메뉴 건너뛰기




Volumn 9, Issue 7, 2006, Pages 907-916

JNK mediates pathogenic effects of polyglutamine-expanded androgen receptor on fast axonal transport

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTOR; KINESIN; KINESIN 1; POLYGLUTAMINE; STRESS ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE INHIBITOR; UNCLASSIFIED DRUG;

EID: 33745520772     PISSN: 10976256     EISSN: None     Source Type: Journal    
DOI: 10.1038/nn1717     Document Type: Article
Times cited : (169)

References (50)
  • 1
    • 0034094873 scopus 로고    scopus 로고
    • Glutamine repeats and neurodegeneration
    • Zoghbi, H.Y. & Orr, H.T. Glutamine repeats and neurodegeneration. Annu. Rev. Neurosci. 23, 217-247 (2000).
    • (2000) Annu. Rev. Neurosci. , vol.23 , pp. 217-247
    • Zoghbi, H.Y.1    Orr, H.T.2
  • 2
    • 13244297167 scopus 로고    scopus 로고
    • Polyglutamine expansion diseases: Failing to deliver
    • Morfini, G., Pigino, G. & Brady, S.T. Polyglutamine expansion diseases: failing to deliver. Trends Mol. Med. 11, 64-70 (2005).
    • (2005) Trends Mol. Med. , vol.11 , pp. 64-70
    • Morfini, G.1    Pigino, G.2    Brady, S.T.3
  • 3
    • 0029129227 scopus 로고
    • Spinal and bulbar muscular atrophy: A trinucleotide-repeat expansion neurodegenerative disease
    • Brooks, B.P. & Fischbeck, K.H. Spinal and bulbar muscular atrophy: a trinucleotide-repeat expansion neurodegenerative disease. Trends Neurosci. 18, 459-461 (1995).
    • (1995) Trends Neurosci. , vol.18 , pp. 459-461
    • Brooks, B.P.1    Fischbeck, K.H.2
  • 4
    • 0029893047 scopus 로고    scopus 로고
    • A and B forms of the androgen receptor are expressed in a variety of human tissues
    • Wilson, C. M. & McPhaul, M.J. A and B forms of the androgen receptor are expressed in a variety of human tissues. Mol. Cell Endocrinol. 120, 51-57 (1996).
    • (1996) Mol. Cell Endocrinol. , vol.120 , pp. 51-57
    • Wilson, C.M.1    McPhaul, M.J.2
  • 5
    • 0642377462 scopus 로고    scopus 로고
    • Biochemical and molecular characterization of diseases linked to motor proteins
    • Hirokawa, N. & Takemura, R. Biochemical and molecular characterization of diseases linked to motor proteins. Trends Biochem. Sci. 28, 558-565 (2003).
    • (2003) Trends Biochem. Sci. , vol.28 , pp. 558-565
    • Hirokawa, N.1    Takemura, R.2
  • 7
    • 0037734370 scopus 로고    scopus 로고
    • Mutations in dynein link motor neuron degeneration to defects in retrograde transport
    • Hafezparast, M. et al. Mutations in dynein link motor neuron degeneration to defects in retrograde transport. Science 300, 808-812 (2003).
    • (2003) Science , vol.300 , pp. 808-812
    • Hafezparast, M.1
  • 8
    • 18644365196 scopus 로고    scopus 로고
    • A kinesin heavy chain (KIF5A) mutation in hereditary spastic paraplegia (SPG10)
    • Reid, E. et al. A kinesin heavy chain (KIF5A) mutation in hereditary spastic paraplegia (SPG10). Am. J. Hum. Genet. 71, 1189-1194 (2002).
    • (2002) Am. J. Hum. Genet. , vol.71 , pp. 1189-1194
    • Reid, E.1
  • 9
    • 0141750470 scopus 로고    scopus 로고
    • Disruption of axonal transport by loss of huntingtin or expression of pathogenic polyQ proteins in Drosophila
    • Gunawardena, S. et al. Disruption of axonal transport by loss of huntingtin or expression of pathogenic polyQ proteins in Drosophila. Neuron 40, 25-40 (2003).
