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Volumn 7, Issue 2, 2007, Pages 109-117

Peroxisome proliferator-activated receptor-γ in vascular biology

Author keywords

Cardiovascular risk; Diabetes; Metabolic syndrome; Peroxisome proliferator activated receptor; Thiazolidinediones

Indexed keywords

15 PROSTAGLANDIN J2; 2 [1 CARBOXY 2 [4 [2 (5 METHYL 2 PHENYL 4 OXAZOLYL)ETHOXY]PHENYL]ETHYLAMINO]BENZOIC ACID METHYL ESTER; GLITAZONE DERIVATIVE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; PIOGLITAZONE; PLACEBO; ROSIGLITAZONE; TROGLITAZONE; UNCLASSIFIED DRUG;

EID: 34347375795     PISSN: 1871529X     EISSN: None     Source Type: Journal    
DOI: 10.2174/187152907780830932     Document Type: Review
Times cited : (15)

References (105)
  • 1
    • 0030047806 scopus 로고    scopus 로고
    • Differential expression of peroxisome proliferator-activated receptors (PPARs): Tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat
    • Braissant, O.; Foufelle, F.; Scotto, C.; Dauca, M.; Wahli, W. Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat. Endocrinology, 1996, 137, 354-366.
    • (1996) Endocrinology , vol.137 , pp. 354-366
    • Braissant, O.1    Foufelle, F.2    Scotto, C.3    Dauca, M.4    Wahli, W.5
  • 2
    • 0034057069 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors in the cardiovascular system
    • Bishop-Bailey, D. Peroxisome proliferator-activated receptors in the cardiovascular system. Br. J. Pharmacol., 2000, 129, 823-834.
    • (2000) Br. J. Pharmacol , vol.129 , pp. 823-834
    • Bishop-Bailey, D.1
  • 4
    • 0031944785 scopus 로고    scopus 로고
    • The metabolically obese, normal-weight individual revisited
    • Ruderman, N.; Chisholm, D.; Pi-Sunyer, X.; Schneider, S. The metabolically obese, normal-weight individual revisited. Diabetes, 1998, 47, 699-713.
    • (1998) Diabetes , vol.47 , pp. 699-713
    • Ruderman, N.1    Chisholm, D.2    Pi-Sunyer, X.3    Schneider, S.4
  • 5
    • 0032587328 scopus 로고    scopus 로고
    • PPARgamma activation in human endothelial cells increases plasminogen activator inhibitor type-1 expression: PPARgamma as a potential mediator in vascular disease
    • Marx, N.; Bourcier, T.; Sukhova, G.K.; Libby, P.; Plutzky, J. PPARgamma activation in human endothelial cells increases plasminogen activator inhibitor type-1 expression: PPARgamma as a potential mediator in vascular disease. Arterioscler. Thromb. Vasc. Biol., 1999, 19, 546-551.
    • (1999) Arterioscler. Thromb. Vasc. Biol , vol.19 , pp. 546-551
    • Marx, N.1    Bourcier, T.2    Sukhova, G.K.3    Libby, P.4    Plutzky, J.5
  • 6
    • 0033520304 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor activators inhibit thrombin-induced endothelin-1 production in human vascular endothelial cells by inhibiting the activator protein-1 signaling pathway
    • Delerive, P.; Martin-Nizard, F.; Chinetti, G.; Trottein, F.; Fruchart, J.C.; Najib, J.; Duriez, P.; Staels, B. Peroxisome proliferator-activated receptor activators inhibit thrombin-induced endothelin-1 production in human vascular endothelial cells by inhibiting the activator protein-1 signaling pathway. Circ. Res., 1999, 85, 394-402.
    • (1999) Circ. Res , vol.85 , pp. 394-402
    • Delerive, P.1    Martin-Nizard, F.2    Chinetti, G.3    Trottein, F.4    Fruchart, J.C.5    Najib, J.6    Duriez, P.7    Staels, B.8
  • 7
    • 0029090411 scopus 로고
    • Coronary plaque disruption
    • Falk, E.; Shah, P.K.; Fuster, V. Coronary plaque disruption. Circulation, 1995, 92, 657-671.
    • (1995) Circulation , vol.92 , pp. 657-671
    • Falk, E.1    Shah, P.K.2    Fuster, V.3
  • 9
    • 0034711678 scopus 로고    scopus 로고
    • Modulation of vascular inflammation in vitro and in vivo by peroxisome proliferator-activated receptor-gamma activators
    • Pasceri, V.; Wu, H.D.; Willerson, J.T.; Yeh, E.T. Modulation of vascular inflammation in vitro and in vivo by peroxisome proliferator-activated receptor-gamma activators. Circulation, 2000, 101, 235-238.
    • (2000) Circulation , vol.101 , pp. 235-238
    • Pasceri, V.1    Wu, H.D.2    Willerson, J.T.3    Yeh, E.T.4
  • 10
    • 0032847680 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor activators target human endothelial cells to inhibit leukocyte-endothelial cell interaction
    • Jackson, S.M.; Parhami, F.; Xi, X.P.; Berliner, J.A.; Hsueh, W.A.; Law, R.E.; Demer, L.L. Peroxisome proliferator-activated receptor activators target human endothelial cells to inhibit leukocyte-endothelial cell interaction. Arterioscler. Thromb. Vasc. Biol., 1999, 19, 2094-2104.
    • (1999) Arterioscler. Thromb. Vasc. Biol , vol.19 , pp. 2094-2104
    • Jackson, S.M.1    Parhami, F.2    Xi, X.P.3    Berliner, J.A.4    Hsueh, W.A.5    Law, R.E.6    Demer, L.L.7
  • 11
    • 15244349695 scopus 로고    scopus 로고
    • Troglitazone, a PPAR-gamma activator prevents endothelial cell adhesion molecule expression and lymphocyte adhesion mediated by TNF-alpha
    • Sasaki, M.; Jordan, P.; Welbourne, T.; Minagar, A.; Joh, T.; Itoh, M.; Elrod, J.W.; Alexander, J.S. Troglitazone, a PPAR-gamma activator prevents endothelial cell adhesion molecule expression and lymphocyte adhesion mediated by TNF-alpha. BMC. Physiol., 2005, 5, 3.
    • (2005) BMC. Physiol , vol.5 , pp. 3
    • Sasaki, M.1    Jordan, P.2    Welbourne, T.3    Minagar, A.4    Joh, T.5    Itoh, M.6    Elrod, J.W.7    Alexander, J.S.8
  • 13
    • 0037076294 scopus 로고    scopus 로고
    • Structure, endothelial function, cell growth, and inflammation in blood vessels of angiotensin II-infused rats: Role of peroxisome proliferator-activated recept-orgamma
    • Diep, Q.N.; El Mabrouk, M.; Cohn, J.S.; Endemann, D.; Amiri, F.; Virdis, A.; Neves, M.F.; Schiffrin, E.L. Structure, endothelial function, cell growth, and inflammation in blood vessels of angiotensin II-infused rats: role of peroxisome proliferator-activated recept-orgamma. Circulation, 2002, 105, 2296-2302.
