15-Deoxy-Δ12,14-postaglandin J2 (15d-PGJ2) signals through retinoic acid receptor-related orphan receptor-α but not peroxisome proliferator-activated receptor-γ in human vascular endothelial cells: The effect of 15d-PGJ2 on tumor necrosis factor-α-induced gene expression

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 25, Issue 4, 2005, Pages 710-716

  Migita, Hideyuki ^a,b   Morser, John ^b  

^a BAYER AG   (Germany)

^b Regenerative Medicine   (Japan)

Author keywords

15 deoxy 12,14 prostaglandin J2; Endothelium; Inflammation; Peroxisome proliferator activated receptor ; Retinoic acid receptor related orphan receptor

Indexed keywords

15 DEOXY DELTA12,14 PROSTAGLANDIN J2; INTERCELLULAR ADHESION MOLECULE 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PIOGLITAZONE; RETINOIC ACID RECEPTOR; TUMOR NECROSIS FACTOR ALPHA; VASCULAR CELL ADHESION MOLECULE 1; 15 DEOXY DELTA(12,14) PROSTAGLANDIN J2; 15-DEOXY-DELTA(12,14)-PROSTAGLANDIN J2; BIOLOGICAL RESPONSE MODIFIER; DRUG DERIVATIVE; PROSTAGLANDIN D2; RETINOIC ACID RECEPTOR ALPHA;

ADENOVIRUS; ARTICLE; ATTENUATION; CONTROLLED STUDY; DRUG EFFECT; DRUG INHIBITION; ENDOTHELIUM CELL; GENE EXPRESSION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; MUTANT; PRIORITY JOURNAL; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; CELL CULTURE; CYTOLOGY; DOMINANT GENE; GENETICS; IMMUNOLOGY; METABOLISM; UMBILICAL VEIN; VASCULAR ENDOTHELIUM;

BIOLOGICAL RESPONSE MODIFIERS; CELLS, CULTURED; ENDOTHELIUM, VASCULAR; GENE EXPRESSION; GENES, DOMINANT; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; PPAR GAMMA; PROSTAGLANDIN D2; RECEPTORS, RETINOIC ACID; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA; UMBILICAL VEINS; VASCULAR CELL ADHESION MOLECULE-1;

EID: 16244399864     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.0000156482.76228.d1     Document Type: Article

References (47)

