Insulin protects liver cells from saturated fatty acid-induced apoptosis via inhibition of c-Jun NH2 terminal kinase activity

Endocrinology

Volumn 148, Issue 7, 2007, Pages 3338-3345

  Pagliassotti, Michael J ^a   Wei, Y ^a   Wang, D ^a  

^a Department of Environmental and Radiological Health Sciences   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CASPASE 3; DNA FRAGMENT; INSULIN; OLEIC ACID; PALMITIC ACID; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; SATURATED FATTY ACID; STRESS ACTIVATED PROTEIN KINASE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; GENE EXPRESSION; HEPATOMA CELL; LIVER CELL; LIVER CELL DAMAGE; NONHUMAN; PRIORITY JOURNAL; RAT;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANDROSTADIENES; ANIMALS; ANTHRACENES; APOPTOSIS; CASPASE 3; CELL LINE, TUMOR; CELLS, CULTURED; CHROMONES; DNA FRAGMENTATION; ENZYME ACTIVATION; FATTY ACIDS; FEMALE; HEPATOCYTES; IMMUNOBLOTTING; INHIBITOR OF APOPTOSIS PROTEINS; INSULIN; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MORPHOLINES; PALMITATES; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, WISTAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; THAPSIGARGIN;

EID: 34347223254     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2006-1710     Document Type: Article

References (42)