    • (2002) Circulation , vol.105 , pp. 2296-2302
    • Diep, Q.N.1    El Mabrouk, M.2    Cohn, J.S.3    Endemann, D.4    Amiri, F.5    Virdis, A.6    Neves, M.F.7    Schiffrin, E.L.8
  • 14
    • 0034660182 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-gamma activators inhibit IFN-gamma-induced expression of the T cell-active CXC chemokines IP-10, Mig, and I-TAC in human endothelial cells
    • Marx, N.; Mach, F.; Sauty, A.; Leung, J.H.; Sarafi, M.N.; Ransohoff, R.M.; Libby, P.; Plutzky, J.; Luster, A.D. Peroxisome proliferator-activated receptor-gamma activators inhibit IFN-gamma-induced expression of the T cell-active CXC chemokines IP-10, Mig, and I-TAC in human endothelial cells. J. Immunol., 2000, 164, 6503-6508.
    • (2000) J. Immunol , vol.164 , pp. 6503-6508
    • Marx, N.1    Mach, F.2    Sauty, A.3    Leung, J.H.4    Sarafi, M.N.5    Ransohoff, R.M.6    Libby, P.7    Plutzky, J.8    Luster, A.D.9
  • 15
    • 0034769830 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors in endothelial cell biology
    • Plutzky J. Peroxisome proliferator-activated receptors in endothelial cell biology. Curr. Opin. Lipidol., 2001, 12, 511-518.
    • (2001) Curr. Opin. Lipidol , vol.12 , pp. 511-518
    • Plutzky, J.1
  • 16
    • 0033520304 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor activators inhibit thrombin-induced endothelin-1 production in human vascular endothelial cells by inhibiting the activator protein-1 signaling pathway
    • Delerive P.; Martin-Nizard, F.; Chinetti, G.; Trottein, F.; Fruchart, J.C.; Najib, J.; Duriez, P.; Staels, B. Peroxisome proliferator-activated receptor activators inhibit thrombin-induced endothelin-1 production in human vascular endothelial cells by inhibiting the activator protein-1 signaling pathway. Circ. Res., 1999, 85, 394-402.
    • (1999) Circ. Res , vol.85 , pp. 394-402
    • Delerive, P.1    Martin-Nizard, F.2    Chinetti, G.3    Trottein, F.4    Fruchart, J.C.5    Najib, J.6    Duriez, P.7    Staels, B.8
  • 17
    • 0033608242 scopus 로고    scopus 로고
    • Thiazolidinediones suppress endothelin-1 secretion from bovine vascular endothelial cells: A new possible role of PPARgamma on vascular endothelial function
    • Satoh, H.; Tsukamoto, K.; Hashimoto, Y.; Hashimoto, N.; Togo, M.; Hara, M.; Maekawa, H.; Isoo, N.; Kimura, S.; Watanabe, T. Thiazolidinediones suppress endothelin-1 secretion from bovine vascular endothelial cells: a new possible role of PPARgamma on vascular endothelial function. Biochem. Biophys Res. Commun., 1999, 254, 757-763.
    • (1999) Biochem. Biophys Res. Commun , vol.254 , pp. 757-763
    • Satoh, H.1    Tsukamoto, K.2    Hashimoto, Y.3    Hashimoto, N.4    Togo, M.5    Hara, M.6    Maekawa, H.7    Isoo, N.8    Kimura, S.9    Watanabe, T.10
  • 18
    • 0037072826 scopus 로고    scopus 로고
    • Constitutive activation of peroxisome proliferator-activated receptor-gamma suppresses pro-inflammatory adhesion molecules in human vascular endothelial cells
    • Wang, N.; Verna, L.; Chen, N.G.; Chen, J.; Li, H.; Forman, B.M.; Stemerman, M.B. Constitutive activation of peroxisome proliferator-activated receptor-gamma suppresses pro-inflammatory adhesion molecules in human vascular endothelial cells. J. Biol. Chem., 2002, 277, 34176-34181.
    • (2002) J. Biol. Chem , vol.277 , pp. 34176-34181
    • Wang, N.1    Verna, L.2    Chen, N.G.3    Chen, J.4    Li, H.5    Forman, B.M.6    Stemerman, M.B.7
  • 20
    • 16244399864 scopus 로고    scopus 로고
    • 15-deoxy-Delta12,14-prostaglandin J2 (15d-PGJ2) signals through retinoic acid receptor-related orphan receptor-alpha but not peroxisome proliferator-activated receptor-gamma in human vascular endothelial cells: The effect of 15d-PGJ2 on tumor necrosis factor-alpha-induced gene expression
    • Migita, H.; Morser, J. 15-deoxy-Delta12,14-prostaglandin J2 (15d-PGJ2) signals through retinoic acid receptor-related orphan receptor-alpha but not peroxisome proliferator-activated receptor-gamma in human vascular endothelial cells: the effect of 15d-PGJ2 on tumor necrosis factor-alpha-induced gene expression. Arterioscler. Thromb. Vasc. Biol., 2005, 25, 710-716.
    • (2005) Arterioscler. Thromb. Vasc. Biol , vol.25 , pp. 710-716
    • Migita, H.1    Morser, J.2
  • 21
    • 0027443636 scopus 로고
    • Pioglitazone attenuates hypertension and inhibits growth of renal arteriolar smooth muscle in rats
    • Dubey, R.K.; Zhang, H.Y.; Reddy, S.R.; Boegehold, M.A.; Kotchen, T.A. Pioglitazone attenuates hypertension and inhibits growth of renal arteriolar smooth muscle in rats. Am. J. Physiol., 1993, 265, 726-732.
    • (1993) Am. J. Physiol , vol.265 , pp. 726-732
    • Dubey, R.K.1    Zhang, H.Y.2    Reddy, S.R.3    Boegehold, M.A.4    Kotchen, T.A.5
  • 24
    • 0344333464 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma activators inhibit gene expression and migration in human vascular smooth muscle cells
    • Marx, N.; Schonbeck, U.; Lazar, M.A.; Libby, P.; Plutzky, J. Peroxisome proliferator-activated receptor gamma activators inhibit gene expression and migration in human vascular smooth muscle cells. Circ. Res., 1998, 83, 1097-1103.
    • (1998) Circ. Res , vol.83 , pp. 1097-1103
    • Marx, N.1    Schonbeck, U.2    Lazar, M.A.3    Libby, P.4    Plutzky, J.5
  • 27
    • 0037503920 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma inhibits expression of minichromosome maintenance proteins in vascular smooth muscle cells
    • Bruemmer, D.; Yin, F.; Liu, J.; Berger, J.P.; Kiyono, T.; Chen, J.; Fleck, E.; Van Herle, A.J.; Forman, B.M.; Law, R.E. Peroxisome proliferator-activated receptor gamma inhibits expression of minichromosome maintenance proteins in vascular smooth muscle cells. Mol. Endocrinol., 2003, 17, 1005-1018.