    • (2003) Neuron , vol.40 , pp. 25-40
    • Gunawardena, S.1
  • 10
    • 1542267796 scopus 로고    scopus 로고
    • Cytoplasmic aggregates trap polyglutamine-containing proteins and block axonal transport in a Drosophila model of Huntington's disease
    • Lee, W.C., Yoshihara, M. & Littleton, J.T. Cytoplasmic aggregates trap polyglutamine-containing proteins and block axonal transport in a Drosophila model of Huntington's disease. Proc. Natl. Acad. Sci. USA 101, 3224-3229 (2004).
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 3224-3229
    • Lee, W.C.1    Yoshihara, M.2    Littleton, J.T.3
  • 11
    • 10744224530 scopus 로고    scopus 로고
    • Neuropathogenic forms of huntingtin and androgen receptor inhibit fast axonal transport
    • Szebenyi, G. et al. Neuropathogenic forms of huntingtin and androgen receptor inhibit fast axonal transport. Neuron 40, 41-52 (2003).
    • (2003) Neuron , vol.40 , pp. 41-52
    • Szebenyi, G.1
  • 12
    • 0028019867 scopus 로고
    • Kinesin-mediated organelle translocation revealed by specific cellular manipulations
    • Feiguin, F., Ferreira, A., Kosik, K.S. & Caceres, A. Kinesin-mediated organelle translocation revealed by specific cellular manipulations. J. Cell Biol. 127, 1021-1039 (1994).
    • (1994) J. Cell Biol. , vol.127 , pp. 1021-1039
    • Feiguin, F.1    Ferreira, A.2    Kosik, K.S.3    Caceres, A.4
  • 13
    • 0036469290 scopus 로고    scopus 로고
    • Glycogen synthase kinase 3 phosphorylates kinesin light chains and negatively regulates kinesin-based motility
    • Morfini, G., Szebenyi, G., Elluru, R., Ratner, N. & Brady, S.T. Glycogen synthase kinase 3 phosphorylates kinesin light chains and negatively regulates kinesin-based motility. EMBO J. 23, 281-293 (2002).
    • (2002) EMBO J. , vol.23 , pp. 281-293
    • Morfini, G.1    Szebenyi, G.2    Elluru, R.3    Ratner, N.4    Brady, S.T.5
  • 14
    • 0035678626 scopus 로고    scopus 로고
    • Regulation of kinesin: Implications for neuronal development
    • Morfini, G., Szebenyi, G., Richards, B. & Brady, S.T. Regulation of kinesin: implications for neuronal development. Dev. Neurosci. 23, 364-376 (2001).
    • (2001) Dev. Neurosci. , vol.23 , pp. 364-376
    • Morfini, G.1    Szebenyi, G.2    Richards, B.3    Brady, S.T.4
  • 16
    • 0038118207 scopus 로고    scopus 로고
    • Alzheimer's presenilin 1 mutations impair kinesin-based axonal transport
    • Pigino, G., Morfini, G., Mattson, M.P., Brady, S.T. & Busciglio, J. Alzheimer's presenilin 1 mutations impair kinesin-based axonal transport. J. Neurosci. 23, 4499-4508 (2003).
    • (2003) J. Neurosci. , vol.23 , pp. 4499-4508
    • Pigino, G.1    Morfini, G.2    Mattson, M.P.3    Brady, S.T.4    Busciglio, J.5
  • 17
    • 2442719008 scopus 로고    scopus 로고
    • Castration restores function and neurofilament alterations of aged symptomatic males in a transgenic mouse model of spinal and bulbar muscular atrophy
    • Chevalier-Larsen, E.S. et al. Castration restores function and neurofilament alterations of aged symptomatic males in a transgenic mouse model of spinal and bulbar muscular atrophy. J. Neurosci. 24, 4778-4786 (2004).