1. Clark JM, Diehl A 2003 Nonalcoholic fatty liver disease: an underrecognized cause of cryptogenic cirrhosis. JAMA 289:3000-3004
2. Festi D, Colecchia A, Sacco T, Bondi M, Roda E, Marchesini G 2004 Hepatic steatosis in obese patients: clinical aspects and prognostic significance. Obes Rev 5:27-42
3. Day CP, James O 1998 Steatohepatitis: a tale of two "hits"? Gastroenterology 114:842-845
4. Feldstein AE, Canbay A, Angulo P, Taniai M, Burgart LJ, Lindor KD, Gores GJ 2003 Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis. Gastroenterology 125:437-443
5. Wieckowska A, Zein NN, Yerian LM, Lopez AR, McCullough AJ, Feldstein AE 2006 In vivo assessment of liver cell apoptosis as a novel biomarker of disease severity in nonalcoholic fatty liver disease. Hepatology 44:27-33
6. de Vries JE, Vork MM, Roemen TH, de Jong YF, Cleutjens JP, van der Vusse GJ, van Bilsen M 1997 Saturated but not mono-unsaturated fatty acids induce apoptotic cell death in neonatal rat ventricular myocytes. J Lipid Res 38:1384-1394
7. Listenberger LL, Ory DS, Schaffer JE 2001 Palmitate-induced apoptosis can occur through a ceramide-independent pathway. J Biol Chem 276:14890-14895
8. Malhi H, Bronk SF, Werneburg NW, Gores GJ 2006 Free fatty acids induce JNK-dependent hepatocyte lipoapoptosis. J Biol Chem 281:12093-12101
9. Shimabukuro M, Zhou Y-T, Levi M, Unger RH 1998 Fatty acid-induced B cell apoptosis: a link between obesity and diabetes. Proc Natl Acad Sci USA 95:2498-2502
10. Wang D, Wei Y, Pagliassotti MJ 2006 Saturated fatty acids promote endoplasmic reticulum stress and liver injury in rats with hepatic steatosis. Endocrinology 147:943-951
11. Wei Y, Wang D, Topczewski F, Pagliassotti MJ 2006 Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cells. Am J Physiol Endocrinol Metab 291:E275-E281
12. Clark J, Diehl A 2002 Hepatic steatosis and type 2 diabetes mellitus. Curr Diab Rep 2:210-215
13. Machado M, Marques-Vidal P, Cortez-Pinto H 2006 Hepatic histology in obese patients undergoing bariatric surgery. J Hepatol 45:600-606
14. Colon E, Zaman F, Axelsson M, Larsson O, Carlsson-Skwirut C, Svechnikov KV, Soder O 2007 Insulin-like growth factor-I is an important anti-apoptotic factor for rat Leydig cells during postnatal development. Endocrinology 148:128-139
15. Dudek H, Datta SR, Franke TF, Birnbaum MJ, Yao R, Cooper GM, Segal RA, Hemmings BA 1997 Regulation of neuronal survival by the serine-threonine protein kinase Akt. Science 275:661-665
16. Gu X, Feng Y, Shi C, Li M, Fu Z, Zhang X 2005 Antiapoptotic mechanism of insulin in reoxygenation-induced injury in cultured cardiomyocytes of neonatal rats. J Huazhong Univ Sci Technolog Med Sci 25:632-635
17. Hu P, Han Z, Couvillon AD, Exton JH 2004 Critical role of endogenous Akt/IAPs and MEK1/ERK pathways in counteracting endoplasmic reticulum stress-induced cell death. J Biol Chem 279:49420-49429
18. Berry M, Friend D 1969 High-yield preparation of isolated rat liver parenchymal cells. A biochemical and fine structural study. J Cell Biol 43:506-519
19. Wang D, Wei Y, Schmoll D, Maclean KN, Pagliassotti MJ 2006 Endoplasmic reticulum stress increases glucose-6-phosphatase and glucose cycling in liver cells. Endocrinology 147:350-358
20. Muller PY, Janovjak H, Miserez AR, Dobbie Z 2002 Processing of gene expression data generated by quantitative real-time RT-PCR. Biotechniques 32:1372-1379
21. Bialik S, Geenen DL, Sasson IE, Cheng R, Horner JW, Evans SM, Lord EM, Koch CJ, Kitsis RN 1997 Myocyte apoptosis during acute myocardial infarction in the mouse localizes to hypoxic regions but occurs independently of p53. J Clin Invest 100:1363-1372
22. Kharroubi I, Ladriere L, Cardozo AK, Dogusan Z, Cnop M, Eizirik DL 2004 Free fatty acids and cytokines induce pancreatic B-cell apoptosis by different mechanisms: role of nuclear factor-KB and endoplasmic reticulum stress. Endocrinology 145:5087-5096
23. Kaufman RJ 1999 Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls. Genes Dev 13:1211-1233
24. Srivastava RK, Sollott SJ, Khan L, Hansford R, Lakatta EG, Longo DL 1999 Bcl-2 and Bcl-X(L) block thapsigargin-induced nitric oxide generation, c-Jun NH(2)-terminal kinase activity, and apoptosis. Mol Cell Biol 19:5659-5674
25. Marchesini G, Brizi M, Morselli-Labate AM, Bianci G, Bugianesi E, McCullough AJ, Forlani G, Melchionda N 1999 Association of nonalcoholic fatty liver disease with insulin resistance. Am J Med 107:450-455
26. Samuel VT, Liu Z-X, Qu X, Elder BD, Bilz S, Befroy D, Romanelli AJ, Shulman GI 2004 Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease. J Biol Chem 279:32345-32353
27. Seppala-Lindroos A, Vehkavaara S, Hakkinen A-M, Goto T, Westerbacka J, Sovijarvi A, Halavaara J, Yki-Jarvinen H 2002 Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men. J Clin Endocrinol Metab 87:3023-3028
28. Canbay A, Friedman S, Gores GJ 2004 Apoptosis: the nexus of liver injury and fibrosis. Hepatology 39:273-278
29. Natori S, Rust C, Stadheim LM, Burgart LJ, Gores GJ 2001 Hepatocyte apoptosis is a pathologic feature of human alcoholic hepatitis. J Hepatol 34:248-253
30. Hyoda K, Hosoi T, Horie N, Okuma Y, Ozawa K, Nomura Y 2006 PI3K-Akt inactivation induced CHOP expression in endoplasmic reticulum-stressed cells. Biochem Biophys Res Commun 340:286-290
31. Misra UK, Pizzo SV 2005 Up-regulation of GRP78 and antiapoptotic signaling in murine peritoneal macrophages exposed to insulin. J Leukoc Biol 78:187-194
32. Czaja MJ 2002 The future of GI and liver research: editorial perspectives III. JNK/AP-1 regulation of hepatocyte death. Am J Physiol Gastrointest Liver Physiol 284:G875-G879
33. Lin A 2002 Activation of the JNK signaling pathway: breaking the brake on apoptosis. Bioessays 25:17-24
34. Wellen KE, Hotamisligil GS 2005 Inflammation, stress, and diabetes. J Clin Invest 115:1111-1119
35. Listenberger LJ, Han X, Lewis SE, Cases S, Farese RV, Ory DS, Schaffer JE 2003 Triglyceride accumulation protects against fatty acid-induced lipotoxicity. Proc Natl Acad Sci USA 100:3077-3082
36. Moffitt JH, Fielding BA, Evershed R, Berstan R, Currie JM, Clark A 2005 Adverse physicochemical properties of tripalmitin in β cells lead to morphological changes and lipotoxicity in vitro. Diabetologia 48:1819-1829
37. Bakan E, Yildirim A, Kurtul N, Polat MF, Dursun H, Cayir K 2006 Effects of type 2 diabetes mellitus on plasma fatty acid composition and cholesterol content of erythrocyte and leukocyte membranes. Acta Diabetol 8:109-113
38. Angulo P 2002 Nonalcoholic fatty liver disease. N Engl J Med 346:1221-1231
39. Bergman RN 1997 New concepts in extracellular signaling for insulin action: the single gateway hypothesis. Recent Prog Horm Res 52:359-385; discussion 385-387
40. Kelley DE, McKolanis TM, Hegazi RA, Kuller LH, Kalhan SC 2003 Fatty liver in type 2 diabetes mellitus: relation to regional adiposity, fatty acids, and insulin resistance. Am J Physiol Endocrinol Metab 285:E906-E916
41. Michael MD, Kulkarni RN, Postic C, Previs SF, Shulman GI, Magnuson MA, Kahn CR 2000 Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction. Mol Cell 6:87-97
42. Farrell GC, Larter CZ 2006 Nonalcoholic fatty liver disease: from steatosis to cirrhosis. Hepatology 43:S99-S112