-
1
-
-
23244444668
-
IL-21 sustains CD28 expression on IL-15-activated human naive CD8+ T cells
-
Alves NL, Arosa FA, van Lier RA (2005) IL-21 sustains CD28 expression on IL-15-activated human naive CD8+ T cells. J Immunol 175:755-762
-
(2005)
J Immunol
, vol.175
, pp. 755-762
-
-
Alves, N.L.1
Arosa, F.A.2
Van Lier, R.A.3
-
2
-
-
0035400054
-
Cutting edge: The common gamma-chain is an indispensable subunit of the IL-21 receptor complex
-
Asao H, Okuyama C, Kumaki S, Ishii N, Tsuchiya S, Foster D, Sugamura K (2001) Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex. J Immunol 167:1-5
-
(2001)
J Immunol
, vol.167
, pp. 1-5
-
-
Asao, H.1
Okuyama, C.2
Kumaki, S.3
Ishii, N.4
Tsuchiya, S.5
Foster, D.6
Sugamura, K.7
-
3
-
-
22544436066
-
Prostaglandin E2 induces FOXP3 gene expression and T regulatory cell function in human CD4+ T cells
-
Baratelli F, Lin Y, Zhu L, Yang SC, Heuze-Vourc'h N, Zeng G, Reckamp K, Dohadwala M, Sharma S, Dubinett SM (2005) Prostaglandin E2 induces FOXP3 gene expression and T regulatory cell function in human CD4+ T cells. J Immunol 175:1483-1490
-
(2005)
J Immunol
, vol.175
, pp. 1483-1490
-
-
Baratelli, F.1
Lin, Y.2
Zhu, L.3
Yang, S.C.4
Heuze-Vourc'H, N.5
Zeng, G.6
Reckamp, K.7
Dohadwala, M.8
Sharma, S.9
Dubinett, S.M.10
-
4
-
-
15544384475
-
Essential role for interleukin-2 for CD4(+)CD25(+) T regulatory cell development during the neonatal period
-
Bayer AL, Yu A, Adeegbe D, Malek TR (2005) Essential role for interleukin-2 for CD4(+)CD25(+) T regulatory cell development during the neonatal period. J Exp Med 201:769-777
-
(2005)
J Exp Med
, vol.201
, pp. 769-777
-
-
Bayer, A.L.1
Yu, A.2
Adeegbe, D.3
Malek, T.R.4
-
5
-
-
33745411739
-
Increased level and longevity of protective immune responses induced by DNA vaccine expressing the HIV-1 Env glycoprotein when combined with IL-21 and IL-15 gene delivery
-
Bolesta E, Kowalczyk A, Wierzbicki A, Eppolito C, Kaneko Y, Takiguchi M, Stamatatos L, Shrikant PA, Kozbor D (2006) Increased level and longevity of protective immune responses induced by DNA vaccine expressing the HIV-1 Env glycoprotein when combined with IL-21 and IL-15 gene delivery. J Immunol 177:177-191
-
(2006)
J Immunol
, vol.177
, pp. 177-191
-
-
Bolesta, E.1
Kowalczyk, A.2
Wierzbicki, A.3
Eppolito, C.4
Kaneko, Y.5
Takiguchi, M.6
Stamatatos, L.7
Shrikant, P.A.8
Kozbor, D.9
-
6
-
-
33846878993
-
Cyclophosphamide enhances the antitumor efficacy of adoptively transferred immune cells through the induction of cytokine expression, B-Cell and T-Cell homeostatic proliferation, and specific tumor infiltration
-
Bracci L, Moschella F, Sestili P, La Sorsa V, Valentini M, Canini I, Baccarini S, Maccari S, Ramoni C, Belardelli F, Proietti E (2007) Cyclophosphamide enhances the antitumor efficacy of adoptively transferred immune cells through the induction of cytokine expression, B-Cell and T-Cell homeostatic proliferation, and specific tumor infiltration. Clin Cancer Res 13:644-653
-
(2007)
Clin Cancer Res
, vol.13
, pp. 644-653
-
-
Bracci, L.1
Moschella, F.2
Sestili, P.3
La Sorsa, V.4
Valentini, M.5
Canini, I.6
Baccarini, S.7
MacCari, S.8
Ramoni, C.9
Belardelli, F.10
Proietti, E.11
-
7
-
-
0842278642
-
IL-21 induces the functional maturation of murine NK cells
-
Brady J, Hayakawa Y, Smyth MJ, Nutt SL (2004) IL-21 induces the functional maturation of murine NK cells. J Immunol 172:2048-2058
-
(2004)
J Immunol
, vol.172
, pp. 2048-2058
-
-
Brady, J.1
Hayakawa, Y.2
Smyth, M.J.3
Nutt, S.L.4
-
8
-
-
0345257344
-
Interleukin-21 inhibits dendritic cell activation and maturation
-
Brandt K, Bulfone-Paus S, Foster DC, Ruckert R (2003) Interleukin-21 inhibits dendritic cell activation and maturation. Blood 102:4090-4098
-
(2003)
Blood
, vol.102
, pp. 4090-4098
-
-
Brandt, K.1
Bulfone-Paus, S.2
Foster, D.C.3
Ruckert, R.4
-
9
-
-
0037093258
-
Interleukin-21 is a growth and survival factor for human myeloma cells
-
Brenne AT, Ro TB, Waage A, Sundan A, Borset M, Hjorth-Hansen H (2002) Interleukin-21 is a growth and survival factor for human myeloma cells. Blood 99:3756-3762
-
(2002)
Blood
, vol.99
, pp. 3756-3762
-
-
Brenne, A.T.1
Ro, T.B.2
Waage, A.3
Sundan, A.4
Borset, M.5
Hjorth-Hansen, H.6
-
10
-
-
31144479124
-
IL-21 down-regulates NKG2D/DAP10 expression on human NK and CD8+ T cells
-
Burgess SJ, Marusina AI, Pathmanathan I, Borrego F, Coligan JE (2006) IL-21 down-regulates NKG2D/DAP10 expression on human NK and CD8+ T cells. J Immunol 176:1490-1497
-
(2006)
J Immunol
, vol.176
, pp. 1490-1497
-
-
Burgess, S.J.1
Marusina, A.I.2
Pathmanathan, I.3
Borrego, F.4
Coligan, J.E.5
-
11
-
-
33746918946
-
Cancer immunotherapy by interleukin-21: Potential treatment strategies evaluated in a mathematical model
-
Cappuccio A, Elishmereni M, Agur Z (2006) Cancer immunotherapy by interleukin-21: potential treatment strategies evaluated in a mathematical model. Cancer Res 66:7293-7300
-
(2006)
Cancer Res
, vol.66
, pp. 7293-7300
-
-
Cappuccio, A.1
Elishmereni, M.2
Agur, Z.3
-
12
-
-
33846248387
-
A functional role for interleukin-21 in promoting the synthesis of the T-Cell Chemoattractant, MIP-3alpha, by gut epithelial cells
-
Caruso R, Fina D, Peluso I, Stolfi C, Fantini MC, Gioia V, Caprioli F, Del Vecchio Blanco G, Paoluzi OA, Macdonald TT, Pallone F, Monteleone G (2007) A functional role for interleukin-21 in promoting the synthesis of the T-Cell Chemoattractant, MIP-3alpha, by gut epithelial cells. Gastroenterology 132:166-175
-
(2007)
Gastroenterology
, vol.132
, pp. 166-175
-
-
Caruso, R.1
Fina, D.2
Peluso, I.3
Stolfi, C.4
Fantini, M.C.5
Gioia, V.6
Caprioli, F.7
