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Volumn 177, Issue 12, 2006, Pages 8381-8392

Identification of cellular intermediates and molecular pathways induced by IL-21 in human B cells

Author keywords

[No Author keywords available]

Indexed keywords

CD19 ANTIGEN; CD20 ANTIGEN; CD23 ANTIGEN; CD38 ANTIGEN; CD4 ANTIGEN; CYCLIN DEPENDENT KINASE INHIBITOR 1B; HLA DR ANTIGEN; IMMUNOGLOBULIN G; INTERLEUKIN 21; JANUS KINASE; JANUS KINASE INHIBITOR; MYC PROTEIN; STAT PROTEIN; STAT1 PROTEIN; STAT3 PROTEIN;

EID: 33845438994     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.177.12.8381     Document Type: Article
Times cited : (48)

References (60)
  • 1
    • 9644295710 scopus 로고    scopus 로고
    • c-dependent cytokines interleukins 2, 4, 7, 9, 15, and 21, and their signaling pathways
    • c-dependent cytokines interleukins 2, 4, 7, 9, 15, and 21, and their signaling pathways. Immunol. Rev. 202: 67-83.
    • (2004) Immunol. Rev. , vol.202 , pp. 67-83
    • Kovanen, P.E.1    Leonard, W.J.2
  • 2
    • 0027751556 scopus 로고
    • Interleukin-2 receptor γ chain: A functional component of the interleukin-7 receptor
    • Noguchi, M., Y. Nakamura, S. M. Russell, S. F. Ziegler, M. Tsang, X. Cao, and W. J. Leonard. 1993. Interleukin-2 receptor γ chain: a functional component of the interleukin-7 receptor. Science 262: 1877-1880.
    • (1993) Science , vol.262 , pp. 1877-1880
    • Noguchi, M.1    Nakamura, Y.2    Russell, S.M.3    Ziegler, S.F.4    Tsang, M.5    Cao, X.6    Leonard, W.J.7
  • 4
    • 0036852893 scopus 로고    scopus 로고
    • Interleukin-21 and the IL-21 receptor: Novel effectors of NK and T cell responses
    • Parrish-Novak, J., D. C. Foster, R. D. Holly, and C. H. Clegg. 2002. Interleukin-21 and the IL-21 receptor: novel effectors of NK and T cell responses. J. Leukocyte Biol. 72: 856-863.
    • (2002) J. Leukocyte Biol. , vol.72 , pp. 856-863
    • Parrish-Novak, J.1    Foster, D.C.2    Holly, R.D.3    Clegg, C.H.4
  • 5
    • 2942755979 scopus 로고    scopus 로고
    • T follicular helper cells express a distinctive transcriptional profile, reflecting their role as non-Th1/Th2 effector cells that provide help for B cells
    • Chtanova, T., S. G. Tangye, R. Newton, N. Frank, M. R. Hodge, M. S. Rolph, and C. R. Mackay. 2004. T follicular helper cells express a distinctive transcriptional profile, reflecting their role as non-Th1/Th2 effector cells that provide help for B cells. J. Immunol. 173: 68-78.
    • (2004) J. Immunol. , vol.173 , pp. 68-78
    • Chtanova, T.1    Tangye, S.G.2    Newton, R.3    Frank, N.4    Hodge, M.R.5    Rolph, M.S.6    Mackay, C.R.7
  • 6
    • 13844319581 scopus 로고    scopus 로고
    • NFATc2 and T-bet contribute to T-helper-cell-subset-specific regulation of IL-21 expression
    • Mehta, D. S., A. L. Wurster, A. S. Weinmann, and M. J. Grusby. 2005. NFATc2 and T-bet contribute to T-helper-cell-subset-specific regulation of IL-21 expression. Proc. Natl. Acad. Sci. USA 102: 2016-2021.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 2016-2021
    • Mehta, D.S.1    Wurster, A.L.2    Weinmann, A.S.3    Grusby, M.J.4
  • 8
    • 0038784488 scopus 로고    scopus 로고
    • IL-21 activates both innate and adaptive immunity to generate potent antitumor responses that require perforin but are independent of IFN-γ
    • Ma, H. L., M. J. Whitters, R. F. Konz, M. Senices, D. A. Young, M. J. Grusby, M. Collins, and K. Dunussi-Joannopoulos. 2003. IL-21 activates both innate and adaptive immunity to generate potent antitumor responses that require perforin but are independent of IFN-γ. J. Immunol. 171: 608-615.