    • (2003) Mol. Endocrinol , vol.17 , pp. 1005-1018
    • Bruemmer, D.1    Yin, F.2    Liu, J.3    Berger, J.P.4    Kiyono, T.5    Chen, J.6    Fleck, E.7    Van Herle, A.J.8    Forman, B.M.9    Law, R.E.10
  • 28
    • 0037155906 scopus 로고    scopus 로고
    • Transcription suppression of thromboxane receptor gene by peroxisome proliferator-activated receptor-gamma via an interaction with Sp1 in vascular smooth muscle cells
    • Sugawara, A.; Uruno, A.; Kudo, M.; Ikeda, Y.; Sato, K.; Taniyama, Y.; Ito, S.; Takeuchi, K. Transcription suppression of thromboxane receptor gene by peroxisome proliferator-activated receptor-gamma via an interaction with Sp1 in vascular smooth muscle cells. J. Biol. Chem., 2002, 277, 9676-9683.
    • (2002) J. Biol. Chem , vol.277 , pp. 9676-9683
    • Sugawara, A.1    Uruno, A.2    Kudo, M.3    Ikeda, Y.4    Sato, K.5    Taniyama, Y.6    Ito, S.7    Takeuchi, K.8
  • 29
    • 0141886991 scopus 로고    scopus 로고
    • Regulation of the growth arrest and DNA damage-inducible gene 45 (GADD45) by peroxisome proliferator-activated receptor gamma in vascular smooth muscle cells
    • Bruemmer, D.; Yin, F.; Liu, J.; Berger, J.P.; Sakai, T.; Blaschke, F.; Fleck, E.; Van Herle, A.J.; Forman, B.M.; Law, R.E. Regulation of the growth arrest and DNA damage-inducible gene 45 (GADD45) by peroxisome proliferator-activated receptor gamma in vascular smooth muscle cells. Circ. Res., 2003, 93, e38-e47.
    • (2003) Circ. Res , vol.93
    • Bruemmer, D.1    Yin, F.2    Liu, J.3    Berger, J.P.4    Sakai, T.5    Blaschke, F.6    Fleck, E.7    Van Herle, A.J.8    Forman, B.M.9    Law, R.E.10
  • 30
    • 0034698074 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma ligands inhibit retinoblastoma phosphorylation and G1--> S transition in vascular smooth muscle cells
    • Wakino, S.; Kintscher, U.; Kim, S.; Yin, F.; Hsueh, W.A.; Law, R.E. Peroxisome proliferator-activated receptor gamma ligands inhibit retinoblastoma phosphorylation and G1--> S transition in vascular smooth muscle cells. J. Biol. Chem., 2000, 275, 22435-22441.
    • (2000) J. Biol. Chem , vol.275 , pp. 22435-22441
    • Wakino, S.1    Kintscher, U.2    Kim, S.3    Yin, F.4    Hsueh, W.A.5    Law, R.E.6
  • 31
    • 0035861760 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma ligands inhibit mitogenic induction of p21(Cip1) by modulating the protein kinase Cdelta pathway in vascular smooth muscle cells
    • Wakino, S.; Kintscher, U.; Liu, Z.; Kim, S.; Yin, F.; Ohba, M.; Kuroki, T.; Schonthal, A.H.; Hsueh, W.A.; Law, R.E. Peroxisome proliferator-activated receptor gamma ligands inhibit mitogenic induction of p21(Cip1) by modulating the protein kinase Cdelta pathway in vascular smooth muscle cells. J. Biol. Chem., 2001, 276, 47650-47657.
    • (2001) J. Biol. Chem , vol.276 , pp. 47650-47657
    • Wakino, S.1    Kintscher, U.2    Liu, Z.3    Kim, S.4    Yin, F.5    Ohba, M.6    Kuroki, T.7    Schonthal, A.H.8    Hsueh, W.A.9    Law, R.E.10
  • 32
    • 0346668393 scopus 로고    scopus 로고
    • A non-thiazolidinedione partial peroxisome proliferator-activated receptor gamma ligand inhibits vascular smooth muscle cell growth
    • Bruemmer, D.; Berger, J.P.; Liu, J.; Kintscher, U.; Wakino, S.; Fleck, E.; Moller, D.E.; Law, R.E. A non-thiazolidinedione partial peroxisome proliferator-activated receptor gamma ligand inhibits vascular smooth muscle cell growth. Eur. J. Pharmacol., 2003, 466, 225-234.
    • (2003) Eur. J. Pharmacol , vol.466 , pp. 225-234
    • Bruemmer, D.1    Berger, J.P.2    Liu, J.3    Kintscher, U.4    Wakino, S.5    Fleck, E.6    Moller, D.E.7    Law, R.E.8
  • 33
    • 0037674923 scopus 로고    scopus 로고
    • Inhibitory activity of clinical thiazolidinedione peroxisome proliferator activating receptor-gamma ligands toward internal mammary artery, radial artery, and saphenous vein smooth muscle cell proliferation
    • de Dios, S.T.; Bruemmer, D.; Dilley, R.J.; Ivey, M.E.; Jennings, G.L.; Law, R.E.; Little, P.J. Inhibitory activity of clinical thiazolidinedione peroxisome proliferator activating receptor-gamma ligands toward internal mammary artery, radial artery, and saphenous vein smooth muscle cell proliferation. Circulation, 2003, 107, 2548-2550.
    • (2003) Circulation , vol.107 , pp. 2548-2550
    • de Dios, S.T.1    Bruemmer, D.2    Dilley, R.J.3    Ivey, M.E.4    Jennings, G.L.5    Law, R.E.6    Little, P.J.7
  • 35
    • 0031886864 scopus 로고    scopus 로고
    • The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation
    • Ricote, M.; Li, A.C.; Willson, T.M.; Kelly, C.J.; Glass, C.K. The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation. Nature, 1998, 391, 79-82.
    • (1998) Nature , vol.391 , pp. 79-82
    • Ricote, M.1    Li, A.C.2    Willson, T.M.3    Kelly, C.J.4    Glass, C.K.5
  • 36
    • 0035018327 scopus 로고    scopus 로고
    • Troglitazone, but not rosiglitazone, inhibits Na/H exchange activity and proliferation of macrovascular endothelial cells
    • de Dios, S.T.; Hannan, K.M.; Dilley, R.J.; Hill, M.A.; Little, P.J. Troglitazone, but not rosiglitazone, inhibits Na/H exchange activity and proliferation of macrovascular endothelial cells. J. Diabetes Complications, 2001, 15, 120-127.
    • (2001) J. Diabetes Complications , vol.15 , pp. 120-127
    • de Dios, S.T.1    Hannan, K.M.2    Dilley, R.J.3    Hill, M.A.4    Little, P.J.5
  • 37
    • 0036205029 scopus 로고    scopus 로고
    • Inhibition of the Low Density Lipoprotein-Induced Vascular Smooth Muscle Cell Growth by PPARgamma Ligands
    • Gouni-Berthold, I.; Sachinidis, A. Inhibition of the Low Density Lipoprotein-Induced Vascular Smooth Muscle Cell Growth by PPARgamma Ligands. Drug News Perspect, 2002, 15, 5-9.
