Upscaling and automation of electrophysiology: Toward high throughput screening in ion channel drug discovery

Receptors and Channels

Volumn 9, Issue 1, 2003, Pages 49-58

  Asmild, Margit ^a   Oswald, Nicholas ^a   Krzywkowski, Karen M ^a   Friis, Søren ^a   Jacobsen, Rasmus B ^a   Reuter, Dirk ^a   Taboryski, Rafael ^a   Kutchinsky, Jonathan ^a   Vestergaard, Ras K ^a   Schrøder, Rikke L ^a   Sørensen, Claus B ^a   Bech, Morten ^a   Korsgaard, Mads P G ^c   Willumsen, Niels J ^a,b  

^a Sophion Bioscience A/S   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c NONE

Author keywords

Drug discovery; HTS electrophysiology; Ion channels; Patch clamp; Silicon chip

Indexed keywords

IBERIOTOXIN; ION CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM CHANNEL STIMULATING AGENT; POTASSIUM ION; SILICON; SODIUM ION; TRIETHYLAMINE;

ANALYTIC METHOD; AUTOMATION; COMPUTER SYSTEM; CONTROLLED STUDY; DATA BASE; DRUG ACTIVATION; DRUG INHIBITION; DRUG MECHANISM; DRUG SCREENING; ELECTRONICS; ELECTROPHYSIOLOGY; HUMAN; HUMAN CELL; HUMAN COMPUTER INTERACTION; IC 50; INTERNET; LABORATORY PERSONNEL; MICROPIPETTE; MOLECULAR LIBRARY; PATCH CLAMP; PERFORMANCE; PRIORITY JOURNAL; REVIEW; ROBOTICS;

ANIMALS; AUTOMATION; DRUG DESIGN; ELECTROPHYSIOLOGY; ION CHANNELS; IONS; PATCH-CLAMP TECHNIQUES; SILICON; SOFTWARE; TIME FACTORS;

EID: 12244299864     PISSN: 10606823     EISSN: None     Source Type: Journal    
DOI: 10.1080/10606820308258     Document Type: Review

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