Effect of suppressive DNA on CpG-induced immune activation

Journal of Immunology

Volumn 169, Issue 10, 2002, Pages 5590-5594

  Yamada, Hiroshi ^a   Gursel, Ihsan ^a   Takeshita, Fumihiko ^a   Conover, Jackie ^a   Ishii, Ken J ^a   Gursel, Mayda ^a   Takeshita, Saoko ^a   Klinman, Dennis M ^a  

^a CENTER FOR BIOLOGICS EVALUATION AND RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL DNA; CONCANAVALIN A; LIPOPOLYSACCHARIDE; OLIGODEOXYNUCLEOTIDE;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIGEN RECOGNITION; ARTICLE; CONTROLLED STUDY; CPG ISLAND; FEMALE; IMMUNE RESPONSE; IMMUNOREACTIVITY; IMMUNOSTIMULATION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN MOTIF;

EID: 0037111465     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.169.10.5590     Document Type: Article

References (37)

1. Hemmi, H., O. Takeuchi, T. Kawai, S. Sato, H. Sanjo, M. Matsumoto, K. Hoshino, H. Wagner, K. Takeda, and S. Akira. 2000. A Toll-like receptor recognizes bacterial DNA. Nature 408:740.
2. Klinman, D. M., A. Yi, S. L. Beaucage, J. Conover, and A. M. Krieg. 1996. CpG motifs expressed by bacterial DNA rapidly induce lymphocytes to secrete IL-6, IL-12 and IFN-γ. Proc. Natl. Acad. Sci. USA 93:2879.
3. Roman, M., E. Martin-Orozco, J. S. Goodman, M. Nguyen, Y. Sato, A. Ronaghy, R. S. Kornbluth, D. D. Richman, D. A. Carson, and E. Raz. 1997. Immunostimulatory DNA sequences function as T helper-I promoting adjuvants. Nat. Med. 3:849.
4. Yamamoto, S., T. Yamamoto, T. Katoaka, E. Kuramoto, O. Yano, and T. Tokunaga. 1992. Unique palindromic sequences in synthetic oligonucleotides are required to induce IFN and augment IFN-mediated natural killer activity. J. Immunol. 148:4072.
5. Krieg, A. M., A. Yi, S. Matson, T. J. Waldschmidt, G. A. Bishop, R. Teasdale, G. A. Koretzky, and D. M. Klinman. 1995. CpG motifs in bacterial DNA trigger direct B-cell activation. Nature 374:546.
6. Takeshita, F., C. A. Leifer, I. Gursel, K. Ishii, S. Takeshita, M. Gursel, and D. M. Klinman. 2001. Cutting wdge: Role of Toll-like receptor 9 in CpG DNA-induced activation of human cells. J. Immunol. 167:3555.
7. Elkins, K. L., T. R. Rhinehart-Jones, S. Stibitz, J. S. Conover, and D. M. Klinman. 1999. Bacterial DNA containing CpG motifs stimulates lymphocyte-dependent protection of mice against lethal infection with intracellular bacteria. J. Immunol. 162: 2291.
8. Klinman, D. M., D. Verthelyi, F. Takeshita, and K. J. Ishii. 1999. Immune recognition of foreign DNA: A cure for bioterrorism? Immunity 11:123.
9. Krieg, A. M., L. L. Homan, A. K. Yi, and J. T. Harty. 1998. CpG DNA induces sustained IL-12 expression in vivo and resistance to Listeria monocytogenes challenge. J. Immunol. 161:2428.
10. Zimmermann, S., O. Egeter, S. Hausmann, G. B. Lipford, M. Rocken, H. Wagner, and K. Heeg. 1998. CpG oligodeoxynucleotides trigger protective and curative Th1 responses in lethal murine leishmaniasis. J. Immunol. 160:3627.
11. Sparwasser, T., T. Meithke, G. Lipford, K. Borschert, H. Hicker, K. Heeg, and H. Wagner. 1997. Bacterial DNA causes septic shock. Nature 386:336.
12. Pisetsky, D. S. 1997. Immunostimulatory DNA: A clear and present danger? Nat. Med. 3:829.
13. Cowdery, J. S., J. H. Chace, A.-K. Yi, and A. M. Krieg. 1996. Bacterial DNA induces NK cells to produce IFN-γ in vivo and increases the toxicity of lipopolysaccharides. J. Immunol. 156:4570.
14. Segal, B. M., D. M. Klinman, and E. M. Shevach. 1997. Microbial products induce autoimmune disease by an IL-12 dependent process. J. Immunol. 158: 5087.
15. Deng, G. M., I. M. Nilsson, M. Verdrengh, L. V. Collins, and A. Tarkowski. 1999. Intra-articularly localized bacterial DNA containing CpG motifs induces arthritis. Nat. Med. 5:702.
16. Krieg, A. M., T. Wu, R. Weeratna, S. M. Efler, L. Love, L. Yang, A. Yi, D. Short, and H. L. Davis. 1998. Sequence motifs in adenoviral DNA block immune activation by stimulatory CpG motifs. Proc. Natl. Acad. Sci. USA 95:12631.
