Metabolic activity: A novel indicator of neuronal survival in the murine dopaminergic cell line CAD

Journal of Molecular Neuroscience

Volumn 27, Issue 1, 2005, Pages 65-78

  Arboleda, Gonzalo ^a,b   Waters, Catherine ^a   Gibson, Rosemary M ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNIVERSIDAD DEL ROSARIO   (Colombia)

Author keywords

CAD; Caspase inhibitor; Catecholaminergic cells; Ceramide; Metabolic activity; Microphysiometer; Neuronal apoptosis; Neurotrophin 3

Indexed keywords

BIOLOGICAL MARKER; CARBACHOL; CASPASE INHIBITOR; CERAMIDE; MUSCARINIC RECEPTOR; NEUROTROPHIC FACTOR; NEUROTROPHIN 3; SPHINGOSINE DERIVATIVE;

ANIMAL CELL; APOPTOSIS; ARTICLE; BRAIN FUNCTION; CATECHOLAMINE NERVE CELL; CELL ACTIVITY; CELL DEATH; CELL FUNCTION; CELL LINE; CELL METABOLISM; CELL SURVIVAL; CELL VIABILITY; CENTRAL NERVOUS SYSTEM; DOPAMINERGIC NERVE CELL; IN VITRO STUDY; METABOLIC ACTIVATION; MOLECULAR MODEL; MOUSE; NERVE CELL; NONHUMAN; PARKINSON DISEASE; RECEPTOR UPREGULATION;

AMINO ACID CHLOROMETHYL KETONES; ANIMALS; APOPTOSIS; CASPASES; CELL LINE; CELL SURVIVAL; CYSTEINE PROTEINASE INHIBITORS; DOPAMINE; ENERGY METABOLISM; MICE; NEURONS; NEUROPROTECTIVE AGENTS; NEUROTROPHIN 3; SPHINGOSINE;

MURINAE;

EID: 23444461167     PISSN: 08958696     EISSN: None     Source Type: Journal    
DOI: 10.1385/JMN:27:01:65     Document Type: Article

References (33)

