Troglitazone inhibits oxidized low-density lipoprotein-induced macrophage proliferation: Impact of the suppression of nuclear translocation of ERK1/2

Atherosclerosis

Volumn 191, Issue 1, 2007, Pages 22-32

  Yano, Miyuki ^a   Matsumura, Takeshi ^a   Senokuchi, Takafumi ^a   Ishii, Norio ^a   Motoshima, Hiroyuki ^a   Taguchi, Tetsuya ^a   Matsuo, Tomoko ^a   Sonoda, Kazuhiro ^a   Kukidome, Daisuke ^a   Sakai, Masakazu ^a   Kawada, Teruo ^b   Nishikawa, Takeshi ^a   Araki, Eiichi ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

^b Graduate School of Agriculture   (Japan)

Author keywords

Atherosclerosis; Growth factor; Macrophage; Ox LDL; Thiazolidinedione

Indexed keywords

ACETYLCYSTEINE; ANTIOXIDANT; CIGLITAZONE; GLITAZONE DERIVATIVE; GLYCINE DERIVATIVE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INSULIN SENSITIZING AGENT; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; N (2 MERCAPTOPROCINYL)GLYCINE; OXIDIZED LOW DENSITY LIPOPROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROSTAGLANDIN J2; REACTIVE OXYGEN METABOLITE; THYMIDINE; TROGLITAZONE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFECT; DRUG RECEPTOR BINDING; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME PHOSPHORYLATION; ENZYME REPRESSION; IMMUNOFLUORESCENCE; MACROPHAGE; MOUSE; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; WESTERN BLOTTING;

ANIMALS; CELL PROLIFERATION; CHROMANS; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HYPOGLYCEMIC AGENTS; LIPOPROTEINS, LDL; MACROPHAGES, PERITONEAL; MALE; MICE; MICE, INBRED C3H; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; THIAZOLIDINEDIONES;

EID: 33846876582     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2006.04.022     Document Type: Article

References (41)