    • (2004) J. Neurosci. , vol.24 , pp. 4778-4786
    • Chevalier-Larsen, E.S.1
  • 18
    • 0038039288 scopus 로고    scopus 로고
    • Polyglutamine protein aggregation and toxicity are linked to the cellular stress response
    • Cowan, K.J., Diamond, M.I. & Welch, W.J. Polyglutamine protein aggregation and toxicity are linked to the cellular stress response. Hum. Mol. Genet. 12, 1377-1391 (2003).
    • (2003) Hum. Mol. Genet. , vol.12 , pp. 1377-1391
    • Cowan, K.J.1    Diamond, M.I.2    Welch, W.J.3
  • 19
    • 0041816369 scopus 로고    scopus 로고
    • Kennedy's disease. Phosphorylation of the polyglutamine-expanded form of androgen receptor regulates its cleavage by caspase-3 and enhances cell death
    • LaFevre-Bernt, M.A. & Ellerby, L.M. Kennedy's disease. Phosphorylation of the polyglutamine-expanded form of androgen receptor regulates its cleavage by caspase-3 and enhances cell death. J. Biol. Chem. 278, 34918-34924 (2003).
    • (2003) J. Biol. Chem. , vol.278 , pp. 34918-34924
    • LaFevre-Bernt, M.A.1    Ellerby, L.M.2
  • 20
    • 0025021497 scopus 로고
    • A monoclonal antibody against kinesin inhibits both anterograde and retrograde fast axonal transport in squid axoplasm
    • Brady, S.T., Pfister, K.K. & Bloom, G.S. A monoclonal antibody against kinesin inhibits both anterograde and retrograde fast axonal transport in squid axoplasm. Proc. Natl. Acad. Sci. USA 87, 1061-1065 (1990).
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 1061-1065
    • Brady, S.T.1    Pfister, K.K.2    Bloom, G.S.3
  • 21
    • 0141736846 scopus 로고    scopus 로고
    • Androgen receptors containing expanded polyglutamine tracts exhibit progressive toxicity when stably expressed in the neuroblastoma cell line, SH-SY 5Y
    • Avila, D.M., Allman, D.R., Gallo, J.M. & McPhaul, M.J. Androgen receptors containing expanded polyglutamine tracts exhibit progressive toxicity when stably expressed in the neuroblastoma cell line, SH-SY 5Y. Exp. Biol. Med. (Maywood) 228, 982-990 (2003).
    • (2003) Exp. Biol. Med. (Maywood) , vol.228 , pp. 982-990
    • Avila, D.M.1    Allman, D.R.2    Gallo, J.M.3    McPhaul, M.J.4
  • 22
    • 0037024694 scopus 로고    scopus 로고
    • 2+-dependent dephosphorylation of kinesin heavy chain on β-granules in pancreatic β-cells. Implications for regulated β-granule transport and insulin exocytosis
    • 2+-dependent dephosphorylation of kinesin heavy chain on β-granules in pancreatic β-cells. Implications for regulated β-granule transport and insulin exocytosis. J. Biol. Chem. 277, 24232-24242 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 24232-24242
    • Donelan, M.J.1
  • 23
    • 0027263661 scopus 로고
    • Phosphorylation of neuronal kinesin heavy and light chains in vivo
    • Hollenbeck, P.J. Phosphorylation of neuronal kinesin heavy and light chains in vivo. J. Neurochem. 60, 2265-2275 (1993).
    • (1993) J. Neurochem. , vol.60 , pp. 2265-2275
    • Hollenbeck, P.J.1
  • 24
    • 0034433275 scopus 로고    scopus 로고
    • Neurofilament protein synthesis and phosphorylation
    • Grant, P. & Pant, H.C. Neurofilament protein synthesis and phosphorylation. J. Neurocytol. 29, 843-872 (2000).
    • (2000) J. Neurocytol. , vol.29 , pp. 843-872
    • Grant, P.1    Pant, H.C.2
  • 25
    • 3042634127 scopus 로고    scopus 로고
    • A novel CDK5-dependent pathway for regulating GSK3 activity and kinesin-driven motility in neurons
    • Morfini, G. et al. A novel CDK5-dependent pathway for regulating GSK3 activity and kinesin-driven motility in neurons. EMBO J. 23, 2235-2245 (2004).