    • (2003) J. Immunol. , vol.171 , pp. 608-615
    • Ma, H.L.1    Whitters, M.J.2    Konz, R.F.3    Senices, M.4    Young, D.A.5    Grusby, M.J.6    Collins, M.7    Dunussi-Joannopoulos, K.8
  • 10
    • 0842278642 scopus 로고    scopus 로고
    • IL-21 induces the functional maturation of murine NK cells
    • Brady, J., Y. Hayakawa, M. J. Smyth, and S. L. Nutt. 2004. IL-21 induces the functional maturation of murine NK cells. J. Immunol. 172: 2048-2058.
    • (2004) J. Immunol. , vol.172 , pp. 2048-2058
    • Brady, J.1    Hayakawa, Y.2    Smyth, M.J.3    Nutt, S.L.4
  • 12
  • 13
    • 10744230081 scopus 로고    scopus 로고
    • Interleukin (IL)-21 and IL-15 genetic transfer synergistically augments therapeutic antitumor immunity and promotes regression of metastatic lymphoma
    • Kishida, T., H. Asada, Y. Itokawa, F. D. Cui, M. Shin-Ya, S. Gojo, K. Yasutomi, Y. Ueda, H. Yamagishi, J. Imanishi, and O. Mazda. 2003. Interleukin (IL)-21 and IL-15 genetic transfer synergistically augments therapeutic antitumor immunity and promotes regression of metastatic lymphoma. Mol. Ther. 8: 552-558.
    • (2003) Mol. Ther. , vol.8 , pp. 552-558
    • Kishida, T.1    Asada, H.2    Itokawa, Y.3    Cui, F.D.4    Shin-Ya, M.5    Gojo, S.6    Yasutomi, K.7    Ueda, Y.8    Yamagishi, H.9    Imanishi, J.10    Mazda, O.11
  • 14
    • 2942709751 scopus 로고    scopus 로고
    • Distinct activation signals determine whether IL-21 induces B cell costimulation, growth arrest, or Bim-dependent apoptosis
    • Jin, H., R. Carrio, A. Yu, and T. R. Malek. 2004. Distinct activation signals determine whether IL-21 induces B cell costimulation, growth arrest, or Bim-dependent apoptosis. J. Immunol. 173: 657-665.
    • (2004) J. Immunol. , vol.173 , pp. 657-665
    • Jin, H.1    Carrio, R.2    Yu, A.3    Malek, T.R.4
  • 17
    • 0037093258 scopus 로고    scopus 로고
    • Interleukin-21 is a growth and survival factor for human myeloma cells
    • Brenne, A. T., T. Baade Ro, A. Waage, A. Sundan, M. Borset, and H. Hjorth-Hansen. 2002. Interleukin-21 is a growth and survival factor for human myeloma cells. Blood 99: 3756-3762.
    • (2002) Blood , vol.99 , pp. 3756-3762
    • Brenne, A.T.1    Baade Ro, T.2    Waage, A.3    Sundan, A.4    Borset, M.5    Hjorth-Hansen, H.6
  • 18
    • 33646410652 scopus 로고    scopus 로고
    • Interleukin-21 receptor (IL-21R) is up-regulated by CD40 triggering and mediates pro-apoptotic signals in chronic lymphocytic leukemia B cells
    • de Totero, D., R. Meazza, S. Zupo, G. Cutrona, S. Maus, M. Colombo, E. Balleari, I. Pierri, M. Fabbi, M. Capaia, et al. 2006. Interleukin-21 receptor (IL-21R) is up-regulated by CD40 triggering and mediates pro-apoptotic signals in chronic lymphocytic leukemia B cells. Blood 107: 3708-3715.