17. Lenert, P., L. Stunz, A. K. Yi, A. M. Krieg, and R. F. Ashman. 2001. CpG stimulation of primary mouse B cells is blocked by inhibitory oligodeoxyribonucleotides at a site proximal to NF-κB activation. Antisense Nucleic Acid Drug Dev. 11:247.
18. Chen, Y., P. Lenert, R. Weeratna, M. McCluskie, T. Wu, H. L. Davis, and A. M. Krieg. 2001. Identification of methylated CpG motifs as inhibitors of the immune stimulatory CpG motifs. Gene Ther. 8:1024.
19. Verthelyi, D., K. J. Ishii, M. Gursel, F. Takeshita, and D. M. Klinman. 2001. Human peripheral blood cells differentially recognize and respond to two distinct CpG motifs. J. Immunol. 166:2372.
20. Klinman, D. M., G. Yamshchikov, and Y. Ishigatsubo. 1997. Contribution of CpG motifs to the immunogenicity of DNA vaccines. J. Immunol. 158:3635.
21. Klinman, D. M., and T. B. Nutman. 1994. ELIspot assay to detect cytokine-secreting murine and human cells. In Current Protocols in Immunology. J. E. Coligan, A. M. Kruisbeek, D. H. Margulies, E. M. Shevach, and W. Strober, eds. Greene Publishing Associates, Brooklyn.
22. Gursel, M., D. Verthelyi, I. Gursel, K. J. Ishii, and D. M. Klinman. 2002. Differential and competitive activation of human immune cells by distinct classes of CpG oligodeoxynucleotides. J. Leukocyte Biol. 71:813.
23. Pisetsky, D. S., C. Reich, S. D. Crowley, and M. D. Halpern. 1995. Immunological properties of bacterial DNA. Ann. NY Acad. Sci. 772:152.
24. Klinman, D. M., J. Conover, and C. Coban. 1999. Repeated administration of synthetic oligodeoxynucleotides expressing CpG motifs provides long-term protection against bacterial infection. Infect. Immun. 67:5658.
25. Krieg, A. M. 1995. CpG DNA: A pathogenic factor in systemic lupus erythematosus? J Clin. Immunol. 15:284.
26. Gilkeson, G. S., J. P. Grudier, D. G. Karounos, and D. S. Pisetsky. 1989. Induction of anti-double stranded DNA antibodies in normal mice by immunization with bacterial DNA. J. Immunol. 142:1482.
27. Yi, A., R. Tuetken, T. Redford, M. Waldschmidt, J. Kirsch, and A. M. Krieg. 1998. CpG motifs in bacterial DNA activate leukocytes through the pH-dependent generation of reactive oxygen species. J. Immunol. 160:4755.
28. Hacker, H., H. Mischak, T. Miethke, S. Liptay, R. Schmid, T. Sparwasser, K. Heeg, G. B. Lipford, and H. Wagner. 1998. CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by nonspecific endocytosis and endosomal maturation. EMBO 17:6230.
29. Takeshita, F., K. J. Ishii, A. Ueda, Y. Ishigatsubo, and D. M. Klinman. 2000. Positive and negative regulatory elements contribute to CpG ODN mediated regulation of human IL-6 gene expression. Eur. J. Immunol. 30:108.
30. Liang, H., Y. Nishioka, C. F. Reich, D. S. Pisetsky, and P. E. Lipsky. 1996. Activation of human B cells by phosphorothioate oligodeoxynucleotides. J. Clin. Invest. 98:1119.
31. Zhao, H., S. H. Cheng, and N. S. Yew. 2000. Requirements for effective inhibition of immunostimulatory CpG motifs by neutralizing motifs. Antisense Nucleic Acid Drug Dev. 10:381.
32. Halpern, M. D., and D. S. Pisetsky. 1995. In vitro inhibition of murine IFN γ production by phosphorothioate deoxyguanosine oligomers. Immunopharmacology 29:47.
33. Han, H., and H. L. Hurley. 2000. G-quadruplex DNA: A potential target for anti-cancer drug design. Trends Pharmacol. Sci. 21:136.
34. Murhie, A. I., and D. M. Lilley. 1994. Tetraplex folding of telomere sequences and the inclusion of adenine bases. EMBO J. 13:993.
35. Tan, Y., S. Li, B. R. Pitt, and L. Huang. 1999. The inhibitory role of CpG immunostimulatory motifs in cationic lipid vector-mediated transgene expression in vivo. Hum. Gene. Ther. 10:2153.
36. Lipford, G. B., T. Sparwasser, M. Bauer, S. Zimmermann, E. Koch, KI. Heeg, and H. Wagner. 1997. Immunostimulatory DNA: Sequence-dependent production of potentially harmful or useful cytokines. Eur. J. Immunol. 27:3420.
37. Sparwasser, T., T. Miethke, G. Lipford, A. Erdmann, H. Hacker, K. Heeg, and H. Wagner. 1997. Macrophages sense pathogens via DNA motifs: Induction of tumor necrosis factor-α-mediated shock. Eur. J. Immunol. 27:1671.