1. Carlos TM, Harlan JM. Leukocyte-endothelial adhesion molecules. Blood. 1994;84:2068-2101.
2. Springer TM. Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell. 1994;76:301-314.
3. Neish AS, Read MA, Thanos D, Pine R, Maniatis T, Collins T. Endothelial interferon regulatory factor 1 cooperates with NF-κ as a transcriptional activator of vascular cell adhesion molecule 1. Mol Cell Biol. 1995;15:2558-2569.
4. Ledebur HC, Parks TP. Transcriptional regulation of the intercellular adhesion molecule-1 gene by inflammatory cytokines in human endothelial cells. Essential roles of a variant NF-κB site and p65 homodimers. J Biol Chem. 1995;270:933-943.
5. Perkins ND. The Rel/NF-κB family: friend and foe. Trends Biochem Sci. 2000;25:434-440.
6. Li H, Cybulsky MI, Gimbrone MA Jr, Libby P. Inducible expression of vascular cell adhesion molecule-1 by vascular smooth muscle cells. in vitro and within rabbit atheroma. Am J Pathol. 1993;143:1551-1559.
7. Cybulsky MI, Gimbrone MA Jr. Endothelial expression of a mononuclear leukocyte adhesion molecule during atherogenesis. Science. 1991;251:788-791.
8. van der Wal AC, Das PK, Tigges AJ, Becker AE. Adhesion molecules on the endothelium and mononuclear cells in human atherosclerotic lesions. Am J Pathol. 1992;141:1427-1433.
9. Abe Y, Sugisaki K, Dannenberg AM Jr. Rabbit vascular endothelial adhesion molecules: ELAM-1 is most elevated in acute inflammation, whereas VCAM-1 and ICAM-1 predominate in chronic inflammation. J Leukoc Biol. 1996;60:692-703.
10. Delerive P, Fruchart JC, Staels B. Peroxisome proliferator-activated receptors in inflammation control. J Endocrinol. 2001;169:453-459.
11. Duval C, Chinetti G, Trottein F, Fruchart JC, Staels B. The role of PPARs in atherosclerosis. Trends Mol Med. 2002;8:422-430.
12. Daynes RA, Jones DC. Emerging roles of PPARs in inflammation and immunity. Nat Rev Immunol. 2002;2:748-759.
13. Jiang C, Ting AT, Seed B. PPAR-γ agonists inhibit production of monocyte inflammatory cytokines. Nature. 1998;391:82-86.
14. Ricote M, Li AC, Willson TM, Kelly CJ, Glass CK. The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation. Nature. 1998;391:79-82.
15. Murphy GJ, Holder JC. PPAR-α agonists: therapeutic role in diabetes, inflammation and cancer. Trends Pharmacol Sci. 2000;21:469-474.
16. Chen J, Li D, Zhang X, Mehta JL. Tumor necrosis factor-α-induced apoptosis of human coronary artery endothelial cells: modulation by the peroxisome proliferator-activated receptor-γ ligand pioglitazone. J Cardiovasc Pharmacol Ther. 2004;9:35-41.
17. Li M, Pascual G, Glass CK. Peroxisome proliferator-activated receptor γ-dependent repression of the inducible nitric oxide synthase gene. Mol Cell Biol. 2000;20:4699-4707.
18. Yang XY, Wang LH, Chen T, Hodge DR, Resau JH, DaSilva L, Farrar WL. Activation of human T lymphocytes is inhibited by peroxisome proliferator-activated receptor γ (PPARγ) agonists. PPARγ co-association with transcription factor NFAT. J Biol Chem. 2000;275:4541-4544.
19. Nosjean O, Boutin JA. Natural ligands of PPARγ: are prostaglandin J2 derivatives really playing the part? Cell Signal. 2002;14:573-583.
20. Kliewer SA, Lenhard JM, Willson TM, Patel I, Morris DC, Lehmann JM. A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation. Cell. 1995;83:813-819.
21. 12,14 prostaglandin J2 is a ligand for the adipocyte determination factor PPAR γ. Cell. 1995;83:803-812.
22. 12,14-prostaglandin J2. Proc Natl Acad Sci U S A. 1999;96:4668-4673.
23. 12,14-prostaglandin J2 inhibits the β2 integrin-dependent oxidative burst: involvement of a mechanism distinct from peroxisome proliferator-activated receptor γ ligation. J Immunol 1999;163:6187-6192.
24. Jackson SM, Parhami F, Xi XP, Berliner JA, Hsueh WA, Law RE, Demer LL. Peroxisome proliferator-activated receptor activators target human endothelial cells to inhibit leukocyte-endothelial cell interaction. Arterioscler Thromb Vasc Biol. 1999;19:2094-2104.
25. Pasceri V, Wu HD, Willerson JT, Yeh ET. Modulation of vascular inflammation in vitro and. in vivo by peroxisome proliferator-activated receptor-γ activators. Circulation. 2000;101:235-238.
