Comparison of block among cloned cardiac potassium channels by non-antiarrhythmic drugs

European Heart Journal, Supplement

Volumn 3, Issue K, 2001, Pages

  Lacerda, Antonio E ^a,b   Kramer, J ^a   Shen, K Z ^b   Thomas, D ^c   Brown, A M ^a,b  

^a ChanTest Corporation   (United States)

^b CASE WESTERN RESERVE UNIVERSITY   (United States)

^c UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

Author keywords

Acquired long QT syndrome; Cardiac potassium channels; Drug induced QT prolongation; HERG; Non antiarrhythmic drugs

Indexed keywords

ANTIARRHYTHMIC AGENT; ANTIBIOTIC AGENT; ANTIHISTAMINIC AGENT; CISAPRIDE; GENE PRODUCT; NEUROLEPTIC AGENT; POTASSIUM CHANNEL; POTASSIUM ION; PROKINETIC AGENT; PROTEIN HERG; SERTINDOLE; TERFENADINE; UNCLASSIFIED DRUG;

ANIMAL CELL; CONFERENCE PAPER; CONTROLLED STUDY; HEART REPOLARIZATION; IC 50; LONG QT SYNDROME; NONHUMAN; OOCYTE; PATCH CLAMP; POTASSIUM CURRENT; PRIORITY JOURNAL; QT INTERVAL; TEMPERATURE DEPENDENCE; XENOPUS;

EID: 0034801389     PISSN: 1520765X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1520-765X(01)90003-3     Document Type: Conference Paper

References (41)

1. A family of potassium channel genes related to eag in Drosophila and mammals
2. Kr potassium channel
3. Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias
4. Molecular cloning sequence analysis of human genomic DNA encoding a novel membrane protein which exhibits a slowly activating potassium channel activity
5. Ks potassium channel
6. Mutations in the hminK gene cause long QT syndrome and suppress IKs function
7. MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia
8. Molecular mechanism for an inherited cardiac arrhythmia
9. SCN5A mutations associated with an inherited cardiac arrhythmia, long QT syndrome
10. HERG, a primary human ventricular target of the nonsedating antihistamine terfenadine
11. Cardiovascular safety of fexofenadine HCl
12. High affinity blockade of the HERG cardiac K(+) channel by the neuroleptic pimozide
13. The antipsychotic agent sertindole is a high affinity antagonist of the human cardiac potassium channel HERG
14. A mechanism for the proarrhythmic effects of cisapride (Propulsid): High affinity blockade of the human cardiac potassium channel HERG
15. + channel by the gastrointestinal prokinetic agent cisapridee
16. + channel current
17. + channel cDNAs from human ventricle
18. Rapid and slow components of delayed rectifier current in human atrial myocytes
19. Effects of flecainide, quinidine, and 4-aminopyridine on transient outward and ultrarapid delayed rectifier currents in human atrial myocytes
20. + currents in human atrium and in cells expressing a Kv1·5-type cloned channel
21. + channel cloned from human heart
22. Interactions of the nonsedating antihistamine loratadine with a Kv1·5-type potassium channel cloned from human heart
23. + current, on repolarization in human and guinea pig ventricular myocytes
24. + current, by the diuretic agent indapamide in guinea pig myocytes
25. Dual actions of the novel class III antiarrhythmic drug NE-10 064 on delayed potassium channel currents in guinea pig ventricular and sinoatrial node cells
26. Rate-dependent blockade of a potassium current in human atrium by the antihistamine loratadine
27. Novel mechanism associated with an inherited cardiac arrhythmia: Defective protein trafficking by the mutant HERG (G601S) potassium channel
28. Drug-induced long QT syndrome: Is HERG the root of all evil
29. 1-receptor antagonists astemizole and terfenadine compared with chlorpheniramine and pyrilamine
30. Effects of histamine H1 receptor antagonists on action potentials in guinea-pig isolated papillary muscles
31. Voltage-dependent potassium channels cloned from human heart: New tools to predict the pro-arrhythmic potential of drugs
32. + channel Kv1·5 by the antibiotic erythromycin
33. Kr
34. + channels
35. Molecular physiology and pharmacology of HERG: Single channel currents and block by dofetilide
36. Block of HERG potassium channels by the antihistamine astemizole and its metabolites desmethylastemizole and norastemizole
37. + channel block-related cardiotoxicity by the H1 receptor blocker cetirizine compared with other second-generation antihistamines
38. Mechanism of block of a human cardiac potassium channel by terfenadine racemate and enantiomers
39. Molecular determinant of high-affinity dofetilide binding to HERG1 expressed in Xenopus oocytes: Involvement of S6 sites
40. Risperidone compared with new and reference antipsychotic drugs: In vitro and in vivo receptor binding
41. Comparison of effect of mosapride citrate and existing 5-HT4 receptor agonists on gastrointestinal motility in vivo and in vitro