메뉴 건너뛰기




Volumn , Issue , 2005, Pages 67-81

HERG assay, QT liability, and sudden cardiac death

Author keywords

[No Author keywords available]

Indexed keywords


EID: 34347212034     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-1-59259-884-7_4     Document Type: Chapter
Times cited : (7)

References (50)
  • 1
    • 0027330322 scopus 로고
    • Variability of the QTc interval: Impact on defining drug effect and low-frequency cardiac event
    • Morganroth J, Brown AM, Critz S, et al. Variability of the QTc interval: Impact on defining drug effect and low-frequency cardiac event. Am J Cardiol 1993;72:26B-31B
    • (1993) Am J Cardiol , vol.72
    • Morganroth, J.1    Brown, A.M.2    Critz, S.3
  • 2
    • 0027474601 scopus 로고
    • Mechanism of the cardiotoxic actions of terfenadine
    • Woosley RL, Chen Y, Froiman JP, Gillis RA. Mechanism of the cardiotoxic actions of terfenadine. JAMA 1993;269:1532-1536.
    • (1993) JAMA , vol.269 , pp. 1532-1536
    • Woosley, R.L.1    Chen, Y.2    Froiman, J.P.3    Gillis, R.A.4
  • 3
    • 0030704669 scopus 로고    scopus 로고
    • A mechanism for the proarrhythmic effects of cisapride (propulsid): High affinity blockade of the human cardiac potassium channel herg
    • Rampe D, Roy ML, Dennis A, Brown AM. A mechanism for the proarrhythmic effects of cisapride (Propulsid): High affinity blockade of the human cardiac potassium channel hERG. FEBS Lett 1997;417:28-32.
    • (1997) FEBS Lett , vol.417 , pp. 28-32
    • Rampe, D.1    Roy, M.L.2    Dennis, A.3    Brown, A.M.4
  • 4
    • 4244207380 scopus 로고    scopus 로고
    • Blockage of the hERG human cardiac K+ channel by the gastrointestinal prokinetic agent cisapride
    • Mohammad S, Zhou Z, Gong Q, January CT. Blockage of the hERG human cardiac K+ channel by the gastrointestinal prokinetic agent cisapride. Am J Physiol 1997;273:H2534-H2538.
    • (1997) Am J Physiol , vol.273
    • Mohammad, S.1    Zhou, Z.2    Gong, Q.3    January, C.T.4
  • 5
    • 0034737431 scopus 로고    scopus 로고
    • High affinity blockade of the hERG cardiac K(+) channel by the neoruleptic pimozide
    • Kang J, Wang L. Cai F, Rampe D. High affinity blockade of the hERG cardiac K(+) channel by the neoruleptic pimozide. Eur J Pharmacol 2000;392(3):137-140.
    • (2000) Eur J Pharmacol , vol.392 , Issue.3 , pp. 137-140
    • Kang, J.1    Wang, L.2    Cai, F.3    Rampe, D.4
  • 6
    • 0030913545 scopus 로고    scopus 로고
    • Cardiac potassium channels in health and disease
    • Brown AM. Cardiac Potassium Channels in Health and Disease. Trends Cardiovasc Med 1997;7(4): 118-124.
    • (1997) Trends Cardiovasc Med , vol.7 , Issue.4 , pp. 118-124
    • Brown, A.M.1
  • 8
    • 0029002969 scopus 로고
    • A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel
    • Sanguinetti MC, Jiang C, Curran ME, Keating MT. A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel. Cell 1995;81:299-307.
    • (1995) Cell , vol.81 , pp. 299-307
    • Sanguinetti, M.C.1    Jiang, C.2    Curran, M.E.3    Keating, M.T.4
  • 9
    • 0029761822 scopus 로고    scopus 로고
    • HERG, a primary human ventricular target of the nonsedating antihistamine terfenadine
    • Roy M-L, Dumaine R, Brown AM. HERG, a primary human ventricular target of the nonsedating antihistamine terfenadine. Circulation 1996;94(4):817-823.
    • (1996) Circulation , vol.94 , Issue.4 , pp. 817-823
    • Roy, M.-L.1    Dumaine, R.2    Brown, A.M.3
  • 11
    • 2442464375 scopus 로고    scopus 로고
    • Role of the cytosolic chaperones Hsp70 and Hsp90 in maturation of the cardiac potassium channel hERG
    • Ficker E, Dennis AT, Wang L, Brown AM. Role of the cytosolic chaperones Hsp70 and Hsp90 in maturation of the cardiac potassium channel hERG. Circ Res 2003;92:e87-e100.
