A comparison of the receptor binding and HERG channel affinities for a series of antipsychotic drugs

European Journal of Pharmacology

Volumn 450, Issue 1, 2002, Pages 37-41

  Kongsamut, Sathapana ^a   Kang, Jiesheng ^a   Chen, Xiao Liang ^a   Roehr, Joachim ^a   Rampe, David ^a  

^a SANOFI   (France)

Author keywords

Antipsychotic; Arrhythmia; HERG channel; K + channel; QT prolongation

Indexed keywords

DOPAMINE 2 RECEPTOR; NEUROLEPTIC AGENT; OLANZAPINE; PIMOZIDE; POTASSIUM CHANNEL; QUETIAPINE; RISPERIDONE; SEROTONIN 2A RECEPTOR; SERTINDOLE; THIORIDAZINE; ZIPRASIDONE; CATION TRANSPORT PROTEIN; DNA BINDING PROTEIN; ERG PROTEIN, HUMAN; ERG1 POTASSIUM CHANNEL; KCNH2 PROTEIN, HUMAN; KCNH6 PROTEIN, HUMAN; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM CHANNEL HERG; SEROTONIN RECEPTOR; TRANSACTIVATOR PROTEIN; VOLTAGE GATED POTASSIUM CHANNEL;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING ASSAY; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG PROTEIN BINDING; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; ELECTROCARDIOGRAM; ELECTROPHYSIOLOGY; IC 50; MEMBRANE POTENTIAL; NONHUMAN; PATCH CLAMP; PREDICTION; PRIORITY JOURNAL; QT INTERVAL; RECEPTOR AFFINITY; ANIMAL; BLOOD; CELL LINE; CHEMICALLY INDUCED DISORDER; CLINICAL TRIAL; COMPARATIVE STUDY; HAMSTER; HUMAN; LONG QT SYNDROME; METABOLISM; PHYSIOLOGY; RADIOASSAY;

ANIMAL; ANTIPSYCHOTIC AGENTS; CELL LINE; CLINICAL TRIALS; COMPARATIVE STUDY; HAMSTERS; HUMAN; LONG QT SYNDROME; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; RADIOLIGAND ASSAY; RECEPTORS, DOPAMINE D2; RECEPTORS, SEROTONIN; ANIMALS; CATION TRANSPORT PROTEINS; CRICETINAE; DNA-BINDING PROTEINS; ETHER-A-GO-GO POTASSIUM CHANNELS; HUMANS; POTASSIUM CHANNELS, VOLTAGE-GATED; RECEPTOR, SEROTONIN, 5-HT2A; TRANS-ACTIVATORS;

EID: 0037118903     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(02)02074-5     Document Type: Article

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