Activation of a Src-dependent Raf-MEK1/2-ERK signaling pathway is required for IL-1 α-induced upregulation of β-defensin 2 in human middle ear epithelial cells

Biochimica et Biophysica Acta - Molecular Cell Research

Volumn 1590, Issue 1-3, 2002, Pages 41-51

  Moon, Sung Kyun ^a   Lee, Haa Yung ^a   Li, Jian Dong ^a   Nagura, Mitsuyoshi ^a   Kang, Sung Ho ^a   Chun, Young Myoung ^b   Linthicum, Fred H ^a   Ganz, Tomas ^c   Andalibi, Ali ^a   Lim, David J ^a  

^a HOUSE EAR INSTITUTE   (United States)

^b Ajou University School of Medicine   (South Korea)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

defensin 2; Middle ear epithelial cell; Src dependent

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; BETA DEFENSIN; BETA DEFENSIN 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 1ALPHA; LACTOFERRIN; LIPOPOLYSACCHARIDE; LYSOZYME; MITOGEN ACTIVATED PROTEIN KINASE 1; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; RAF PROTEIN; TUMOR NECROSIS FACTOR ALPHA; TYRPHOSTIN AG126; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; EPITHELIUM CELL; GENE CONTROL; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HUMAN TISSUE; MIDDLE EAR; MOLECULE; NONHUMAN; OTITIS MEDIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SEQUENCE HOMOLOGY; TRANSCRIPTION INITIATION;

ANIMALS; BETA-DEFENSINS; CELLS, CULTURED; EAR, MIDDLE; EPITHELIAL CELLS; HUMANS; IMMUNOHISTOCHEMISTRY; INTERLEUKIN-1; LIPOPOLYSACCHARIDES; MAP KINASE KINASE 1; MAP KINASE KINASE 2; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; MODELS, BIOLOGICAL; MUCOUS MEMBRANE; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS C-RAF; RATS; RNA, MESSENGER; SIGNAL TRANSDUCTION; SRC-FAMILY KINASES; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 18444367057     PISSN: 01674889     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-4889(02)00196-9     Document Type: Article

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