Thermodynamics of binding interactions in the rational drug design process

Expert Opinion on Drug Discovery

Volumn 2, Issue 8, 2007, Pages 1103-1114

  Holdgate, Geoff A ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

DSC; ITC; Ligand binding; Structure based drug design; Thermodynamics

Indexed keywords

AMINOTRANSFERASE; BACTERIAL PROTEIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; ROSUVASTATIN; WATER;

BINDING AFFINITY; DRUG DESIGN; DRUG PROTEIN BINDING; DRUG RESEARCH; DRUG STRUCTURE; ENTHALPY; ENTROPY; ENZYME MECHANISM; ENZYME SUBSTRATE COMPLEX; HIGH THROUGHPUT SCREENING; HYDROGEN BOND; MATHEMATICAL ANALYSIS; METHODOLOGY; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN TARGETING; REVIEW; STRUCTURE ACTIVITY RELATION; THERMODYNAMICS; THERMOSTABILITY;

EID: 34548421643     PISSN: 17460441     EISSN: None     Source Type: Journal    
DOI: 10.1517/17460441.2.8.1103     Document Type: Review

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