    • (2004) EMBO J. , vol.23 , pp. 2235-2245
    • Morfini, G.1
  • 26
    • 19744365702 scopus 로고    scopus 로고
    • A small molecule-kinase interaction map for clinical kinase inhibitors
    • Fabian, M.A. et al. A small molecule-kinase interaction map for clinical kinase inhibitors. Nat. Biotechnol. 23, 329-336 (2005).
    • (2005) Nat. Biotechnol. , vol.23 , pp. 329-336
    • Fabian, M.A.1
  • 27
    • 0036615741 scopus 로고    scopus 로고
    • c-Jun N-terminal protein kinase (JNK) 2/3 is specifically activated by stress, mediating c-Jun activation, in the presence of constitutive JNK1 activity in cerebellar neurons
    • Coffey, E.T. et al. c-Jun N-terminal protein kinase (JNK) 2/3 is specifically activated by stress, mediating c-Jun activation, in the presence of constitutive JNK1 activity in cerebellar neurons. J. Neurosci. 22, 4335-4345 (2002).
    • (2002) J. Neurosci. , vol.22 , pp. 4335-4345
    • Coffey, E.T.1
  • 28
    • 0034667705 scopus 로고    scopus 로고
    • Dual roles for c-Jun N-terminal kinase in developmental and stress responses in cerebellar granule neurons
    • Coffey, E.T., Hongisto, V., Dickens, M., Davis, R.J. & Courtney, M.J. Dual roles for c-Jun N-terminal kinase in developmental and stress responses in cerebellar granule neurons. J. Neurosci. 20, 7602-7613 (2000).
    • (2000) J. Neurosci. , vol.20 , pp. 7602-7613
    • Coffey, E.T.1    Hongisto, V.2    Dickens, M.3    Davis, R.J.4    Courtney, M.J.5
  • 29
    • 0035923665 scopus 로고    scopus 로고
    • SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase
    • Bennett, B. L. et al. SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase. Proc. Natl. Acad. Sci. USA 98, 13681-13686 (2001).
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 13681-13686
    • Bennett, B.L.1
  • 30
    • 0037192843 scopus 로고    scopus 로고
    • Identification of the critical features of a small peptide inhibitor of JNK activity
    • Barr, R.K., Kendrick, T.S. & Bogoyevitch, M.A. Identification of the critical features of a small peptide inhibitor of JNK activity. J. Biol. Chem. 277, 10987-10997 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 10987-10997
    • Barr, R.K.1    Kendrick, T.S.2    Bogoyevitch, M.A.3
  • 31
    • 3142514201 scopus 로고    scopus 로고
    • Protein aggregation and neurodegenerative disease
    • Ross, C.A. & Poirier, M.A. Protein aggregation and neurodegenerative disease. Nat. Med. 10 suppl. Suppl,: S10-S17 (2004).
    • (2004) Nat. Med. , vol.10 , Issue.SUPPL.
    • Ross, C.A.1    Poirier, M.A.2
  • 32
    • 12144286872 scopus 로고    scopus 로고
    • Androgen receptor YAC transgenic mice recapitulate SBMA motor neuronopathy and implicate VEGF164 in the motor neuron degeneration
    • Sopher, B.L. et al. Androgen receptor YAC transgenic mice recapitulate SBMA motor neuronopathy and implicate VEGF164 in the motor neuron degeneration. Neuron 41, 687-699 (2004).
    • (2004) Neuron , vol.41 , pp. 687-699
    • Sopher, B.L.1
  • 33
    • 0037032817 scopus 로고    scopus 로고
    • Mitogenactivated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases
    • Johnson, G.L. & Lapadat, R. Mitogenactivated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science 298, 1911-1912 (2002).
    • (2002) Science , vol.298 , pp. 1911-1912
    • Johnson, G.L.1    Lapadat, R.2
  • 34
    • 0034823950 scopus 로고    scopus 로고
    • AR suppresses transcription of the á glycoprotein hormone subunit gene through protein-protein interactions with cJun and activation transcription factor 2
    • Jorgensen, J.S. & Nilson, J.H. AR suppresses transcription of the á glycoprotein hormone subunit gene through protein-protein interactions with cJun and activation transcription factor 2. Mol. Endocrinol. 15, 1496-1504 (2001).