Del Vecchio Blanco, G.8
Paoluzi, O.A.9
MacDonald, T.T.10
Pallone, F.11
Monteleone, G.12
-
13
-
-
0348223787
-
Conversion of peripheral CD4 + CD25- naive T cells to CD4 + CD25 + regulatory T cells by TGF-beta induction of transcription factor Foxp3
-
Chen W, Jin W, Hardegen N, Lei KJ, Li L, Marinos N, McGrady G, Wahl SM (2003) Conversion of peripheral CD4 + CD25- naive T cells to CD4 + CD25 + regulatory T cells by TGF-beta induction of transcription factor Foxp3. J Exp Med 198:1875-1886
-
(2003)
J Exp Med
, vol.198
, pp. 1875-1886
-
-
Chen, W.1
Jin, W.2
Hardegen, N.3
Lei, K.J.4
Li, L.5
Marinos, N.6
McGrady, G.7
Wahl, S.M.8
-
14
-
-
31144434868
-
CD25 + regulatory T cell depletion augments immunotherapy of micrometastases by an IL-21-secreting cellular vaccine
-
Comes A, Rosso O, Orengo AM, Di Carlo E, Sorrentino C, Meazza R, Piazza T, Valzasina B, Nanni P, Colombo MP, Ferrini S (2006) CD25 + regulatory T cell depletion augments immunotherapy of micrometastases by an IL-21-secreting cellular vaccine. J Immunol 176:1750-1758
-
(2006)
J Immunol
, vol.176
, pp. 1750-1758
-
-
Comes, A.1
Rosso, O.2
Orengo, A.M.3
Di Carlo, E.4
Sorrentino, C.5
Meazza, R.6
Piazza, T.7
Valzasina, B.8
Nanni, P.9
Colombo, M.P.10
Ferrini, S.11
-
15
-
-
33745139171
-
Immunomodulatory and antitumor effects of interleukin-21 in patients with renal cell carcinoma (review)
-
Curti BD (2006) Immunomodulatory and antitumor effects of interleukin-21 in patients with renal cell carcinoma (review). Expert Rev Anticancer Ther 6:905-909
-
(2006)
Expert Rev Anticancer Ther
, vol.6
, pp. 905-909
-
-
Curti, B.D.1
-
16
-
-
0029086786
-
The IL-2 receptor complex: Expression and function on normal and leukemic B cells (review)
-
de Totero D, Francia di Celle P, Cignetti A, Foa R (1995) The IL-2 receptor complex: expression and function on normal and leukemic B cells (review). Leukemia 9:1425-1431
-
(1995)
Leukemia
, vol.9
, pp. 1425-1431
-
-
De Totero, D.1
Francia Di Celle, P.2
Cignetti, A.3
Foa, R.4
-
17
-
-
33646410652
-
Interleukin-21 receptor (IL-21R) is up-regulated by CD40 triggering and mediates proapoptotic signals in chronic lymphocytic leukemia B cells
-
de Totero D, Meazza R, Zupo S, Cutrona G, Matis S, Colombo M, Balleari E, Pierri I, Fabbi M, Capaia M, Azzarone B, Gobbi M, Ferrarini M, Ferrini S (2006) Interleukin-21 receptor (IL-21R) is up-regulated by CD40 triggering and mediates proapoptotic signals in chronic lymphocytic leukemia B cells. Blood 107:3708-3715
-
(2006)
Blood
, vol.107
, pp. 3708-3715
-
-
De Totero, D.1
Meazza, R.2
Zupo, S.3
Cutrona, G.4
Matis, S.5
Colombo, M.6
Balleari, E.7
Pierri, I.8
Fabbi, M.9
Capaia, M.10
Azzarone, B.11
Gobbi, M.12
Ferrarini, M.13
Ferrini, S.14
-
18
-
-
1642444178
-
IL-21 induces tumor rejection by specific CTL and IFN-gamma-dependent CXC chemokines in syngeneic mice
-
Di Carlo E, Comes A, Orengo AM, Rosso O, Meazza R, Musiani P, Colombo MP, Ferrini S (2004) IL-21 induces tumor rejection by specific CTL and IFN-gamma-dependent CXC chemokines in syngeneic mice. J Immunol 172:1540-1547
-
(2004)
J Immunol
, vol.172
, pp. 1540-1547
-
-
Di Carlo, E.1
Comes, A.2
Orengo, A.M.3
Rosso, O.4
Meazza, R.5
Musiani, P.6
Colombo, M.P.7
Ferrini, S.8
-
19
-
-
17044401460
-
Fas-ligand (CD178) and TRAIL synergistically induce apoptosis of CD40-activated chronic lymphocytic leukemia B cells
-
Dicker F, Kater AP, Fukuda T, Kipps TJ (2005) Fas-ligand (CD178) and TRAIL synergistically induce apoptosis of CD40-activated chronic lymphocytic leukemia B cells. Blood 105:3193-3198
-
(2005)
Blood
, vol.105
, pp. 3193-3198
-
-
Dicker, F.1
Kater, A.P.2
Fukuda, T.3
Kipps, T.J.4
-
20
-
-
20144362420
-
Expression of interleukin-21 receptor in epidermis from patients with systemic sclerosis
-
Distler JH, Jungel A, Kowal-Bielecka O, Michel BA, Gay RE, Sprott H, Matucci-Cerinic M, Chilla M, Reich K, Kalden JR, Muller-Ladner U, Lorenz HM, Gay S, Distler O (2005) Expression of interleukin-21 receptor in epidermis from patients with systemic sclerosis. Arthritis 52:856-864
-
(2005)
Arthritis
, vol.52
, pp. 856-864
-
-
Distler, J.H.1
Jungel, A.2
Kowal-Bielecka, O.3
Michel, B.A.4
Gay, R.E.5
Sprott, H.6
Matucci-Cerinic, M.7
Chilla, M.8
Reich, K.9
Kalden, J.R.10
Muller-Ladner, U.11
Lorenz, H.M.12
Gay, S.13
Distler, O.14
-
21
-
-
33749350789
-
Adjuvanticity of plasmid DNA encoding cytokines fused to immunoglobulin Fc domains
-
Ferrone CR, Perales MA, Goldberg SM, Somberg CJ, Hirschhorn-Cymerman D, Gregor PD, Turk MJ, Ramirez-Montagut T, Gold JS, Houghton AN, Wolchok JD (2006) Adjuvanticity of plasmid DNA encoding cytokines fused to immunoglobulin Fc domains. Clin Cancer Res 12:5511-5519
-
(2006)
Clin Cancer Res
, vol.12
, pp. 5511-5519
-
-
Ferrone, C.R.1
Perales, M.A.2
Goldberg, S.M.3
Somberg, C.J.4
Hirschhorn-Cymerman, D.5
Gregor, P.D.6
Turk, M.J.7
Ramirez-Montagut, T.8
Gold, J.S.9
Houghton, A.N.10
Wolchok, J.D.11
-
22
-
-
33847412873
-
IL-21 receptor signaling is integral to the development of Th2 effector responses in vivo
-
Frohlich A, Marsland BJ, Sonderegger I, Kurrer M, Hodge MR, Harris NL, Kopf M (2007) IL-21 receptor signaling is integral to the development of Th2 effector responses in vivo. Blood 109:2023-2031
-
(2007)
Blood
, vol.109
, pp. 2023-2031
-
-
Frohlich, A.1
Marsland, B.J.2
Sonderegger, I.3
Kurrer, M.4
Hodge, M.R.5
Harris, N.L.6
Kopf, M.7
-
23
-
-
33746479282
-
Interleukin-21 gene transfection into mouse bladder cancer cells results in tumor rejection through the cytotoxic T lymphocyte response
-