    • (2003) Circ Res , vol.92
    • Ficker, E.1    Dennis, A.T.2    Wang, L.3    Brown, A.M.4
  • 12
    • 3042528658 scopus 로고    scopus 로고
    • Arsenic-induced prolongation of cardiac repolarization and block of hERG trafficking
    • Ficker E, Kuryshev Y, Dennis AT, et al. Arsenic-induced prolongation of cardiac repolarization and block of hERG trafficking. Mol Pharmacol 2004;66:33-44.
    • (2004) Mol Pharmacol , vol.66 , pp. 33-44
    • Ficker, E.1    Kuryshev, Y.2    Dennis, A.T.3
  • 13
    • 0027213816 scopus 로고
    • Current status of class III antiarrhythmic drug therapy
    • Roden DM. Current status of class III antiarrhythmic drug therapy. Am J Cardiol 1993;72:44B-49B
    • (1993) Am J Cardiol , vol.72
    • Roden, D.M.1
  • 14
    • 0033553504 scopus 로고    scopus 로고
    • Mechanism of block and identification of the verapamil binding domain to HERG potassium channels
    • Zhang S; Zhou Z; Gong Q; Makielski JC; January CT. Mechanism of block and identification of the verapamil binding domain to HERG potassium channels. Circ Res 1999;89:989-998.
    • (1999) Circ Res , vol.89 , pp. 989-998
    • Zhang, S.1    Zhou, Z.2    Gong, Q.3    Makielski, J.C.4    January, C.T.5
  • 15
    • 1342323337 scopus 로고    scopus 로고
    • Cardiac ion channel effects of tolterodine
    • Kang J, Chen XL, Wang H, et al. Cardiac ion channel effects of tolterodine. J Pharmacol Exp Ther. 2004;308:935-940.
    • (2004) J Pharmacol Exp Ther , vol.308 , pp. 935-940
    • Kang, J.1    Chen, X.L.2    Wang, H.3
  • 16
    • 4644257489 scopus 로고    scopus 로고
    • Variability in the measurement of herg potassium channel inhibition: Effects of temperature and stimulus pattern
    • Kirsch GE, Trepakova ES, Brimecombe JC, et al. Variability in the measurement of hERG potassium channel inhibition: Effects of temperature and stimulus pattern. 2004 J Pharmacol Toxicol Methods. Accepted
    • (2004) J Pharmacol Toxicol Methods. Accepted
    • Kirsch, G.E.1    Trepakova, E.S.2    Brimecombe, J.C.3
  • 17
    • 0344492207 scopus 로고    scopus 로고
    • Relationships between non-clinical cardiac electrophysiology, clinical QT interval prolongation and torsade De pointes for a broad range of drugs: Evidence for a provisional safety margin in drug development
    • Review
    • Redfern WS, Carlsson L, Davis AS, et al. Relationships between non-clinical cardiac electrophysiology, clinical QT interval prolongation and torsade De pointes for a broad range of drugs: Evidence for a provisional safety margin in drug development. Cardiovasc Res 2003;58(1):32-45. Review
    • (2003) Cardiovasc Res , vol.58 , Issue.1 , pp. 32-45
    • Redfern, W.S.1    Carlsson, L.2    Davis, A.S.3
  • 18
    • 0034067415 scopus 로고    scopus 로고
    • Effects of calcium channel blockers on cloned cardiac K+ channels IKr and IKs
    • Chouabe C, Drici MD, Romey G, Barhanin J. Effects of calcium channel blockers on cloned cardiac K+ channels IKr and IKs. Therapie 2000;55:195-202.
    • (2000) Therapie , vol.55 , pp. 195-202
    • Chouabe, C.1    Drici, M.D.2    Romey, G.3    Barhanin, J.4
  • 19
    • 0343485099 scopus 로고    scopus 로고
    • Loratadine blockade of K+ channels in human heart: Comparison with terfenadine under physiological conditions
    • Crumb WJ. Loratadine blockade of K+ channels in human heart: Comparison with terfenadine under physiological conditions. J Pharmacol Exp Ther 2000;292:261-264.
    • (2000) J Pharmacol Exp Ther , vol.292 , pp. 261-264
    • Crumb, W.J.1
  • 20
    • 0029066446 scopus 로고
    • Erythromycin blocks the rapid component of the delayed rectifier potassium current and lengthens repolarization of guinea pig ventricular myocytes
    • Daleau P, Lessard E, Groleau MF, Turgeon J. Erythromycin blocks the rapid component of the delayed rectifier potassium current and lengthens repolarization of guinea pig ventricular myocytes. Circulation 1995;91:3010-3016.