    • (2001) Mol. Endocrinol. , vol.15 , pp. 1496-1504
    • Jorgensen, J.S.1    Nilson, J.H.2
  • 35
    • 18644379256 scopus 로고    scopus 로고
    • Testosterone reduction prevents phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophy
    • Katsuno, M. et al. Testosterone reduction prevents phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophy. Neuron 35, 843-854 (2002).
    • (2002) Neuron , vol.35 , pp. 843-854
    • Katsuno, M.1
  • 36
    • 0034793311 scopus 로고    scopus 로고
    • Clinical features and skewed X-chromosome inactivation in female carriers of X-linked recessive spinal and bulbar muscular atrophy
    • Ishihara, H., Kanda, F., Nishio, H., Sumino, K. & Chihara, K. Clinical features and skewed X-chromosome inactivation in female carriers of X-linked recessive spinal and bulbar muscular atrophy. J. Neurol. 248, 856-860 (2001).
    • (2001) J. Neurol. , vol.248 , pp. 856-860
    • Ishihara, H.1    Kanda, F.2    Nishio, H.3    Sumino, K.4    Chihara, K.5
  • 37
    • 0037056302 scopus 로고    scopus 로고
    • Expression of X-linked bulbospinal muscular atrophy (Kennedy disease) in two homozygous women
    • Schmidt, B.J., Greenberg, C.R., Allingham-Hawkins, D.J. & Spriggs, E.L. Expression of X-linked bulbospinal muscular atrophy (Kennedy disease) in two homozygous women. Neurology 59, 770-772 (2002).
    • (2002) Neurology , vol.59 , pp. 770-772
    • Schmidt, B.J.1    Greenberg, C.R.2    Allingham-Hawkins, D.J.3    Spriggs, E.L.4
  • 38
    • 24744471465 scopus 로고    scopus 로고
    • Regulation of androgen receptor levels: Implications for prostate cancer progression and therapy
    • Burnstein, K.L. Regulation of androgen receptor levels: implications for prostate cancer progression and therapy. J. Cell. Biochem. 95, 657-669 (2005).
    • (2005) J. Cell. Biochem. , vol.95 , pp. 657-669
    • Burnstein, K.L.1
  • 39
    • 0036713608 scopus 로고    scopus 로고
    • A mouse model of spinal and bulbar muscular atrophy
    • McManamny, P. et al. A mouse model of spinal and bulbar muscular atrophy. Hum. Mol. Genet. 11, 2103-2111 (2002).
    • (2002) Hum. Mol. Genet. , vol.11 , pp. 2103-2111
    • McManamny, P.1
  • 40
    • 0035862754 scopus 로고    scopus 로고
    • Expression of expanded repeat androgen receptor produces neurologic disease in transgenic mice
    • Abel, A., Walcott, J., Woods, J., Duda, J. & Merry, D.E. Expression of expanded repeat androgen receptor produces neurologic disease in transgenic mice. Hum. Mol. Genet. 10, 107-116 (2001).
    • (2001) Hum. Mol. Genet. , vol.10 , pp. 107-116
    • Abel, A.1    Walcott, J.2    Woods, J.3    Duda, J.4    Merry, D.E.5
  • 41
    • 0024462479 scopus 로고
    • Retardation in axonal transport of cytoskeletal elements during maturation and aging
    • McQuarrie, I.G., Brady, S.T. & Lasek, R.J. Retardation in axonal transport of cytoskeletal elements during maturation and aging. Neurobiol. Aging 10, 359-365 (1989).
    • (1989) Neurobiol. Aging , vol.10 , pp. 359-365
    • McQuarrie, I.G.1    Brady, S.T.2    Lasek, R.J.3
  • 42
    • 85003072920 scopus 로고
    • Binding of 7 α, 17 α-dimethyl-19-nortestosterone (mibolerone) to androgen and progesterone receptors in human and animal tissues
    • Traish, A.M., Muller, R.E. & Wotiz, H.H. Binding of 7 α, 17 α-dimethyl-19-nortestosterone (mibolerone) to androgen and progesterone receptors in human and animal tissues. Endocrinology 118, 1327-1333 (1986).
