Peroxisome Proliferator-activated Receptor γ Ligands Inhibit Mitogenic Induction of p21Cip1 by Modulating the Protein Kinase Cδ Pathway in Vascular Smooth Muscle Cells

Journal of Biological Chemistry

Volumn 276, Issue 50, 2001, Pages 47650-47657

  Wakino, Shu ^a   Kintscher, Ulrich ^a   Liu, Zhaowei ^a   Kim, Sarah ^a   Yin, Fen ^a   Ohba, Motoi ^b   Kuroki, Toshio ^b   Schönthal, Axel H ^c   Hsueh, Willa A ^a   Law, Ronald E ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b SHOWA UNIVERSITY   (Japan)

^c UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATTENUATION; CELLS; INSULIN; MUSCLE; RNA; SYNTHESIS (CHEMICAL);

PHOSPHORYLATION;

ENZYMES;

12 (2 CYANOETHYL) 6,7,12,13 TETRAHYDRO 13 METHYL 5 OXOINDOLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE; 2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; ADENOVIRUS VECTOR; CALPHOSTIN C; CYCLIN DEPENDENT KINASE INHIBITOR; CYCLOHEXIMIDE; DEPHOSTATIN; INSULIN; LIGAND; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PLATELET DERIVED GROWTH FACTOR; PROTEIN KINASE C DELTA; PROTEIN KINASE C INHIBITOR; PROTEIN P21; PROTEIN SYNTHESIS INHIBITOR; PROTEIN TYROSINE PHOSPHATASE INHIBITOR; ROSIGLITAZONE; ROTTLERIN; TROGLITAZONE; UNCLASSIFIED DRUG; VANADATE SODIUM; ACETOPHENONE DERIVATIVE; BENZOPYRAN DERIVATIVE; CARBAZOLE DERIVATIVE; CELL RECEPTOR; CHROMAN DERIVATIVE; CIP1 PROTEIN; CYCLINE; ENZYME INHIBITOR; HYDROQUINONE DERIVATIVE; INDOLE DERIVATIVE; ISOENZYME; MITOGENIC AGENT; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR; PROTEIN KINASE C; PROTEIN KINASE C-DELTA; PROTEIN TYROSINE PHOSPHATASE; RECOMBINANT PROTEIN; RNA; THIAZOLE DERIVATIVE; TRANSCRIPTION FACTOR; TYROSINE; VANADIC ACID;

ANIMAL CELL; AORTA MEDIA; ARTICLE; ATTENUATION; CONTROLLED STUDY; DRUG ACTIVITY; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME PHOSPHORYLATION; ENZYME REGULATION; GENE OVEREXPRESSION; HALF LIFE TIME; INHIBITION KINETICS; INSULIN RESPONSE; LIGAND BINDING; MITOGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN METABOLISM; PROTEIN SYNTHESIS INHIBITION; RAT; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE; ADENOVIRUS; ANIMAL; APOPTOSIS; BIOLOGICAL MODEL; CELL CULTURE; CELL DIVISION; CYTOLOGY; DOSE RESPONSE; DOWN REGULATION; ENZYMOLOGY; GENETICS; KINETICS; METABOLISM; MOUSE; PHOSPHORYLATION; PROTEIN PROCESSING; RAT STRAIN; SERODIAGNOSIS; THORACIC AORTA; TIME; UPREGULATION; WESTERN BLOTTING;

ADENOVIRIDAE; ANIMALIA;

ACETOPHENONES; ADENOVIRIDAE; ANIMAL; AORTA, THORACIC; APOPTOSIS; BENZOPYRANS; BLOTTING, WESTERN; CARBAZOLES; CELL DIVISION; CELLS, CULTURED; CHROMANS; CYCLINS; CYCLOHEXIMIDE; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; ENZYME INHIBITORS; HYDROQUINONES; INDOLES; INSULIN; ISOENZYMES; KINETICS; LIGANDS; MICE; MITOGENS; MODELS, BIOLOGICAL; MUSCLE, SMOOTH, VASCULAR; PHOSPHORYLATION; PLATELET-DERIVED GROWTH FACTOR; PRECIPITIN TESTS; PROTEIN KINASE C; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN SYNTHESIS INHIBITORS; PROTEIN-TYROSINE-PHOSPHATASE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECOMBINANT PROTEINS; RNA; SIGNAL TRANSDUCTION; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; THIAZOLES; TIME FACTORS; TRANSCRIPTION FACTORS; TYROSINE; UP-REGULATION; VANADATES;

EID: 0035861760     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M108719200     Document Type: Article

References (44)

