Capacity of human β-defensin expression in gene-transduced and cytokine-induced cells

Biochemical and Biophysical Research Communications

Volumn 339, Issue 1, 2006, Pages 344-354

  Yin, Chunyi ^a   Dang, Hoa N ^a   Zhang, Hai Bo ^a,c   Gazor, Farzad ^a   Kim, Daniel ^a   Sorensen, Ole E ^b,d   Huang, George T J ^a,e  

^a UCLA SCHOOL OF DENTISTRY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c CAPITAL MEDICAL UNIVERSITY   (China)

^d LUND UNIVERSITY   (Sweden)

^e UNIVERSITY OF MARYLAND DENTAL SCHOOL   (United States)

Author keywords

Gingival epithelial cells; HBD 2; HBD 3; IL 1; Lentiviral vectors; Retroviral vectors; TNF

Indexed keywords

BETA DEFENSIN; CYTOKINE; INTERLEUKIN 1; LENTIVIRUS VECTOR; PEPTIDE DERIVATIVE; RETROVIRUS VECTOR; TUMOR NECROSIS FACTOR ALPHA; VIRUS VECTOR;

ANIMAL CELL; ANTIMICROBIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; EPITHELIUM CELL; FIBROBLAST; GENE TRANSFER; GENETIC TRANSDUCTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RETROVIRUS; VIRAL GENE DELIVERY SYSTEM;

ANIMALS; BETA-DEFENSINS; CELLS, CULTURED; CYTOKINES; EPITHELIAL CELLS; FIBROBLASTS; GENETIC VECTORS; GINGIVA; GREEN FLUORESCENT PROTEINS; HUMANS; INTERLEUKIN-1; MICE; RETROVIRIDAE; TRANSDUCTION, GENETIC; TUMOR NECROSIS FACTOR-ALPHA;

ANIMALIA; LENTIVIRUS;

EID: 28144446129     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2005.11.020     Document Type: Article

References (65)

