Thermal Denaturation: A Method to Rank Slow Binding, High-Affinity P38α MAP Kinase Inhibitors

Journal of Medicinal Chemistry

Volumn 46, Issue 22, 2003, Pages 4669-4675

  Kroe, Rachel R ^a   Regan, John ^a   Proto, Al ^b   Peet, Gregory W ^a   Roy, Tapon ^a   Landro, Laura D ^c   Fuschetto, Natalie G ^a   Pargellis, Christopher A ^a   Ingraham, Richard H ^a  

^a BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

^b UNIVERSIDAD AUTÓNOMA DE GUADALAJARA   (Mexico)

^c Bristol Central High School   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE P38; UNCLASSIFIED DRUG;

ALLOSTERISM; ARTICLE; BINDING AFFINITY; BINDING KINETICS; DENATURATION; DRUG PROTEIN BINDING; DRUG STRUCTURE; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME INHIBITION; STRUCTURE ACTIVITY RELATION; THERMAL ANALYSIS;

ALGORITHMS; ALLOSTERIC SITE; ANIMALS; BINDING SITES; CALORIMETRY, DIFFERENTIAL SCANNING; ENZYME INHIBITORS; FLUORESCENCE; HEATING; HUMANS; MICE; MITOGEN-ACTIVATED PROTEIN KINASE 14; MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN BINDING; PROTEIN DENATURATION; PROTEIN FOLDING; SPECTROPHOTOMETRY, ULTRAVIOLET; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS; UREA;

EID: 0142028929     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm030120s     Document Type: Article

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