NF-κB-mediated transcriptional regulation of human β-defensin-2 gene following lipopolysaccharide stimulation

Journal of Leukocyte Biology

Volumn 71, Issue 1, 2002, Pages 154-162

  Tsutsumi Ishii, Yuko ^a   Nagaoka, Isao ^a  

^a JUNTENDO UNIVERSITY   (Japan)

Author keywords

Antimicrobial peptide; Epithelia; Host defense; Innate immunity; Macrophage; NF IL 6

Indexed keywords

BETA DEFENSIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; LUCIFERASE; PROTEIN P50; STAT PROTEIN;

ANIMAL CELL; ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL INFECTION; CONTROLLED STUDY; ELECTROPHORETIC MOBILITY; GENE ACTIVITY; GENE CONTROL; GENE EXPRESSION; GENETIC ANALYSIS; HOST RESISTANCE; MONONUCLEAR PHAGOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRANSCRIPTION REGULATION;

ANIMALS; ANTI-INFECTIVE AGENTS; BETA-DEFENSINS; CCAAT-ENHANCER-BINDING PROTEIN-BETA; CELL LINE; HUMANS; LIPOPOLYSACCHARIDES; MICE; NF-KAPPA B; TRANS-ACTIVATION (GENETICS); TRANS-ACTIVATORS; TRANSFECTION;

ANIMALIA; BACTERIA (MICROORGANISMS);

EID: 0036142740     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (54)

1. Defensins: Antimicrobial and cytotoxic peptides of mammalian cells
2. Antimicrobial peptides of phagocytes and epithelia
3. β-Defensins: Endogenous antibiotics of the innate host defense response
4. A cyclic antimicrobial peptide produced in primate leukocytes by the ligation of two truncated β-defensins
5. Role of CCAAT/enhancer-binding protein site in transcription of human neutrophil peptide-1 and -3 defensin genes
6. Expression of mammalian defensin genes
7. Antimicrobial peptides as mediators of epithelial host defense
8. hBD-1: A novel β-defensin from human plasma
9. A peptide antibiotic from human skin
10. Structure and mapping of the human β-defensin HBD-2 gene and its expression at sites of inflammation
11. Isolation and characterization of human β-defensin-3, a novel human inducible peptide antibiotic
12. Discovery of new human β-defensins using a genomics-based approach
13. Human β-defensin 2 is a salt-sensitive peptide antibiotic expressed in human lung
14. Expression and regulation of the human β-defensins hBD-1 and hBD-2 in intestinal epithelium
15. Antibacterial components in bronchoalveolar lavage fluid from healthy individuals and sarcoidosis patients
16. Inhibition of hBD-3, but not hBD-1 and hBD-2, mRNA expression by corticosteroids
17. β-Defensins: Linking innate and adaptive immunity through dendritic and T cell CCR6
18. 2 production from mast cells
19. Human airway epithelia express a β-defensin
20. Widespread expression of β-defensin hBD-1 in human secretory glands and epithelial cells
21. Mucoid Pseadomonas aeruginosa, TNF-α, and IL-β, but not IL-6, induce human β-defensin-2 in respiratory epithelia
22. CD14-dependent lipopolysaccharide-induced β-defensin-2 expression in human tracheobronchial epithelium
23. Transcriptional regulation of β-defensin gene expression in tracheal epithelial cells
24. Inducible expression of an antibiotic peptide gene in lipopolysaccharide-challenged tracheal epithelial cells
25. Evaluation of CD14 in host defence
26. CD14: Cell surface receptor and differentiation marker
27. The role of Toll-like receptors in host defense against microbial infection
28. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei
29. MatInd and MatInspector: New fast and versatile tools for detection of consensus matches in nucleotide sequence data
30. Expanding the TRANSFAC database towards an expert system of regulatory molecular mechanisms
31. Multiple sequence alignment with Divide-and-Conquer method
32. Multiple DNA and protein sequence alignment based on segment-to-segment comparison
33. DIALIGN: Finding local similarities by multiple sequence alignment
34. IL-6-regulated transcription factors
35. Synergistic action of pro-inflammatory agents: Cellular and molecular aspects
36. A novel mouse β defensin, Defb2, which is upregulated in the airways by lipopolysaccharide
37. Mouse β-defensin 3 is an inducible antimicrobial peptide expressed in the epithelia of multiple organs
38. The role of cationic antimicrobial peptides in innate host defences
39. Epithelial antimicrobial peptides in host defense against infection
40. LL-37, the neutrophil granule- and epithelial cell-derived cathelicidin, utilizes formyl peptide receptor-like 1 (FPRL1) as a receptor to chemoattract human peripheral blood neutrophils, monocytes, and T cells
41. The expression of the gene coding for the antibacterial peptide LL-37 is induced in human keratinocytes during inflammatory disorders
42. Role of CD14 in cellular recognition of bacterial lipopolysaccharides
43. NF-κB and the innate immune response
44. Toll-like receptors in the induction of the innate immune response
45. Recognition of Gram-negative bacteria and endotoxin by the innate immune system
46. Lipopolysaccharide activates distinct signaling pathways in intestinal epithelial cell lines expressing Toll-like receptors
47. Transcription factors NF-IL-6 and NF-κB synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8
48. Targeted disruption of the NF-IL-6 gene discloses its essential role in bacterial killing and tumor cytotoxicity by macrophages
49. Endotoxin signal transduction in macrophages
50. NF-κB and Rel proteins: Evolutionarily conserved mediators of immune responses
51. Regulation of DNA binding by Rel/NF-κB transcription factors: Structural views
52. The p65 subunit is responsible for the strong transcription activating potential of NF-κB
53. NF-κB1 (p50) is up-regulated in lipopolysaccharide tolerance and can block tumor necrosis factor gene expression
54. Helicobacter pylori-mediated transcriptional regulation of the human β-defensin 2 gene requires NF-κB