Effect of defensin peptides on eukaryotic cells: Primary epithelial cells, fibroblasts and squamous cell carcinoma cell lines

Journal of Dermatological Science

Volumn 36, Issue 2, 2004, Pages 87-95

  Nishimura, Michiko ^a   Abiko, Yoshihiro ^a   Kurashige, Yoshihito ^a   Takeshima, Maiko ^a   Yamazaki, Mami ^a   Kusano, Kaoru ^a   Saitoh, Masato ^a   Nakashima, Keisuke ^a   Inoue, Takashi ^b   Kaku, Tohru ^a  

^a HEALTH SCIENCES UNIVERSITY OF HOKKAIDO   (Japan)

^b TOKYO DENTAL COLLEGE   (Japan)

Author keywords

Antimicrobial peptide; Cell culture; Defensin; Host response; Oral; Skin

Indexed keywords

ALPHA DEFENSIN; BETA DEFENSIN 1; BETA DEFENSIN 2; BETA DEFENSIN 3;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CARCINOMA CELL; CELL COUNT; CELL PROLIFERATION; CYTOTOXICITY; DRUG EFFECT; EPITHELIUM CELL; EUKARYOTIC CELL; FIBROBLAST; HUMAN; HUMAN CELL; HUMAN TISSUE; NONHUMAN; PRIORITY JOURNAL; SQUAMOUS CELL CARCINOMA;

ALPHA-DEFENSINS; ANIMALS; BETA-DEFENSINS; CARCINOMA, SQUAMOUS CELL; CELL COUNT; CELL DIVISION; CELL LINE, TUMOR; DEFENSINS; DOSE-RESPONSE RELATIONSHIP, DRUG; EPITHELIAL CELLS; FIBROBLASTS; GINGIVA; HUMANS; SWINE;

EID: 7044262888     PISSN: 09231811     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jdermsci.2004.07.001     Document Type: Article

References (34)