    • (2006) Blood , vol.107 , pp. 3708-3715
    • De Totero, D.1    Meazza, R.2    Zupo, S.3    Cutrona, G.4    Maus, S.5    Colombo, M.6    Balleari, E.7    Pierri, I.8    Fabbi, M.9    Capaia, M.10
  • 20
    • 14944362858 scopus 로고    scopus 로고
    • Regulation of plasma-cell development
    • Shapiro-Shelef, M., and K. Calame. 2005. Regulation of plasma-cell development. Nat. Rev. Immunol. 5: 230-242.
    • (2005) Nat. Rev. Immunol. , vol.5 , pp. 230-242
    • Shapiro-Shelef, M.1    Calame, K.2
  • 21
    • 4944266319 scopus 로고    scopus 로고
    • Epstein-Barr virus: 40 Years on
    • Young, L. S., and A. B. Rickinson. 2004. Epstein-Barr virus: 40 years on. Nat. Rev. Cancer 4: 757-768.
    • (2004) Nat. Rev. Cancer , vol.4 , pp. 757-768
    • Young, L.S.1    Rickinson, A.B.2
  • 22
    • 25444434157 scopus 로고    scopus 로고
    • Interleukin-21: A modulator of lymphoid proliferation, apoptosis and differentiation
    • Leonard, W. J., and R. Spolski. 2005. Interleukin-21: a modulator of lymphoid proliferation, apoptosis and differentiation. Nat. Rev. Immunol. 5: 688-698.
    • (2005) Nat. Rev. Immunol. , vol.5 , pp. 688-698
    • Leonard, W.J.1    Spolski, R.2
  • 23
    • 0035200379 scopus 로고    scopus 로고
    • EBNA2 and Notch signalling in Epstein-Barr virus mediated immortalization of B lymphocytes
    • Zimber-Strobl, U., and L. J. Strobl. 2001. EBNA2 and Notch signalling in Epstein-Barr virus mediated immortalization of B lymphocytes. Semin. Cancer Biol. 11: 423-434.
    • (2001) Semin. Cancer Biol. , vol.11 , pp. 423-434
    • Zimber-Strobl, U.1    Strobl, L.J.2
  • 25
    • 23144464363 scopus 로고    scopus 로고
    • Transcriptional regulation and transformation by Myc proteins
    • Adhikary, S., and M. Eilers. 2005. Transcriptional regulation and transformation by Myc proteins. Nat. Rev. Mol. Cell Biol. 6: 635-645.
    • (2005) Nat. Rev. Mol. Cell Biol. , vol.6 , pp. 635-645
    • Adhikary, S.1    Eilers, M.2
  • 26
    • 0030766009 scopus 로고    scopus 로고
    • B-lymphocyte-lineage cells from early precursors to Ig-secreting plasma cells: Targets of regulation by the myc/mad/max families of genes?
    • Melchers, F. 1997. B-lymphocyte-lineage cells from early precursors to Ig-secreting plasma cells: targets of regulation by the myc/mad/max families of genes? Curr. Top. Microbiol. Immunol. 224: 19-30.
    • (1997) Curr. Top. Microbiol. Immunol. , vol.224 , pp. 19-30
    • Melchers, F.1
  • 29
    • 0033680860 scopus 로고    scopus 로고
    • BCL-6 represses genes that function in lymphocyte differentiation, inflammation, and cell cycle control
    • Shaffer, A. L., X. Yu, Y. He, J. Boldrick, E. P. Chan, and L. M. Staudt. 2000. BCL-6 represses genes that function in lymphocyte differentiation, inflammation, and cell cycle control. Immunity 13: 199-212.