Furukawa J, Hara I, Nagai H, Yao A, Oniki S, Fujisawa M (2006) Interleukin-21 gene transfection into mouse bladder cancer cells results in tumor rejection through the cytotoxic T lymphocyte response. J Urol 176:1198-1203
-
(2006)
J Urol
, vol.176
, pp. 1198-1203
-
-
Furukawa, J.1
Hara, I.2
Nagai, H.3
Yao, A.4
Oniki, S.5
Fujisawa, M.6
-
24
-
-
33847074166
-
Regulation of IL-21 signaling by suppressor of cytokine signaling-1 (SOCS1) in CD8(+) T lymphocytes
-
Gagnon J, Ramanathan S, Leblanc C, Ilangumaran S (2007) Regulation of IL-21 signaling by suppressor of cytokine signaling-1 (SOCS1) in CD8(+) T lymphocytes. Cell Signal 19:806-816
-
(2007)
Cell Signal
, vol.19
, pp. 806-816
-
-
Gagnon, J.1
Ramanathan, S.2
Leblanc, C.3
Ilangumaran, S.4
-
25
-
-
33749531054
-
Kinetics of human B cell behavior and amplification of proliferative responses following stimulation with IL-21
-
Good KL, Bryant VL, Tangye SG (2006) Kinetics of human B cell behavior and amplification of proliferative responses following stimulation with IL-21. J Immunol 177:5236-5247
-
(2006)
J Immunol
, vol.177
, pp. 5236-5247
-
-
Good, K.L.1
Bryant, V.L.2
Tangye, S.G.3
-
26
-
-
0037047025
-
The common gamma chain (gamma c) is a required signaling component of the IL-21 receptor and supports IL-21-induced cell proliferation via JAK3
-
Habib T, Senadheera S, Weinberg K, Kaushansky K (2002) The common gamma chain (gamma c) is a required signaling component of the IL-21 receptor and supports IL-21-induced cell proliferation via JAK3. Biochemistry 41:8725-8731
-
(2002)
Biochemistry
, vol.41
, pp. 8725-8731
-
-
Habib, T.1
Senadheera, S.2
Weinberg, K.3
Kaushansky, K.4
-
27
-
-
33845903869
-
IL-21-induced Bepsilon cell apoptosis mediated by natural killer T cells suppresses IgE responses
-
Harada M, Magara-Koyanagi K, Watarai H, Nagata Y, Ishii Y, Kojo S, Horiguchi S, Okamoto Y, Nakayama T, Suzuki N, Yeh WC, Akira S, Kitamura H, Ohara O, Seino K, Taniguchi M (2006) IL-21-induced Bepsilon cell apoptosis mediated by natural killer T cells suppresses IgE responses. J Exp Med 203:2929-2937
-
(2006)
J Exp Med
, vol.203
, pp. 2929-2937
-
-
Harada, M.1
Magara-Koyanagi, K.2
Watarai, H.3
Nagata, Y.4
Ishii, Y.5
Kojo, S.6
Horiguchi, S.7
Okamoto, Y.8
Nakayama, T.9
Suzuki, N.10
Yeh, W.C.11
Akira, S.12
Kitamura, H.13
Ohara, O.14
Seino, K.15
Taniguchi, M.16
-
28
-
-
33746088835
-
Combined IL-21 and low-dose IL-2 therapy induces anti-tumor immunity and long-term curative effects in a murine melanoma tumor model
-
He H, Wisner P, Yang G, Hu HM, Haley D, Miller W, O'hara A, Alvord WG, Clegg CH, Fox BA, Urba WJ, Walker EB (2006) Combined IL-21 and low-dose IL-2 therapy induces anti-tumor immunity and long-term curative effects in a murine melanoma tumor model. J Transl Med 4:24
-
(2006)
J Transl Med
, vol.4
, pp. 24
-
-
He, H.1
Wisner, P.2
Yang, G.3
Hu, H.M.4
Haley, D.5
Miller, W.6
O'Hara, A.7
Alvord, W.G.8
Clegg, C.H.9
Fox, B.A.10
Urba, W.J.11
Walker, E.B.12
-
29
-
-
33947215987
-
IL-21 has a pathogenic role in a lupus-prone mouse model and its blockade with IL-21R.Fc reduces disease progression
-
Herber D, Brown TP, Liang S, Young DA, Collins M, Dunussi-Joannopoulos K (2007) IL-21 has a pathogenic role in a lupus-prone mouse model and its blockade with IL-21R.Fc reduces disease progression. J Immunol 178:3822-3830
-
(2007)
J Immunol
, vol.178
, pp. 3822-3830
-
-
Herber, D.1
Brown, T.P.2
Liang, S.3
Young, D.A.4
Collins, M.5
Dunussi-Joannopoulos, K.6
-
30
-
-
33750626239
-
B-chronic lymphocytic leukemia cells and other B cells can produce granzyme B and gain cytotoxic potential after interleukin-21-based activation
-
Jahrsdorfer B, Blackwell SE, Wooldridge JE, Huang J, Andreski MW, Jacobus LS, Taylor CM, Weiner GJ (2006) B-chronic lymphocytic leukemia cells and other B cells can produce granzyme B and gain cytotoxic potential after interleukin-21-based activation. Blood 108:2712-2719
-
(2006)
Blood
, vol.108
, pp. 2712-2719
-
-
Jahrsdorfer, B.1
Blackwell, S.E.2
Wooldridge, J.E.3
Huang, J.4
Andreski, M.W.5
Jacobus, L.S.6
Taylor, C.M.7
Weiner, G.J.8
-
31
-
-
2942709751
-
Distinct activation signals determine whether IL-21 induces B cell costimulation, growth arrest, or Bim-dependent apoptosis
-
Jin H, Carrio R, Yu A, Malek TR (2004) Distinct activation signals determine whether IL-21 induces B cell costimulation, growth arrest, or Bim-dependent apoptosis. J Immunol 173:657-665
-
(2004)
J Immunol
, vol.173
, pp. 657-665
-
-
Jin, H.1
Carrio, R.2
Yu, A.3
Malek, T.R.4
-
32
-
-
2342491493
-
Expression of interleukin-21 receptor, but not interleukin-21, in synovial fibroblasts and synovial macrophages of patients with rheumatoid arthritis
-
Jungel A, Distler JH, Kurowska-Stolarska M, Seemayer CA, Seibl R, Forster A, Michel BA, Gay RE, Emmrich F, Gay S, Distler O (2004) Expression of interleukin-21 receptor, but not interleukin-21, in synovial fibroblasts and synovial macrophages of patients with rheumatoid arthritis. Arthritis Rheum 50:1468-1476
-
(2004)
Arthritis Rheum
, vol.50
, pp. 1468-1476
-
-
Jungel, A.1
Distler, J.H.2
Kurowska-Stolarska, M.3
Seemayer, C.A.4
Seibl, R.5
Forster, A.6
Michel, B.A.7
Gay, R.E.8
Emmrich, F.9
Gay, S.10
Distler, O.11
-
33
-
-
18344394955
-
IL-21 limits NK cell responses and promotes antigen-specific T cell activation: A mediator of the transition from innate to adaptive immunity
-
Kasaian MT, Whitters MJ, Carter LL, Lowe LD, Jussif JM, Deng B, Johnson KA, Witek JS, Senices M, Konz RF, Wurster AL, Donaldson DD, Collins M, Young DA, Grusby MJ (2002) IL-21 limits NK cell responses and promotes antigen-specific T cell activation: a mediator of the transition from innate to adaptive immunity. Immunity 16:559-569
-
(2002)
