Structural determinants for ligand-receptor conformational selection in a peptide G protein-coupled receptor

Journal of Biological Chemistry

Volumn 282, Issue 24, 2007, Pages 17921-17929

  Lu, Zhi Liang ^a   Coetsee, Marla ^a,b   White, Colin D ^a   Millar, Robert P ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF CAPE TOWN   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING SITES; CONFORMATIONS; HORMONES; LIGANDS; MOLECULAR INTERACTIONS; MUTAGENESIS;

CONFORMATIONAL SELECTION; GONADOTROPIN; RECEPTOR CONFORMATIONS; STRUCTURAL ELEMENTS;

PEPTIDES;

G PROTEIN COUPLED RECEPTOR; GONADORELIN; LIGAND;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING SITE; BIOLOGICAL PHENOMENA AND FUNCTIONS CONCERNING THE ENTIRE ORGANISM; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; LIGAND BINDING; MOLECULAR MODEL; MUTAGENESIS; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; RECEPTOR AFFINITY; STRUCTURE ANALYSIS;

ALANINE; ANIMALS; ASPARAGINE; GONADOTROPIN-RELEASING HORMONE; HUMANS; LIGANDS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, LHRH;

EID: 34547096510     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M610413200     Document Type: Article

References (61)

1. Fredriksson, R., Lagerstrom, M. C., Lundin, L. G., and Schioth, H. B. (2003) Mol. Pharmacol. 63, 1256-1272
2. Vauquelin, G., and Van Liefde, I. (2005) Fundam. Clin. Pharmacol. 19, 45-56
3. Lu, Z. L., Saldanha, J. W., and Hulme, E. C. (2002) Trends Pharmacol. Sci. 23, 140-146
4. Mirzadegan, T., Benko, G., Filipek, S., and Palczewski, K. (2003) Biochemistry 42, 2759-2767
5. Schulz, A., and Schoneberg, T. (2003) J. Biol. Chem. 278, 35531-35541
6. Millar, R. P., Lu, Z. L., Pawson, A. J., Flanagan, C. A., Morgan, K., and Maudsley, S. R. (2004) Endocr. Rev. 25, 235-275
7. Millar, R. P., and Pawson, A. J. (2004) Endocrinology 145, 3590-3593
8. Perez, D. M., and Karnik, S. S. (2005) Pharmacol. Rev. 57, 147-161
9. Urban, J. D., Clarke, W. P., von Zastrow, M., Nichols, D. E., Kobilka, B., Weinstein, H., Javitch, J. A., Roth, B. L., Christopoulos, A., Sexton, P. M., Miller, K. J., Spedding, M., and Mailman, R. B. (2007) J. Pharmacol. Exp. Ther. 320, 1-13
10. Lu, Z. L., Gallagher, R., Sellar, R., Coetsee, M., and Millar, R. P. (2005) J. Biol. Chem. 280, 29796-29803
11. Millar, R. P., Lowe, S., Conklin, D., Pawson, A., Maudsley, S., Troskie, B., Ott, T., Millar, M., Lincoln, G., Sellar, R., Faurholm, B., Scobie, G., Kuestner, R., Terasawa, E., and Katz, A. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 9636-9641
12. Morgan, K., Sellar, R., Pawson, A. J., Lu, Z. L., and Millar, R. P. (2006) Endocrinology 147, 5041-5051
13. Sealfon, S. C., Weinstein, H., and Millar, R. P. (1997) Endocr. Rev. 18, 180-205
14. Okada, T., Sugihara, M., Bondar, A. N., Elstner, M., Entel, P., and Buss, V. (2004) J. Mol. Biol. 342, 571-583