    • (2000) Immunity , vol.13 , pp. 199-212
    • Shaffer, A.L.1    Yu, X.2    He, Y.3    Boldrick, J.4    Chan, E.P.5    Staudt, L.M.6
  • 31
    • 0026599838 scopus 로고
    • Generation of nondividing high rate Ig-secreting plasma cells in cultures of human B cells stimulated with anti-CD3-activated T cells
    • Vernino, L., L. M. McAnally, J. Ramberg, and P. E. Lipsky. 1992. Generation of nondividing high rate Ig-secreting plasma cells in cultures of human B cells stimulated with anti-CD3-activated T cells. J. Immunol. 148: 404-410.
    • (1992) J. Immunol. , vol.148 , pp. 404-410
    • Vernino, L.1    McAnally, L.M.2    Ramberg, J.3    Lipsky, P.E.4
  • 32
    • 0028963846 scopus 로고
    • T cell-induced B cell blasts differentiate into plasma cells when cultured on bone marrow stroma with IL-3 and IL-10
    • Merville, P., J. Dechanet, G. Grouard, I. Durand, and J. Banchereau. 1995. T cell-induced B cell blasts differentiate into plasma cells when cultured on bone marrow stroma with IL-3 and IL-10. Int. Immunol. 7: 635-643.
    • (1995) Int. Immunol. , vol.7 , pp. 635-643
    • Merville, P.1    Dechanet, J.2    Grouard, G.3    Durand, I.4    Banchereau, J.5
  • 34
    • 0037220807 scopus 로고    scopus 로고
    • A division-linked mechanism for the rapid generation of Ig-secreting cells from human memory B cells
    • Tangye, S. G., D. T. Avery, and P. D. Hodgkin. 2003. A division-linked mechanism for the rapid generation of Ig-secreting cells from human memory B cells. J. Immunol. 170: 261-269.
    • (2003) J. Immunol. , vol.170 , pp. 261-269
    • Tangye, S.G.1    Avery, D.T.2    Hodgkin, P.D.3
  • 35
    • 15444378323 scopus 로고    scopus 로고
    • Increased expression of CD27 on activated human memory B cells correlates with their commitment to the plasma cell lineage
    • Avery, D. T., J. I. Ellyard, F. Mackay, L. M. Corcoran, P. D. Hodgkin, and S. G. Tangye. 2005. Increased expression of CD27 on activated human memory B cells correlates with their commitment to the plasma cell lineage. J. Immunol. 174: 4034-4042.
    • (2005) J. Immunol. , vol.174 , pp. 4034-4042
    • Avery, D.T.1    Ellyard, J.I.2    Mackay, F.3    Corcoran, L.M.4    Hodgkin, P.D.5    Tangye, S.G.6
  • 37
    • 1642334164 scopus 로고    scopus 로고
    • Persistence of the Epstein-Barr virus and the origins of associated lymphomas
    • Thorley-Lawson, D. A., and A. Gross. 2004. Persistence of the Epstein-Barr virus and the origins of associated lymphomas. N. Engl. J. Med. 350: 1328-1337.
    • (2004) N. Engl. J. Med. , vol.350 , pp. 1328-1337
    • Thorley-Lawson, D.A.1    Gross, A.2
  • 40
    • 0038636287 scopus 로고    scopus 로고
    • Pax-5 is a key regulator of the B cell-restricted expression of the CD23a isoform
    • Visan, I., M. Goller, I. Berberich, C. Kneitz, and H. P. Tony. 2003. Pax-5 is a key regulator of the B cell-restricted expression of the CD23a isoform. Eur. J. Immunol. 33: 1163-1173.
    • (2003) Eur. J. Immunol. , vol.33 , pp. 1163-1173
    • Visan, I.1    Goller, M.2    Berberich, I.3    Kneitz, C.4    Tony, H.P.5
  • 41
    • 0031923038 scopus 로고    scopus 로고
    • The JAK-STAT pathway: Signal transduction involved in proliferation, differentiation and transformation
    • Weber-Nordt, R. M., R. Mertelsmann, and J. Finke. 1998. The JAK-STAT pathway: signal transduction involved in proliferation, differentiation and transformation. Leak. Lymphoma 28: 459-467.
