Defensin-I, an antimicrobial peptide present in the saliva of patients with oral diseases

Oral Diseases

Volumn 5, Issue 2, 1999, Pages 139-142

  Mizukawa, N ^a   Sugiyama, K ^a   Ueno, T ^a   Mishima, K ^a   Takagi, S ^a   Sugahara, T ^a  

^a OKAYAMA UNIVERSITY   (Japan)

Author keywords

Defensin; HNP I; Oral disease; Reversed phase HPLC; Saliva

Indexed keywords

DEFENSIN; ALPHA DEFENSIN; ANTIINFECTIVE AGENT; DEFENSIN 1; IRON; PROTEIN; SALIVA PROTEIN;

ADULT; AMINO ACID SEQUENCE; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GLOSSITIS; GLOSSODYNIA; HUMAN; IRON DEFICIENCY; LEUKOPLAKIA; LICHEN PLANUS; MALE; MASS SPECTROMETRY; MOUTH DISEASE; PRIORITY JOURNAL; PROTEIN ISOLATION; PROTEIN PURIFICATION; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SQUAMOUS CELL CARCINOMA; AGED; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOLATION AND PURIFICATION; METABOLISM; MIDDLE AGED; MOLECULAR WEIGHT; MOUTH MUCOSA;

ADULT; AGED; AGED, 80 AND OVER; ALPHA-DEFENSINS; AMINO ACID SEQUENCE; ANTI-INFECTIVE AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DEFENSINS; FEMALE; GLOSSALGIA; GLOSSITIS; HUMANS; IRON; LEUKOPLAKIA, ORAL; LICHEN PLANUS; MALE; MIDDLE AGED; MOLECULAR WEIGHT; MOUTH DISEASES; MOUTH MUCOSA; PROTEINS; SALIVARY PROTEINS;

EID: 0032589454     PISSN: 1354523X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1601-0825.1999.tb00078.x     Document Type: Article

References (21)

1. Ashkenazi M, Dennison DK (1989). A new method for isolation of salivary neutrophils and determination of their functional activity. J Dent Res 68: 1256-1261.
2. Bhaskar SN (1981a). Synopsis of oral pathology sixth edition. In: Pathology of oral mucosa, tongue, and salivary glands. The C. V. Mosby Company: St Louis, pp 373-380.
3. Bhaskar SN (1981b). Synopsis of oral pathology sixth edition. In: Pathology of oral mucosa, tongue, and salivary glands. The C.V. Mosby Company: St Louis, pp 387-390.
4. Brandtzaeg p (1989). Salivary immunoglobulins. In: Tenovuo J. ed. Human saliva: clinical chemistry and microbiology. Volume II. CRC press: Boca Raton, pp 2-54.
5. Daher KA, Selsted ME, Lehrer RI (1986). Direct inactivation of viruses by human granulocyte defensins. J Virol 60: 1068-1074.
6. David RM, Shihabi ZK (1985). Serum iron determination with Ferene-S: application to the RA-1000 analyzer. J Med Tech 2: 469-472.
7. Ganz T, Selsted ME, Harwig SSL et al (1985). Defensins. Natural peptide antibiotics of human neutrophils. J Clin Invest 76: 1427-1435.
8. Ganz T, Selsted ME, Lehrer RI (1990). Defensins. Eur J Haematol 44: 1-8.
9. Lehrer RI, Ganz T, Selsted ME (1991). Defensins: Endogenous antibiotic peptides of animal cells. Cell 64: 229-230.
10. Lichtenstein A, Ganz T, Selsted ME et al (1986). In vitro tumor cell cytolysis mediated by peptide defensins of human and rabbit granulocytes. Blood 68: 1407-1410.
11. Mizukawa N, Sugiyama K, Fukunaga J et al (1998a). A peptide detected in the saliva of oral-cancer patients. J Dent Res 77: 1309.
12. Mizukawa N, Sugiyama K, Fukunaga J et al (1998b). Defensin-1, a peptide detected in the saliva of oral squamous cell carcinoma patients. Anticancer Res 18: 4645-4650.
13. Mizukawa N (1998c). Defensin, a peptide detected in the saliva of patients with oral cancer. Jpn J Oral Maxillofac Surg 44: 931-940.
14. Okrent DG, Lichtenstein AK, Ganz T (1990). Direct cytotoxicity of polymorphonuclear leukocyte granule proteins to human lung-derived cells and endothelial cells. Am Rev Respir Dis 141: 179-185.
15. Patterson DJ, Martinez RJ, Lehrer RI (1980). Microbicidal cationic proteins in rabbit alveolar macrophages: a potential host defence mechanism. Infect Immun 30: 180-192.
16. Regezi JA, Sciubba JJ (1989). Oral pathology. In: Lichen planus. W. B. Saunders Company: Philadelphia, pp 105-110.
17. Schonwetter BS, Stolzenberg ED, Zasloff MA (1995). Epithelial antibiotics induced at sites of inflammation. Science 267: 1645-1648.
18. Selsted ME, Szklarek D, Ganz T et al (1985). Activity of rabbit leukocyte peptides against Candida albicans. Infect Immun 49: 202-206.
19. Sugiyama K, Suzuki Y, Furuta H (1985). Isolation and characterization of histamine-releasing peptides from human saliva. Life Sci 37: 475-480.
20. Suomalainen K, Saxen L, Vilja P et al (1996). Peroxidases, lactoferrin and lysozyme in peripheral blood neutrophils, gingival crevicular fluid and whole saliva of patients with localized juvenile periodontitis. Oral Dis 2: 129-134.
21. Xu T, Levitz SM, Diamond RD et al (1991). Anticandidal activity of major human salivary histatins. Infect Immun 59: 2549-2554.