메뉴 건너뛰기




Volumn 70, Issue 6, 2007, Pages 483-492

Antitumor effects of two less-calcemic vitamin D analogs (paricalcitol and QW-1624F2-2) in squamous cell carcinoma cells

Author keywords

1,25 Dihydroxyvitamin D3; Calcitriol; Molecular response; Paricalcitol; QW 1624F2 2; Squamous cell carcinoma cells; Vitamin D; Vitamin D analogs

Indexed keywords

1ALPHA HYDROXYMETHYL 16 ENE 24,24 DIFLUORO 25 HYDROXY 26,27 BIS HOMOVITAMIN D3; CASPASE 3; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE INHIBITOR 1; CYCLIN DEPENDENT KINASE INHIBITOR 1B; DNA; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE 1; PARICALCITOL; PROTEIN KINASE B; QW 1624F2 2; UNCLASSIFIED DRUG; VITAMIN D DERIVATIVE;

EID: 33847343428     PISSN: 00302414     EISSN: None     Source Type: Journal    
DOI: 10.1159/000098813     Document Type: Article
Times cited : (25)

References (53)
  • 1
    • 0001860244 scopus 로고
    • The photobiology of vitamin D3 in man
    • Kuman R ed, Boston, Martinus Nijhoff
    • Holick MF: The photobiology of vitamin D3 in man; in Kuman R (ed): Vitamin D: Basic and Clinical Aspects. Boston, Martinus Nijhoff, 1984, pp 197-216.
    • (1984) Vitamin D: Basic and Clinical Aspects , pp. 197-216
    • Holick, M.F.1
  • 2
    • 0027404624 scopus 로고
    • Vitamin D, calcium, and epidermal differentiation
    • Bikle DD, Pillai S: Vitamin D, calcium, and epidermal differentiation. Endocr Rev 1993;14:3-19.
    • (1993) Endocr Rev , vol.14 , pp. 3-19
    • Bikle, D.D.1    Pillai, S.2
  • 3
    • 0023913120 scopus 로고    scopus 로고
    • The steroid and thyroid hormone receptor superfamily
    • Evans RM: The steroid and thyroid hormone receptor superfamily. Science 1998;240:889-895.
    • (1998) Science , vol.240 , pp. 889-895
    • Evans, R.M.1
  • 4
    • 0030013405 scopus 로고    scopus 로고
    • Genomic mechanisms involved in the pleiotropic actions of 1,25-dihydroxyvitamin D3
    • Christakos S, Raval-Pandya M, Wernyj RP, Yang W: Genomic mechanisms involved in the pleiotropic actions of 1,25-dihydroxyvitamin D3. Biochem J 1996;316:361-371.
    • (1996) Biochem J , vol.316 , pp. 361-371
    • Christakos, S.1    Raval-Pandya, M.2    Wernyj, R.P.3    Yang, W.4
  • 7
    • 0026702938 scopus 로고
    • Effects of synthetic vitamin D analogues on breast cancer cell proliferation in vivo and in vitro
    • Colston KW, Chander SK, Mackay AG, Coombes RC: Effects of synthetic vitamin D analogues on breast cancer cell proliferation in vivo and in vitro. Biochem Pharmacol 1992;44:693-702.
    • (1992) Biochem Pharmacol , vol.44 , pp. 693-702
    • Colston, K.W.1    Chander, S.K.2    Mackay, A.G.3    Coombes, R.C.4
  • 8
    • 0027176480 scopus 로고
    • 1,25-Dihydroxyvitamin D3 receptor as a marker of human colon carcinoma cell line differentiation and growth inhibition
    • Shabahang M, Buras RR, Davoodi F, Schumaker LM, Nauta RJ, Evans SR: 1,25-Dihydroxyvitamin D3 receptor as a marker of human colon carcinoma cell line differentiation and growth inhibition. Cancer Res 1993;53:3712-3718.
    • (1993) Cancer Res , vol.53 , pp. 3712-3718
    • Shabahang, M.1    Buras, R.R.2    Davoodi, F.3    Schumaker, L.M.4    Nauta, R.J.5    Evans, S.R.6
  • 10
    • 0029966737 scopus 로고    scopus 로고
    • Antineoplastic effect of 1,25-dihydroxy-16-ene-23-yne-vitamin D3 analogue in transgenic mice with retinoblastoma
    • Shternfeld IS, Lasudry JG, Chappell RJ, Darjatmoko SR, Albert DM: Antineoplastic effect of 1,25-dihydroxy-16-ene-23-yne-vitamin D3 analogue in transgenic mice with retinoblastoma. Arch Ophthalmol 1996;114:1396-1401.
    • (1996) Arch Ophthalmol , vol.114 , pp. 1396-1401
    • Shternfeld, I.S.1    Lasudry, J.G.2    Chappell, R.J.3    Darjatmoko, S.R.4    Albert, D.M.5
