) in human beta-defensin 1: High-throughput SNP assays and association with Candida carriage in type I diabetics and nondiabetic controls
    • Jurevic RJ, Bai M, Chadwick RB, White TC, Dale BA. Single-nucleotide polymorphisms (SNPs) in human beta-defensin 1: High-throughput SNP assays and association with Candida carriage in type I diabetics and nondiabetic controls. J Clin Microbiol 2003; 41: 90-6.
    • (2003) J Clin Microbiol , vol.41 , pp. 90-96
    • Jurevic, R.J.1    Bai, M.2    Chadwick, R.B.3    White, T.C.4    Dale, B.A.5
  • 97
    • 3242723228 scopus 로고    scopus 로고
    • Novel hairpin-shaped primer assay to study the association of the -44 single-nucleotide polymorphism of the DEFB1 gene with early-onset periodontal disease
    • Boniotto M, Hazbon MH, Jordan WJ, Lennon GP, Eskdale J, Alland D, et al. Novel hairpin-shaped primer assay to study the association of the -44 single-nucleotide polymorphism of the DEFB1 gene with early-onset periodontal disease. Clin Diagn Lab Immun 2004; 11: 766-9.
    • (2004) Clin Diagn Lab Immun , vol.11 , pp. 766-769
    • Boniotto, M.1    Hazbon, M.H.2    Jordan, W.J.3    Lennon, G.P.4    Eskdale, J.5    Alland, D.6
  • 98
    • 33646352728 scopus 로고    scopus 로고
    • No association between selected candidate gene polymorphisms and severe chronic periodontitis
    • Wohlfahrt JC, Wu T, Hodges JS, Hinrichs JE, Michalowicz BS. No association between selected candidate gene polymorphisms and severe chronic periodontitis. J Periodontol 2006; 77: 426-36.
    • (2006) J Periodontol , vol.77 , pp. 426-436
    • Wohlfahrt, J.C.1    Wu, T.2    Hodges, J.S.3    Hinrichs, J.E.4    Michalowicz, B.S.5
  • 99
    • 0027438777 scopus 로고
    • Establishment of radioimmunoassay for human neutrophil peptides and their increases in plasma and neutrophil in infection. Biochem
    • Shiomi K, Nakazato M, Ihi T, Kanagawa K, Matsuo H, Matsukura S. Establishment of radioimmunoassay for human neutrophil peptides and their increases in plasma and neutrophil in infection. Biochem Biophys Res Common 1993; 195: 1336-44.
    • (1993) Biophys Res Common , vol.195 , pp. 1336-1344
    • Shiomi, K.1    Nakazato, M.2    Ihi, T.3    Kanagawa, K.4    Matsuo, H.5    Matsukura, S.6
  • 100
    • 0004301704 scopus 로고
    • Dorland WAN. Editor, 28th ed. Philadelphia, W.B. Saunders co
    • Dorland WAN. Editor. Dorland's illustrated medical dictionary, 28th ed. Philadelphia, W.B. Saunders co. 1994;
    • (1994) Dorland's illustrated medical dictionary
  • 101
    • 0032843093 scopus 로고    scopus 로고
    • The antimicrobial treatment of periodontal disease: Changing the treatment paradigm
    • Loesche WJ. The antimicrobial treatment of periodontal disease: Changing the treatment paradigm. Crit Rev Oral Biol Med 1999; 10: 245-75.
    • (1999) Crit Rev Oral Biol Med , vol.10 , pp. 245-275
    • Loesche, W.J.1
  • 102
    • 0034266038 scopus 로고    scopus 로고
    • Efficient antimicrobial treatment in periodontal maintenance care
    • Slots J, Jorgensen MG. Efficient antimicrobial treatment in periodontal maintenance care. J Am Dent Assoc 2000; 131: 1293-304
    • (2000) J Am Dent Assoc , vol.131 , pp. 1293-1304
    • Slots, J.1    Jorgensen, M.G.2
  • 103
    • 0031925507 scopus 로고    scopus 로고
    • Beta-sheet antibiotic peptides as potential dental therapeutics
    • Miyasaki KT, Lehrer RI. Beta-sheet antibiotic peptides as potential dental therapeutics. Int J Antimicrob Agents 1998; 9: 269-80
    • (1998) Int J Antimicrob Agents , vol.9 , pp. 269-280
    • Miyasaki, K.T.1    Lehrer, R.I.2
  • 104
    • 0032086253 scopus 로고    scopus 로고
    • Chemical treatment of periodontitis: Local delivery of antimicrobials
    • Killoy WJ. Chemical treatment of periodontitis: Local delivery of antimicrobials. Int Dent J 1998; 48(Suppl 1): 305-15.
