Recent progress on the molecular organization of myelinated axons

Journal of the Peripheral Nervous System

Volumn 7, Issue 1, 2002, Pages 1-12

  Scherer, Steven S ^a   Arroyo, Edgardo J ^a  

^a HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Cell adhesion molecules; Channels; Junctions; Neuropathy; Schwann cells

Indexed keywords

ALPHA6 INTEGRIN; BETA4 INTEGRIN; CELL ADHESION MOLECULE; CONTACTIN; DIMER; DYSTROGLYCAN; DYSTROGLYCAN RELATED PROTEIN 2; ERYTHROCYTE BAND 4.1 PROTEIN; F ACTIN; INTEGRIN; LAMININ 2 RECEPTOR; LAMININ RECEPTOR; MEROSIN; NEUROFASCIN; PARANODIN; POTASSIUM CHANNEL; PROTEIN DP116; PROTEIN KV1.1; PROTEIN KV1.2; PROTEIN SUBUNIT; SODIUM CHANNEL; UNCLASSIFIED DRUG; UTROPHIN;

ACTIN FILAMENT; ANIMAL CELL; BASEMENT MEMBRANE; BINDING SITE; CASPR GENE; CELL INTERACTION; CGT GENE; CONFERENCE PAPER; CONTACTIN GENE; CYTOARCHITECTURE; CYTOSKELETON; ELECTRIC POTENTIAL; GAP JUNCTION; GENE DISRUPTION; GENE ISOLATION; GENE LOCATION; GENE MUTATION; MICROVILLUS; MOLECULAR BIOLOGY; MOUSE; MYELINATION; NERVE FIBER GROWTH; NERVE FIBER MEMBRANE; NONHUMAN; PATHOGENESIS; PERIPHERAL NEUROPATHY; PRIORITY JOURNAL; PROTEIN BINDING; SCHWANN CELL;

ANIMALS; CELL ADHESION MOLECULES; HUMANS; MYELIN SHEATH; NERVE FIBERS, MYELINATED; PERIPHERAL NERVOUS SYSTEM; SCHWANN CELLS;

EID: 0036130074     PISSN: 10859489     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1529-8027.2002.02001.x     Document Type: Conference Paper

References (125)

