High affinity blockade of the HERG cardiac K+ channel by the neuroleptic pimozide

European Journal of Pharmacology

Volumn 392, Issue 3, 2000, Pages 137-140

  Kang, Jiesheng ^a   Wang, Lin ^a   Cai, Feng ^a   Rampe, David ^a  

^a SANOFI   (France)

Author keywords

Antipsychotic agent; Arrhythmia; HERG (human ether a go go related gene); K+ channel; Pimozide

Indexed keywords

NEUROLEPTIC AGENT; PIMOZIDE; POTASSIUM CHANNEL;

ARTICLE; CELL LINE; CHO CELL; GENE EXPRESSION; IN VITRO STUDY; LONG QT SYNDROME; MOLECULAR CLONING; PATCH CLAMP; PRIORITY JOURNAL;

ANIMALS; ANTIPSYCHOTIC AGENTS; CATION TRANSPORT PROTEINS; CELL LINE; CHO CELLS; CRICETINAE; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHER-A-GO-GO POTASSIUM CHANNELS; HUMANS; MEMBRANE POTENTIALS; PATCH-CLAMP TECHNIQUES; PIMOZIDE; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; POTASSIUM CHANNELS, VOLTAGE-GATED; TRANS-ACTIVATORS;

EID: 0034737431     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(00)00123-0     Document Type: Article

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