Immunity
, vol.16
, pp. 559-569
-
-
Kasaian, M.T.1
Whitters, M.J.2
Carter, L.L.3
Lowe, L.D.4
Jussif, J.M.5
Deng, B.6
Johnson, K.A.7
Witek, J.S.8
Senices, M.9
Konz, R.F.10
Wurster, A.L.11
Donaldson, D.D.12
Collins, M.13
Young, D.A.14
Grusby, M.J.15
-
34
-
-
21644473448
-
Calcium-dependent activation of interleukin-21 gene expression in T cells
-
Kim HP, Korn LL, Gamero AM, Leonard WJ (2005) Calcium-dependent activation of interleukin-21 gene expression in T cells. J Biol Chem 280:25291-25297
-
(2005)
J Biol Chem
, vol.280
, pp. 25291-25297
-
-
Kim, H.P.1
Korn, L.L.2
Gamero, A.M.3
Leonard, W.J.4
-
35
-
-
1942453326
-
Homeostatic expansion of T cells during immune insufficiency generates autoimmunity
-
King C, Ilic A, Koelsch K, Sarvetnick N (2004) Homeostatic expansion of T cells during immune insufficiency generates autoimmunity. Cell 117:265-277
-
(2004)
Cell
, vol.117
, pp. 265-277
-
-
King, C.1
Ilic, A.2
Koelsch, K.3
Sarvetnick, N.4
-
36
-
-
10744230081
-
Interleukin (IL)-21 and IL-15 genetic transfer synergistically augments therapeutic antitumor immunity and promotes regression of metastatic lymphoma
-
Kishida T, Asada H, Itokawa Y, Cui FD, Shin-Ya M, Gojo S, Yasutomi K, Ueda Y, Yamagishi H, Imanishi J, Mazda O (2003) Interleukin (IL)-21 and IL-15 genetic transfer synergistically augments therapeutic antitumor immunity and promotes regression of metastatic lymphoma. Mol Ther 8:552-558
-
(2003)
Mol Ther
, vol.8
, pp. 552-558
-
-
Kishida, T.1
Asada, H.2
Itokawa, Y.3
Cui, F.D.4
Shin-Ya, M.5
Gojo, S.6
Yasutomi, K.7
Ueda, Y.8
Yamagishi, H.9
Imanishi, J.10
Mazda, O.11
-
37
-
-
25844517914
-
Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3 + CD25 + CD4 + regulatory T cells
-
Ko K, Yamazaki S, Nakamura K, Nishioka T, Hirota K, Yamaguchi T, Shimizu J, Nomura T, Chiba T, Sakaguchi S (2005) Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3 + CD25 + CD4 + regulatory T cells. J Exp Med 202:885-891
-
(2005)
J Exp Med
, vol.202
, pp. 885-891
-
-
Ko, K.1
Yamazaki, S.2
Nakamura, K.3
Nishioka, T.4
Hirota, K.5
Yamaguchi, T.6
Shimizu, J.7
Nomura, T.8
Chiba, T.9
Sakaguchi, S.10
-
38
-
-
33845438994
-
Identification of cellular intermediates and molecular pathways induced by IL-21 in human B cells
-
Konforte D, Paige CJ (2006) Identification of cellular intermediates and molecular pathways induced by IL-21 in human B cells. J Immunol 177:8381-8392
-
(2006)
J Immunol
, vol.177
, pp. 8381-8392
-
-
Konforte, D.1
Paige, C.J.2
-
39
-
-
9644295710
-
Cytokines and immunodeficiency diseases: Critical roles of the gamma(c)-dependent cytokines interleukins 2, 4, 7, 9, 15, and 21, and their signaling pathways (review)
-
Kovanen PE, Leonard WJ (2004) Cytokines and immunodeficiency diseases: critical roles of the gamma(c)-dependent cytokines interleukins 2, 4, 7, 9, 15, and 21, and their signaling pathways (review). Immunol Rev 202:67-83
-
(2004)
Immunol Rev
, vol.202
, pp. 67-83
-
-
Kovanen, P.E.1
Leonard, W.J.2
-
40
-
-
25444434157
-
Interleukin-21: A modulator of lymphoid proliferation, apoptosis and differentiation (review)
-
Leonard WJ, Spolski R (2005) Interleukin-21: a modulator of lymphoid proliferation, apoptosis and differentiation (review). Nat Rev Immunol 5:688-698
-
(2005)
Nat Rev Immunol
, vol.5
, pp. 688-698
-
-
Leonard, W.J.1
Spolski, R.2
-
41
-
-
23444445913
-
IL-21 influences the frequency, phenotype, and affinity of the antigen-specific CD8 T cell response
-
Li Y, Bleakley M, Yee C (2005) IL-21 influences the frequency, phenotype, and affinity of the antigen-specific CD8 T cell response. J Immunol 175:2261-2269
-
(2005)
J Immunol
, vol.175
, pp. 2261-2269
-
-
Li, Y.1
Bleakley, M.2
Yee, C.3
-
42
-
-
33749552196
-
Interleukin-21 induces T-cell activation and proinflammatory cytokine secretion in rheumatoid arthritis
-
Li J, Shen W, Kong K, Liu Z (2006) Interleukin-21 induces T-cell activation and proinflammatory cytokine secretion in rheumatoid arthritis. Scand J Immunol 64:515-522
-
(2006)
Scand J Immunol
, vol.64
, pp. 515-522
-
-
Li, J.1
Shen, W.2
Kong, K.3
Liu, Z.4
-
43
-
-
0038784488
-
IL-21 activates both innate and adaptive immunity to generate potent antitumor responses that require perforin but are independent of IFN-gamma
-
Ma HL, Whitters MJ, Konz RF, Senices M, Young DA, Grusby MJ, Collins M, Dunussi-Joannopoulos K (2003) IL-21 activates both innate and adaptive immunity to generate potent antitumor responses that require perforin but are independent of IFN-gamma. J Immunol 171:608-615
-
(2003)
J Immunol
, vol.171
, pp. 608-615
-
-
Ma, H.L.1
Whitters, M.J.2
Konz, R.F.3
Senices, M.4
Young, D.A.5
Grusby, M.J.6
Collins, M.7
Dunussi-Joannopoulos, K.8
-
44
-
-
4544241811
-
Tolerance, not immunity, crucially depends on IL-2 (review)
-
Malek TR, Bayer AL (2004) Tolerance, not immunity, crucially depends on IL-2 (review). Nat Rev Immunol 4:665-674
-
(2004)
Nat Rev Immunol
, vol.4
, pp. 665-674
-
-
Malek, T.R.1
Bayer, A.L.2
-
45
-
-
0037446642
-
IL-21 induces the apoptosis of resting and activated primary B cells
-
Mehta DS, Wurster AL, Whitters MJ, Young DA, Collins M, Grusby MJ (2003) IL-21 induces the apoptosis of resting and activated primary B cells. J Immunol 170:4111-4118
-
(2003)
J Immunol
, vol.170
, pp. 4111-4118
-
-
Mehta, D.S.1
Wurster, A.L.2
Whitters, M.J.3
Young, D.A.4
Collins, M.5
Grusby, M.J.6
-
46
-
-
13844319581
-
NFATc2 and T-bet contribute to T-helper-cell-subset-specific regulation of IL-21 expression
-
Mehta DS, Wurster AL, Weinmann AS, Grusby MJ (2005) NFATc2 and T-bet contribute to T-helper-cell-subset-specific regulation of IL-21 expression. Proc Natl Acad Sci USA 102:2016-2021