15. Salom, D., Lodowski, D. T., Stenkamp, R. E., Le Trong, I., Golczak, M., Jastrzebska, B., Harris, T., Ballesteros, J. A., and Palczewski, K. (2006) Proc. Natl. Acad. Sci. U. S. A. 103, 16123-16128
16. Lu, Z. L., Saldanha, J. W., and Hulme, E. C. (2001) J. Biol. Chem. 276, 34098-34104
17. Mamputha, S., Lu, Z. L., Roeske, R. W., Millar, R. P., Katz, A. A., and Flanagan, C. A. (2007) Mol. Endocrinol. 21, 281-292
18. Fanelli, F., and De Benedetti, P. G. (2005) Chem. Rev. 105, 3297-3351
19. Baldwin, J. M., Schertler, G. F. X., and Unger, V. M. (1997) J. Mol. Biol. 272, 144-164
20. Söderhall, J. A., Polymeropoulos, E. E., Paulini, K., Gunther, E., and Kühne, R. (2005) Biochem. Biophys. Res. Commun. 333, 568-582
21. Hövelmann, S., Hoffmann, S. H., Kühne, R., ter Laak, T., Reilander, H., and Beckers, T. (2002) Biochemistry 41, 1129-1136
22. Betz, S. F., Reinhart, G. J., Lio, F. M., Chen, C., and Struthers, R. S. (2006) J. Med. Chem. 49, 637-647
23. Brooks, B. R., Bruccoleri, R. E., Olason, B. D., States, D. J., Swaminathan, S., and Karplus, M. (1983) J. Comp. Chem. 4, 187-217
24. Favre, N., Fanelli, F., Missotten, M., Nichols, A., Wilson, J., di Tiani, M., Rommel, C., and Scheer, A. (2005) Biochemistry 44, 9990-10008
25. Davidson, J. S., Assefa, D., Pawson, A., Davies, P., Hapgood, J., Becker, I., Flanagan, C., Roeske, R., and Millar, R. (1997) Biochemistry 36, 12881-12889
26. Furse, K. E., and Lybrand, T. P. (2003) J. Med. Chem. 46, 4450-4462
27. Brothers, S. P., Cornea, A., Janovick, J. A., and Conn, P. M. (2004) Mol. Endocrinol. 18, 1787-1797
28. Ulloa-Aguirre, A., Janovick, J. A., Brothers, S. P., and Conn, P. M. (2004) Traffic 5, 821-837
29. Knollman, P. E., Janovick, J. A., Brothers, S. P., and Conn, P. M. (2005) J. Biol. Chem. 280, 24506-24514
30. Janovick, J. A., Knollman, P. E., Brothers, S. P., Ayala-Yanez, R., Aziz, A. S., and Conn, P. M. (2006) J. Biol. Chem. 281, 8417-8425
31. Lu, Z. L., and Hulme, E. C. (1999) J. Biol. Chem. 274, 7309-7315
32. Petaja-Repo, U. E., Hogue, M., Bhalla, S., Laperriere, A., Morello, J. P., and Bouvier, M. (2002) EMBO J. 21, 1628-1637
33. Wuller, S., Wiesner, B., Loffler, A., Furkert, J., Krause, G., Hermosilla, R., Schaefer, M., Schulein, R., Rosenthal, W., and Oksche, A. (2004) J. Biol. Chem. 279, 47254-47263
34. Bernier, V., Lagace, M., Lonergan, M., Arthus, M. F., Bichet, D. G., and Bouvier, M. (2004) Mol. Endocrinol. 18, 2074-2084
35. Robben, J. H., Sze, M., Knoers, N. V., and Deen, P. M. (2006) Mol. Biol. Cell 17, 379-386
36. Hawtin, S. R. (2006) J. Biol. Chem. 281, 14604-14614
37. Bernier, V., Bichet, D. G., and Bouvier, M. (2004) Curr. Opin. Pharmacol. 4, 528-533
38. Bernier, V., Lagace, M., Bichet, D. G., and Bouvier, M. (2004) Trends Endocrinol. Metab. 15, 222-228
39. Milligan, G., Stevens, P. A., Ramsay, D., and McLean, A. J. (2002) Neurosignals 11, 29-33
40. Darlison, M. G., and Richter, D. (1999) Trends Neurosci. 22, 81-88