1. Hanke, H. (1996) Circulation 93, 202
2. Ross, R. (1995) Annu. Rev. Physiol. 57, 791-804
3. Sherr, C. J., and Roberts, J. M. (1999) Genes Dev. 13, 1501-1512
4. Morgan, D. O. (1995) Nature 374, 131-134
5. Tanner, F. C., Boehm, M., Akyurek, L. M., San, H., Yang, Z. Y., Tashiro, J., Nabel, G. J., and Nabel, E. G. (2000) Circulation 101, 2022-2025
6. Chen, J., Willingham, T., Shuford, M., and Nisen, P. D. (1996) J. Clin. Invest. 97, 1983-1988
7. LaBaer, J., Garrett, M. D., Stevenson, L. F., Slingerland, J. M., Sandhu, C., Chou, H. S., Fattaey, A., and Harlow, E. (1997) Genes Dev. 11, 847-862
8. Rao, G. N. (1999) Biochim. Biophys. Acta 1448, 525-532
9. Li, Y., Jenkins, C. W., Nichols, M. A., and Xiong, Y. (1994) Oncogene 9, 2261-2268
10. Weiss, R. H., Joo, A., and Randour, C. (2000) J. Biol. Chem. 275, 10285-10290
11. Wakino, S., Kintscher, U., Kim, S., Yin, F., Hsueh, W. A., and Law, R. E. (2000) J. Biol. Chem. 275, 22435-22441
12. Black, J. D. (2000) Front. Biosci. 5, D406-D423
13. Zezula, J., Sexl, V., Hutter, C., Karel, A., Schutz, W., and Freissmuth, M. (1997) J. Biol. Chem. 272, 29967-29974
14. Akashi, M., Osawa, Y., Koeffler, H. P., and Hachiya, M. (1999) Biochem. J. 337, 607-616
15. Yasunari, K., Kohno, M., Kano, H., Yokokawa, K., Minami, M., and Yoshikawa, J. (1997) Circ. Res. 81, 953-962
16. Kanoh, Y., Bandyopadhyay, G., Sajan, M. P., Standaert, M. L., and Farese, R. V. (2000) J. Biol. Chem. 275, 16690-16696
17. Hanke, J. H., Gardner, J. P., Dow, R. L., Changelian, P. S., Brissette, W. H., Weringer, E. J., Pollok, B. A., and Connelly, P. A. (1996) J. Biol. Chem. 271, 695-701
18. Ohba, M., Ishino, K., Kashiwagi, M., Kawabe, S., Chida, K., Huh, N. H., and Kuroki, T. (1998) Mol. Cell. Biol. 18, 5199-5207
19. Tang, S., Morgan, K. G., Parker, C., and Ware, J. A. (1997) J. Biol. Chem. 272, 28704-28711
20. Feiken, E., van Etten, I., Gebbink, M. F. B. G., Moolenaar, W. H., and Zondag, G. C. M. (2000) J. Biol. Chem. 275, 15350-15356
21. Balciunaite, E., Jones, S., Toker, A., and Kazlauskas, A. (2000) Curr. Biol. 10, 261-267
22. Li, W., Mischak, H., Yu, J. C., Wang, L. M., Mushinski, J. F., Heidaran, M. A., and Pierce, J. H. (1994) J. Biol. Chem. 269, 2349-2352
23. Denning, M. F., Dlugosz, A. A., Threadgill, D. W., Magnuson, T., and Yuspa, S. H. (1996) J. Biol. Chem. 271, 5325-5331
24. Blake, R. A., Garcia, P. P., Parker, P. J., and Courtneidge, S. A. (1999) Cell Growth Differ. 10, 231-241
25. Kronfeld, I., Kazimirsky, G., Lorenzo, P. S., Garfield, S. H., Blumberg, P. M., and Brodie, C. (2000) J. Biol. Chem. 275, 35491-35498
26. Kmiecik, T. E., and Shalloway, D. (1987) Cell. 49, 65-73
27. Leng, L., Du, B., Consigli, S., and McCaffrey, T. A. (1996) Artery 22, 140-154
28. Perrotti, D., Iervolino, A., Cesi, V., Cirinna, M., Lombardini, S., Grassilli, E., Bonatti, S., Claudio, P. P., and Calabretta, B. (2000) Mol. Cell. Biol. 20, 6159-6169
29. Bao, J., Alroy, I., Waterman, H., Schejter, E. D., Brodie, C., Gruenberg, J., and Yarden, Y. (2000) J. Biol. Chem. 275, 26178-26186
30. Scott, M. T., Morrice, N., and Ball, K. L. (2000) J. Biol. Chem. 275, 11529-11537
31. Li, W., Yu, J. C., Michieli, P., Beeler, J. F., Ellmore, N., Heidaran, M. A., and Pierce, J. H. (1994) Mol. Cell. Biol. 14, 6727-6735
32. Sundaresan, M., Yu, Z. X., Ferrans, V. J., Irani, K., and Finkel, T. (1995) Science 270, 296-299
33. Konishi, H., Tanaka, M., Takemura, Y., Matsuzaki, H., Ono, Y., Kikkawa, U., and Nishizuka, Y. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 11233-11237
34. Freiss, G., and Vignon, F. (1994) Mol. Endocrinol. 8, 1389-1396
35. Parekh, D. B., Katso, R. M., Leslie, N. R., Downes, C. P., Procyk, K. J., Waterfield, M. D., and Parker, P. J. (2000) Biochem. J. 2, 425-433
36. Assender, J. W., Irenius, E., and Fredholm, B. B. (1996) Acta Physiol. Scand. 157, 451-460
37. Fukumoto, S., Nishizawa, Y., Hosoi, M., Koyama, H., Yamakawa, K., Ohno, S., and Morii, H. (1997) J. Biol. Chem. 272, 13816-13822
38. Yang, Z. Y., Simari, R. D., Perkins, N. D., San, H., Gordon, D., Nabel, G. J., and Nabel, E. G. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 7905-7910
39. Tanner, F. C., Yang, Z. Y., Duckers, E., Gordon, D., Nabel, G. J., and Nabel, E. G. (1998) Circ. Res. 82, 396-403
40. Lawlor, M. A., and Rotwein, P. (2000) J. Cell Biol. 151, 1131-1140
41. Bennett, M. R., Evan, G. I., and Schwartz, S. M. (1995) J. Clin. Invest. 95, 2266-2274
42. Gouni, B. I., Berthold, H. K., Weber, A. A., Ko, Y., Seul, C., Vetter, H., and Sachinidis, A. (2001) Naunyn Schmiedebergs Arch. Pharmacol. 363, 215-221
43. Elstner, E., Muller, C., Koshizuka, K., Williamson, E. A., Park, D., Asou, H., Shintaku, P., Said, J. W., Heber, D., and Koeffler, H. P. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 8806-8811
44. Hsueh, W. A., Jackson, S., and Law, R. E. (2001) Diabetes Care 24, 392-397