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 2016-2021
-
-
Mehta, D.S.1
Wurster, A.L.2
Weinmann, A.S.3
Grusby, M.J.4
-
47
-
-
15744390341
-
Interleukin-21 enhances T-helper cell type I signaling and interferon-gamma production in Crohn's disease
-
Monteleone G, Monteleone I, Fina D, Vavassori P, Del Vecchio Blanco G, Caruso R, Tersigni R, Alessandroni L, Biancone L, Naccari GC, MacDonald TT, Pallone F (2005) Interleukin-21 enhances T-helper cell type I signaling and interferon-gamma production in Crohn's disease. Gastroenterology 128:687-694
-
(2005)
Gastroenterology
, vol.128
, pp. 687-694
-
-
Monteleone, G.1
Monteleone, I.2
Fina, D.3
Vavassori, P.4
Del Vecchio Blanco, G.5
Caruso, R.6
Tersigni, R.7
Alessandroni, L.8
Biancone, L.9
Naccari, G.C.10
MacDonald, T.T.11
Pallone, F.12
-
48
-
-
2542595794
-
IL-21 enhances and sustains CD8+ T cell responses to achieve durable tumor immunity: Comparative evaluation of IL-2, IL-15, and IL-21
-
Moroz A, Eppolito C, Li Q, Tao J, Clegg CH, Shrikant PA (2004) IL-21 enhances and sustains CD8+ T cell responses to achieve durable tumor immunity: comparative evaluation of IL-2, IL-15, and IL-21. J Immunol 173:900-909
-
(2004)
J Immunol
, vol.173
, pp. 900-909
-
-
Moroz, A.1
Eppolito, C.2
Li, Q.3
Tao, J.4
Clegg, C.H.5
Shrikant, P.A.6
-
49
-
-
0033168037
-
Tumor rejection by in vivo administration of anti-CD25 (interleukin-2 receptor alpha) monoclonal antibody
-
Onizuka S, Tawara I, Shimizu J, Sakaguchi S, Fujita T, Nakayama E (1999) Tumor rejection by in vivo administration of anti-CD25 (interleukin-2 receptor alpha) monoclonal antibody. Cancer Res 59:3128-3133
-
(1999)
Cancer Res
, vol.59
, pp. 3128-3133
-
-
Onizuka, S.1
Tawara, I.2
Shimizu, J.3
Sakaguchi, S.4
Fujita, T.5
Nakayama, E.6
-
50
-
-
33750360839
-
Overexpression of interleukin 21 induces expansion of hematopoietic progenitor cells
-
Ozaki K, Hishiya A, Hatanaka K, Nakajima H, Wang G, Hwu P, Kitamura T, Ozawa K, Leonard WJ, Nosaka T (2006) Overexpression of interleukin 21 induces expansion of hematopoietic progenitor cells. Int J Hematol 84:224-230
-
(2006)
Int J Hematol
, vol.84
, pp. 224-230
-
-
Ozaki, K.1
Hishiya, A.2
Hatanaka, K.3
Nakajima, H.4
Wang, G.5
Hwu, P.6
Kitamura, T.7
Ozawa, K.8
Leonard, W.J.9
Nosaka, T.10
-
51
-
-
0034633734
-
Cloning of a type I cytokine receptor most related to the IL-2 receptor beta chain
-
Ozaki K, Kikly K, Michalovich D, Young PR, Leonard WJ (2000) Cloning of a type I cytokine receptor most related to the IL-2 receptor beta chain. Proc Natl Acad Sci USA 97:11439-11444
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 11439-11444
-
-
Ozaki, K.1
Kikly, K.2
Michalovich, D.3
Young, P.R.4
Leonard, W.J.5
-
52
-
-
0037119351
-
Cytokine and cytokine receptor pleiotropy and redundancy (review)
-
Ozaki K, Leonard WJ (2002) Cytokine and cytokine receptor pleiotropy and redundancy (review). J Biol Chem 277:29355-29358
-
(2002)
J Biol Chem
, vol.277
, pp. 29355-29358
-
-
Ozaki, K.1
Leonard, W.J.2
-
53
-
-
6344269331
-
Regulation of B cell differentiation and plasma cell generation by IL-21, a novel inducer of Blimp-1 and Bcl-6
-
Ozaki K, Spolski R, Ettinger R, Kim HP, Wang G, Qi CF, Hwu P, Shaffer DJ, Akilesh S, Roopenian DC, Morse HC 3rd, Lipsky PE, Leonard WJ (2004) Regulation of B cell differentiation and plasma cell generation by IL-21, a novel inducer of Blimp-1 and Bcl-6. J Immunol 173:5361-5371
-
(2004)
J Immunol
, vol.173
, pp. 5361-5371
-
-
Ozaki, K.1
Spolski, R.2
Ettinger, R.3
Kim, H.P.4
Wang, G.5
Qi, C.F.6
Hwu, P.7
Shaffer, D.J.8
Akilesh, S.9
Roopenian, D.C.10
Morse III, H.C.11
Lipsky, P.E.12
Leonard, W.J.13
-
54
-
-
0037159687
-
A critical role for IL-21 in regulating immunoglobulin production
-
Ozaki K, Spolski R, Feng CG, Qi CF, Cheng J, Sher A, Morse HC 3rd, Liu C, Schwartzberg PL, Leonard WJ (2002) A critical role for IL-21 in regulating immunoglobulin production. Science 298:1630-1634
-
(2002)
Science
, vol.298
, pp. 1630-1634
-
-
Ozaki, K.1
Spolski, R.2
Feng, C.G.3
Qi, C.F.4
Cheng, J.5
Sher, A.6
Morse III, H.C.7
Liu, C.8
Schwartzberg, P.L.9
Leonard, W.J.10
-
55
-
-
0030627634
-
Cytokine gene transduction in the immunotherapy of cancer (review)
-
Parmiani G, Colombo MP, Melani C, Arienti F (1997) Cytokine gene transduction in the immunotherapy of cancer (review). Adv Pharmacol 40:259-307
-
(1997)
Adv Pharmacol
, vol.40
, pp. 259-307
-
-
Parmiani, G.1
Colombo, M.P.2
Melani, C.3
Arienti, F.4
-
56
-
-
0034597789
-
Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function
-
Parrish-Novak J, Dillon SR, Nelson A, Hammond A, Sprecher C, Gross JA, Johnston J, Madden K, Xu W, West J, Schrader S, Burkhead S, Heipel M, Brandt C, Kuijper JL, Kramer J, Conklin D, Presnell SR, Berry J, Shiota F, Bort S, Hambly K, Mudri S, Clegg C, Moore M, Grant FJ, Lofton-Day C, Gilbert T, Rayond F, Ching A, Yao L, Smith D, Webster P, Whitmore T, Maurer M, Kaushansky K, Holly RD, Foster D (2000) Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function. Nature 408:57-63
-
(2000)
Nature
, vol.408
, pp. 57-63
-
-
Parrish-Novak, J.1
Dillon, S.R.2
Nelson, A.3
Hammond, A.4
Sprecher, C.5
Gross, J.A.6
Johnston, J.7
Madden, K.8
Xu, W.9
West, J.10
Schrader, S.11
Burkhead, S.12
Heipel, M.13
Brandt, C.14
Kuijper, J.L.15
Kramer, J.16
Conklin, D.17
Presnell, S.R.18
Berry, J.19
Shiota, F.20
Bort, S.21
Hambly, K.22
Mudri, S.23
Clegg, C.24
Moore, M.25
Grant, F.J.26
Lofton-Day, C.27
Gilbert, T.28
Rayond, F.29
Ching, A.30
Yao, L.31
Smith, D.32
Webster, P.33
Whitmore, T.34
Maurer, M.35
Kaushansky, K.36
Holly, R.D.37
Foster, D.38
more..