    • (1998) Leak. Lymphoma , vol.28 , pp. 459-467
    • Weber-Nordt, R.M.1    Mertelsmann, R.2    Finke, J.3
  • 42
  • 43
    • 0035313701 scopus 로고    scopus 로고
    • The Stat family in cytokine signaling
    • Ihle, J. N. 2001. The Stat family in cytokine signaling. Curr. Opin. Cell Biol. 13: 211-217.
    • (2001) Curr. Opin. Cell Biol. , vol.13 , pp. 211-217
    • Ihle, J.N.1
  • 44
    • 0034460636 scopus 로고    scopus 로고
    • Repression of c-myc is necessary but not sufficient for terminal differentiation of B lymphocytes in vitro
    • Lin, K. I., Y. Lin, and K. Calame. 2000. Repression of c-myc is necessary but not sufficient for terminal differentiation of B lymphocytes in vitro. Mol. Cell Biol. 20: 8684-8695.
    • (2000) Mol. Cell Biol. , vol.20 , pp. 8684-8695
    • Lin, K.I.1    Lin, Y.2    Calame, K.3
  • 45
    • 0026073347 scopus 로고
    • Expression of the c-myc protein is down-regulated at the terminal stages during in vitro differentiation of B-type chronic lymphocytic leukemia cells
    • Larsson, L. G., M. Schena, M. Carlsson, J. Sallstrom, and K. Nilsson. 1991. Expression of the c-myc protein is down-regulated at the terminal stages during in vitro differentiation of B-type chronic lymphocytic leukemia cells. Blood 77: 1025-1032.
    • (1991) Blood , vol.77 , pp. 1025-1032
    • Larsson, L.G.1    Schena, M.2    Carlsson, M.3    Sallstrom, J.4    Nilsson, K.5
  • 46
    • 0030950523 scopus 로고    scopus 로고
    • Repression of c-myc transcription by Blimp-1, an inducer of terminal B cell differentiation
    • Lin, Y., K. Wong, and K. Calame. 1997. Repression of c-myc transcription by Blimp-1, an inducer of terminal B cell differentiation. Science 276: 596-599.
    • (1997) Science , vol.276 , pp. 596-599
    • Lin, Y.1    Wong, K.2    Calame, K.3
  • 47
    • 11144237694 scopus 로고    scopus 로고
    • Interleukin 21: A key player in lymphocyte maturation
    • Nutt, S. L., J. Brady, Y. Hayakawa, and M. J. Smyth. 2004. Interleukin 21: a key player in lymphocyte maturation. Crit. Rev. Immunol. 24: 239-250.
    • (2004) Crit. Rev. Immunol. , vol.24 , pp. 239-250
    • Nutt, S.L.1    Brady, J.2    Hayakawa, Y.3    Smyth, M.J.4
  • 48
    • 9644278059 scopus 로고    scopus 로고
    • Biology of IL-21 and the IL-21 receptor
    • Mehta, D. S., A. L. Wurster, and M. J. Grusby. 2004. Biology of IL-21 and the IL-21 receptor. Immunol. Rev. 202: 84-95.
    • (2004) Immunol. Rev. , vol.202 , pp. 84-95
    • Mehta, D.S.1    Wurster, A.L.2    Grusby, M.J.3
  • 49
    • 0027675064 scopus 로고
    • Protein and lipid kinase activation cascades in interleukin-2 receptor signalling
    • Williamson, P., I. Merida, and G. Gaulton. 1993. Protein and lipid kinase activation cascades in interleukin-2 receptor signalling. Semin. Immunol. 5: 337-344.
    • (1993) Semin. Immunol. , vol.5 , pp. 337-344
    • Williamson, P.1    Merida, I.2    Gaulton, G.3
  • 50
    • 2542497114 scopus 로고    scopus 로고
    • The interleukin (lL)-2 family cytokines: Survival and proliferation signaling pathways in T lymphocytes
    • Benczik, M., and S. L. Gaffen. 2004. The interleukin (lL)-2 family cytokines: survival and proliferation signaling pathways in T lymphocytes. Immunol. Invest. 33: 109-142.
