A mechanism for the proarrhythmic effects of cisapride (Propulsid): High affinity blockade of the human cardiac potassium channel HERG

FEBS Letters

Volumn 417, Issue 1, 1997, Pages 28-32

  Rampe, David ^a   Roy, Mary Louise ^b   Dennis, Adrienne ^b   Brown, Arthur M ^b  

^a SANOFI   (France)

^b METROHEALTH MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CISAPRIDE; DOFETILIDE; POTASSIUM CHANNEL; TERFENADINE;

ARTICLE; CARDIOTOXICITY; CONTROLLED STUDY; ELECTROPHYSIOLOGY; GENE; HEART ARRHYTHMIA; HUMAN; HUMAN CELL; PATCH CLAMP; PRIORITY JOURNAL; QT INTERVAL;

ARRHYTHMIA; CATION TRANSPORT PROTEINS; CELL LINE; CISAPRIDE; DNA-BINDING PROTEINS; ELECTROPHYSIOLOGY; ETHER-A-GO-GO POTASSIUM CHANNELS; HEART; HUMANS; KV1.5 POTASSIUM CHANNEL; MYOCARDIUM; PATCH-CLAMP TECHNIQUES; PHENETHYLAMINES; PIPERIDINES; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; POTASSIUM CHANNELS, VOLTAGE-GATED; SULFONAMIDES; TERFENADINE; TRANS-ACTIVATORS; TRANSFECTION; TUMOR CELLS, CULTURED;

MAMMALIA;

EID: 0030704669     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-5793(97)01249-0     Document Type: Article

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