    • (2002) Drug News Perspect , vol.15 , pp. 5-9
    • Gouni-Berthold, I.1    Sachinidis, A.2
  • 38
    • 33646149159 scopus 로고    scopus 로고
    • Activation of peroxisome proliferator-activated receptor gamma suppresses telomerase activity in vascular smooth muscle cells
    • Ogawa, D.; Nomiyama, T.; Nakamachi, T.; Heywood, E.B.; Stone, J.F.; Berger, J.P.; Law, R.E.; Bruemmer, D. Activation of peroxisome proliferator-activated receptor gamma suppresses telomerase activity in vascular smooth muscle cells. Circ. Res., 2006, 98, e50-e59.
    • (2006) Circ. Res , vol.98
    • Ogawa, D.1    Nomiyama, T.2    Nakamachi, T.3    Heywood, E.B.4    Stone, J.F.5    Berger, J.P.6    Law, R.E.7    Bruemmer, D.8
  • 40
    • 0034968295 scopus 로고    scopus 로고
    • Differential effects among thiazolidinediones on the transcription of thromboxane receptor and angiotensin II type 1 receptor genes
    • Sugawara, A.; Takeuchi, K.; Uruno, A.; Ikeda, Y.; Arima, S.; Sato, K.; Kudo, M.; Taniyama, Y.; Ito, S. Differential effects among thiazolidinediones on the transcription of thromboxane receptor and angiotensin II type 1 receptor genes. Hypertens. Res., 2001, 24, 229-233.
    • (2001) Hypertens. Res , vol.24 , pp. 229-233
    • Sugawara, A.1    Takeuchi, K.2    Uruno, A.3    Ikeda, Y.4    Arima, S.5    Sato, K.6    Kudo, M.7    Taniyama, Y.8    Ito, S.9
  • 41
    • 0034989969 scopus 로고    scopus 로고
    • Transcriptional suppression of type 1 angiotensin II receptor gene expression by peroxisome proliferator-activated receptor-gamma in vascular smooth muscle cells
    • Sugawara, A.; Takeuchi, K.; Uruno, A.; Ikeda, Y.; Arima, S.; Kudo, M.; Sato, K.; Taniyama, Y.; Ito, S. Transcriptional suppression of type 1 angiotensin II receptor gene expression by peroxisome proliferator-activated receptor-gamma in vascular smooth muscle cells. Endocrinology, 2001, 142, 3125-3134.
    • (2001) Endocrinology , vol.142 , pp. 3125-3134
    • Sugawara, A.1    Takeuchi, K.2    Uruno, A.3    Ikeda, Y.4    Arima, S.5    Kudo, M.6    Sato, K.7    Taniyama, Y.8    Ito, S.9
  • 42
    • 0034602547 scopus 로고    scopus 로고
    • Troglitazone induces apoptosis via the p53 and Gadd45 pathway in vascular smooth muscle cells
    • Okura, T.; Nakamura, M.; Takata, Y.; Watanabe, S.; Kitami, Y.; Hiwada, K. Troglitazone induces apoptosis via the p53 and Gadd45 pathway in vascular smooth muscle cells. Eur. J. Pharmacol., 2000, 407, 227-235.
    • (2000) Eur. J. Pharmacol , vol.407 , pp. 227-235
    • Okura, T.1    Nakamura, M.2    Takata, Y.3    Watanabe, S.4    Kitami, Y.5    Hiwada, K.6
  • 43
    • 1042279525 scopus 로고    scopus 로고
    • Interferon regulatory factor-1 mediates PPARgamma-induced apoptosis in vascular smooth muscle cells
    • Lin, Y.; Zhu, X.; McLntee, F.L.; Xiao, H.; Zhang, J.; Fu, M.; Chen, Y.E. Interferon regulatory factor-1 mediates PPARgamma-induced apoptosis in vascular smooth muscle cells. Arterioscler. Thromb. Vasc. Biol., 2004, 24, 257-263.
    • (2004) Arterioscler. Thromb. Vasc. Biol , vol.24 , pp. 257-263
    • Lin, Y.1    Zhu, X.2    McLntee, F.L.3    Xiao, H.4    Zhang, J.5    Fu, M.6    Chen, Y.E.7
  • 44
    • 14644439839 scopus 로고    scopus 로고
    • Pioglitazone induces vascular smooth muscle cell apoptosis through a peroxisome proliferator-activated receptor-gamma, transforming growth factor-beta1, and a Smad2-dependent mechanism
    • Redondo, S.; Ruiz, E.; Santos-Gallego, C.G.; Padilla, E.; Tejerina, T. Pioglitazone induces vascular smooth muscle cell apoptosis through a peroxisome proliferator-activated receptor-gamma, transforming growth factor-beta1, and a Smad2-dependent mechanism. Diabetes, 2005, 54, 811-817.
    • (2005) Diabetes , vol.54 , pp. 811-817
    • Redondo, S.1    Ruiz, E.2    Santos-Gallego, C.G.3    Padilla, E.4    Tejerina, T.5
  • 45
  • 46
    • 0032540012 scopus 로고    scopus 로고
    • PPARgamma promotes monocyte/macrophage differentiation and uptake of oxidized LDL
    • Tontonoz, P.; Nagy, L.; Alvarez, J.G.; Thomazy, V.A.; Evans, R.M. PPARgamma promotes monocyte/macrophage differentiation and uptake of oxidized LDL. Cell, 1998, 93, 241-252.
    • (1998) Cell , vol.93 , pp. 241-252
    • Tontonoz, P.1    Nagy, L.2    Alvarez, J.G.3    Thomazy, V.A.4    Evans, R.M.5
  • 47
    • 0032540325 scopus 로고    scopus 로고
    • Oxidized LDL regulates macrophage gene expression through ligand activation of PPARgamma
    • Nagy, L.; Tontonoz, P.; Alvarez, J.G.; Chen, H.; Evans, R.M. Oxidized LDL regulates macrophage gene expression through ligand activation of PPARgamma. Cell, 1998, 93, 229-240.
    • (1998) Cell , vol.93 , pp. 229-240
    • Nagy, L.1    Tontonoz, P.2    Alvarez, J.G.3    Chen, H.4    Evans, R.M.5
  • 49
    • 0033864582 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma ligands inhibit development of atherosclerosis in LDL receptor-deficient mice
    • Li, A.C.; Brown, K.K.; Silvestre, M.J.; Willson, T.M.; Palinski, W.; Glass, C.K. Peroxisome proliferator-activated receptor gamma ligands inhibit development of atherosclerosis in LDL receptor-deficient mice. Clin. Invest., 2000, 106, 523-531.
    • (2000) Clin. Invest , vol.106 , pp. 523-531
    • Li, A.C.1    Brown, K.K.2    Silvestre, M.J.3    Willson, T.M.4    Palinski, W.5    Glass, C.K.6
  • 50
    • 0035132330 scopus 로고    scopus 로고
    • PAR-gamma dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation
    • Chawla, A.; Barak, Y.; Nagy, L.; Liao, D.; Tontonoz, P.; Evans, R.M. PAR-gamma dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation. Nat. Med., 2001, 7, 48-52.