    • (1986) Endocrinology , vol.118 , pp. 1327-1333
    • Traish, A.M.1    Muller, R.E.2    Wotiz, H.H.3
  • 43
    • 16844387124 scopus 로고    scopus 로고
    • Role of JNK activation in apoptosis: A double-edged sword
    • Liu, J. & Lin, A. Role of JNK activation in apoptosis: a double-edged sword. Cell Res. 15, 36-42 (2005).
    • (2005) Cell Res. , vol.15 , pp. 36-42
    • Liu, J.1    Lin, A.2
  • 44
    • 0036716277 scopus 로고    scopus 로고
    • Androgen receptor with elongated polyglutamine tract forms aggregates that alter axonal trafficking and mitochondrial distribution in motor neuronal processes
    • Piccioni, F. et al. Androgen receptor with elongated polyglutamine tract forms aggregates that alter axonal trafficking and mitochondrial distribution in motor neuronal processes. FASEB J. 16, 1418-1420 (2002).
    • (2002) FASEB J. , vol.16 , pp. 1418-1420
    • Piccioni, F.1
  • 46
    • 25844487226 scopus 로고    scopus 로고
    • Diseases of unstable repeat expansion: Mechanisms and common principles
    • Gatchel, J.R. & Zoghbi, H.Y. Diseases of unstable repeat expansion: mechanisms and common principles. Nat. Rev. Genet. 6, 743-755 (2005).
    • (2005) Nat. Rev. Genet. , vol.6 , pp. 743-755
    • Gatchel, J.R.1    Zoghbi, H.Y.2
  • 47
    • 33344467745 scopus 로고    scopus 로고
    • Stress kinase signaling regulates androgen receptor phosphorylation, transcription, and localization
    • Gioeli, D. et al. Stress kinase signaling regulates androgen receptor phosphorylation, transcription, and localization. Mol. Endocrinol. 20, 503-515 (2006).
    • (2006) Mol. Endocrinol. , vol.20 , pp. 503-515
    • Gioeli, D.1
  • 48
    • 4143083990 scopus 로고    scopus 로고
    • Distinct requirements for p38á and c-Jun N-terminal kinase stress-activated protein kinases in different forms of apoptotic neuronal death
    • Cao, J. et al. Distinct requirements for p38á and c-Jun N-terminal kinase stress-activated protein kinases in different forms of apoptotic neuronal death. J. Biol. Chem. 279, 35903-35913 (2004).
    • (2004) J. Biol. Chem. , vol.279 , pp. 35903-35913
    • Cao, J.1
  • 49
    • 0035220961 scopus 로고    scopus 로고
    • Approaches to study interactions between kinesin motors and membrains
    • ed. Vernos, I. Humana Press, Totowa, New Jersey
    • Morfini, G., Tsai, M., Szebenyi, G. & Brady, S.T. Approaches to study interactions between kinesin motors and membrains. in Kinesin Protocols (ed. Vernos, I.) 147-162 (Humana Press, Totowa, New Jersey, 2000).
    • (2000) Kinesin Protocols , pp. 147-162
    • Morfini, G.1    Tsai, M.2    Szebenyi, G.3    Brady, S.T.4
  • 50
    • 0027436256 scopus 로고
    • In vitro translation of androgen receptor cRNA results in an activated androgen receptor protein
    • Kuiper, G.G., de Ruiter, P.E., Trapman, J., Jenster, G. & Brinkmann, A.O. In vitro translation of androgen receptor cRNA results in an activated androgen receptor protein. Biochem. J. 296, 161-167 (1993).
    • (1993) Biochem. J. , vol.296 , pp. 161-167
    • Kuiper, G.G.1    De Ruiter, P.E.2    Trapman, J.3    Jenster, G.4    Brinkmann, A.O.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.