1. Bradbury E. J., King V. R., Simmons L. J., Priestley J. V., and McMahon S. B. (1998) NT-3, but not BDNF, prevents atrophy and death of axotomized spinal cord projection neurons. Eur. J. Neurosci. 10, 3058-3068.
2. Casaccia-Bonnefil P., Gu C., and Chao M. V. (1999) Neurotrophins in cell survival/death decisions. Adv. Exp. Med. Biol. 468, 275-282.
3. Chang L. K., Putcha G. V., Deshmukh M., and Johnson E. M. Jr. (2002) Mitochondrial involvement in the point of no return in neuronal apoptosis. Biochimie 84, 223-231.
4. Dawson T. M. and Dawson V. L. (2002) Neuroprotective and neurorestorative strategies for Parkinson's disease. Nat. Neurosci. 5(Suppl.), 1058-1061.
5. Deshmukh M., Kuida K., and Johnson E. M. Jr. (2000) Caspase inhibition extends the commitment to neuronal death beyond cytochrome c release to the point of mitochondrial depolarization. J. Cell Biol. 150, 131-143.
6. Dudek H., Datta S. R., Franke T. F., Birnbaum M. J., Yao R., Cooper G. M., et al. (1997) Regulation of neuronal survival by the serine-threonine protein kinase Akt. Science 275, 661-665.
7. Eberhardt O., Coelln R. V., Kugler S., Lindenau J., Rathke-Hartlieb S., Gerhardt E., et al. (2000) Protection by synergistic effects of adenovirus-mediated X-chromosome-linked inhibitor of apoptosis and glial cell line-derived neurotrophic factor gene transfer in the 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine model of Parkinson's disease. J. Neurosci. 20, 9126-9134.
8. Garcia-Ruiz C., Colell A., Mari M., Morales A., and Fernandez-Checa J. C. (1997) Direct effect of ceramide on the mitochondrial electron transport chain leads to generation of reactive oxygen species. Role of mitochondrial glutathione. J. Biol. Chem. 272, 11369-11377.
9. Gibson R. M. (1999) Caspase activation is downstream of commitment to apoptosis of Ntera-2 neuronal cells. Exp. Cell Res. 251, 203-212.
10. Gozuacik D. and Kimchi A. (2004) Autophagy as a cell death and tumor suppressor mechanism. Oncogene 23, 2891-2906.
11. Hafner F. (2000) Cytosensor Microphysiometer: technology and recent applications. Biosens. Bioelectron. 15, 149-158.
12. Honig L. S. and Rosenberg R. N. (2000) Apoptosis and neurologic disease. Am. J. Med. 108, 317-330.
13. Horton C. D., Qi Y., Chikaraishi D., and Wang J. K. (2001) Neurotrophin-3 mediates the autocrine survival of the catecholaminergic CAD CNS neuronal cell line. J. Neurochem. 76, 201-209.
14. Kennedy S. G., Wagner A. J., Conzen S. D., Jordan J., Bellacosa A., Tsichlis P. N., and Hay N. (1997) The PI 3-kinase/Akt signaling pathway delivers an antiapoptotic signal. Genes Dev. 11, 701-713.
15. Martin S. J., O'Brien G. A., Nishioka W. K., McGahon A. J., Mahboubi A., Saido T. C., and Green D. R. 1995. Proteolysis of fodrin (non-erythroid spectrin) during apoptosis. J. Biol. Chem. 270, 6425-6428.
16. Marzo I., Susin S. A., Petit P. X., Ravagnan L., Brenner C., Larochette N., et al. (1998) Caspases disrupt mitochondrial membrane barrier function. FEBS Lett. 427, 198-202.
17. Mattson M. P. (2000) Apoptosis in neurodegenerative disorders. Nat. Rev. Mol. Cell Biol. 1, 120-129.
18. McCarthy N. J., Whyte M. K., Gilbert C. S., and Evan G. I. (1997) Inhibition of Ced-3/ICE-related proteases does not prevent cell death induced by oncogenes, DNA damage, or the Bcl-2 homologue Bak. J. Cell Biol. 136, 215-227.
19. Miller F. D. and Kaplan D. R. (2001) Neurotrophin signalling pathways regulating neuronal apoptosis. Cell Mol. Life Sci. 58, 1045-1053.
20. Mochizuki T., Asai A., Saito N., Tanaka S., Katagiri H., Asano T., et al. (2002) Akt protein kinase inhibits non-apoptotic programmed cell death inducedby ceramide. J. Biol. Chem. 277, 2790-2797.
21. Moore J. D., Rothwell N. J., and Gibson R. M. (2002) Involvement of caspases and calpains in cerebrocortical neuronal cell death is stimulus-dependent. Br. J. Pharmacol. 135, 1067-1077.
22. Nicholson D. W. (2000) From bench to clinic with apoptosis-based therapeutic agents. Nature 407, 810-816.
23. Pasuit J. B., Li Z., and Kuzhikandathil E. V. (2004) Multi-modal regulation of endogenous D dopamine receptor expression and function in the CAD catecholaminergic cell line. J. Neurochem. 89, 1508-1519.
24. Pettus B. J., Chalfant C. E., and Hannun Y. A. (2002) Ceramide in apoptosis: an overview and current perspectives. Biochim. Biophys. Acta 1585, 114-125.
25. Qi Y., Wang J. K., McMillian M., and Chikaraishi D. M. (1997) Characterization of a CNS cell line, CAD, in which morphological differentiation is initiated by serum deprivation. J. Neurosci. 17, 1217-1225.
26. Roy S. (2000) Caspases at the heart of the apoptotic cell death pathway. Chem. Res. Toxicol. 13, 961-962.
27. Santhanagopal A., Chidiac P., Horne W. C., Baron R., and Dixon S. J. (2001) Calcitonin (CT) rapidly increases NA(+)/H(+) exchange and metabolic acid production: effects mediated selectively by the C1A CT receptor isoform. Endocrinology 142, 4401-4413.
28. Thornberry N. A. (1998) Caspases: key mediators of apoptosis. Chem. Biol. 5, R97-103.
29. Toman R. E., Spiegel S., and Faden A. I. (2000) Role of ceramide in neuronal cell death and differentiation. J. Neurotmuma 17, 891-898.
30. Vander Heiden M. G., Plas D. R., Rathmell J. C., Fox C. J., Harris M. H., and Thompson C. B. (2001) Growth factors can influence cell growth and survival through effects on glucose metabolism. Mol. Cell. Biol. 21, 5899-5912.
31. von Coelln R., Kugler S., Bahr M., Weller M., Dichgans J., and Schulz J. B. (2001) Rescue from death but not from functional impairment: caspase inhibition protects dopaminergic cells against 6-hydroxydopamine-induced apoptosis but not against the loss of their terminals. J. Neurochem. 77, 263-273.
32. Waldmeier P. C. and Tatton W. G. (2004) Interrupting apoptosis in neurodegenerative disease: potential for effective therapy? Drug Discov. Today 9, 210-218.
33. Wang H. and Oxford G. S. (2000) Voltage-dependent ion channels in CAD cells: a catecholaminergic neuronal line that exhibits inducible differentiation. J. Neurophysiol. 84, 2888-2895.