    • (1998) Int Dent J , vol.48 , Issue.SUPPL. 1 , pp. 305-315
    • Killoy, W.J.1
  • 105
    • 0033084658 scopus 로고    scopus 로고
    • Site specific delivary of antimicrobial agents for periodontal disease
    • Ciancio SG. Site specific delivary of antimicrobial agents for periodontal disease. Gen Dent 1999; 47: 172-8.
    • (1999) Gen Dent , vol.47 , pp. 172-178
    • Ciancio, S.G.1
  • 106
    • 0034601246 scopus 로고    scopus 로고
    • Local delivery of antimicrobial agents for the treatment of periodontal diseases
    • Schwach-Abdellaoui K, Vivien-Castioni N, Gurry R. Local delivery of antimicrobial agents for the treatment of periodontal diseases. Eur J Pharm Biopharm 2000; 50: 83-99.
    • (2000) Eur J Pharm Biopharm , vol.50 , pp. 83-99
    • Schwach-Abdellaoui, K.1    Vivien-Castioni, N.2    Gurry, R.3
  • 107
    • 19944413653 scopus 로고    scopus 로고
    • Beta defensin-3 engineered epidermis shows highly protective effect for bacterial infection
    • Sawamura D, Goto M, Shibaki A, Akiyama M, McMillan JR, Abiko Y, et al. Beta defensin-3 engineered epidermis shows highly protective effect for bacterial infection. Gene Ther 2005; 12: 857-61.
    • (2005) Gene Ther , vol.12 , pp. 857-861
    • Sawamura, D.1    Goto, M.2    Shibaki, A.3    Akiyama, M.4    McMillan, J.R.5    Abiko, Y.6
  • 109
    • 0034585457 scopus 로고    scopus 로고
    • Prospect for re-engineering salivary glands
    • Baum BJ. Prospect for re-engineering salivary glands. Adv Dent Res 2000; 14: 84-8.
    • (2000) Adv Dent Res , vol.14 , pp. 84-88
    • Baum, B.J.1
  • 110
    • 0036362007 scopus 로고    scopus 로고
    • The impact of gene therapy on dentistry: A revisiting after therapies
    • Baum BJ, Kok M, Tran SD, Yamano S. The impact of gene therapy on dentistry: A revisiting after therapies. J Am Dent Assoc 2002; 133: 35-44.
    • (2002) J Am Dent Assoc , vol.133 , pp. 35-44
    • Baum, B.J.1    Kok, M.2    Tran, S.D.3    Yamano, S.4
  • 111
    • 33748744782 scopus 로고    scopus 로고
    • Mouse salivary glands and human beta-defensin-2 as a study model for antimicrobial gene therapy: Technical considerations
    • Yin C, Dang HN, Gazor F, Huang GT. Mouse salivary glands and human beta-defensin-2 as a study model for antimicrobial gene therapy: technical considerations. Int J Antimicrob Agents 2006; 28: 352-60.
    • (2006) Int J Antimicrob Agents , vol.28 , pp. 352-360
    • Yin, C.1    Dang, H.N.2    Gazor, F.3    Huang, G.T.4
  • 113
    • 0022886732 scopus 로고    scopus 로고
    • In vitro tumor cell cytolysis mediated by peptide defensins of human and rabbit granulocytes
    • Lichtenstein A, Ganz T, Selested ME, Lehrer RI. In vitro tumor cell cytolysis mediated by peptide defensins of human and rabbit granulocytes. Blood 1996; 69: 1407-10.