41. Fromme, B. J., Katz, A. A., Roeske, R. W., Millar, R. P., and Flanagan, C. A. (2001) Mol. Pharmacol. 60, 1280-1287
42. Ghanouni, P., Gryczynski, Z., Steenhuis, J. J., Lee, T. W., Farrens, D. L., Lakowicz, J. R., and Kobilka, B. K. (2001) J. Biol. Chem. 276, 24433-24436
43. Yao, X., Parnot, C., Deupi, X., Ratnala, V. R., Swaminath, G., Farrens, D., and Kobilka, B. (2006) Nat. Chem. Biol. 2, 417-422
44. Cussac, D., Newman-Tancredi, A., Duqueyroix, D., Pasteau, V., and Millan, M. J. (2002) Mol. Pharmacol. 62, 578-589
45. Gay, E. A., Urban, J. D., Nichols, D. E., Oxford, G. S., and Mailman, R. B. (2004) Mol. Pharmacol. 66, 97-105
46. Urban, J. D., Vargas, G. A., von Zastrow, M., and Mailman, R. B. (2007) Neuropsychopharmacology 32, 67-77
47. Robb, S., Cheek, T. R., Hannan, F. L., Hall, L. M., Midgley, J. M., and Evans, P. D. (1994) EMBO J. 13, 1325-1330
48. Calabro, V., Daugherty, M. D., and Frankel, A. D. (2005) Proc. Natl. Acad. Sci. U. S. A. 102, 6849-6854
49. Swaminath, G., Deupi, X., Lee, T. W., Zhu, W., Thian, F. S., Kobilka, T. S., and Kobilka, B. (2005) J. Biol. Chem. 280, 22165-22171
50. Nikolaev, V. O., Hoffmann, C., Bunemann, M., Lohse, M. J., and Vilardaga, J. P. (2006) J. Biol. Chem. 281, 24506-24511
51. Baneres, J. L., Mesnier, D., Martin, A., Joubert, L., Dumuis, A., and Bockaert, J. (2005) J. Biol. Chem. 280, 20253-20260
52. Coetsee, M., Gallagher, R., Millar, R. P., Flanagan, C. A., and Lu, Z. L. (2006) BioScience 2006, Glasgow, UK, July 23-27, 2006, Abstract 0518, The Biochemical Society, London, UK
53. Zhou, W., Flanagan, C., Ballesteros, J. A., Konvicka, K., Davidson, J. S., Weinstein, H., Millar, R. P., and Sealon, S. C. (1994) Mol. Pharmacol. 45, 165-170
54. Flanagan, C. A., Zhou, W., Chi, L., Yuen, T., Rodic, V., Robertson, D., Johnson, M., Holland, P., Millar, R. P., Weinstein, H., Mitchell, R., and Sealfon, S. C. (1999) J. Biol. Chem. 274, 28880-28886
55. Ballesteros, J., Kitanovic, S., Guarnieri, F., Davies, P., Fromme, B. J., Konvicka, K., Chi, L., Millar, R. P., Davidson, J. S., Weinstein, H., and Sealfon, S. C. (1998) J. Biol. Chem. 273, 10445-10453
56. Flanagan, C. A., Rodic, V., Konvicka, K., Yuen, T., Chi, L., Rivier, J. E., Millar, R. P., Weinstein, H., and Sealfon, S. C. (2000) Biochemistry 39, 8133-8141
57. Shi, L., Liapakis, G., Xu, R., Guarnieri, F., Ballesteros, J. A., and Javitch, J. A. (2002) J. Biol. Chem. 277, 40989-40996
58. Jongejan, A., Bruysters, M., Ballesteros, J. A., Haaksma, E., Bakker, R. A., Pardo, L., and Leurs, R. (2005) Nat. Chem. Biol. 1, 98-103
59. Nakamichi, H., and Okada, T. (2006) Proc. Natl. Acad. Sci. U. S. A. 103, 12729-12734
60. Cheng, C. K., and Leung, P. C. (2005) Endocr. Rev. 26, 283-306
61. Mitchell, R., McCulloch, D., Lutz, E., Johnson, M., MacKenzie, C., Fennell, M., Fink, G., Zhou, W., and Sealfon, S. C. (1998) Nature 392, 411-414