D-glucose prevents glutathione oxidation and mitochondrial damage after glutamate receptor stimulation in rat cortical primary neurons

Journal of Neurochemistry

Volumn 75, Issue 4, 2000, Pages 1618-1624

  Delgado Esteban, María ^a   Almeida, Angeles ^a   Bolaños, Juan P ^a  

^a UNIVERSITY OF SALAMANCA   (Spain)

Author keywords

Glutamate; Glutathione; Mitochondria; Neurodegeneration; Nitric oxide

Indexed keywords

2 AMINO 5 PHOSPHONOVALERIC ACID; CYTOCHROME B5 REDUCTASE; GLUCOSE; GLUTAMATE RECEPTOR; GLUTATHIONE; N(G) NITROARGININE METHYL ESTER; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE; SUCCINIC ACID; UBIQUINONE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN CELL; CONTROLLED STUDY; FEMALE; GLUTATHIONE METABOLISM; MITOCHONDRIAL RESPIRATION; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; OXIDATION; PENTOSE PHOSPHATE CYCLE; PRIORITY JOURNAL; RAT; RECEPTOR UPREGULATION;

ADENOSINE TRIPHOSPHATE; ANIMALS; CELL DEATH; CELLS, CULTURED; CEREBRAL CORTEX; ENERGY METABOLISM; GLUCOSE; GLUTATHIONE; LACTIC ACID; MITOCHONDRIA; NAD; NEURONS; NEUROPROTECTIVE AGENTS; NITRIC OXIDE; OXIDATION-REDUCTION; RATS; RATS, WISTAR; RECEPTORS, GLUTAMATE; RECEPTORS, N-METHYL-D-ASPARTATE;

ANIMALIA;

EID: 0033822094     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2000.0751618.x     Document Type: Article

References (32)

1. Glutamate neurotoxicity is associated with nitric oxide-mediated mitochondrial dysfunction and glutathione depletion
2. Glutamate-induced neuronal death: A succession of necrosis or apoptosis depending on mitochondrial function
3. Structure and function of mammalian facilitative sugar transporters
4. Assessment of the role of the glutathione and pentose phosphate pathways in the protection of primary cerebrocortical cultures from oxidative stress
5. Effect of peroxynitrite on the mitochondrial respiratory chain: Differential susceptibility of neurones and astrocytes in primary cultures
6. Nitric oxide-mediated mitochondrial damage in the brain: Mechanisms and implications for neurodegenerative diseases
7. Ionic dependence of glutamate neurotoxicity in cortical cell culture
8. Persistent inhibition of cell respiration by nitric oxide: Crucial role of S-nitrosylation of mitochondrial complex I and protective action of glutathione
9. Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures
10. Mechanisms of nitric oxide-mediated neurotoxicity in primary brain cultures
11. Glutathione content as an indicator for the presence of metabolic pathways of amino acids in astroglial cultures
12. Induction of glucose-6-phosphate dehydrogenase by lipopolysaccharide contributes to preventing nitric oxide-mediated glutathione depletion in cultured rat astrocytes
13. Endothelium-derived relaxing factor release on activation of NMDA receptors suggests a role as intercellular messenger in the brain
14. L-(+)-Lactate. Determination with lactate dehydrogenase and NAD
15. Preparation of succinate cytochrome c reductase and the cytochrome b-cl particle, and reconstitution of succinate cytochrome c reductase
16. NADH/NADPH. UV-methods
17. Vulnerability of cultured cortical neurons to damage by excitotoxins: Differential susceptibility of neurons containing NADPH-diaphorase
18. The detoxification of cumene hydroperoxide by the glutathione system of cultured astroglial cells hinges on hexose availability for the regeneration of NADPH
19. NMDA-dependent superoxide production and neurotoxicity
20. Nitric oxide and peroxynitrite exert distinct effects on mitochondrial respiration which are differentially blocked by glutathione or glucose
21. Protein measurement with the Folin phenol reagent
22. Glucose transporter proteins in brain
23. 2-induced neuronal apoptosis
24. Glutamate toxicity in a neuronal cell line involves inhibition of cystine transport leading to oxidative stress
25. Effects of antimycin, glucose deprivation, and serum on cultures of neurons, astrocytes, and neuroblastoma cells
26. Peroxynitrite oxidation of sulfhydryls. The cytotoxic potential of superoxide and nitric oxide
27. Peroxynitrite-induced membrane lipid peroxidation: The cytotoxic potential of superoxide and nitric oxide
28. Subfractionation of mitochondria and isolation of the proeins of oxidative phosphorylation
29. Blockade of neuronal nitric oxide synthase protects against excitotoxicity in vivo
30. Cytochrome oxidase from beef heart mitochondria
31. NADH/NADPH. Luminometric method
32. Nitric oxide activation of poly(ADP-ribose) synthetase in neurotoxicity