    • (1996) Blood , vol.69 , pp. 1407-1410
    • Lichtenstein, A.1    Ganz, T.2    Selested, M.E.3    Lehrer, R.I.4
  • 114
    • 0023905142 scopus 로고
    • Mechanism of target cytolysis by peptide defensins: Target cell; metabolic activity, possibly endocytosis, are crucial for expression of cytotoxity
    • Lichtenstein A, Ganz T, Nguyen TM, Selsted ME, Lehrer RI. Mechanism of target cytolysis by peptide defensins: Target cell; metabolic activity, possibly endocytosis, are crucial for expression of cytotoxity. J Immunol 1988; 140: 2686-94.
    • (1988) J Immunol , vol.140 , pp. 2686-2694
    • Lichtenstein, A.1    Ganz, T.2    Nguyen, T.M.3    Selsted, M.E.4    Lehrer, R.I.5
  • 115
    • 0025738532 scopus 로고
    • Mechanism of mammalian cell lysis mediated by peptide defensisn. Evidence for an initial alteration of the plasma membrane
    • Lichtenstein A. Mechanism of mammalian cell lysis mediated by peptide defensisn. Evidence for an initial alteration of the plasma membrane. J Clin Invest 1991; 88: 93-100.
    • (1991) J Clin Invest , vol.88 , pp. 93-100
    • Lichtenstein, A.1
  • 117
    • 7044262888 scopus 로고    scopus 로고
    • Effect of defensin peptides on eukaryotic cells: Primary epithelial cells, fibroblasts and squamous cell carcinoma cell lines
    • Nishimura M, Abiko Y, Kurashige Y, Takeshima M, Yamazaki M, Kusano K, et al. Effect of defensin peptides on eukaryotic cells: Primary epithelial cells, fibroblasts and squamous cell carcinoma cell lines. J Dermatol Sci 2004; 36: 87-95.
    • (2004) J Dermatol Sci , vol.36 , pp. 87-95
    • Nishimura, M.1    Abiko, Y.2    Kurashige, Y.3    Takeshima, M.4    Yamazaki, M.5    Kusano, K.6
  • 118
    • 0033569408 scopus 로고    scopus 로고
    • β-Defensin: Linking innate and adaptive immunity through dendritic and T cell CCR6
    • Yang D, Chetrov O, Bykovskaia SN, Chen Q, Buffo MJ, Shogan J, et al. β-Defensin: Linking innate and adaptive immunity through dendritic and T cell CCR6. Science 1999; 286: 525-8.
    • (1999) Science , vol.286 , pp. 525-528
    • Yang, D.1    Chetrov, O.2    Bykovskaia, S.N.3    Chen, Q.4    Buffo, M.J.5    Shogan, J.6
  • 120
    • 33846151995 scopus 로고    scopus 로고
    • Chemokines and defensins as HIV suppressive factors: An evolving story
    • Garzino-Demo A. Chemokines and defensins as HIV suppressive factors: An evolving story. Curr Pharm Des 2007; 13(2): 163-72.
    • (2007) Curr Pharm Des , vol.13 , Issue.2 , pp. 163-172
    • Garzino-Demo, A.1
  • 121
    • 18744406713 scopus 로고    scopus 로고
    • The effects of non-steroidal anti-inflammatory drugs (selective and non-selective) on the treatment of periodontal diseases
    • Salvi GE, Lang NP. The effects of non-steroidal anti-inflammatory drugs (selective and non-selective) on the treatment of periodontal diseases. Curr Pharm Des 2005; 11(14): 1757-69.
    • (2005) Curr Pharm Des , vol.11 , Issue.14 , pp. 1757-1769
    • Salvi, G.E.1    Lang, N.P.2
  • 122
    • 33646515568 scopus 로고    scopus 로고
    • Emerging therapeutic potential of whey proteins and peptides
    • Yalcin AS. Emerging therapeutic potential of whey proteins and peptides. Curr Pharm Des 2006; 12(13): 1637-43.
    • (2006) Curr Pharm Des , vol.12 , Issue.13 , pp. 1637-1643
    • Yalcin, A.S.1


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