메뉴 건너뛰기




Volumn 177, Issue 6, 2006, Pages 3721-3727

IL-21 inhibits IFN-γ production in developing Th1 cells through the repression of Eomesodermin expression

Author keywords

[No Author keywords available]

Indexed keywords

EOMESODERMIN; GAMMA INTERFERON; INTERLEUKIN 21; MESSENGER RNA; STAT1 PROTEIN; STAT4 PROTEIN; T BOX TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR T BET; UNCLASSIFIED DRUG;

EID: 33748494020     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.177.6.3721     Document Type: Article
Times cited : (131)

References (25)
  • 1
    • 0029847368 scopus 로고    scopus 로고
    • Functional diversity of helper T lymphocytes
    • Abbas, A. K., K. M. Murphy, and A. Sher. 1996. Functional diversity of helper T lymphocytes. Nature 383: 787-793.
    • (1996) Nature , vol.383 , pp. 787-793
    • Abbas, A.K.1    Murphy, K.M.2    Sher, A.3
  • 2
    • 0028179006 scopus 로고
    • Lymphocyte responses and cytokines
    • Paul, W. E., and R. A. Seder. 1994. Lymphocyte responses and cytokines. Cell 76: 241-251.
    • (1994) Cell , vol.76 , pp. 241-251
    • Paul, W.E.1    Seder, R.A.2
  • 3
    • 0034677646 scopus 로고    scopus 로고
    • A novel transcription factor, T-bet, directs Th1 lineage commitment
    • Szabo, S. J., S. T. Kim, G. L. Costa, X. Zhang, G. C. Fathman, and L. H. Glimcher. 2000. A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell 100: 655-669.
    • (2000) Cell , vol.100 , pp. 655-669
    • Szabo, S.J.1    Kim, S.T.2    Costa, G.L.3    Zhang, X.4    Fathman, G.C.5    Glimcher, L.H.6
  • 4
    • 0033152267 scopus 로고    scopus 로고
    • The transcription factor c-Maf controls the production of interleukin-4 but not other Th2 cytokines
    • Kim, J. I., I.-C. Ho, M. J. Grusby, and L. H. Glimcher. 1999. The transcription factor c-Maf controls the production of interleukin-4 but not other Th2 cytokines. Immunity 10: 745-751.
    • (1999) Immunity , vol.10 , pp. 745-751
    • Kim, J.I.1    Ho, I.-C.2    Grusby, M.J.3    Glimcher, L.H.4
  • 5
    • 0030810155 scopus 로고    scopus 로고
    • The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells
    • Zheng, W.-P., and R. A. Flavell. 1997. The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell 89: 587-596.
    • (1997) Cell , vol.89 , pp. 587-596
    • Zheng, W.-P.1    Flavell, R.A.2
  • 6
    • 0032538985 scopus 로고    scopus 로고
    • C-maf promotes T helper cell type 2 (Th2) and attenuates Th1 differentiation by both interleukin 4-dependent and -independent mechanisms
    • Ho, I.-C., D. Lo, and L. H. Glimcher. 1998. C-maf promotes T helper cell type 2 (Th2) and attenuates Th1 differentiation by both interleukin 4-dependent and -independent mechanisms. J. Exp. Med. 188: 1859-1866.
    • (1998) J. Exp. Med. , vol.188 , pp. 1859-1866
    • Ho, I.-C.1    Lo, D.2    Glimcher, L.H.3
  • 7
    • 0033973582 scopus 로고    scopus 로고
    • State-independent GATA-3 autoactivation directs IL-4-independent Th2 development and commitment
    • Ouyang, W., M. Lohning, Z. Gao, M. Assenmacher, S. Ranganath, A. Radbruch, and K. M. Murphy. 2000. State-independent GATA-3 autoactivation directs IL-4-independent Th2 development and commitment. Immunity 12: 27-37.
    • (2000) Immunity , vol.12 , pp. 27-37
    • Ouyang, W.1    Lohning, M.2    Gao, Z.3    Assenmacher, M.4    Ranganath, S.5    Radbruch, A.6    Murphy, K.M.7
  • 8
    • 8544234990 scopus 로고    scopus 로고
    • Recent developments in the transcriptional regulation of cytolytic effector cells
    • Glimcher, L. H., M. J. Townsend, B. M. Sullivan, and G. M. Lord. 2004. Recent developments in the transcriptional regulation of cytolytic effector cells. Nat. Rev. Immunol. 4: 900-911.
    • (2004) Nat. Rev. Immunol. , vol.4 , pp. 900-911
    • Glimcher, L.H.1    Townsend, M.J.2    Sullivan, B.M.3    Lord, G.M.4
  • 10
    • 0030582733 scopus 로고    scopus 로고
