Functional analysis of FHA and BRCT domains of NBS1 in chromatin association and DNA damage responses

Nucleic Acids Research

Volumn 30, Issue 22, 2002, Pages 4815-4822

  Zhao, Song ^a   Renthal, William ^a   Lee, Eva Y H P ^a  

^a Mays Cancer Center at UT Health San Antonio   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATM PROTEIN; BINDING PROTEIN; NIBRIN; SERINE; UNCLASSIFIED DRUG;

BREAST CANCER; CARBOXY TERMINAL SEQUENCE; CELL CYCLE PARAMETERS; CELL CYCLE S PHASE; CELL SURVIVAL; CHROMATIN; COMPLEX FORMATION; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; DNA REPLICATION; GENE MUTATION; GENETIC CONSERVATION; HUMAN; HUMAN CELL; IONIZING RADIATION; NIJMEGEN BREAKAGE SYNDROME; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; REVIEW;

ATAXIA; ATAXIA TELANGIECTASIA;

EID: 0037112610     PISSN: 03051048     EISSN: None     Source Type: Journal    
DOI: 10.1093/nar/gkf612     Document Type: Review

References (41)

1. Dasika, G.K., Lin, S.C., Zhao, S., Sung, P., Tomkinson, A. and Lee, E.Y. (1999) DNA damage-induced cell cycle checkpoints and DNA strand break repair in development and tumorigenesis. Oncogene, 18, 7883-7899.
2. Zhou, B.B. and Elledge, S.J. (2000) The DNA damage response: putting checkpoints in perspective. Nature, 408, 433-439.
3. Varon, R., Vissinga, C., Platzer, M., Cerosaletti, K.M., Chrzanowska, K.H, Saar, K., Beckmann, G., Seemanova, E., Cooper, P.R., Nowak, N.J et al. (1998) Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome. Cell, 93, 467-476.
4. Carney, J.P., Maser, R.S., Olivares, H., Davis, E.M., Le Beau, M., Yates, J.R., III, Hays, L., Morgan, W.F. and Petrini, J.H. (1998) The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response. Cell, 93, 477-486.
5. O'Driscoll, M., Cerosaletti, K.M., Girard, P.M., Dai, Y., Stumm, M., Kysela, B., Hirsch, B., Gennery, A., Palmer, S.E., Seidel, J. et al. (2001) DNA ligase IV mutations identified in patients exhibiting developmental delay and immunodeficiency. Mol. Cell, 8, 1175-1185.
6. Haber, J.E. (1998) The many interfaces of Mre11. Cell, 95, 583-586.
7. D'Amours, D. and Jackson, S.P. (2002) The mre11 complex: at the crossroads of DNA repair and checkpoint signalling. Nature Rev. Mol. Cell. Biol., 3, 317-327.
8. Paull, T.T. and Gellert, M. (1998) The 3′ to 5′ exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks. Mol. Cell, 1, 969-979.
9. Usui, T., Ohta, T., Oshiumi, H., Tomizawa, J., Ogawa, H. and Ogawa, T. (1998) Complex formation and functional versatility of Mre11 of budding yeast in recombination. Cell, 95, 705-716.
10. Trujillo, K.M., Yuan, S.S., Lee, E.Y. and Sung, P. (1998) Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11 and p95. J. Biol. Chem., 273, 21447-21450.
11. Paull, T.T. and Gellert, M. (1999) Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex. Genes Dev., 13, 1276-1288.
12. Furuse, M., Nagase, Y., Tsubouchi, H., Murakami-Murofushi, K., Shibata, T. and Ohta, K. (1998) Distinct roles of two separable in vitro activities of yeast Mre11 in mitotic and meiotic recombination. EMBO J., 17, 6412-6425.
13. Trujillo, K.M. and Sung, P. (2001) DNA structure-specific nuclease activities in the Saccharomyces cerevisiae Rad50*Mre11 complex. J. Biol. Chem., 276, 35458-35464.
14. Maser, R.S., Mirzoeva, O.K., Wells, J., Olivares, H., Williams, B.R., Zinkel, R.A., Farnham, P.J. and Petrini, J.H. (2001) Mre11 complex and DNA replication: linkage to E2F and sites of DNA synthesis. Mol. Cell. Biol., 21, 6006-6016.
15. Franchitto, A. and Pichierri, P. (2002) Bloom's syndrome protein is required for correct relocalization of RAD50/MRE11/NBS1 complex after replication fork arrest. J. Cell Biol., 157, 19-30.
16. Lim, D.S., Kim, S.T., Xu, B., Maser, R.S., Lin, J., Petrini, J.H. and Kastan, M.B. (2000) ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway. Nature, 404, 613-617.
17. Zhao, S., Weng, Y.C., Yuan, S.S., Lin, Y.T., Hsu, H.C., Lin, S.C., Gerbino, E., Song, M.H., Zdzienicka, M.Z., Gatti, R.A. et al. (2000) Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products. Nature, 405, 473-477.
18. Wu, X., Ranganathan, V., Weisman, D.S., Heine, W.F., Ciccone, D.N., O'Neil], T.B., Crick, K.E., Pierce, K.A., Lane, W.S., Rathbun, G. et al. (2000) ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response. Nature, 405, 477-482.