1. R. Bals, D.J. Weiner, A.D. Moscioni, R.L. Meegalla, and J.M. Wilson Augmentation of innate host defense by expression of a cathelicidin antimicrobial peptide Infect Immun. 67 1999 6084 6089
2. B.C. O'Connell, T. Xu, T.J. Walsh, T. Sein, A. Mastrangeli, R.G. Crystal, F.G. Oppenheim, and B.J. Baum Transfer of a gene encoding the anticandidal protein histatin 3 to salivary glands Hum. Gene Ther. 7 1996 2255 2261
3. S. Yarus, J.M. Rosen, A.M. Cole, and G. Diamond Production of active bovine tracheal antimicrobial peptide in milk of transgenic mice Proc. Natl. Acad. Sci. USA 93 1996 14118 14121
4. R. Bals, D.J. Weiner, R.L. Meegalla, and J.M. Wilson Transfer of a cathelicidin peptide antibiotic gene restores bacterial killing in a cystic fibrosis xenograft model J. Clin. Invest. 103 1999 1113 1117
5. R. Bals, W. Xiao, N. Sang, D.J. Weiner, R.L. Meegalla, and J.M. Wilson Transduction of well-differentiated airway epithelium by recombinant adeno-associated virus is limited by vector entry J. Virol. 73 1999 6085 6088
6. G.T. Huang, H.B. Zhang, D. Kim, L. Liu, and T. Ganz A model for antimicrobial gene therapy: demonstration of human beta-defensin 2 antimicrobial activities in vivo Hum. Gene Ther. 13 2002 2017 2025
7. M. Carretero, M. Del Rio, M. Garcia, M.J. Escamez, I. Mirones, L. Rivas, C. Balague, J.L. Jorcano, and F. Larcher A cutaneous gene therapy approach to treat infection through keratinocyte-targeted overexpression of antimicrobial peptides FASEB J. 18 2004 1931 1933
8. D. Sawamura, M. Goto, A. Shibaki, M. Akiyama, J.R. McMillan, Y. Abiko, and H. Shimizu Beta defensin-3 engineered epidermis shows highly protective effect for bacterial infection Gene Ther. 12 2005 857 861
9. C. Zhao, I. Wang, and R.I. Lehrer Widespread expression of beta-defensin hBD-1 in human secretory glands and epithelial cells FEBS Lett. 396 1996 319 322
10. A.Y. Liu, D. Destoumieux, A.V. Wong, C.H. Park, E.V. Valore, L. Liu, and T. Ganz Human beta-defensin-2 production in keratinocytes is regulated by interleukin-1, bacteria, and the state of differentiation J. Invest. Dermatol. 118 2002 275 281
11. A. Dunsche, Y. Acil, R. Siebert, J. Harder, J.M. Schroder, and S. Jepsen Expression profile of human defensins and antimicrobial proteins in oral tissues J. Oral Pathol. Med. 30 2001 154 158
12. J.R. Garcia, A. Krause, S. Schulz, F.J. Rodriguez-Jimenez, E. Kluver, K. Adermann, U. Forssmann, A. Frimpong-Boateng, R. Bals, and W.G. Forssmann Human beta-defensin 4: a novel inducible peptide with a specific salt-sensitive spectrum of antimicrobial activity FASEB J. 15 2001 1819 1821
13. D. Yang, A. Biragyn, D.M. Hoover, J. Lubkowski, and J.J. Oppenheim Multiple roles of antimicrobial defensins, cathelicidins, and eosinophil-derived neurotoxin in host defense Annu. Rev. Immunol. 22 2004 181 215
14. M.E. Quinones-Mateu, M.M. Lederman, Z. Feng, B. Chakraborty, J. Weber, H.R. Rangel, M.L. Marotta, M. Mirza, B. Jiang, P. Kiser, K. Medvik, S.F. Sieg, and A. Weinberg Human epithelial beta-defensins 2 and 3 inhibit HIV-1 replication Aids 17 2003 F39 F48
15. M.D. Howell, J.F. Jones, K.O. Kisich, J.E. Streib, R.L. Gallo, and D.Y. Leung Selective killing of vaccinia virus by LL-37: implications for eczema vaccinatum J. Immunol. 172 2004 1763 1767
16. L. Liu, L. Wang, H.P. Jia, C. Zhao, H.H. Heng, B.C. Schutte, P.B. McCray Jr., and T. Ganz Structure and mapping of the human beta-defensin HBD-2 gene and its expression at sites of inflammation Gene 222 1998 237 244
17. E.V. Valore, C.H. Park, A.J. Quayle, K.R. Wiles, P.B. McCray Jr., and T. Ganz Human beta-defensin-1: an antimicrobial peptide of urogenital tissues J. Clin. Invest. 101 1998 1633 1642
18. J. Harder, and J.M. Schroder Psoriatic scales: a promising source for the isolation of human skin-derived antimicrobial proteins J. Leukoc. Biol. 77 2005 476 486
19. C.L. Bevins, E. Martin-Porter, and T. Ganz Defensins and innate host defence of the gastrointestinal tract Gut 45 1999 911 915
20. J.M. Schroder, and J. Harder Human beta-defensin-2 Int. J. Biochem. Cell Biol. 31 1999 645 651
21. J. Shi, G. Zhang, H. Wu, C. Ross, F. Blecha, and T. Ganz Porcine epithelial beta-defensin 1 is expressed in the dorsal tongue at antimicrobial concentrations Infect. Immun. 67 1999 3121 3127
22. C.R. Tunzi, P.A. Harper, B. Bar-Oz, E.V. Valore, J.L. Semple, J. Watson-MacDonell, T. Ganz, and S. Ito Beta-defensin expression in human mammary gland epithelia Pediatr. Res. 48 2000 30 35
23. M. Mathews, H.P. Jia, J.M. Guthmiller, G. Losh, S. Graham, G.K. Johnson, B.F. Tack, and P.B. McCray Jr. Production of beta-defensin antimicrobial peptides by the oral mucosa and salivary glands Infect Immun. 67 1999 2740 2745