1. Episodic ataxia results from voltage-dependent potassium channels with altered functions
2. On the molecular architecture of myelinated fibers
3. Myelinating Schwann cells determine the internodal localization of Kv1.1, Kv1.2, Kvβ2, and Caspr
4. Functional gap junctions in the Schwann cell myelin sheath
5. Expression of janusin (J1-160/180) in the retina and optic nerve of the developing and adult mouse
6. Molecular architecture of the specialized axonal membrane at the node of Ranvier
7. Beta IV spectrin, a new spectrin localized at axon initial segments and nodes of Ranvier in the central and peripheral nervous system
8. Connexin mutations in X-linked Charcot-Marie-Tooth disease
9. Axon-glia interactions and the domain organization of myelinated axons requires Neurexin IV/Caspr/Paranodin
10. Periaxin mutations cause recessive Dejerine-Sottas neuropathy
11. Compact myelin dictates the differential targeting of two sodium channel isoforms in the same axon
12. Functional breakdown of the lipid bilayer of the myelin membrane in central and peripheral nervous system myelin by disrupted galactocerebroside synthesis
13. Galactosphingolipids and axon-glial interaction in myelin of the central nervous system
14. Contactin orchestrates assembly of the septatelike junctions at the paranode in myelinated peripheral nerve
15. Episodic ataxia/myokymia syndrome is associated with point mutations in the human potassium channel gene, KCNA1
16. Familial paroxysmal kinesigenic ataxia and continuous myokymia
17. Schwann Cell Regulation of Extracellular Matrix Biosynthesis and Assembly
18. Mutation of a new sodium channel gene, Scn8a, in the mouse mutant 'motor endplate disease'
19. v1.6 is localized at nodes of Ranvier, dendrites, and synapses
20. Altered connexin expression after peripheral nerve injury
21. Potassium channels in nodal and internodal axonal membrane of mammalian myelinated fibres
22. Demyelination and altered expression of myelin-associated glycoprotein isoforms in the central nervous system of galactolipid-deficient mice
23. Myelination in the absence of galactocerebroside and sulfatide: Normal structure with abnormal function and regional instability
24. +1→ A transversion at the 5′ splice site of intron 69 of the dystrophin gene causing the absence of peripheral nerve Dp116 and severe clinical involvement in a DMD patient
25. Peripheral myelin protein 22 and protein zero: A novel association in peripheral nervous system myelin
26. Overloaded endoplasmic reticulum-Golgi compartments, a possible pathomechanism of peripheral neuropathies caused by mutations of the peripheral myelin protein PMP22
27. Ankyrin binding activity shared by the neurofascin/L1/NrCAM family of nervous system cell adhesion molecules
28. Molecular composition of the node of Ranvier: Identification of ankyrin-binding cell adhesion molecules neurofascin (mucin+ third FNIII domain-) and NrCAM at nodal axon segments
29. Ankyrin-binding proteins related to nervous system cell adhesion molecules: Candidates to provide transmembrane and intercellular connections in adult brain
30. Electrophysiological studies of neuromuscular transmission hereditary "motor end-plate disease" of the mouse
31. Myelin galactolipids are essential for proper node of Ranvier formation in the CNS
32. Axo-glial interactions regulate the localization of axonal paranodal proteins
33. Axonal regulation of Schwann cell integrin expression suggests a role for α6β4 in myelination
34. The axonal membrane protein Caspr/Neurexin IV is a component of the septate-like paranodal junctions that assemble during myelination
35. Immunocytochemical localization of sodium channel distributions in the excitable membranes of Electrophorus electricus
36. Novel E-cadherin mediated adhesion in peripheral nerve: Schwann cell architecture is stabilized by autotypic adherens junctions
37. Microperoxidase - An ultrastructural tracer of low molecular weight
38. β4 integrin expression in myelinating Schwann cells is ab-axonally polarized, developmentally-regulated, and axonally-dependent
39. Molecular specialization of astrocyte processes at nodes of Ranvier in rat optic nerve
40. Localization of the tetrodotoxin-resistant sodium channel NaN in nociceptors
41. Myelin formation by Schwann cells in the absence of β4 integrin
42. Measurement of myelin sheath resistances: Implications for axonal conduction and pathophysiology
43. Two divergent types of nerve pathology in patients with different PO mutations in Charcot-Marie-Tooth disease
44. o gene disruption leads to hypomyelination, abnormal expression of recognition molecules, and degeneration of myelin and axons
45. Peripheral demyelination and neuropathic pain behavior in periaxin-deficient mice
46. A mutation in periaxin is responsible for CMT4F, an autosomal recessive form of Charcot-Marie-Tooth disease
47. + channel beta subunit
48. Immunocytochemical localization of the mammalian voltage-dependent sodium channel using polyclonal antibodies against the purified protein
49. Studies on the 'incisures' of Schmidt and Lanterman
50. Immunofluorescence detection of ezrin/radixin/moesin (ERM) proteins with their carboxyl-terminal threonine phosphorylated in cultured cells and tissues. Application of a novel fixation protocol using trichloroacetic acid (TCA) as a fixative
51. Myelination and myelin sheath remodelling in normal and pathological PNS nerve fibres
52. Isolation of the periaxonal space of the central myelinated nerve fiber with regard to the diffusion of peroxidase
53. + currents expressed in Xenopus oocytes by mKv1.1, mKv1.2 and their heteromultimers as revealed by mutagenesis of the dendrotoxin-binding site in Kv1.1
54. Three-dimensional fine structure of cytoskeletal-membrane interactions at nodes of Ranvier
55. A sarcoglycan-dystrophin complex anchors DP116 and utrophin in the peripheral nervous system
56. v1.6 at developing CNS nodes of Ranvier
57. Maturation of mammalian myelinated fibers: Changes in action-potential characteristics following 4-aminopyridine application
58. A regional analysis of α-spectrin in the isolated Mauthner neuron and in isolated axons of the goldfish and rabbit