    • (2004) Immunol. Invest. , vol.33 , pp. 109-142
    • Benczik, M.1    Gaffen, S.L.2
  • 52
    • 32544448486 scopus 로고    scopus 로고
    • IL-7: A key regulator of B lymphopoiesis
    • Milne, C. D., and C. J. Paige. 2006. IL-7: a key regulator of B lymphopoiesis. Semin. Immunol. 18: 20-30.
    • (2006) Semin. Immunol. , vol.18 , pp. 20-30
    • Milne, C.D.1    Paige, C.J.2
  • 53
    • 32144463144 scopus 로고    scopus 로고
    • Opposing actions of STAT-1 and STAT-3
    • Stephanou, A., and D. S. Latchman. 2005. Opposing actions of STAT-1 and STAT-3. Growth Factors 23: 177-182.
    • (2005) Growth Factors , vol.23 , pp. 177-182
    • Stephanou, A.1    Latchman, D.S.2
  • 55
    • 0030024563 scopus 로고    scopus 로고
    • Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease
    • Durbin, J. E., R. Hackenmiller, M. C. Simon, and D. E. Levy. 1996. Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease. Cell 84: 443-450.
    • (1996) Cell , vol.84 , pp. 443-450
    • Durbin, J.E.1    Hackenmiller, R.2    Simon, M.C.3    Levy, D.E.4
  • 56
    • 0034142230 scopus 로고    scopus 로고
    • STAT1 affects lymphocyte survival and proliferation partially independent of its role downstream of IFN-γ
    • Lee, C. K., E. Smith, R. Gimeno, R. Gertner, and D. E. Levy. 2000. STAT1 affects lymphocyte survival and proliferation partially independent of its role downstream of IFN-γ. J. Immunol. 164: 1286-1292.
    • (2000) J. Immunol. , vol.164 , pp. 1286-1292
    • Lee, C.K.1    Smith, E.2    Gimeno, R.3    Gertner, R.4    Levy, D.E.5
  • 57
    • 0030659512 scopus 로고    scopus 로고
    • Defective TNF-α-induced apoptosis in STAT1-null cells due to low constitutive levels of caspases
    • Kumar, A., M. Commane, T. W. Flickinger, C. M. Horvath, and G. R. Stark. 1997. Defective TNF-α-induced apoptosis in STAT1-null cells due to low constitutive levels of caspases. Science 278: 1630-1632.
    • (1997) Science , vol.278 , pp. 1630-1632
    • Kumar, A.1    Commane, M.2    Flickinger, T.W.3    Horvath, C.M.4    Stark, G.R.5
  • 59
    • 0035799531 scopus 로고    scopus 로고
    • Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells
    • Garcia, R., T. L. Bowman, G. Niu, H. Yu, S. Minton, C. A. Muro-Cacho, C. E. Cox, R. Falcone, R. Fairclough, S. Parsons, et al. 2001. Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells. Oncogene 20: 2499-2513.
    • (2001) Oncogene , vol.20 , pp. 2499-2513
    • Garcia, R.1    Bowman, T.L.2    Niu, G.3    Yu, H.4    Minton, S.5    Muro-Cacho, C.A.6    Cox, C.E.7    Falcone, R.8    Fairclough, R.9    Parsons, S.10
  • 60
    • 0013689209 scopus 로고    scopus 로고
    • Requirement of Stat3 but not Stat1 activation for epidermal growth factor receptor-mediated cell growth in vitro
    • Grandis, J. R., S. D. Drenning, A. Chakraborty, M. Y. Zhou, Q. Zeng, A. S. Pitt, and D. J. Tweardy. 1998. Requirement of Stat3 but not Stat1 activation for epidermal growth factor receptor-mediated cell growth In vitro. J. Clin. Invest. 102: 1385-1392.
    • (1998) J. Clin. Invest. , vol.102 , pp. 1385-1392
    • Grandis, J.R.1    Drenning, S.D.2    Chakraborty, A.3    Zhou, M.Y.4    Zeng, Q.5    Pitt, A.S.6    Tweardy, D.J.7


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