1. R.I. Lehrer, A.K. Lichtenstein, and T. Ganz Defensins: antimicrobial and cytotoxic peptides of mammalian cells Annu Rev Immunol 11 1993 105 128
2. J. Harder, J. Bartels, E. Christopher, and J.M. Schroder A peptide antibiotic from human skin Nature 387 1997 861
3. R.I. Lehrer, and T. Ganz Defensins of vertebrate animals Curr Opin Immunol 14 2002 96 102
4. B.A. Dale Periodontal epithelium: a newly recognized role in health and disease Periodontol 2000 30 2000 70 78
5. S. Sinha, N. Cheshenko, R.I. Lehrer, and B.C. Herold NP-1, a rabbit alpha defensin, prevents the entry and intercellular spread of herpes simplex virus type 2 Antimicrob Agents Chemother 47 2003 494 500
6. T. Ganz, and L.R.I. Defensins Curr Opin Immunol 6 1994 584 589
7. A. Risso Leukocyte antimicrobial peptides: multifunctional effector molecules of innate immunity J Leukocyte Biol 68 2000 785 792
8. A.J. Ouellette, and M.E. Selested Paneth cell defensins: endogenous peptide components of intestinal host defense FASEB J 10 1996 1280 1289
9. G. Hecht Innate mechanism of epithelial host defense: spotlight on intestine Am J Physiol 277 1999 351 358
10. J.M. Schroder, and J. Harder Human beta-defensin-2 Int J Biochem Cell Biol 31 1999 645 651
11. B.A. Dale, and S. Krisanaprakornkit Defensin antimicrobial peptides in the oral cavity J Oral Pathol Med 30 2001 321 327
12. J.-R.C. Garcia, F. Jaumann, S. Schulz, A. Krause, J.F. Rodriguez, and U. Forssmann Identification of a novel multifunctional β-defensin (human β-defensin 3) with specific antimicrobial activity Cell Tiss Res 306 2001 257 264
13. J. Harder, J. Bartels, E. Christophers, and J.M. Schroder Isolation and characterization of human beta-defensin-3, a novel human inducible peptide antibiotics J Biol Chem 276 2001 5707 5713
14. J.-R.C. Garcia, A. Krause, S. Schulz, J.F. Rodriguez, E. Kluver, and K. Adermann β-Defensin 4: a novel inducible peptide with a specific salt-sensitive spectrum of antimicrobial activity FASEB J 15 2001 1819 1821
15. Y. Yamaguchi, T. Nagase, R. Makita, S. Fukuhara, T. Tomita, and T. Tominaga Identification of multiple novel epididymis-specific β defensin isoforms in human and mice J Immunol 169 2002 2516 2523
16. T. Ganz, and J. Weiss Antimicrobial peptides of phagocytes and epithelia Semin Hematol 34 1997 343 354
17. K.S. Sahasrabudhe, J.R. Kimball, T.H. Morton, A. Weinberg, and B.A. Dale Expression of the antimicrobial peptide, human beta-defensin 1, in duct cells of minor salivary gland and detection in saliva J Dent Res 79 2000 1669 1674
18. M. Nishimura, Y. Abiko, J. Mitamura, and T. Kaku Effect of cell plating density and extracellular matrix protein on cell growth of epithelial rests of Malassez in vitro Med Electron Microsc 32 1999 127 132
19. M.E. Selsted, S.S.L. Harwig, T. Ganz, J.W. Schilling, and R.I. Lehrer Primary structure of three human neutrophil defensins J Clin Invest 76 1985 1436 1439
20. M.J. Goldman, G.M. Anderson, E.D. Stolzenberg, U.P. Kari, M. Zasloff, and J.M. Wilson Human β-defensin-1 is a salt-sensitive antibiotic in lung that is inactivated cystic fibrosis Cell 88 1997 553 560
21. T. Hiratsuka, M. Nakazato, Y. Date, J. Ashitani, T. Minematsu, and N. Chino Identification of human beta-defensin-2 in respiratory tract and plasma and its increase in bacterial pneumonia Biochem Biophys Res Commun 249 1998 943 947
22. T. Hiratsuka, M. Nakazato, T. Ihi, T. Minematsu, N. Chino, and T. Nakanishi Structural analysis of human β-defensin-1 and its significance in urinary tract infection Nephron 85 2000 34 40
23. E. Nishimura, A. Eto, M. Kato, S. Hashizume, S. Imai, and T. Nisizawa Oral streptococci exhibit diverse susceptibility to human β-defensin-2: antimicrobial effects of hBD-2 on oral streptococci Curr Microbiol 48 2004 85 87
24. C.J. Murphy, B.A. Foster, M.J. Mannis, M.E. Selsted, and T.W. Reid Defensins are mitogenic for epithelial cells and fibroblasts J Cell Physiol 155 1993 408 413
25. J. Aarbiou, M. Ertmann, S. Wetering, P. Noort, D. Rook, and K.F. Rabe Human neutrophil defensins induce lung epithelial cell proliferation in vitro J Leukocyte Biol 72 2002 167 174
26. K. Mishima, K. Inoue, and Y. Hayashi Overexpression of extracellular-signal regulated kinases on oral squamous cell carcinoma Oral Oncol 38 2002 468 474
27. Y. Abiko, J. Mitamura, M. Nishimura, T. Muramatsu, T. Inoue, and M. Shimono Pattern of expression of beta-defensins in oral squamous cell carcinoma Cancer Lett 143 1999 37 43
28. M. Zasloff Antimicrobial peptides of multicellular organisms Nature 415 2002 389 395
29. K. Okumura, A. Itoh, E. Isogai, K. Hirose, Y. Hosokawa, Y. Abiko, T. Shibata, M. Hirata, and H. Isogai C-terminal domain of human CAP18 antimicrobial peptides induces apoptosis in oral squamous cell carcinoma SAS-H1 cells Cancer Lett 212 2004 185 194
30. K.T. Miyasaki, and R.I. Lehrer Beta-sheet antibiotic peptides as potential dental therapeutics Int J Antimicrob Agents 9 1998 269 280
31. F. Mineshiba, S. Takashiba, J. Mineshiba, K. Matsuura, S. Kokeguchi, and Y. Murayama Antibacterial activity of synthetic human β defensin-2 against periodontal bacteria J Int Acad Periodontol 5 2003 35 40
32. G.T.-J. Huang, H.-B. Zang, D. Kim, L. Liu, and T. Ganz A model for antimicrobial gene therapy demonstration of human β-defensin 2 antimicrobial activities in vitro Human Gene Ther 13 1999 2017 2025
33. D. Yang, O. Chertov, S.N. Bykovskaia, Q. Chen, M.J. Buffo, and J. Shogan Beta-defensin: linking innate and adaptive immunity through dendritic and T cell CCR6 Science 286 1999 525 528
34. A. Biragyn, P.A. Ruffini, C.A. Leifer, E. Klyushnenkova, A. Shakhov, and O. Chertov Toll-like receptor 4-dependent activation of dendritic cells by beta-defensin 2 Science 298 2002 1025 1029