26. Marx N, Sukhova GK, Collins T, Libby P, Plutzky J. PPARα activators inhibit cytokine-induced vascular cell adhesion molecule-1 expression in human endothelial cells. Circulation, 1999;99:3125-3131.
27. Jetten AM, Kurebayashi S, Ueda E. The ROR nuclear orphan receptor subfamily: critical regulators of multiple biological processes. Prog Nucleic Acid Res Mol Biol. 2001;69:205-247.
28. Besnard S, Heymes C, Merval R, Rodriguez M, Galizzi JP, Boutin JA, Mariani J, Tedgui A. Expression and regulation of the nuclear receptor RORα in human vascular cells. FEBS Lett. 2002;511:36-40.
29. Migita H, Satozawa N, Lin JH, Morser J, Kawai K. RORα1 and RORα4 suppress TNF-α-induced VCAM-1 and ICAM-1 expression in human endothelial cells. FEBS Lett. 2004;557:269-274.
30. Delerive P, Monte D, Dubois G, Trottein F, Fruchart-Najib J, Mariani J, Fruchart JC, Staels B. The orphan nuclear receptor RORα is a negative regulator of the inflammatory response. EMBO Rep. 2001;2:42-48.
31. Migita H, Morser J, Kawai K. Rev-erbα upregulates NF-κB-responsive genes in vascular smooth muscle cells. FEBS Lett. 2004;561:69-74.
32. Nawa T, Nawa MT, Cai Y, Zhang C, Uchimura I, Narumi S, Numano F, Kitajima S. Repression of TNF-α-induced E-selectin expression by PPAR activators: involvement of transcriptional repressor LRF-1/ATF3. Biochem Biophys Res Commun. 2000;275:406-411.
33. 12,14- prostaglandin J2 inhibits multiple steps in the NF-κB signaling pathway. Proc Natl Acad Sci U S A. 2000;97:4844-4849.
34. Rossi A, Kapahi P, Natoli G, Takahashi T, Chen Y, Karin M, Santoro MG. Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IκB kinase. Nature. 2000;403:103-108.
35. Wright HM, Clish CB, Mikami T, Hauser S, Yanagi K, Hiramatsu R, Serhan CN, Spiegelman BM. A synthetic antagonist for the peroxisome proliferator-activated receptor γ inhibits adipocyte differentiation. J Biol Chem. 2000;275:1873-1877.
36. 12,14-prostaglandin J2. J Biol Chem. 1999;274:17042-17048.
37. Erl W, Weber C, Zernecke A, Neuzil J, Vosseler CA, Kim HJ, Weber PC. Cyclopentenone prostaglandins induce endothelial cell apoptosis independent of the peroxisome proliferator-activated receptor-γ. Eur J Immunol. 2004;34:241-250.
38. 12,14- prostaglandin J2 on glutathione induction and apoptosis in human endothelial cells. Arterioscler Thromb Vasc Biol. 2001;11:1846-1851.
39. Hamilton BA, Frankel WN, Kerrebrock AW, Hawkins TL, FitzHugh W, Kusumi K, Russell LB, Mueller KL, van Berkel V, Birren BW, Kruglyak L, Lander ES. Disruption of the nuclear hormone receptor RORα in staggerer mice. Nature. 1996;379:736-739.
40. Mamontova A, Seguret-Mace S, Esposito B, Chaniale C, Bouly M, Delhaye-Bouchaud N, Luc G, Staels B, Duverger N, Mariani J, Tedgui A. Severe atherosclerosis and hypoalphalipoproteinemia in the staggerer mouse, a mutant of the nuclear receptor RORα. Circulation. 1998;98:2738-2743.
41. Besnard S, Silvestre JS, Duriez M, Bakouche J, Lemaigre-Dubreuil Y, Mariani J, Levy BI, Tedgui A. Increased ischemia-induced angiogenesis in the staggerer mouse, a mutant of the nuclear receptor RORα. Circ Res. 2001;89:1209-1215.
42. Kallen JA, Schlaeppi JM, Bitsch F, Geisse S, Geiser M, Delhon I, Fournier B. X-ray structure of the hRORα LBD at 1.63 A: structural and functional data that cholesterol or a cholesterol derivative is the natural ligand of RORα. Structure (Cambridge). 2002;10:1697-1707.
43. Kallen J, Schlaeppi JM, Bitsch F, Delhon I, Fournier B. Crystal structure of the human RORα Ligand binding domain in complex with cholesterol sulfate at 2.2 A. J Biol Chem. 2004;279:14033-14038.
44. Straus DS, Glass CK. Cyclopentenone prostaglandins: new insights on biological activities and cellular targets. Med Res Rev. 2001;21:185-210.
45. Gilroy DW, Colville-Nash PR, Willis D, Chivers J, Paul-Clark MJ. Willoughby DA. Inducible cyclooxygenase may have anti-inflammatory properties. Nat Med. 1999;5:698-701.
46. 12,14-PGJ2 and the ligation of PPARγ. J Clin Invest. 2003;112:945-955.
47. 12,14-prostaglandin J2. A prostaglandin D2 metabolite generated during inflammatory processes. J Biol Chem. 2002;277:10459-10466.