    • (1995) Circulation , vol.91 , pp. 3010-3016
    • Daleau, P.1    Lessard, E.2    Groleau, M.F.3    Turgeon, J.4
  • 21
    • 0033052403 scopus 로고    scopus 로고
    • Thioridazine lengthens repolarization of cardiac ventricular myocytes by blocking the delayed rectifier potassium current
    • Drolet B, Vincent F, Rail J, et al. Thioridazine lengthens repolarization of cardiac ventricular myocytes by blocking the delayed rectifier potassium current. J Pharmacol Exp Ther 1999;288:1261-1268.
    • (1999) J Pharmacol Exp Ther , vol.288 , pp. 1261-1268
    • Drolet, B.1    Vincent, F.2    Rail, J.3
  • 22
    • 0036229805 scopus 로고    scopus 로고
    • Three-dimensional quantitative structureactivity relationship for inhibition of human ether-A-go-go-related gene potassium channel
    • Ekins S, Crumb WJ, Sarazan RD, Wikel JH, Wrighton SA. Three-dimensional quantitative structureactivity relationship for inhibition of human ether-A-go-go-related gene potassium channel. J Pharmacol Exp Ther 2002;301:427-434.
    • (2002) J Pharmacol Exp Ther , vol.301 , pp. 427-434
    • Ekins, S.1    Crumb, W.J.2    Sarazan, R.D.3    Wikel, J.H.4    Wrighton, S.A.5
  • 23
    • 0041664962 scopus 로고    scopus 로고
    • Inhibitory effect of erythromycin on potassium currents in rat ventricular myocytes in comparison with disopyramide
    • Hanada E, Ohtani H, Hirota M, et al. Inhibitory effect of erythromycin on potassium currents in rat ventricular myocytes in comparison with disopyramide. J Pharm Pharmacol 2003;55:995-1002.
    • (2003) J Pharm Pharmacol , vol.55 , pp. 995-1002
    • Hanada, E.1    Ohtani, H.2    Hirota, M.3
  • 25
    • 0033061074 scopus 로고    scopus 로고
    • Block of potassium currents in guinea pig ventricular myocytes and lengthening of cardiac repolarization in man by the histamine H1 receptor antagonist diphenhydramine
    • Khalifa M, Drolet B, Daleau P, et al. Block of potassium currents in guinea pig ventricular myocytes and lengthening of cardiac repolarization in man by the histamine H1 receptor antagonist diphenhydramine. J Pharmacol Exp Ther 1999;288:858-865.
    • (1999) J Pharmacol Exp Ther , vol.288 , pp. 858-865
    • Khalifa, M.1    Drolet, B.2    Daleau, P.3
  • 26
    • 0037118903 scopus 로고    scopus 로고
    • A comparison of the receptor binding and HERG channel affinities for a series of antipsychotic drugs
    • Kongsamut S, Kang J, Chen XL, Roehr J, Rampe D. A comparison of the receptor binding and HERG channel affinities for a series of antipsychotic drugs. Eur J Pharmacol 2002;450:37-41.
    • (2002) Eur J Pharmacol , vol.450 , pp. 37-41
    • Kongsamut, S.1    Kang, J.2    Chen, X.L.3    Roehr, J.4    Rampe, D.5
  • 27
    • 0642364448 scopus 로고    scopus 로고
    • The IKr drug response is modulated by KCR1 in transfected cardiac and noncardiac cell lines
    • Kupershmidt S, Yang IC, Hayashi K, et al. The IKr drug response is modulated by KCR1 in transfected cardiac and noncardiac cell lines. FASEB Journal 2003;17:2263-2265.
    • (2003) FASEB Journal , vol.17 , pp. 2263-2265
    • Kupershmidt, S.1    Yang, I.C.2    Hayashi, K.3
  • 29
    • 0034711465 scopus 로고    scopus 로고
    • Probing the interaction between inactivation gating and dl-sotalol block of hERG
    • Numaguchi H, Mullins FM, Johnson JP Jr, et al. Probing the interaction between inactivation gating and dl-sotalol block of hERG. Circ Res 2000;87:1012-1018.
    • (2000) Circ Res , vol.87 , pp. 1012-1018
    • Numaguchi, H.1    Mullins, F.M.2    Johnson Jr., J.P.3
  • 31
    • 0025351245 scopus 로고
    • Two components of cardiac delayed rectifier K+ current. Differential sensitivity to block by class III antiarrhythmic agents
    • Sanguinetti MC, Jurkiewicz NK. Two components of cardiac delayed rectifier K+ current. Differential sensitivity to block by class III antiarrhythmic agents. J Gen Physiol 1990;96:195-215.
