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Volumn 277, Issue 7, 2002, Pages 4989-4998
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The binding site for channel blockers that rescue misprocessed human long QT syndrome type 2 ether-a-gogo-related gene (HERG) mutations
a
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Author keywords
[No Author keywords available]
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Indexed keywords
BIOLOGICAL MEMBRANES;
ELECTROCARDIOGRAPHY;
ETHERS;
GENES;
HYDROPHOBICITY;
MUTAGENESIS;
POSITIVE IONS;
PLASMA MEMBRANES;
BIOCHEMISTRY;
CELL PROTEIN;
CHAPERONE;
GENE PRODUCT;
POTASSIUM CHANNEL;
POTASSIUM ION;
PROTEIN HERG;
UNCLASSIFIED DRUG;
ARTICLE;
BINDING SITE;
CELL MEMBRANE;
CELL SURFACE;
CHANNEL GATING;
CHROMOSOME 7;
CONTROLLED STUDY;
ELECTROCARDIOGRAM;
ENDOPLASMIC RETICULUM;
GENE FUNCTION;
GENE MUTATION;
GENETIC LINKAGE;
HEART ARRHYTHMIA;
HUMAN;
HUMAN CELL;
LONG QT SYNDROME;
PHENOTYPE;
PRIORITY JOURNAL;
PROTEIN BINDING;
PROTEIN EXPRESSION;
PROTEIN FOLDING;
PROTEIN FUNCTION;
SITE DIRECTED MUTAGENESIS;
STRUCTURE ACTIVITY RELATION;
ANTI-ARRHYTHMIA AGENTS;
ASTEMIZOLE;
BENZIMIDAZOLES;
BINDING SITES;
BLOTTING, WESTERN;
CATION TRANSPORT PROTEINS;
CELL LINE;
CELL MEMBRANE;
CISAPRIDE;
DNA-BINDING PROTEINS;
DOSE-RESPONSE RELATIONSHIP, DRUG;
ELECTROPHYSIOLOGY;
ETHER-A-GO-GO POTASSIUM CHANNELS;
GASTROINTESTINAL AGENTS;
HISTAMINE H1 ANTAGONISTS;
HUMANS;
INHIBITORY CONCENTRATION 50;
IONS;
LONG QT SYNDROME;
MODELS, CHEMICAL;
MUTAGENESIS, SITE-DIRECTED;
MUTATION;
PATCH-CLAMP TECHNIQUES;
PIPERIDINES;
POTASSIUM CHANNELS;
POTASSIUM CHANNELS, VOLTAGE-GATED;
PROTEIN FOLDING;
PYRIDINES;
QUATERNARY AMMONIUM COMPOUNDS;
QUINIDINE;
STRUCTURE-ACTIVITY RELATIONSHIP;
TRANS-ACTIVATORS;
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EID: 0037085464
PISSN: 00219258
EISSN: None
Source Type: Journal
DOI: 10.1074/jbc.M107345200 Document Type: Article |
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Times cited : (161)
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References (42)
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