Potent, low-calcemic, selective inhibitors of CYP24 hydroxylase: 24-Sulfone analogs of the hormone 1α,25-dihydroxyvitamin D3

Journal of Steroid Biochemistry and Molecular Biology

Volumn 89-90, Issue , 2004, Pages 5-12

  Posner, Gary H ^a   Crawford, Kenneth R ^a   Yang, Hong Woon ^a   Kahraman, Mehmet ^a   Jeon, Heung Bae ^a   Li, Hongbin ^a   Lee, Jae Kyoo ^a   Suh, Byung Chul ^a   Hatcher, Mark A ^a   Labonte, Tanzina ^a   Usera, Aimee ^a   Dolan, Patrick M ^b   Kensler, Thomas W ^b   Peleg, Sara ^c   Jones, Glenville ^d   Zhang, Anqi ^e   Korczak, Bozena ^e   Saha, Uttam ^e   Chuang, Samuel S ^e  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b The Johns Hopkins University   (United States)

^c UNIVERSITY OF TEXAS   (United States)

^d QUEEN S UNIVERSITY   (Canada)

^e Cytochroma Inc   (Canada)

Author keywords

Catabolism inhibitor; Low calcemic; Vitamin D analogs

Indexed keywords

CALCITRIOL DERIVATIVE; CYTOCHROME P450 INHIBITOR; CYTOCHROME P450 ISOENZYME; OXYGENASE; SULFONE DERIVATIVE;

ANIMAL CELL; CALCIUM BLOOD LEVEL; CONFERENCE PAPER; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENCY; DRUG STRUCTURE; ENZYME INHIBITION; HUMAN; IC 50; NONHUMAN; STEREOCHEMISTRY;

ANIMALS; CALCITRIOL; CELL LINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, THIN LAYER; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INHIBITORS; HUMANS; SPECTRUM ANALYSIS; STEROID HYDROXYLASES; SULFONES; TRANSCRIPTION, GENETIC;

EID: 3042831508     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2004.03.044     Document Type: Conference Paper

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