    • (1990) J Gen Physiol , vol.96 , pp. 195-215
    • Sanguinetti, M.C.1    Jurkiewicz, N.K.2
  • 32
    • 0037235024 scopus 로고    scopus 로고
    • Functional and pharmacological properties of canine ERG potassium channels
    • Wang J, Della Penna K, Wang H, Karczewski J, et al. Functional and pharmacological properties of canine ERG potassium channels. Am J Physiol 2003;284:H256-H267.
    • (2003) Am J Physiol , vol.284
    • Wang, J.1    Della Penna, K.2    Wang, H.3    Karczewski, J.4
  • 33
    • 0033408458 scopus 로고    scopus 로고
    • Bepridil differentially inhibits two delayed rectifier K+ currents, IKr and IKs, in guinea-pig ventricular myocytes
    • Wang JC, Kiyosue T, Kiriyama K, Arita M. Bepridil differentially inhibits two delayed rectifier K+ currents, IKr and IKs, in guinea-pig ventricular myocytes. Br J Pharmacol 1999;128:1733-1738.
    • (1999) Br J Pharmacol , vol.128 , pp. 1733-1738
    • Wang, J.C.1    Kiyosue, T.2    Kiriyama, K.3    Arita, M.4
  • 34
    • 0036554839 scopus 로고    scopus 로고
    • A comparison of currents carried by HERG, with and without coexpression of MiRP1, and the native rapid delayed rectifier current is MiRP1 the missing link?
    • Weerapura M, Nattel S, Chartier D, Caballero R, Hebert TE. A comparison of currents carried by HERG, with and without coexpression of MiRP1, and the native rapid delayed rectifier current. Is MiRP1 the missing link? J Physiol 2002;540:15-27.
    • (2002) J Physiol , vol.540 , pp. 15-27
    • Weerapura, M.1    Nattel, S.2    Chartier, D.3    Caballero, R.4    Hebert, T.E.5
  • 35
    • 0142107369 scopus 로고    scopus 로고
    • Troubleshooting problems with in vitro screening of drugs for QT interval prolongation using HERG K+ channels expressed in mammalian cell lines and Xenopus oocytes
    • Witchel HJ, Milnes JT, Mitcheson JS, Hancox JC. Troubleshooting problems with in vitro screening of drugs for QT interval prolongation using HERG K+ channels expressed in mammalian cell lines and Xenopus oocytes. J Pharmacol Toxicol Methods 2002a;48:65-80.
    • (2002) J Pharmacol Toxicol Methods , vol.48 , pp. 65-80
    • Witchel, H.J.1    Milnes, J.T.2    Mitcheson, J.S.3    Hancox, J.C.4
  • 36
    • 0037070199 scopus 로고    scopus 로고
    • Inhibitory actions of the selective serotonin re-uptake inhibitor citalopram on HERG and ventricular L-Type calcium currents
    • Witchel HJ, Pabbathi VK, Hofmann G, Paul AA, Hancox JC. Inhibitory actions of the selective serotonin re-uptake inhibitor citalopram on HERG and ventricular L-Type calcium currents. FEBS Lett 2002b;512:59-66.
    • (2002) FEBS Lett , vol.512 , pp. 59-66
    • Witchel, H.J.1    Pabbathi, V.K.2    Hofmann, G.3    Paul, A.A.4    Hancox, J.C.5
  • 37
    • 0031982513 scopus 로고    scopus 로고
    • Properties of hERG channels stably expressed in HEK 293 cells studied at physiological temperature
    • Zhou Z, Gong Q, Ye B, et al. Properties of hERG channels stably expressed in HEK 293 cells studied at physiological temperature. Biophys J 1998;74:230-241.
    • (1998) Biophys J , vol.74 , pp. 230-241
    • Zhou, Z.1    Gong, Q.2    Ye, B.3
  • 39
    • 0027296372 scopus 로고
    • Measurement of the qt interval and the risk associated with qtc interval prolongation: A review
    • Moss AJ. Measurement of the QT Interval and the Risk Associated with QTc Interval Prolongation: A Review. Am J Cardiol 1993;72:23B-25B.
    • (1993) Am J Cardiol , vol.72
    • Moss, A.J.1
  • 40
    • 84900222697 scopus 로고    scopus 로고
    • Accessed at
    • (Accessed at http://www.eudravigilence.org
  • 41
    • 0035038217 scopus 로고    scopus 로고
    • The canine Purkinje fiber: An in vitro model aystem for acquired long QT syndrome and drug-induced arrhythmogenesis
    • Gintant GA, Limberis JT, McDermott JS, Wegner CD, Cox BF. The canine Purkinje fiber: An in vitro model aystem for acquired long QT syndrome and drug-induced arrhythmogenesis. J Cardiovasc Pharmacol 2001;37:607-618.