24. J. Harder, J. Bartels, E. Christophers, and J.M. Schroder Isolation and characterization of human beta-defensin-3, a novel human inducible peptide antibiotic J. Biol. Chem. 276 2001 5707 5713
25. H.P. Jia, B.C. Schutte, A. Schudy, R. Linzmeier, J.M. Guthmiller, G.K. Johnson, B.F. Tack, J.P. Mitros, A. Rosenthal, T. Ganz, and P.B. McCray Jr. Discovery of new human beta-defensins using a genomics-based approach Gene 263 2001 211 218
26. B.C. Schutte, J.P. Mitros, J.A. Bartlett, J.D. Walters, H.P. Jia, M.J. Welsh, T.L. Casavant, and P.B. McCray Jr. Discovery of five conserved beta-defensin gene clusters using a computational search strategy Proc. Natl. Acad. Sci. USA 99 2002 2129 2133
27. P. Premratanachai, S. Joly, G.K. Johnson, P.B. McCray Jr., H.P. Jia, and J.M. Guthmiller Expression and regulation of novel human beta-defensins in gingival keratinocytes Oral Microbiol. Immunol. 19 2004 111 117
28. J. Harder, U. Meyer-Hoffert, L.M. Teran, L. Schwichtenberg, J. Bartels, S. Maune, and J.M. Schroder Mucoid Pseudomonas aeruginosa, TNF-alpha, and IL-1beta, but not IL-6, induce human beta-defensin-2 in respiratory epithelia Am. J. Respir. Cell Mol. Biol. 22 2000 714 721
29. O.E. Sorensen, D.R. Thapa, A. Rosenthal, L. Liu, A.A. Roberts, and T. Ganz Differential regulation of beta-defensin expression in human skin by microbial stimuli J. Immunol. 174 2005 4870 4879
30. D.L. Diamond, J.R. Kimball, S. Krisanaprakornkit, T. Ganz, and B.A. Dale Detection of beta-defensins secreted by human oral epithelial cells J. Immunol. Methods 256 2001 65 76
31. A. Dunsche, Y. Acil, H. Dommisch, R. Siebert, J.M. Schroder, and S. Jepsen The novel human beta-defensin-3 is widely expressed in oral tissues Eur. J. Oral Sci. 110 2002 121 124
32. M. Nishimura, Y. Abiko, K. Kusano, M. Yamazaki, M. Saitoh, I. Mizoguchi, Y. Jinbu, T. Noguchi, and T. Kaku Localization of human beta-defensin 3 mRNA in normal oral epithelium, leukoplakia, and lichen planus: an in situ hybridization study Med. Electron Microsc. 36 2003 94 97
33. Y. Abiko, A.K. Suraweera, M. Nishimura, T. Arakawa, T. Takuma, I. Mizoguchi, and T. Kaku Differential expression of human beta-defensin 2 in keratinized and non-keratinized oral epithelial lesions; immunohistochemistry and in situ hybridization Virchows Arch. 438 2001 248 253
34. Y. Abiko, Y. Jinbu, T. Noguchi, M. Nishimura, K. Kusano, P. Amaratunga, T. Shibata, and T. Kaku Upregulation of human beta-defensin 2 peptide expression in oral lichen planus, leukoplakia and candidiasis. an immunohistochemical study Pathol. Res. Pract. 198 2002 537 542
35. K.S. Sahasrabudhe, J.R. Kimball, T.H. Morton, A. Weinberg, and B.A. Dale Expression of the antimicrobial peptide, human beta-defensin 1, in duct cells of minor salivary glands and detection in saliva J. Dent. Res. 79 2000 1669 1674
36. K. Sawaki, N. Mizukawa, T. Yamaai, J. Fukunaga, and T. Sugahara Immunohistochemical study on expression of alpha-defensin and beta-defensin-2 in human buccal epithelia with candidiasis Oral Dis. 8 2002 37 41
37. K. Sawaki, N. Mizukawa, T. Yamaai, T. Yoshimoto, M. Nakano, and T. Sugahara High concentration of beta-defensin-2 in oral squamous cell carcinoma Anticancer Res. 22 2002 2103 2107
38. J.E. Meyer, J. Harder, T. Gorogh, J.B. Weise, S. Schubert, D. Janssen, and S. Maune Human beta-defensin-2 in oral cancer with opportunistic Candida infection Anticancer Res. 24 2004 1025 1030
39. T. Yoshimoto, T. Yamaai, N. Mizukawa, K. Sawaki, M. Nakano, E. Yamachika, and T. Sugahara Different expression patterns of beta-defensins in human squamous cell carcinomas Anticancer Res. 23 2003 4629 4633
40. B.A. Dale, and L.P. Fredericks Antimicrobial peptides in the oral environment: expression and function in health and disease Curr. Issues Mol. Biol. 7 2005 119 133
41. J. Bissell, S. Joly, G.K. Johnson, C.C. Organ, D. Dawson, P.B. McCray Jr., and J.M. Guthmiller Expression of beta-defensins in gingival health and in periodontal disease J. Oral Pathol. Med. 33 2004 278 285
42. H. Dommisch, J. Winter, Y. Acil, A. Dunsche, M. Tiemann, and S. Jepsen Human beta-defensin (hBD-1, -2) expression in dental pulp Oral Microbiol. Immunol. 20 2005 163 166
43. S. Joly, C.C. Organ, G.K. Johnson, P.B. McCray Jr., and J.M. Guthmiller Correlation between beta-defensin expression and induction profiles in gingival keratinocytes Mol. Immunol. 42 2005 1073 1084
