NMR techniques for characterization of ligand binding: Utility for lead generation and optimization in drug discovery

Biopolymers - Peptide Science Section

Volumn 51, Issue 3, 1999, Pages 221-243

  Moore, Jonathan M ^a  

^a VERTEX PHARMACEUTICALS   (United States)

Author keywords

Drug design; Isotope editing; Library; Ligand binding; Nmr; Screening; SHAPES; Transferred NOE

Indexed keywords

BINDING ENERGY; CHEMICAL BONDS; CONTROLLED DRUG DELIVERY; ENGINEERING RESEARCH; LEAD COMPOUNDS; MOLECULAR STRUCTURE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

LIGAND BINDING; NUCLEAR OVERHAUSER EFFECT;

PROTEINS;

BENZOIC ACID DERIVATIVE; DRUG; FK 506 BINDING PROTEIN; INOSINATE DEHYDROGENASE; MITOGEN ACTIVATED PROTEIN KINASE; MUTANT PROTEIN; MYCOPHENOLIC ACID; NICOTINIC ACID; TACROLIMUS;

ARTICLE; DRUG DESIGN; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG STRUCTURE; DRUG TARGETING; LIGAND BINDING; MOLECULAR DYNAMICS; MOLECULAR SIZE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEAR OVERHAUSER EFFECT; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

BINDING SITES; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; IMMUNOPHILINS; ISOTOPES; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MUTATION; PROTEINS; SOLUTIONS; TACROLIMUS; TACROLIMUS BINDING PROTEINS; THERMODYNAMICS;

EID: 0032710475     PISSN: 00063525     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0282(1999)51:3<221::AID-BIP5>3.0.CO;2-9     Document Type: Article

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