    • (2001) Nat. Med , vol.7 , pp. 48-52
    • Chawla, A.1    Barak, Y.2    Nagy, L.3    Liao, D.4    Tontonoz, P.5    Evans, R.M.6
  • 55
    • 0036205326 scopus 로고    scopus 로고
    • Conditional disruption of the peroxisome proliferator-activated receptor gamma gene in mice results in lowered expression of ABCA1, ABCG1, and apoE in macrophages and reduced cholesterol efflux
    • Akiyama, T.E.; Sakai, S.; Lambert, G.; Nicol, C.J.; Matsusue, K.; Pimprale, S.; Lee, Y.H.; Ricote, M.; Glass, C.K.; Brewer, H.B.; Jr.; Gonzalez, F.J. Conditional disruption of the peroxisome proliferator-activated receptor gamma gene in mice results in lowered expression of ABCA1, ABCG1, and apoE in macrophages and reduced cholesterol efflux. Mol. Cell Biol., 2002, 22, 2607-2619.
    • (2002) Mol. Cell Biol , vol.22 , pp. 2607-2619
    • Akiyama, T.E.1    Sakai, S.2    Lambert, G.3    Nicol, C.J.4    Matsusue, K.5    Pimprale, S.6    Lee, Y.H.7    Ricote, M.8    Glass, C.K.9    Brewer Jr., H.B.10    Gonzalez, F.J.11
  • 57
    • 0031888958 scopus 로고    scopus 로고
    • PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines
    • Jiang, C.; Ting, A.T.; Seed, B. PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines. Nature, 1998, 391, 82-86.
    • (1998) Nature , vol.391 , pp. 82-86
    • Jiang, C.1    Ting, A.T.2    Seed, B.3
  • 58
    • 0038460253 scopus 로고    scopus 로고
    • PPARgamma and PPARdelta negatively regulate specific subsets of lipopolysaccharide and IFN-gamma target genes in macrophages
    • Welch, J.S.; Ricote, M.; Akiyama, T.E.; Gonzalez, F.J.; Glass, C.K. PPARgamma and PPARdelta negatively regulate specific subsets of lipopolysaccharide and IFN-gamma target genes in macrophages. Proc. Natl. Acad. Sci. USA, 2003, 100, 6712-6717.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 6712-6717
    • Welch, J.S.1    Ricote, M.2    Akiyama, T.E.3    Gonzalez, F.J.4    Glass, C.K.5
  • 59
    • 0034637218 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor and retinoid X receptor ligands inhibit monocyte chemotactic protein-1-directed migration of monocytes
    • Kintscher, U.; Goetze, S.; Wakino, S.; Kim, S.; Nagpal, S.; Chandraratna, R.A.; Graf, K.; Fleck, E.; Hsueh, W.A.; Law, R.E. Peroxisome proliferator-activated receptor and retinoid X receptor ligands inhibit monocyte chemotactic protein-1-directed migration of monocytes. Eur. J. Pharmacol., 2000, 401, 259-270.
    • (2000) Eur. J. Pharmacol , vol.401 , pp. 259-270
    • Kintscher, U.1    Goetze, S.2    Wakino, S.3    Kim, S.4    Nagpal, S.5    Chandraratna, R.A.6    Graf, K.7    Fleck, E.8    Hsueh, W.A.9    Law, R.E.10
  • 60
    • 0001538199 scopus 로고    scopus 로고
    • Oxidized LDL reduces monocyte CCR2 expression through pathways involving peroxisome proliferator-activated receptor gamma
    • Han, K.H.; Chang, M.K.; Boullier, A.; Green, S.R.; Li, A.; Glass, C.K.; Quehenberger, O. Oxidized LDL reduces monocyte CCR2 expression through pathways involving peroxisome proliferator-activated receptor gamma. Clin. Invest., 2000, 106, 793-802.
    • (2000) Clin. Invest , vol.106 , pp. 793-802
    • Han, K.H.1    Chang, M.K.2    Boullier, A.3    Green, S.R.4    Li, A.5    Glass, C.K.6    Quehenberger, O.7
  • 63
    • 26444471700 scopus 로고    scopus 로고
    • Pascual, G.; Fong, A.L.; Ogawa, S.; Gamliel, A.; Li, A.C.; Perissi, V.; Rose, D.W.; Willson, T.M.; Rosenfeld, M.G.; Glass, C.K. A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-gamma. Nature, 2005, 437, 759-763.
    • Pascual, G.; Fong, A.L.; Ogawa, S.; Gamliel, A.; Li, A.C.; Perissi, V.; Rose, D.W.; Willson, T.M.; Rosenfeld, M.G.; Glass, C.K. A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-gamma. Nature, 2005, 437, 759-763.
  • 64
    • 28944446431 scopus 로고    scopus 로고
    • The many faces of PPARgamma
    • Lehrke, M.; Lazar, M.A. The many faces of PPARgamma. Cell, 2005, 123, 993-999.
    • (2005) Cell , vol.123 , pp. 993-999
    • Lehrke, M.1    Lazar, M.A.2
  • 65
    • 0032560807 scopus 로고    scopus 로고
    • Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction
    • Haffner, S.M.; Lehto, S.; Ronnemaa, T.; Pyorala, K.; Laakso, M. Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction. N. Engl. J Med., 1998, 339, 229-234.
    • (1998) N. Engl. J Med , vol.339 , pp. 229-234
    • Haffner, S.M.1    Lehto, S.2    Ronnemaa, T.3    Pyorala, K.4    Laakso, M.5
  • 66
    • 0037031267 scopus 로고    scopus 로고
    • Effect of rosiglitazone treatment on nontraditional markers of cardiovascular disease in patients with type 2 diabetes mellitus
    • Haffner, S.M.; Greenberg, A.S.; Weston, W.M.; Chen, H.; Williams, K.; Freed, M.I. Effect of rosiglitazone treatment on nontraditional markers of cardiovascular disease in patients with type 2 diabetes mellitus. Circulation, 2002, 106, 679-684.
    • (2002) Circulation , vol.106 , pp. 679-684
    • Haffner, S.M.1    Greenberg, A.S.2    Weston, W.M.3    Chen, H.4    Williams, K.5    Freed, M.I.6
  • 67
    • 33645225344 scopus 로고    scopus 로고
    • Effect of rosiglitazone on plasma adiponectin levels and arterial stiffness in subjects with prediabetes or non-diabetic metabolic syndrome
    • Kim, S.G.; Ryu, O.H.; Kim, H.Y.; Lee, K.W.; Seo, J.A.; Kim, N.H.; Choi, K.M.; Lee, J.; Baik, S.H.; Choi, D.S. Effect of rosiglitazone on plasma adiponectin levels and arterial stiffness in subjects with prediabetes or non-diabetic metabolic syndrome. Eur. J. Endocrinol., 2006, 154, 433-440.
    • (2006) Eur. J. Endocrinol , vol.154 , pp. 433-440
    • Kim, S.G.1    Ryu, O.H.2    Kim, H.Y.3    Lee, K.W.4    Seo, J.A.5    Kim, N.H.6    Choi, K.M.7    Lee, J.8    Baik, S.H.9    Choi, D.S.10
  • 68
    • 0036872996 scopus 로고    scopus 로고
    • Addressing the insulin resistance syndrome: A role for the thiazolidinediones
    • Zimmet, P. Addressing the insulin resistance syndrome: a role for the thiazolidinediones. Trends Cardiovasc. Med., 2002, 12, 354-362.