19. Gatei, M., Young, D., Cerosaletti, K.M., Desai-Mehta, A., Spring, K., Kozlov, S., Lavin, M.F., Gatti, R.A., Concannon, P. and Khanna, K. (2000) ATM-dependent phosphorylation of nibrin in response to radiation exposure. Nature Genet., 25, 115-119.
20. Yazdi, P.T., Wang, Y., Zhao, S., Patel, N., Lee, E.Y. and Qin, J. (2002) SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint. Genes Dev., 16, 571-582.
21. Kim, S.T., Xu, B. and Kastan, M.B. (2002) Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage. Genes Dev., 16, 560-570.
22. Featherstone, C. and Jackson, S.P. (1998) DNA repair: the Nijmegen breakage syndrome protein. Curr. Biol., 8, R622-R625.
23. Durocher, D., Henckel, J., Fersht, A.R. and Jackson, S.P. (1999) The FHA domain is a modular phosphopeptide recognition motif. Mol. Cell, 4, 387-394.
24. Sun, Z., Hsiao, J., Fay, D.S. and Stern, D.F. (1998) Rad53 FHA domain associated with phosphorylated Rad9 in the DNA damage checkpoint. Science, 281, 272-274.
25. Kraakman-van der Zwet, M., Overkamp, W.J., Friedl, A.A., Klein, B., Verhaegh, G.W., Jaspers, N.G., Midro, A.T., Eckardt-Schupp, F., Lohman, P.H. and Zdzienicka, M.Z. (1999) Immortalization and characterization of Nijmegen Breakage syndrome fibroblasts. Mutat. Res., 434, 17-27.
26. Chen, P.L., Scully, P., Shew, J.Y., Wang, J.Y. and Lee, W.H. (1989) Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation. Cell, 58, 1193-1198.
27. Chen, G. and Lee, E. (1996) The product of the ATM gene is a 370-kDa nuclear phosphoprotein. J. Biol. Chem., 271, 33693-33697.
28. Mendez, J. and Stillman, B. (2000) Chromatin association of human origin recognition complex, cdc6 and minichromosome maintenance proteins during the cell cycle: assembly of prereplication complexes in late mitosis. Mol. Cell. Biol., 20, 8602-8612.
29. Painter, R.B. and Young, B.R. (1980) Radiosensitivity in ataxia-telangiectasia: a new explanation. Proc. Natl Acad. Sci. USA, 77, 7315-7317.
30. Morgan, S.E., Lovly, C., Pandita, T.K., Shiloh, Y. and Kastan, M.B. (1997) Fragments of ATM which have dominant-negative or complementing activity. Mol. Cell. Biol., 17, 2020-2029.
31. Nelms, B.E., Maser, R.S., MacKay, J.F., Lagally, M.G. and Petrini, J.H. (1998) In situ visualization of DNA double-strand break repair in human fibroblasts. Science, 280, 590-592.
32. Tauchi, H., Kobayashi, J., Morishima, K., Matsuura, S., Nakamura, A., Shiraishi, T., Ito, E., Masnada, D., Delia, D. and Komatsu, K. (2001) The forkhead-associated domain of NBS1 is essential for nuclear foci formation after irradiation but not essential for hRAD50·hMRE11·NBS1 complex DNA repair activity. J. Biol. Chem., 276, 12-15.
33. Desai-Mehta, A., Cerosaletti, K.M. and Concannon, P. (2001) Distinct functional domains of nibrin mediate Mre11 binding, focus formation and nuclear localization. Mol. Cell. Biol., 21, 2184-2191.
34. Young, B.R. and Painter, R.B. (1989) Radioresistant DNA synthesis and human genetic diseases. Hum. Genet., 82, 113-117.
35. Martin, S.G., Laroche, T., Suka, N., Grunstein, M. and Gasser, S.M. (1999) Relocalization of telomeric Ku and SIR proteins in response to DNA strand breaks in yeast. Cell, 97, 621-633.
36. Mills, K.D., Sinclair, D.A. and Guarente, L. (1999) MEC1-dependent redistribution of the Sir3 silencing protein from telomeres to DNA double-strand breaks. Cell, 97, 609-620.
37. Wu, G., Lee, W.H. and Chen, P.L. (2000) NBS1 and TRF1 colocalize at promyelocytic leukemia bodies during late S/G2 phases in immortalized telomerase-negative cells. Implication of NBS1 in alternative lengthening of telomeres. J. Biol. Chem., 275, 30618-30622.
38. Zhu, X.D., Kuster, B., Mann, M., Petrini, J.H. and Lange, T. (2000) Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres. Nature Genet., 25, 347-352.
39. Yamane, K. and Tsuruo, T. (1999) Conserved BRCT regions of TopBP1 and of the tumor suppressor BRCA1 bind strand breaks and termini of DNA. Oncogene, 18, 5194-5203.
40. Girard, P.M., Foray, N., Stumm, M., Waugh, A., Riballo, E., Maser, R.S., Phillips, W.P., Petrini, J., Arlett, C.F. and Jeggo, P.A. (2000) Radiosensitivity in Nijmegen Breakage Syndrome cells is attributable to a repair defect and not cell cycle checkpoint defects. Cancer Res., 60, 4881-4888.
41. Falck, J., Petrini, J.H., Williams, B.R., Lukas, J. and Bartek, J. (2002) The DNA damage-dependent intra-S phase checkpoint is regulated by parallel pathways. Nature Genet., 30, 290-294.