1. Schoonjans K., and Auwerx J. Thiazoledinediones: an update. Lancet 355 (2000) 1008-1010
2. Ricote M., Li A.C., Willson T.M., Kelly C.J., and Glass C.K. The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation. Nature 391 (1998) 79-82
3. Marx N. Peroxisome proliferator-activated receptor gamma and atherosclerosis. Cur Hypertens Rep 4 (2002) 71-77
4. Marx N., Duez H., Fruchart J.C., and Staels B. Peroxisome proliferator-activated receptors and atherogenesis: regulators of gene expression in vascular cells. Circ Res 94 (2004) 1168-1178
5. Li A.C., Brown K.K., Silvestre M.J., Willson T.M., Palinski W., and Glass C.K. Peroxisome proliferator-activated receptor gamma ligands inhibit development of atherosclerosis in LDL receptor-deficient mice. J Clin Invest 106 (2000) 523-531
6. Collins A.R., Meehan W.P., Kintscher U., et al. Troglitazone inhibits formation of early atherosclerotic lesions in diabetic and nondiabetic low density lipoprotein receptor-deficient mice. Arterioscler Thromb Vasc Biol 21 (2001) 365-371
7. Chen Z., Ishibashi S., Perrey S., et al. Troglitazone inhibits atherosclerosis in apolipoprotein E-knockout mice: pleiotropic effects on CD36 expression and HDL. Arterioscler Thromb Vasc Biol 21 (2001) 372-377
8. Ross R. Atherosclerosis-an inflammatory disease. N Engl J Med 340 (1999) 115-126
9. Steinberg D., Parthasarathy S., Carew T.E., Khoo J.C., and Witztum J.L. Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity. N Engl J Med 320 (1989) 915-924
10. Rosenfeld M.E., and Ross R. Macrophage and smooth muscle cell proliferation in atherosclerotic lesions of WHHL and comparably hypercholesterolemic fat-fed rabbits. Arteriosclerosis 10 (1990) 680-687
11. Spagnoli L.G., Orlandi A., and Santeusanio G. Foam cells of the rabbit atherosclerotic plaque arrested in metaphase by colchicine show a macrophage phenotype. Atherosclerosis 88 (1991) 87-92
12. Gordon D., Reidy M.A., Benditt E.P., and Schwartz S.M. Cell proliferation in human coronary arteries. Proc Natl Acad Sci USA 87 (1990) 4600-4604
13. Sakai M., Miyazaki A., Hakamata H., et al. Lysophosphatidylcholine plays an essential role in the mitogenic effect of oxidized low density lipoprotein on murine macrophages. J Biol Chem 269 (1994) 31430-31435
14. Matsumura T., Sakai M., Kobori S., et al. Two intracellular signaling pathways for activation of protein kinase C are involved in oxidized low-density lipoprotein-induced macrophage growth. Arterioscler Thromb Vasc Biol 17 (1997) 3013-3020
15. Martens J.S., Reiner N.E., and Herrera-Velit P. Steinbrecher UP. Phosphatidylinositol 3-kinase is involved in the induction of macrophage growth by oxidized low density lipoprotein. J Biol Chem 273 (1998) 4915-4920
16. Hamilton J.A., Myers D., Jessup W., et al. Oxidized LDL can induce macrophage survival, DNA synthesis, and enhanced proliferative response to CSF-1 andGM-CSF. Arterioscler Thromb Vasc Biol 19 (1999) 98-105
17. Biwa T., Hakamata H., Sakai M., et al. Induction of murine macrophage growth by oxidized low density lipoprotein is mediated by granulocyte macrophage colony-stimulating factor. J Biol Chem 273 (1998) 28305-28313
18. Senokuchi T., Matsumura T., Sakai M., et al. Extracellular signal-regulated kinase and p38 mitogen-activated protein kinase mediate macrophage proliferation induced by oxidized low-density lipoprotein. Atherosclerosis 176 (2004) 233-245
19. Hu Y., Dietrich H., Metzler B., Wick G., and Xu Q. Hyperexpression and activation of extracellular signal-regulated kinases (ERK1/2) in atherosclerotic lesions of cholesterol-fed rabbits. Arterioscler Thromb Vasc Biol 20 (2000) 18-26
20. 2 inhibits oxidized LDL-induced macrophage proliferation by inhibition of GM-CSF production via inactivation of NF-κB. Biochem Biophys Res Commun 314 (2004) 817-823
21. Chodakewitz J.A., Kupper T.S., and Coleman D.L. Keratinocyte-derived granulocyte/macrophage colony-stimulating factor induces DNA synthesis by peritoneal macrophages. J Immunol 140 (1988) 832-836
22. Munker R., Gasson J., Ogawa M., and Koeffler H.P. Recombinant human TNF induces production of granulocyte-monocyte colony-stimulating factor. Nature 323 (1986) 79-82
23. Matsumura T., Sakai M., Matsuda K., Furukawa N., Kaneko K., and Shichiri M. Cis-acting DNA elements of mouse granulocyte/macrophage colony-stimulating factor gene responsive to oxidized low density lipoprotein. J Biol Chem 274 (1999) 37665-37672
24. Takahashi N., Kawada T., Goto T., et al. Dual action of isoprenols from herbal medicines on both PPARγ and PPARα in 3T3-L1 adipocytes and HepG2 hepatocytes. FEBS Lett 514 (2002) 315-322
25. Nishikawa T., Edelstein D., Du X.L., et al. Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage. Nature 404 (2000) 787-790
26. Schreiber E., Matthias P., Muller M.M., and Schaffner W. Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells. Nucleic Acids Res 17 (1989) 6419
27. Inoue I., Katayama S., Takahashi K., et al. Troglitazone has a scavenging effect on reactive oxygen species. Biochem Biophys Res Commun 235 (1997) 113-116
28. Olefsky J.M., and Saltiel A.R. PPAR gamma and the treatment of insulin resistance. Trends Endocrinol Metab 11 (2000) 362-368
29. Hsueh W.A., and Law R.E. PPARγ and atherosclerosis: effects on cell growth and movement. Arterioscler Thromb Vasc Biol 21 (2001) 1891-1895
30. Altiok S., Xu M., and Spiegelman B.M. PPARγ induces cell cycle withdrawal: inhibition of E2F/DP DNA-binding activity via down-regulation of PP2A. Genes Dev 11 (1997) 1987-1998
31. 2. J Biol Chem 274 (1999) 17042-17048
32. Chinetti G., Griglio S., Antonucci M., et al. Activation of proliferator-activated receptors alpha and gamma induces apoptosis of human monocyte-derived macrophages. J Biol Chem 273 (1998) 25573-25580
33. Goetze S., Xi X.P., Kawano Y., et al. TNF-a-induced migration of vascular smooth muscle cells is MAPK dependent. Hypertension 33 (1999) 183-189
34. 2 and thiazolidinediones activate the MEK/ERK pathway through phosphatidylinositol 3-kinase in vascular smooth muscle cells. J Biol Chem 276 (2001) 48950-48955
35. Goetze S., Bungenstock A., Czupalla C., et al. Leptin induces endothelial cell migration through Akt, which is inhibited by PPARγ-ligands. Hypertension 40 (2002) 748-754
36. Gardner O.S., Dewar B.J., Earp H.S., Samet J.M., and Graves L.M. Dependence of peroxisome proliferator-activated receptor ligand-induced mitogen-activated protein kinase signaling on epidermal growth factor receptor transactivation. J Biol Chem 278 (2003) 46261-46269
37. Torii S., Nakayama K., Yamamoto T., and Nishida E. Regulatory mechanisms and function of ERK MAP kinases. J Biochem (Tokyo) 136 (2004) 557-561
38. Kondoh K., Torii S., and Nishida E. Control of MAP kinase signaling to the nucleus. Chromosoma 114 (2005) 86-91
39. Goetze S., Xi X.P., Graf K., Fleck E., Hsueh W.A., and Law R.E. Troglitazone inhibits angiotensin II-induced extracellular signal-regulated kinase 1/2 nuclear translocation and activation in vascular smooth muscle cells. FEBS Lett 452 (1999) 277-282
40. Osawa M., Itoh S., Ohta S., et al. ERK1/2 associates with the c-Met-binding domain of growth factor receptor-bound protein 2 (Grb2)-associated binder-1 (Gabl): role in ERK1/2 and early growth response factor-1 (Egr-1) nuclear accumulation. J Biol Chem 279 (2004) 29691-29699
41. Torii S., Kusakabe M., Yamamoto T., Maekawa M., and Nishida E. Sef is a spatial regulator for Ras/MAP kinase signaling. Dev Cell 7 (2004) 33-44