    • Eomesodermin, a key early gene in Xenopus mesoderm differentiation
    • Ryan, K., N. Garrett, A. Mitchell, and J. B. Gurdon. 1996. Eomesodermin, a key early gene in Xenopus mesoderm differentiation. Cell 87: 989-1000.
    • (1996) Cell , vol.87 , pp. 989-1000
    • Ryan, K.1    Garrett, N.2    Mitchell, A.3    Gurdon, J.B.4
  • 12
    • 0035400054 scopus 로고    scopus 로고
    • Cutting edge: The common γ-chain is an indispensable subunit of the IL-21 receptor complex
    • Asao, H., C. Okuyama, S. Kumaki, N. Ishii, S. Tsuchiya, D. Foster, and K. Sugamura. 2001. Cutting edge: the common γ-chain is an indispensable subunit of the IL-21 receptor complex. J. Immunol. 167: 1-5.
    • (2001) J. Immunol. , vol.167 , pp. 1-5
    • Asao, H.1    Okuyama, C.2    Kumaki, S.3    Ishii, N.4    Tsuchiya, S.5    Foster, D.6    Sugamura, K.7
  • 13
  • 14
    • 0037037544 scopus 로고    scopus 로고
    • Interleukin 21 is a T helper (Th) cell 2 cytokine that specifically inhibits the differentiation of naive Th cells into interferon γ-producing Th1 cells
    • Wurster, A. L., V. L. Rodgers, A. R. Satoskar, M. J. Whitters, D. A. Young, M. Collins, and M. J. Grusby. 2002. Interleukin 21 is a T helper (Th) cell 2 cytokine that specifically inhibits the differentiation of naive Th cells into interferon γ-producing Th1 cells. J. Exp. Med. 196: 969-977.
    • (2002) J. Exp. Med. , vol.196 , pp. 969-977
    • Wurster, A.L.1    Rodgers, V.L.2    Satoskar, A.R.3    Whitters, M.J.4    Young, D.A.5    Collins, M.6    Grusby, M.J.7
  • 16
    • 0035910037 scopus 로고    scopus 로고
    • T-bet is rapidly induced by interferon-γ in lymphoid and myeloid cells
    • Lighvani, A. A., D. M. Frucht, and D. Jankovic. 2001. T-bet is rapidly induced by interferon-γ in lymphoid and myeloid cells. Proc. Natl. Acad. Sci. USA 98: 15137-15142.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 15137-15142
    • Lighvani, A.A.1    Frucht, D.M.2    Jankovic, D.3
  • 18
    • 0037059462 scopus 로고    scopus 로고
    • Distinct effects of T-bet in TH1 lineage commitment and IFN-γ production in CD4 and CD8 T cells
    • Szabo, S. J., B. M. Sullivan, C. Stemmann, A. R. Satoskar, B. P. Sleckman, and L. H. Glimcher. 2002. Distinct effects of T-bet in TH1 lineage commitment and IFN-γ production in CD4 and CD8 T cells. Science 295: 338-342.
    • (2002) Science , vol.295 , pp. 338-342
    • Szabo, S.J.1    Sullivan, B.M.2    Stemmann, C.3    Satoskar, A.R.4    Sleckman, B.P.5    Glimcher, L.H.6
  • 22
    • 0037342749 scopus 로고    scopus 로고
    • GATA-3 suppresses Th1 development by down-regulation of Stat4 and not through effects on IL-12Rβ2 chain or T-bet
    • Usui, T., R. Nishikomori, A. Kitani, and W. Strober. 2003. GATA-3 suppresses Th1 development by down-regulation of Stat4 and not through effects on IL-12Rβ2 chain or T-bet. Immunity 18: 415-428.
    • (2003) Immunity , vol.18 , pp. 415-428
    • Usui, T.1    Nishikomori, R.2    Kitani, A.3    Strober, W.4
  • 24
    • 25444434157 scopus 로고    scopus 로고
    • Interleukin-21: A modulator of lymphoid proliferation, apoptosis and differentiation
    • Leonard, W. J., and R. Spolski. 2005. Interleukin-21: a modulator of lymphoid proliferation, apoptosis and differentiation. Nat. Rev. Immunol. 5: 688-698.
    • (2005) Nat. Rev. Immunol. , vol.5 , pp. 688-698
    • Leonard, W.J.1    Spolski, R.2
  • 25
    • 0028596154 scopus 로고
    • IL-2 induces tyrosine phosphorylation and nuclear translocation of STAT3 in human T lymphocytes
    • Nielsen, M., A. Svejgaard, S. Skov, and N. Odum. 1994. IL-2 induces tyrosine phosphorylation and nuclear translocation of STAT3 in human T lymphocytes. Eur. J. Immunol. 24: 3082-3086.
    • (1994) Eur. J. Immunol. , vol.24 , pp. 3082-3086
    • Nielsen, M.1    Svejgaard, A.2    Skov, S.3    Odum, N.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.