-
57
-
-
33846196712
-
IL-21 counteracts the regulatory T cell-mediated suppression of human CD4 + T lymphocytes
-
Peluso I, Fantini MC, Fina D, Caruso R, Boirivant M, Macdonald TT, Pallone F, Monteleone G (2007) IL-21 counteracts the regulatory T cell-mediated suppression of human CD4 + T lymphocytes. J Immunol 178:732-9
-
(2007)
J Immunol
, vol.178
, pp. 732-9
-
-
Peluso, I.1
Fantini, M.C.2
Fina, D.3
Caruso, R.4
Boirivant, M.5
MacDonald, T.T.6
Pallone, F.7
Monteleone, G.8
-
58
-
-
10344238050
-
In vivo and in vitro roles of IL-21 in inflammation
-
Pelletier M, Bouchard A, Girard D (2004) In vivo and in vitro roles of IL-21 in inflammation. J Immunol 173:7521-7530
-
(2004)
J Immunol
, vol.173
, pp. 7521-7530
-
-
Pelletier, M.1
Bouchard, A.2
Girard, D.3
-
59
-
-
33745840137
-
The IL-21 receptor augments Th2 effector function and alternative macrophage activation
-
Pesce J, Kaviratne M, Ramalingam TR, Thompson RW, Urban JF Jr, Cheever AW, Young DA, Collins M, Grusby MJ, Wynn TA (2006) The IL-21 receptor augments Th2 effector function and alternative macrophage activation. J Clin Invest 116:2044-2055
-
(2006)
J Clin Invest
, vol.116
, pp. 2044-2055
-
-
Pesce, J.1
Kaviratne, M.2
Ramalingam, T.R.3
Thompson, R.W.4
Urban Jr., J.F.5
Cheever, A.W.6
Young, D.A.7
Collins, M.8
Grusby, M.J.9
Wynn, T.A.10
-
60
-
-
17544398702
-
Biochemical mechanisms of IL-2-regulated Fas-mediated T cell apoptosis
-
Refaeli Y, Van Parijs L, London CA, Tschopp J, Abbas AK (1998) Biochemical mechanisms of IL-2-regulated Fas-mediated T cell apoptosis. Immunity 8:615-623
-
(1998)
Immunity
, vol.8
, pp. 615-623
-
-
Refaeli, Y.1
Van Parijs, L.2
London, C.A.3
Tschopp, J.4
Abbas, A.K.5
-
61
-
-
33745298650
-
Interleukin-21 enhances NK cell activation in response to antibody-coated targets
-
Roda JM, Parihar R, Lehman A, Mani A, Tridandapani S, Carson WE 3rd (2006) Interleukin-21 enhances NK cell activation in response to antibody-coated targets. J Immunol 177:120-129
-
(2006)
J Immunol
, vol.177
, pp. 120-129
-
-
Roda, J.M.1
Parihar, R.2
Lehman, A.3
Mani, A.4
Tridandapani, S.5
Carson III, W.E.6
-
62
-
-
33746342994
-
Foxp3 + CD25 + CD4 + natural regulatory T cells in dominant self-tolerance and autoimmune disease (review)
-
Sakaguchi S, Ono M, Setoguchi R, Yagi H, Hori S, Fehervari Z, Shimizu J, Takahashi T, Nomura T (2006) Foxp3 + CD25 + CD4 + natural regulatory T cells in dominant self-tolerance and autoimmune disease (review). Immunol Rev 212:8-27
-
(2006)
Immunol Rev
, vol.212
, pp. 8-27
-
-
Sakaguchi, S.1
Ono, M.2
Setoguchi, R.3
Yagi, H.4
Hori, S.5
Fehervari, Z.6
Shimizu, J.7
Takahashi, T.8
Nomura, T.9
-
63
-
-
0027369395
-
Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene
-
Sadlack B, Merz H, Schorle H, Schimpl A, Feller AC, Horak I (1993) Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell 75:253-261
-
(1993)
Cell
, vol.75
, pp. 253-261
-
-
Sadlack, B.1
Merz, H.2
Schorle, H.3
Schimpl, A.4
Feller, A.C.5
Horak, I.6
-
64
-
-
1442277104
-
Expression of interleukin-21 and -23 in human esophageal tumors produced antitumor effects in nude mice
-
Shan B, Yu L, Shimozato O, Li Q, Tagawa M (2004) Expression of interleukin-21 and -23 in human esophageal tumors produced antitumor effects in nude mice. Anticancer Res 24:79-82
-
(2004)
Anticancer Res
, vol.24
, pp. 79-82
-
-
Shan, B.1
Yu, L.2
Shimozato, O.3
Li, Q.4
Tagawa, M.5
-
65
-
-
0348013081
-
IL-21 induces both rapid maturation of human CD34 + cell precursors towards NK cells and acquisition of surface killer Ig-like receptors
-
Sivori S, Cantoni C, Parolini S, Marcenaro E, Conte R, Moretta L, Moretta A (2003) IL-21 induces both rapid maturation of human CD34 + cell precursors towards NK cells and acquisition of surface killer Ig-like receptors. Eur J Immunol 33:3439-47
-
(2003)
Eur J Immunol
, vol.33
, pp. 3439-47
-
-
Sivori, S.1
Cantoni, C.2
Parolini, S.3
Marcenaro, E.4
Conte, R.5
Moretta, L.6
Moretta, A.7
-
66
-
-
33646489777
-
IL-21 enhances tumor-specific CTL induction by anti-DR5 antibody therapy
-
Smyth MJ, Hayakawa Y, Cretney E, Zerafa N, Sivakumar P, Yagita H, Takeda K (2006) IL-21 enhances tumor-specific CTL induction by anti-DR5 antibody therapy. J Immunol 176:6347-6355
-
(2006)
J Immunol
, vol.176
, pp. 6347-6355
-
-
Smyth, M.J.1
Hayakawa, Y.2
Cretney, E.3
Zerafa, N.4
Sivakumar, P.5
Yagita, H.6
Takeda, K.7
-
67
-
-
22344451592
-
Sequential activation of NKT cells and NK cells provides effective innate immunotherapy of cancer
-
Smyth MJ, Wallace ME, Nutt SL, Yagita H, Godfrey DI, Hayakawa Y (2005) Sequential activation of NKT cells and NK cells provides effective innate immunotherapy of cancer. J Exp Med 201:1973-1985
-
(2005)
J Exp Med
, vol.201
, pp. 1973-1985
-
-
Smyth, M.J.1
Wallace, M.E.2
Nutt, S.L.3
Yagita, H.4
Godfrey, D.I.5
Hayakawa, Y.6
-
68
-
-
34347387967
-
Interleukin 21 therapy increases the density of tumor infiltrating CD8(+) T cells and inhibits the growth of syngeneic tumors
-
(Epub ahead of print)
-
Sondergaard H, Frederiksen KS, Thygesen P, Galsgaard ED, Skak K, Kristjansen PE, Odum N, Kragh M (2007) Interleukin 21 therapy increases the density of tumor infiltrating CD8(+) T cells and inhibits the growth of syngeneic tumors. Cancer Immunol Immunother (Epub ahead of print)
-
(2007)
Cancer Immunol Immunother
-
-
Sondergaard, H.1
Frederiksen, K.S.2
Thygesen, P.3
Galsgaard, E.D.4
Skak, K.5
Kristjansen, P.E.6
Odum, N.7
Kragh, M.8
-
69
-
-
1242292306
-
STAT-1: A novel regulator of apoptosis (review)
-
Stephanou A, Latchman DS (2003) STAT-1: a novel regulator of apoptosis (review). Int J Exp Pathol 84:239-244
-
(2003)
Int J Exp Pathol
, vol.84
, pp. 239-244
-
-
Stephanou, A.1
Latchman, D.S.2
-
70
-
-
33746875244
-
IL-21 enhances SOCS gene expression and inhibits LPS-induced cytokine production in human monocyte-derived dendritic cells