59. An isoform of ankyrin is localized at nodes of Ranvier in myelinated axons of central and peripheral nerves
60. G: A new ankyrin gene with neural-specific isoforms localized at the axonal initial segment and node of Ranvier
61. Crystal structure of the tetramerization domain of the Shaker potassium channel
62. Morphogenesis of the node of Ranvier: Co-clusters of ankyrin and ankyrin-binding integral proteins define early developmental intermediates
63. Nodes of Ranvier and Schmidt-Lanterman incisures: An in vivo lanthanum tracer study
64. Peripheral nerve involvement in merosin-deficient congenital muscular dystrophy and dy mouse
65. Nodes of Ranvier form in association with ezrin-radixin-moesin (ERM)-positive Schwann cell processes
66. Paranodin, a glycoprotein of neuronal paranodal membranes
67. Differential distribution of closely related potassium channels in rat Schwann cells
68. Caveolin-1 expression in Schwann cells
69. Particle rosettes in the periaxonal Schwann cell membrane and particle clusters in the axolemma of rat sciatic nerve
70. The neurobiology of Schwann cells
71. Charcot-Marie-Tooth disease and related inherited neuropathies
72. Aberrant protein trafficking in Trembler suggests a disease mechanism for hereditary human peripheral neuropathies
73. Impaired intracellular trafficking is a common disease mechanism of PMP22 point mutations in peripheral neuropathies
74. Upregulation of the endosomal-lysosomal pathway in the Trembler-J neuropathy
75. Type II brain 4.1 (4.1 B/KIAA0987), a member of the protein 4.1 family, is localized to neuronal paranodes
76. From dystrophinopathy to sarcoglycanopathy: Evolution of the concept of muscular dystrophy
77. Mutant beta-spectrin 4 causes auditory and motor neuropathies in quivering mice
78. Molecular and functional characterization of protein 4.1B, a novel member of the protein 4.1 family with high level, focal expression in brain
79. Molecular domains of myelinated fibers
80. Myelination by Schwann cells in the absence of extracellular matrix assembly
81. + channels
82. Localization of Caspr2 in myelinated nerves depends on axon-glia interactions and the generation of barriers along the axon
83. Myelin galactolipids: Mediators of axon-glial interactions?
84. Differences between the nodes of Ranvier of large and small diameter fibres in the P.N.S.
85. Molecular basis for the peripheral nerve predilection of Mycobacterium leprae
86. Potassium channel distribution, clustering, and function in remyelinating rat axons
87. Neuronal cell adhesion molecules and cytotactin are colocalized at the node of Ranvier
88. Paranodal dysmyelination and increase in tetrodotoxin binding sites in the sciatic nerve of the motor end-plate disease (med/med) mouse during postnatal development
89. Contactin-associated protein (Caspr) and contactin form a complex that is targeted to the paranodal junctions during myelination
90. Intramembranous particle distribution at the node of Ranvier and adjacent axolemma in myelinated axons of the frog brain
91. Impaired sensory function in heterozygous P0 knockout mice is associated with nodal changes in sensory nerves
92. Membrane morphology of the vertebrate nervous system
93. Connexin32 is a myelin-related protein in the PNS and CNS
94. Axon-Schwann cell interactions in peripheral nerve regeneration
95. Ezrin, radixin, and moesin are components of Schwann cell microvilli
96. 0, the major structural protein of peripheral nerve myelin
97. Specific disruption of a Schwann cell dystrophin-related protein complex in a demyelinating neuropathy
98. Demyelinating peripheral neuropathy in merosin-deficient congenital muscular dystrophy
99. Deletion of the Kv1.1 potassium channel causes epilepsy in mice
100. Ankyrin and spectrin associate with voltage-dependent sodium channels in brain
101. Freeze-fracture replication of mammalian peripheral nerve - A review
102. Associated particle aggregates in juxtaparanodal axolemma and adaxonal Schwann cell membrane of rat peripheral nerve
103. Distribution of particle aggregates in the internodal axolemma and adaxonal Schwann cell membrane of rodent peripheral nerve
104. Muscular dystrophies and the dystrophin-glycoprotein complex
105. Deficiency of merosin in dystrophic dy mice and genetic linkage of laminin M chain gene to dy locus
106. Biology and genetics of hereditary motor and sensory neuropathies
107. An oligodendrocyte cell adhesion molecule at the site of assembly of the paranodal axo-glial junction
108. Extranodal particle accumulations in the axolemma of myelinated frog optic axons
109. Microscopic Anatomy and Function of the Connective Tissue Components of Peripheral Nerve
110. Transport of Trembler-J mutant peripheral myelin protein 22 is blocked in the intermediate compartment and affects the transport of the wild-type protein by direct interaction
111. Co-localization of the myelin-associated glycoprotein and the microfilament components, F-actin and spectrin, in Schwann cells of myelinated nerve fibers
112. Ion channel redistribution and function during development of the myelinated axon
113. Dynamic potassium channel distributions during axonal development prevent aberrant firing patterns
114. Ultrastructural PMP22 expression in inherited demyelinating neuropathies
115. Hereditary myokymia and periodic ataxia
116. A reversible abnormal form of myelin: An X-ray scattering study of human sural and rat sciatic nerves
117. + channels in terminal and juxtaparanodal regions of neurons
118. Tenascin-R is a functional modulator of sodium channel beta subunits
119. Murine muscular dystrophy caused by a mutation in the laminin α2 (Lama2) gene
120. Dystroglycan is a dual receptor for agrin and laminin-2 in Schwann cell membrane
121. Episodic ataxia mutations in Kv1.1 alter potassium channel function by dominant negative effects or haploinsufficiency
122. G isoforms targeted to nodes of Ranvier
123. G is required for clustering of voltagegated Na channels at axon initial segments and for normal action potential firing
124. Temperaturesensitive neuromuscular transmission in Kv1.1 null mice: Role of potassium channels under the myelin sheath in young nerves