Overcoming roadblocks in lead optimization: A thermodynamic perspective

Chemical Biology and Drug Design

Volumn 67, Issue 1, 2006, Pages 2-4

  Ruben, Adam J ^a   Kiso, Yoshiaki ^b   Freire, Ernesto ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMALARIAL AGENT; ASPARTIC PROTEINASE INHIBITOR; PLASMEPSIN II;

BINDING AFFINITY; BINDING KINETICS; CONFORMATIONAL TRANSITION; DRUG BIOAVAILABILITY; DRUG RESEARCH; DRUG SCREENING; ENTHALPY; HYDROPHOBICITY; PRIORITY JOURNAL; SHORT SURVEY; THERMODYNAMICS;

ANIMALS; DRUG DESIGN; DRUG INTERACTIONS; HUMANS; KINETICS; PROTEIN BINDING; THERMODYNAMICS;

EID: 33645319676     PISSN: 17470277     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1747-0285.2005.00314.x     Document Type: Short Survey

References (9)

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