    • (2002) Trends Cardiovasc. Med , vol.12 , pp. 354-362
    • Zimmet, P.1
  • 69
    • 33644853793 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-gamma activation with pioglitazone improves endothelium-dependent dilation in nondiabetic patients with major cardiovascular risk factors
    • Campia, U.; Matuskey, L.A.; Panza, J.A. Peroxisome proliferator-activated receptor-gamma activation with pioglitazone improves endothelium-dependent dilation in nondiabetic patients with major cardiovascular risk factors. Circulation, 2006, 113, 867-875.
    • (2006) Circulation , vol.113 , pp. 867-875
    • Campia, U.1    Matuskey, L.A.2    Panza, J.A.3
  • 71
    • 0036890882 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor activators inhibit oxidized low-density lipoprotein-induced endothelin-1 secretion in endothelial cells
    • Martin-Nizard, F.; Furman, C.; Delerive, P.; Kandoussi, A.; Fruchart, J.C.; Staels, B.; Duriez, P. Peroxisome proliferator-activated receptor activators inhibit oxidized low-density lipoprotein-induced endothelin-1 secretion in endothelial cells. J. Cardiovasc. Pharmacol., 2002, 40, 822-831.
    • (2002) J. Cardiovasc. Pharmacol , vol.40 , pp. 822-831
    • Martin-Nizard, F.1    Furman, C.2    Delerive, P.3    Kandoussi, A.4    Fruchart, J.C.5    Staels, B.6    Duriez, P.7
  • 73
    • 1542652475 scopus 로고    scopus 로고
    • Nitric oxide production and regulation of endothelial nitric-oxide synthase phosphorylation by prolonged treatment with troglitazone: Evidence for involvement of peroxisome proliferator-activated receptor (PPAR) gamma-dependent and PPARgamma-independent signaling pathways
    • Cho, D.H.; Choi, Y.J.; Jo, S.A.; Jo, I. Nitric oxide production and regulation of endothelial nitric-oxide synthase phosphorylation by prolonged treatment with troglitazone: evidence for involvement of peroxisome proliferator-activated receptor (PPAR) gamma-dependent and PPARgamma-independent signaling pathways. J. Biol. Chem., 2004, 279, 2499-2506.
    • (2004) J. Biol. Chem , vol.279 , pp. 2499-2506
    • Cho, D.H.1    Choi, Y.J.2    Jo, S.A.3    Jo, I.4
  • 74
    • 3142608994 scopus 로고    scopus 로고
    • Effects of rosiglitazone on endothelial function in men with coronary artery disease without diabetes mellitus
    • Sidhu, J.S.; Cowan, D.; Kaski, J.C. Effects of rosiglitazone on endothelial function in men with coronary artery disease without diabetes mellitus. Am. J. Cardiol., 2004, 94, 151-156.
    • (2004) Am. J. Cardiol , vol.94 , pp. 151-156
    • Sidhu, J.S.1    Cowan, D.2    Kaski, J.C.3
  • 75
    • 0242543997 scopus 로고    scopus 로고
    • The effects of rosiglitazone, a peroxisome proliferator-activated receptor-gamma agonist, on markers of endothelial cell activation, C-reactive protein, and fibrinogen levels in non-diabetic coronary artery disease patients
    • Sidhu, J.S.; Cowan, D.; Kaski, J.C. The effects of rosiglitazone, a peroxisome proliferator-activated receptor-gamma agonist, on markers of endothelial cell activation, C-reactive protein, and fibrinogen levels in non-diabetic coronary artery disease patients. J. Am. Coll. Cardiol., 2003, 42, 1757-1763.
    • (2003) J. Am. Coll. Cardiol , vol.42 , pp. 1757-1763
    • Sidhu, J.S.1    Cowan, D.2    Kaski, J.C.3
  • 76
    • 3042714528 scopus 로고    scopus 로고
    • The prospective pioglitazone clinical trial in macrovascular events (PROactive): Can pioglitazone reduce cardiovascular events in diabetes? Study design and baseline characteristics of 5238 patients
    • Charbonnel, B.; Dormandy, J.; Erdmann, E.; Massi-Benedetti, M.; Skene, A. The prospective pioglitazone clinical trial in macrovascular events (PROactive): can pioglitazone reduce cardiovascular events in diabetes? Study design and baseline characteristics of 5238 patients. Diabetes Care, 2004, 27, 1647-1653.
    • (2004) Diabetes Care , vol.27 , pp. 1647-1653
    • Charbonnel, B.1    Dormandy, J.2    Erdmann, E.3    Massi-Benedetti, M.4    Skene, A.5
  • 77
    • 26244453309 scopus 로고    scopus 로고
    • Dormandy, J.A.; Charbonnel, B.; Eckland, D.J.; Erdmann, E.; Massi-Benedetti, M.; Moules, I.K.; Skene, A.M.; Tan, M.H.; Lefebvre, P.J.; Murray, G.D.; Standl, E.; Wilcox, R.G.; Wilhelmsen, L.; Betteridge, J.; Birkeland, K.; Golay, A.; Heine, R.J.; Koranyi, L.; Laakso, M.; Mokan, M.; Norkus, A.; Pirags, V.; Podar, T.; Scheen, A.; Scherbaum, W.; Schernthaner, G.; Schmitz, O.; Skrha, J.; Smith, U.; Taton, J. Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): a randomised controlled trial. Lancet, 2005, 366, 1279-1289.
    • Dormandy, J.A.; Charbonnel, B.; Eckland, D.J.; Erdmann, E.; Massi-Benedetti, M.; Moules, I.K.; Skene, A.M.; Tan, M.H.; Lefebvre, P.J.; Murray, G.D.; Standl, E.; Wilcox, R.G.; Wilhelmsen, L.; Betteridge, J.; Birkeland, K.; Golay, A.; Heine, R.J.; Koranyi, L.; Laakso, M.; Mokan, M.; Norkus, A.; Pirags, V.; Podar, T.; Scheen, A.; Scherbaum, W.; Schernthaner, G.; Schmitz, O.; Skrha, J.; Smith, U.; Taton, J. Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): a randomised controlled trial. Lancet, 2005, 366, 1279-1289.
  • 78
    • 33644645475 scopus 로고    scopus 로고
    • Commentary on the results and clinical implications of the PROactive study
    • Rizza, R.; Henry, R.; Kahn, R. Commentary on the results and clinical implications of the PROactive study. Diabetes Care, 2005, 28, 2965-2967.
    • (2005) Diabetes Care , vol.28 , pp. 2965-2967
    • Rizza, R.1    Henry, R.2    Kahn, R.3
  • 79
    • 0031724132 scopus 로고    scopus 로고
    • Potent inhibitory effect of troglitazone on carotid arterial wall thickness in type 2 diabetes
    • Minamikawa, J.; Tanaka, S.; Yamauchi, M.; Inoue, D.; Koshiyama, H. Potent inhibitory effect of troglitazone on carotid arterial wall thickness in type 2 diabetes. J. Clin. Endocrinol. Metab., 1998, 83, 1818-1820.