    • (2001) J Cardiovasc Pharmacol , vol.37 , pp. 607-618
    • Gintant, G.A.1    Limberis, J.T.2    McDermott, J.S.3    Wegner, C.D.4    Cox, B.F.5
  • 42
    • 0041888478 scopus 로고    scopus 로고
    • Trezise; jennings worley ionworks(tm) ht: A new high throughput electrophysiology measurement platform
    • Kirk Schroeder; Brad Neagle; Derek J. Trezise; Jennings Worley. Ionworks(tm) HT: A New High Throughput Electrophysiology Measurement Platform. J Biomol Screen 2003;1:50-64.
    • (2003) J Biomol Screen , vol.1 , pp. 50-64
    • Kirk, S.1    Brad, N.2    Derek, J.3
  • 43
    • 12244299864 scopus 로고    scopus 로고
    • Upscaling and automation of electrophysiology: Toward high throughput screening in ion channel drug discovery
    • Asmild M, Oswald N, Krzywkowski KM, et al. Upscaling and automation of electrophysiology: Toward high throughput screening in ion channel drug discovery. Receptors Channels 2003;9:49-58.
    • (2003) Receptors Channels , vol.9 , pp. 49-58
    • Asmild, M.1    Oswald, N.2    Krzywkowski, K.M.3
  • 44
    • 0034752849 scopus 로고    scopus 로고
    • Development and evaluation of high throughput functional assay methods for HERG potassium channel
    • Tang W, Kang J, Wu X, et al. Development and evaluation of high throughput functional assay methods for HERG potassium channel. J Biomol Screen 2001;6:325-331.
    • (2001) J Biomol Screen , vol.6 , pp. 325-331
    • Tang, W.1    Kang, J.2    Wu, X.3
  • 46
    • 0037085464 scopus 로고    scopus 로고
    • The binding site for channel blockers that rescue misprocessed LQT2 hERG mutations
    • Ficker E, Obejero-Paz CA, Zhao S, Brown AM. The binding site for channel blockers that rescue misprocessed LQT2 hERG mutations. J Biol Chem 2002;277:4989-4998.
    • (2002) J Biol Chem , vol.277 , pp. 4989-4998
    • Ficker, E.1    Obejero-Paz, C.A.2    Zhao, S.3    Brown, A.M.4
  • 47
    • 0034610263 scopus 로고    scopus 로고
    • Prolongation of the QT interval and ventricular tachycardia in patients treated with arsenic trioxide for acute promyelocytic leukemia
    • Ohnishi K, Yoshida H, Shigeno K et al. Prolongation of the QT interval and ventricular tachycardia in patients treated with arsenic trioxide for acute promyelocytic leukemia. Ann Intern Med 2000;133: 881-885.
    • (2000) Ann Intern Med , vol.133 , pp. 881-885
    • Ohnishi, K.1    Yoshida, H.2    Shigeno, K.3
  • 48
    • 0035283137 scopus 로고    scopus 로고
    • Torsade De pointes in 3 patients with leukemia treated with arsenic trioxide
    • Unnikrishnan D, Dutcher JP, Varshneya N et al. Torsade De pointes in 3 patients with leukemia treated with arsenic trioxide. Blood 2001;97:1514-1516.
    • (2001) Blood , vol.97 , pp. 1514-1516
    • Unnikrishnan, D.1    Dutcher, J.P.2    Varshneya, N.3
  • 49
    • 0347357886 scopus 로고    scopus 로고
    • Unusual effects of a QT-prolonging drug, arsenic trioxide, on cardiac potassium currents
    • Drolet B, Simard C, Roden DM. Unusual effects of a QT-prolonging drug, arsenic trioxide, on cardiac potassium currents. Circulation 2004;109:26-29.
    • (2004) Circulation , vol.109 , pp. 26-29
    • Drolet, B.1    Simard, C.2    Roden, D.M.3
  • 50
    • 56249123754 scopus 로고    scopus 로고
    • Electrophysiological and pharmacological characterization of a cell line stably expressing hKCNQ1 and hKCNE1 potassium channels
    • abstract
    • Imredy JP, Irving WD, Clouse HK; Salata JJ. Electrophysiological and pharmacological characterization of a cell line stably expressing hKCNQ1 and hKCNE1 potassium channels. 2004 Biophysical Society Annual Meeting, abstract.
    • (2004) Biophysical Society Annual Meeting
    • Imredy, J.P.1    Irving, W.D.2    Clouse, H.K.3    Salata, J.J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.