-
Strengell M, Lehtonen A, Matikainen S, Julkunen I (2006) IL-21 enhances SOCS gene expression and inhibits LPS-induced cytokine production in human monocyte-derived dendritic cells. J Leukoc Biol 79:1279-1285
-
(2006)
J Leukoc Biol
, vol.79
, pp. 1279-1285
-
-
Strengell, M.1
Lehtonen, A.2
Matikainen, S.3
Julkunen, I.4
-
71
-
-
0036784616
-
IL-21 up-regulates the expression of genes associated with innate immunity and Th1 response
-
Strengell M, Sareneva T, Foster D, Julkunen I, Matikainen S (2002) IL-21 up-regulates the expression of genes associated with innate immunity and Th1 response. J Immunol 169:3600-3605
-
(2002)
J Immunol
, vol.169
, pp. 3600-3605
-
-
Strengell, M.1
Sareneva, T.2
Foster, D.3
Julkunen, I.4
Matikainen, S.5
-
72
-
-
0037114638
-
Interleukin 21 prevents antigen-induced IgE production by inhibiting germ line C(epsilon) transcription of IL-4-stimulated B cells
-
Suto A, Nakajima H, Hirose K, Suzuki K, Kagami S, Seto Y, Hoshimoto A, Saito Y, Foster DC, Iwamoto I (2002) Interleukin 21 prevents antigen-induced IgE production by inhibiting germ line C(epsilon) transcription of IL-4-stimulated B cells. Blood 100:4565-4573
-
(2002)
Blood
, vol.100
, pp. 4565-4573
-
-
Suto, A.1
Nakajima, H.2
Hirose, K.3
Suzuki, K.4
Kagami, S.5
Seto, Y.6
Hoshimoto, A.7
Saito, Y.8
Foster, D.C.9
Iwamoto, I.10
-
73
-
-
33748494020
-
IL-21 inhibits IFN-gamma production in developing Th1 cells through the repression of Eomesodermin expression
-
Suto A, Wurster AL, Reiner SL, Grusby MJ (2006) IL-21 inhibits IFN-gamma production in developing Th1 cells through the repression of Eomesodermin expression. J Immunol 177:3721-3727
-
(2006)
J Immunol
, vol.177
, pp. 3721-3727
-
-
Suto, A.1
Wurster, A.L.2
Reiner, S.L.3
Grusby, M.J.4
-
74
-
-
23444459564
-
IL-21 enhances tumor rejection through a NKG2D-dependent mechanism
-
Takaki R, Hayakawa Y, Nelson A, Sivakumar PV, Hughes S, Smyth MJ, Lanier LL (2005) IL-21 enhances tumor rejection through a NKG2D-dependent mechanism. J Immunol 175:2167-2173
-
(2005)
J Immunol
, vol.175
, pp. 2167-2173
-
-
Takaki, R.1
Hayakawa, Y.2
Nelson, A.3
Sivakumar, P.V.4
Hughes, S.5
Smyth, M.J.6
Lanier, L.L.7
-
75
-
-
0041349288
-
Cytokine requirements for the growth and development of mouse NK cells in vitro
-
Toomey JA, Gays F, Foster D, Brooks CG (2003) Cytokine requirements for the growth and development of mouse NK cells in vitro. J Leukoc Biol 74:233-242
-
(2003)
J Leukoc Biol
, vol.74
, pp. 233-242
-
-
Toomey, J.A.1
Gays, F.2
Foster, D.3
Brooks, C.G.4
-
76
-
-
0029939155
-
Interleukin-15 promotes the growth of leukemic cells of patients with B-cell chronic lymphoproliferative disorders
-
Trentin L, Cerutti A, Zambello R, Sancretta R, Tassinari C, Facco M, Adami F, Rodeghiero F, Agostini C, Semenzato G (1996) Interleukin-15 promotes the growth of leukemic cells of patients with B-cell chronic lymphoproliferative disorders. Blood 87:3327-3335
-
(1996)
Blood
, vol.87
, pp. 3327-3335
-
-
Trentin, L.1
Cerutti, A.2
Zambello, R.3
Sancretta, R.4
Tassinari, C.5
Facco, M.6
Adami, F.7
Rodeghiero, F.8
Agostini, C.9
Semenzato, G.10
-
77
-
-
12744261250
-
Expression of functional interleukin-21 receptor on adult T-cell leukaemia cells
-
Ueda M, Imada K, Imura A, Koga H, Hishizawa M, Uchiyama T (2005) Expression of functional interleukin-21 receptor on adult T-cell leukaemia cells. Br J Haematol 128:169-176
-
(2005)
Br J Haematol
, vol.128
, pp. 169-176
-
-
Ueda, M.1
Imada, K.2
Imura, A.3
Koga, H.4
Hishizawa, M.5
Uchiyama, T.6
-
78
-
-
0037347311
-
Expression of the interleukin-21 gene in murine colon carcinoma cells generates systemic immunity in the inoculated hosts
-
Ugai S, Shimozato O, Kawamura K, Wang YQ, Yamaguchi T, Saisho H, Sakiyama S, Tagawa M (2003) Expression of the interleukin-21 gene in murine colon carcinoma cells generates systemic immunity in the inoculated hosts. Cancer Gene Ther 10:187-192
-
(2003)
Cancer Gene Ther
, vol.10
, pp. 187-192
-
-
Ugai, S.1
Shimozato, O.2
Kawamura, K.3
Wang, Y.Q.4
Yamaguchi, T.5
Saisho, H.6
Sakiyama, S.7
Tagawa, M.8
-
79
-
-
12444328351
-
Transduction of the IL-21 and IL-23 genes in human pancreatic carcinoma cells produces natural killer cell-dependent and -independent antitumor effects
-
Ugai S, Shimozato O, Yu L, Wang YQ, Kawamura K, Yamamoto H, Yamaguchi T, Saisho H, Sakiyama S, Tagawa M (2003) Transduction of the IL-21 and IL-23 genes in human pancreatic carcinoma cells produces natural killer cell-dependent and -independent antitumor effects. Cancer Gene Ther 10:771-778
-
(2003)
Cancer Gene Ther
, vol.10
, pp. 771-778
-
-
Ugai, S.1
Shimozato, O.2
Yu, L.3
Wang, Y.Q.4
Kawamura, K.5
Yamamoto, H.6
Yamaguchi, T.7
Saisho, H.8
Sakiyama, S.9
Tagawa, M.10
-
80
-
-
17944364189
-
Elucidating the autoimmune and antitumor effector mechanisms of a treatment based on cytotoxic T lymphocyte antigen-4 blockade in combination with a B16 melanoma vaccine: Comparison of prophylaxis and therapy
-
van Elsas A, Sutmuller RP, Hurwitz AA, Ziskin J, Villasenor J, Medema JP, Overwijk WW, Restifo NP, Melief CJ, Offringa R, Allison JP (2001) Elucidating the autoimmune and antitumor effector mechanisms of a treatment based on cytotoxic T lymphocyte antigen-4 blockade in combination with a B16 melanoma vaccine: comparison of prophylaxis and therapy. J Exp Med 194:481-489
-
(2001)
J Exp Med
, vol.194
, pp. 481-489
-
-
Van Elsas, A.1
Sutmuller, R.P.2
Hurwitz, A.A.3
Ziskin, J.4
Villasenor, J.5
Medema, J.P.6
Overwijk, W.W.7
Restifo, N.P.8
Melief, C.J.9
Offringa, R.10
Allison, J.P.11
-
81
-
-
14744285671
-
Triggering of OX40 (CD134) on CD4(+)CD25+ T cells blocks their inhibitory activity: A novel regulatory role for OX40 and its comparison with GITR
-