44. S. Krisanaprakornkit, J.R. Kimball, A. Weinberg, R.P. Darveau, B.W. Bainbridge, and B.A. Dale Inducible expression of human beta-defensin 2 by Fusobacterium nucleatum in oral epithelial cells: multiple signaling pathways and role of commensal bacteria in innate immunity and the epithelial barrier Infect. Immun. 68 2000 2907 2915
45. S. Krisanaprakornkit, J.R. Kimball, and B.A. Dale Regulation of human beta-defensin-2 in gingival epithelial cells: the involvement of mitogen-activated protein kinase pathways, but not the NF-kappaB transcription factor family J. Immunol. 168 2002 316 324
46. E.C. Feucht, C.L. DeSanti, and A. Weinberg Selective induction of human beta-defensin mRNAs by Actinobacillus actinomycetemcomitans in primary and immortalized oral epithelial cells Oral Microbiol. Immunol. 18 2003 359 363
47. R. Bals, X. Wang, Z. Wu, T. Freeman, V. Bafna, M. Zasloff, and J.M. Wilson Human beta-defensin 2 is a salt-sensitive peptide antibiotic expressed in human lung J. Clin Invest. 102 1998 874 880
48. F. Mineshiba, S. Takashiba, J. Mineshiba, K. Matsuura, S. Kokeguchi, and Y. Murayama Antibacterial activity of synthetic human B defensin-2 against periodontal bacteria J. Int. Acad. Periodontol. 5 2003 35 40
49. G.T. Huang, H.B. Zhang, C. Yin, and S.H. Park Human beta-defensin-2 gene transduction of dental pulp cells: a model for pulp antimicrobial gene therapy Int. J. Oral Biol. 2004 7 12
50. K. Shirasuna, M. Sato, and T. Miyazaki A neoplastic epithelial duct cell line established from an irradiated human salivary gland Cancer 48 1981 745 752
51. K.H. Shin, B.M. Min, H.M. Cherrick, and N.H. Park Combined effects of human papillomavirus-18 and N-methyl-N′-nitro-N-nitrosoguanidine on the transformation of normal human oral keratinocytes Mol. Carcinog. 9 1994 76 86
52. G.T. Huang, S.K. Haake, J.W. Kim, and N.H. Park Differential expression of interleukin-8 and intercellular adhesion molecule-1 by human gingival epithelial cells in response to Actinobacillus actinomycetemcomitans or Porphyromonas gingivalis infection Oral Microbiol. Immunol. 13 1998 301 309
53. T. Patel, S.H. Park, L.M. Lin, F. Chiappelli, and G.T. Huang Substance P induces interleukin-8 secretion from human dental pulp cells Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 96 2003 478 485
54. J.P. Morgenstern, and H. Land Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line Nucleic Acids Res. 18 1990 3587 3596
55. L. Naldini, U. Blomer, F.H. Gage, D. Trono, and I.M. Verma Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector Proc. Natl. Acad. Sci. USA 93 1996 11382 11388
56. L. Naldini, U. Blomer, P. Gallay, D. Ory, R. Mulligan, F.H. Gage, I.M. Verma, and D. Trono In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector Science 272 1996 263 267
57. J.K. Yee, T. Friedmann, and J.C. Burns Generation of high-titer pseudotyped retroviral vectors with very broad host range Methods Cell Biol. 43 Pt. A 1994 99 112
58. D.S. An, R.P. Wersto, B.A. Agricola, M.E. Metzger, S. Lu, R.G. Amado, I.S. Chen, and R.E. Donahue Marking and gene expression by a lentivirus vector in transplanted human and nonhuman primate CD34(+) cells J. Virol. 74 2000 1286 1295
59. S.K. Kung, D.S. An, and I.S. Chen A murine leukemia virus (MuLV) long terminal repeat derived from rhesus macaques in the context of a lentivirus vector and MuLV gag sequence results in high-level gene expression in human T lymphocytes J. Virol. 74 2000 3668 3681
60. M.R. Ortega, T. Ganz, and S.M. Milner Human beta defensin is absent in burn blister fluid Burns 26 2000 724 726
61. G.T. Huang, X. Zhang, and N.H. Park Increased ICAM-1 expression in transformed human oral epithelial cells: molecular mechanism and functional role in peripheral blood mononuclear cell adhesion and lymphokine-activated-killer cell cytotoxicity Int. J. Oncol. 17 2000 479 486
62. E. Shai, H. Falk, A. Honigman, A. Panet, and A. Palmon Gene transfer mediated by different viral vectors following direct cannulation of mouse submandibular salivary glands Eur. J. Oral. Sci. 110 2002 254 260
63. E. Shai, A. Palmon, A. Panet, Y. Marmary, Y. Sherman, M.A. Curran, E. Galun, and R. Condiotti Prolonged transgene expression in murine salivary glands following non-primate lentiviral vector transduction Mol. Ther. 12 2005 137 143
64. S. Joly, C. Maze, P.B. McCray Jr., and J.M. Guthmiller Human beta-defensins 2 and 3 demonstrate strain-selective activity against oral microorganisms J. Clin. Microbiol. 42 2004 1024 1029
65. L. Liu, A.A. Roberts, and T. Ganz By IL-1 signaling, monocyte-derived cells dramatically enhance the epidermal antimicrobial response to lipopolysaccharide J. Immunol. 170 2003 575 580