    • (1998) J. Clin. Endocrinol. Metab , vol.83 , pp. 1818-1820
    • Minamikawa, J.1    Tanaka, S.2    Yamauchi, M.3    Inoue, D.4    Koshiyama, H.5
  • 80
    • 0034920087 scopus 로고    scopus 로고
    • Rapid communication: Inhibitory effect of pioglitazone on carotid arterial wall thickness in type 2 diabetes
    • Koshiyama, H.; Shimono, D.; Kuwamura, N.; Minamikawa, J.; Nakamura, Y. Rapid communication: inhibitory effect of pioglitazone on carotid arterial wall thickness in type 2 diabetes. J. Clin. Endocrinol. Metab., 2001, 86, 3452-3456.
    • (2001) J. Clin. Endocrinol. Metab , vol.86 , pp. 3452-3456
    • Koshiyama, H.1    Shimono, D.2    Kuwamura, N.3    Minamikawa, J.4    Nakamura, Y.5
  • 81
    • 27844538450 scopus 로고    scopus 로고
    • Pioglitazone reduces neointima volume after coronary stent implantation: A randomized, placebo-controlled, double-blind trial in nondiabetic patients
    • Marx, N.; Wohrle, J.; Nusser, T.; Walcher, D.; Rinker, A.; Hombach, V.; Koenig, W.; Hoher, M. Pioglitazone reduces neointima volume after coronary stent implantation: a randomized, placebo-controlled, double-blind trial in nondiabetic patients. Circulation, 2005, 112, 2792-2798.
    • (2005) Circulation , vol.112 , pp. 2792-2798
    • Marx, N.1    Wohrle, J.2    Nusser, T.3    Walcher, D.4    Rinker, A.5    Hombach, V.6    Koenig, W.7    Hoher, M.8
  • 83
    • 0029968957 scopus 로고    scopus 로고
    • A comparison of the hypotensive and hypoglycaemic actions of an angiotensin converting enzyme inhibitor, an AT1a antagonist and troglitazone
    • Chen, S.; Noguchi, Y.; Izumida, T.; Tatebe, J.; Katayama, S. A comparison of the hypotensive and hypoglycaemic actions of an angiotensin converting enzyme inhibitor, an AT1a antagonist and troglitazone. J. Hypertens., 1996, 14, 1325-1330.
    • (1996) J. Hypertens , vol.14 , pp. 1325-1330
    • Chen, S.1    Noguchi, Y.2    Izumida, T.3    Tatebe, J.4    Katayama, S.5
  • 84
    • 0030774760 scopus 로고    scopus 로고
    • Troglitazone lowers blood pressure and enhances insulin sensitivity in Watanabe heritable hyperlipidemic rabbits
    • Saku, K.; Zhang, B.; Ohta, T.; Arakawa, K. Troglitazone lowers blood pressure and enhances insulin sensitivity in Watanabe heritable hyperlipidemic rabbits. Am. J. Hypertens., 1997, 10, 1027-1033.
    • (1997) Am. J. Hypertens , vol.10 , pp. 1027-1033
    • Saku, K.1    Zhang, B.2    Ohta, T.3    Arakawa, K.4
  • 85
    • 4444358440 scopus 로고    scopus 로고
    • Beneficial and deleterious effects of rosiglitazone on hypertension development in spontaneously hypertensive rats
    • Wu, L.; Wang, R.; De Champlain, J.; Wilson, T.W. Beneficial and deleterious effects of rosiglitazone on hypertension development in spontaneously hypertensive rats. Am. J. Hypertens., 2004, 17, 749-756.
    • (2004) Am. J. Hypertens , vol.17 , pp. 749-756
    • Wu, L.1    Wang, R.2    De Champlain, J.3    Wilson, T.W.4
  • 86
    • 0028901028 scopus 로고
    • Enhancement of insulin sensitivity by troglitazone lowers blood pressure in diabetic hypertensives
    • Ogihara, T.; Rakugi, H.; Ikegami, H.; Mikami, H.; Masuo, K. Enhancement of insulin sensitivity by troglitazone lowers blood pressure in diabetic hypertensives. Am. J.Hypertens., 1995, 8, 316-320.
    • (1995) Am. J.Hypertens , vol.8 , pp. 316-320
    • Ogihara, T.1    Rakugi, H.2    Ikegami, H.3    Mikami, H.4    Masuo, K.5
  • 87
    • 0027983920 scopus 로고
    • Improvement in glucose tolerance and insulin resistance in obese subjects treated with troglitazone
    • Nolan, J.J.; Ludvik, B.; Beerdsen, P.; Joyce, M.; Olefsky, J. Improvement in glucose tolerance and insulin resistance in obese subjects treated with troglitazone. N. Engl. J. Med., 1994, 331, 1188-1193.
    • (1994) N. Engl. J. Med , vol.331 , pp. 1188-1193
    • Nolan, J.J.1    Ludvik, B.2    Beerdsen, P.3    Joyce, M.4    Olefsky, J.5
  • 88
    • 0242363724 scopus 로고    scopus 로고
    • Rosiglitazone lowers blood pressure and increases arterial compliance in postmenopausal women with type 2 diabetes
    • Honisett, S.Y.; Stojanovska, L.; Sudhir, K.; Kingwell, B.A.; Dawood, T.; Komesaroff, P.A. Rosiglitazone lowers blood pressure and increases arterial compliance in postmenopausal women with type 2 diabetes. Diabetes Care, 2003, 26, 3194-3195.
    • (2003) Diabetes Care , vol.26 , pp. 3194-3195
    • Honisett, S.Y.1    Stojanovska, L.2    Sudhir, K.3    Kingwell, B.A.4    Dawood, T.5    Komesaroff, P.A.6
  • 91
    • 1442288375 scopus 로고    scopus 로고
    • PPAR(gamma) agonist rosiglitazone improves vascular function and lowers blood pressure in hypertensive transgenic mice
    • Ryan, M.J.; Didion, S.P.; Mathur, S.; Faraci, F.M.; Sigmund, C.D. PPAR(gamma) agonist rosiglitazone improves vascular function and lowers blood pressure in hypertensive transgenic mice. Hypertension, 2004, 43, 661-666.
    • (2004) Hypertension , vol.43 , pp. 661-666
    • Ryan, M.J.1    Didion, S.P.2    Mathur, S.3    Faraci, F.M.4    Sigmund, C.D.5
  • 92
    • 33845203576 scopus 로고    scopus 로고
    • Rosiglitazone inhibits angiotensin II-induced CTGF expression in vascular smooth muscle cells - Role of PPAR-gamma in vascular fibrosis
    • Gao, D.F.; Niu, X.L.; Hao, G.H.; Peng, N.; Wei, J.; Ning, N.; Wang, N.P. Rosiglitazone inhibits angiotensin II-induced CTGF expression in vascular smooth muscle cells - Role of PPAR-gamma in vascular fibrosis. Biochem. Pharmacol., 2007, 73, 185-197.