Valzasina B, Guiducci C, Dislich H, Killeen N, Weinberg AD, Colombo MP (2005) Triggering of OX40 (CD134) on CD4(+)CD25+ T cells blocks their inhibitory activity: a novel regulatory role for OX40 and its comparison with GITR. Blood 105:2845-2851
-
(2005)
Blood
, vol.105
, pp. 2845-2851
-
-
Valzasina, B.1
Guiducci, C.2
Dislich, H.3
Killeen, N.4
Weinberg, A.D.5
Colombo, M.P.6
-
82
-
-
33646239606
-
Tumor-induced expansion of regulatory T cells by conversion of CD4 + CD25- lymphocytes is thymus and proliferation independent
-
Valzasina B, Piconese S, Guiducci C, Colombo MP (2006) Tumor-induced expansion of regulatory T cells by conversion of CD4 + CD25- lymphocytes is thymus and proliferation independent. Cancer Res 66:4488-4495
-
(2006)
Cancer Res
, vol.66
, pp. 4488-4495
-
-
Valzasina, B.1
Piconese, S.2
Guiducci, C.3
Colombo, M.P.4
-
83
-
-
26444539596
-
Functional re-expression of CCR7 on CMV-specific CD8+ T cells upon antigenic stimulation
-
van Leeuwen EM, van Buul JD, Remmerswaal EB, Hordijk PL, ten Berge IJ, van Lier RA (2005) Functional re-expression of CCR7 on CMV-specific CD8+ T cells upon antigenic stimulation. Int Immunol 17:713-719
-
(2005)
Int Immunol
, vol.17
, pp. 713-719
-
-
Van Leeuwen, E.M.1
Van Buul, J.D.2
Remmerswaal, E.B.3
Hordijk, P.L.4
Ten Berge, I.J.5
Van Lier, R.A.6
-
84
-
-
14044262247
-
Differential effects of IL-21 during initiation and progression of autoimmunity against neuroantigen
-
Vollmer TL, Liu R, Price M, Rhodes S, La Cava A, Shi FD (2005) Differential effects of IL-21 during initiation and progression of autoimmunity against neuroantigen. J Immunol 174:2696-2701
-
(2005)
J Immunol
, vol.174
, pp. 2696-2701
-
-
Vollmer, T.L.1
Liu, R.2
Price, M.3
Rhodes, S.4
La Cava, A.5
Shi, F.D.6
-
85
-
-
12444295407
-
Roles for common cytokine receptor gamma-chain-dependent cytokines in the generation, differentiation, and maturation of NK cell precursors and peripheral NK cells in vivo
-
Vosshenrich CA, Ranson T, Samson SI, Corcuff E, Colucci F, Rosmaraki EE, Di Santo JP (2005) Roles for common cytokine receptor gamma-chain-dependent cytokines in the generation, differentiation, and maturation of NK cell precursors and peripheral NK cells in vivo. J Immunol 174:1213-1221
-
(2005)
J Immunol
, vol.174
, pp. 1213-1221
-
-
Vosshenrich, C.A.1
Ranson, T.2
Samson, S.I.3
Corcuff, E.4
Colucci, F.5
Rosmaraki, E.E.6
Di Santo, J.P.7
-
86
-
-
0347320749
-
In vivo antitumor activity of interleukin 21 mediated by natural killer cells
-
Wang G, Tschoi M, Spolski R, Lou Y, Ozaki K, Feng C, Kim G, Leonard WJ, Hwu P (2003) In vivo antitumor activity of interleukin 21 mediated by natural killer cells. Cancer Res 63:9016-9022
-
(2003)
Cancer Res
, vol.63
, pp. 9016-9022
-
-
Wang, G.1
Tschoi, M.2
Spolski, R.3
Lou, Y.4
Ozaki, K.5
Feng, C.6
Kim, G.7
Leonard, W.J.8
Hwu, P.9
-
87
-
-
0028784289
-
Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment
-
Willerford DM, Chen J, Ferry JA, Davidson L, Ma A, Alt FW (1995) Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment. Immunity 3:521-530
-
(1995)
Immunity
, vol.3
, pp. 521-530
-
-
Willerford, D.M.1
Chen, J.2
Ferry, J.A.3
Davidson, L.4
Ma, A.5
Alt, F.W.6
-
88
-
-
34247370175
-
Differential effects of IL-21 and IL-15 on perforin expression, lysosomal degranulation and proliferation in CD8 T cells of patients infected with Human Immunodeficiency Virus-1 (HIV)
-
27 December 2006 (Epub ahead of print)
-
White L, Krishnan S, Strbo N, Liu H, Kolber MA, Lichtenheld MG, Pahwa R, Pahwa S (2007) Differential effects of IL-21 and IL-15 on perforin expression, lysosomal degranulation and proliferation in CD8 T cells of patients infected with Human Immunodeficiency Virus-1 (HIV). Blood 27 December 2006 (Epub ahead of print)
-
(2007)
Blood
-
-
White, L.1
Krishnan, S.2
Strbo, N.3
Liu, H.4
Kolber, M.A.5
Lichtenheld, M.G.6
Pahwa, R.7
Pahwa, S.8
-
89
-
-
0037037544
-
Interleukin 21 is a T helper (Th) cell 2 cytokine that specifically inhibits the differentiation of naive Th cells into interferon gamma-producing Th1 cells
-
Wurster AL, Rodgers VL, Satoskar AR, Whitters MJ, Young DA, Collins M, Grusby MJ (2002) Interleukin 21 is a T helper (Th) cell 2 cytokine that specifically inhibits the differentiation of naive Th cells into interferon gamma-producing Th1 cells. J Exp Med 196:969-977
-
(2002)
J Exp Med
, vol.196
, pp. 969-977
-
-
Wurster, A.L.1
Rodgers, V.L.2
Satoskar, A.R.3
Whitters, M.J.4
Young, D.A.5
Collins, M.6
Grusby, M.J.7
-
90
-
-
27644479966
-
Jak3 negatively regulates dendritic-cell cytokine production and survival
-
Yamaoka K, Min B, Zhou YJ, Paul WE, O'shea JJ (2005) Jak3 negatively regulates dendritic-cell cytokine production and survival. Blood 106:3227-3233
-
(2005)
Blood
, vol.106
, pp. 3227-3233
-
-
Yamaoka, K.1
Min, B.2
Zhou, Y.J.3
Paul, W.E.4
O'Shea, J.J.5
-
91
-
-
34248364008
-
The molecular basis of IL-21-mediated proliferation
-
18 January 2007 (Epub ahead of print)
-
Zeng R, Spolski R, Casas E, Zhu W, Levy DE, Leonard WJ (2007) The molecular basis of IL-21-mediated proliferation. Blood 18 January 2007 (Epub ahead of print)
-
(2007)
Blood
-
-
Zeng, R.1
Spolski, R.2
Casas, E.3
Zhu, W.4
Levy, D.E.5
Leonard, W.J.6
-
92
-
-
19944434230
-
Synergy of IL-21 and IL-15 in regulating CD8 + T cell expansion and function
-
Zeng R, Spolski R, Finkelstein SE, Oh S, Kovanen PE, Hinrichs CS, Pise-Masison CA, Radonovich MF, Brady JN, Restifo NP, Berzofsky JA, Leonard WJ (2005) Synergy of IL-21 and IL-15 in regulating CD8 + T cell expansion and function. J Exp Med 201:139-148
-
(2005)
J Exp Med
, vol.201
, pp. 139-148
-
-
Zeng, R.1
Spolski, R.2
Finkelstein, S.E.3
Oh, S.4
Kovanen, P.E.5
Hinrichs, C.S.6
Pise-Masison, C.A.7
Radonovich, M.F.8
Brady, J.N.9
Restifo, N.P.10
Berzofsky, J.A.11
Leonard, W.J.12
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