    • (2007) Biochem. Pharmacol , vol.73 , pp. 185-197
    • Gao, D.F.1    Niu, X.L.2    Hao, G.H.3    Peng, N.4    Wei, J.5    Ning, N.6    Wang, N.P.7
  • 93
    • 18744383954 scopus 로고    scopus 로고
    • Treating the metabolic syndrome: Telmisartan as a peroxisome proliferator-activated receptor-gamma activator
    • Kurtz, T.W. Treating the metabolic syndrome: telmisartan as a peroxisome proliferator-activated receptor-gamma activator. Acta. Diabetol., 2005, 42(Suppl. 1), S9-16.
    • (2005) Acta. Diabetol , vol.42 , Issue.SUPPL. 1
    • Kurtz, T.W.1
  • 94
    • 33644672013 scopus 로고    scopus 로고
    • Molecular characterization of new selective peroxisome proliferator-activated receptor gamma modulators with angiotensin receptor blocking activity
    • Schupp, M.; Clemenz, M.; Gineste, R.; Witt, H.; Janke, J.; Helleboid, S.; Hennuyer, N.; Ruiz, P.; Unger, T.; Staels, B.; Kintscher, U. Molecular characterization of new selective peroxisome proliferator-activated receptor gamma modulators with angiotensin receptor blocking activity. Diabetes, 2005, 54, 3442-3452.
    • (2005) Diabetes , vol.54 , pp. 3442-3452
    • Schupp, M.1    Clemenz, M.2    Gineste, R.3    Witt, H.4    Janke, J.5    Helleboid, S.6    Hennuyer, N.7    Ruiz, P.8    Unger, T.9    Staels, B.10    Kintscher, U.11
  • 99
    • 33646194995 scopus 로고    scopus 로고
    • Adverse events related to muraglitazar use in diabetes
    • Najman, D.M. Adverse events related to muraglitazar use in diabetes. JAMA, 2006, 295, 1997.
    • (1997) JAMA , vol.2006 , pp. 295
    • Najman, D.M.1
  • 100
    • 33745957332 scopus 로고    scopus 로고
    • Kendall, D.M.; Rubin, C.J.; Mohideen, P.; Ledeine, J.M.; Belder, R.; Gross, J.; Norwood, P.; O'Mahony, M.; Sall, K.; Sloan, G.; Roberts, A.; Fiedorek, F.T.; DeFronzo, R.A. Improvement of glycemic control, triglycerides, and HDL cholesterol levels with muraglitazar, a dual (alpha/gamma) peroxisome proliferator-activated receptor activator, in patients with type 2 diabetes inadequately controlled with metformin monotherapy: A double-blind, randomized, pioglitazone-comparative study. Diabetes Care, 2006, 29, 1016-1023.
    • Kendall, D.M.; Rubin, C.J.; Mohideen, P.; Ledeine, J.M.; Belder, R.; Gross, J.; Norwood, P.; O'Mahony, M.; Sall, K.; Sloan, G.; Roberts, A.; Fiedorek, F.T.; DeFronzo, R.A. Improvement of glycemic control, triglycerides, and HDL cholesterol levels with muraglitazar, a dual (alpha/gamma) peroxisome proliferator-activated receptor activator, in patients with type 2 diabetes inadequately controlled with metformin monotherapy: A double-blind, randomized, pioglitazone-comparative study. Diabetes Care, 2006, 29, 1016-1023.
  • 101
    • 33644783769 scopus 로고    scopus 로고
    • Harrity, T.; Farrelly, D.; Tieman, A.; Chu, C.; Kunselman, L.; Gu, L.; Ponticiello, R.; Cap, M.; Qu, F.; Shao, C.; Wang, W.; Zhang, H.; Fenderson, W.; Chen, S.; Devasthale, P.; Jeon, Y.; Seethala, R.; Yang, W.P.; Ren, J.; Zhou, M.; Ryono, D.; Biller, S.; Mookhtiar, K.A.; Wetterau, J.; Gregg, R.; Cheng, P.T.; Hariharan, N. Muraglitazar, a novel dual (alpha/gamma) peroxisome proliferator-activated receptor activator, improves diabetes and other metabolic abnormalities and preserves beta-cell function in db/db mice. Diabetes, 2006, 55, 240-248.
    • Harrity, T.; Farrelly, D.; Tieman, A.; Chu, C.; Kunselman, L.; Gu, L.; Ponticiello, R.; Cap, M.; Qu, F.; Shao, C.; Wang, W.; Zhang, H.; Fenderson, W.; Chen, S.; Devasthale, P.; Jeon, Y.; Seethala, R.; Yang, W.P.; Ren, J.; Zhou, M.; Ryono, D.; Biller, S.; Mookhtiar, K.A.; Wetterau, J.; Gregg, R.; Cheng, P.T.; Hariharan, N. Muraglitazar, a novel dual (alpha/gamma) peroxisome proliferator-activated receptor activator, improves diabetes and other metabolic abnormalities and preserves beta-cell function in db/db mice. Diabetes, 2006, 55, 240-248.
  • 102
    • 33646073417 scopus 로고    scopus 로고
    • Prevalence of the metabolic syndrome and its relation to cardiovascular disease in an elderly Chinese population
    • He, Y.; Jiang, B.; Wang, J.; Feng, K.; Chang, Q.; Fan, L.; Li, X.; Hu, F.B. Prevalence of the metabolic syndrome and its relation to cardiovascular disease in an elderly Chinese population. J. Am. Coll. Cardiol., 2006, 47, 1588-1594.
    • (2006) J. Am. Coll. Cardiol , vol.47 , pp. 1588-1594
    • He, Y.1    Jiang, B.2    Wang, J.3    Feng, K.4    Chang, Q.5    Fan, L.6    Li, X.7    Hu, F.B.8
  • 103
    • 25144459980 scopus 로고    scopus 로고
    • The metabolic syndrome - a new worldwide definition
    • Alberti, K.G.; Zimmet, P.; Shaw, J. The metabolic syndrome - a new worldwide definition. Lancet, 2005, 366, 1059-1062.
    • (2005) Lancet , vol.366 , pp. 1059-1062
    • Alberti, K.G.1    Zimmet, P.2    Shaw, J.3
  • 104
    • 33747051810 scopus 로고    scopus 로고
    • The metabolic syndrome in China
    • Cheung, B.M. The metabolic syndrome in China. Br. J. Clin. Pharmacol., 2006, 62, 260-263.
    • (2006) Br. J. Clin. Pharmacol , vol.62 , pp. 260-263
    • Cheung, B.M.1
  • 105
    • 17144423522 scopus 로고    scopus 로고
    • Prevalence of the metabolic syndrome and overweight among adults in China
    • Gu, D.; Reynolds, K.; Wu, X.; Chen, J.; Duan, X.; Reynolds, R.F.; Whelton, P.K.; He, J. Prevalence of the metabolic syndrome and overweight among adults in China. Lancet, 2005, 365, 1398-1405.
    • (2005) Lancet , vol.365 , pp. 1398-1405
    • Gu, D.1    Reynolds, K.2    Wu, X.3    Chen, J.4    Duan, X.5    Reynolds, R.F.6    Whelton, P.K.7    He, J.8


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