  • 11
    • 0030828301 scopus 로고    scopus 로고
    • Vitamin D receptors and anti-proliferative effects of vitamin D derivatives in human pancreatic carcinoma cells in vivo and in vitro
    • Colston KW, James SY, Ofori-Kuragu EA, Binderup L, Grant AG: Vitamin D receptors and anti-proliferative effects of vitamin D derivatives in human pancreatic carcinoma cells in vivo and in vitro. Br J Cancer 1997;76:1017-1020.
    • (1997) Br J Cancer , vol.76 , pp. 1017-1020
    • Colston, K.W.1    James, S.Y.2    Ofori-Kuragu, E.A.3    Binderup, L.4    Grant, A.G.5
  • 12
    • 0001208875 scopus 로고    scopus 로고
    • Cyclin-dependent kinase inhibitor p27 as a mediator of the G1-S phase block induced by 1,25-dihydroxyvitamin D3 in HL60 cells
    • Wang QM, Jones JB, Studzinski GP: Cyclin-dependent kinase inhibitor p27 as a mediator of the G1-S phase block induced by 1,25-dihydroxyvitamin D3 in HL60 cells. Cancer Res 1996;56:264-267.
    • (1996) Cancer Res , vol.56 , pp. 264-267
    • Wang, Q.M.1    Jones, J.B.2    Studzinski, G.P.3
  • 13
    • 0030065422 scopus 로고    scopus 로고
    • Transcriptional activation of the Cdk inhibitor p21 by vitamin D3 leads to the induced differentiation of the myelomonocytic cell line U937
    • Liu M, Lee MH, Cohen M, Bommakanti M, Freedman LP: Transcriptional activation of the Cdk inhibitor p21 by vitamin D3 leads to the induced differentiation of the myelomonocytic cell line U937. Genes Dev 1996;10:142-153.
    • (1996) Genes Dev , vol.10 , pp. 142-153
    • Liu, M.1    Lee, M.H.2    Cohen, M.3    Bommakanti, M.4    Freedman, L.P.5
  • 14
    • 85047680777 scopus 로고    scopus 로고
    • Antiproliferative effect of 1alpha,25- dihydroxyvitamin D3 in human prostate cancer cell line LNCaP involves reduction of cyclin-dependent kinase 2 activity and persistent G1 accumulation
    • Zhuang SH, Burnstein KL: Antiproliferative effect of 1alpha,25- dihydroxyvitamin D3 in human prostate cancer cell line LNCaP involves reduction of cyclin-dependent kinase 2 activity and persistent G1 accumulation. Endocrinology 1998;139:1197-1207.
    • (1998) Endocrinology , vol.139 , pp. 1197-1207
    • Zhuang, S.H.1    Burnstein, K.L.2
  • 15
    • 0028973212 scopus 로고
    • Overexpression of p21WAF1/CIP1 induces growth arrest, giant cell formation and apoptosis in human breast carcinoma cell lines
    • Sheikh MS, Rochefort H, Garcia M: Overexpression of p21WAF1/CIP1 induces growth arrest, giant cell formation and apoptosis in human breast carcinoma cell lines. Oncogene 1995;11:1899-1905.
    • (1995) Oncogene , vol.11 , pp. 1899-1905
    • Sheikh, M.S.1    Rochefort, H.2    Garcia, M.3
  • 16
    • 0030880944 scopus 로고    scopus 로고
    • Potentiation of cisplatin antitumor activity using a vitamin D analogue in a murine squamous cell carcinoma model system
    • Light B, Yu W, McElwain M, Russell D, Trump D, Johnson C: Potentiation of cisplatin antitumor activity using a vitamin D analogue in a murine squamous cell carcinoma model system. Cancer Res 1997;57:3759-3764.
    • (1997) Cancer Res , vol.57 , pp. 3759-3764
    • Light, B.1    Yu, W.2    McElwain, M.3    Russell, D.4    Trump, D.5    Johnson, C.6
  • 17
    • 0033152196 scopus 로고    scopus 로고
    • 1,25-Dihydroxycholecalciferol (1,25-D3) inhibits the growth of squamous cell carcinoma and down-modulates p21(Waf1/Cip1) in vitro and in vivo
    • Hershberger PA, Modzelewski RA, Shurin ZR, Rueger RM, Trump DL, Johnson CS: 1,25-Dihydroxycholecalciferol (1,25-D3) inhibits the growth of squamous cell carcinoma and down-modulates p21(Waf1/Cip1) in vitro and in vivo. Cancer Res 1999;59:2644-2649.
    • (1999) Cancer Res , vol.59 , pp. 2644-2649
    • Hershberger, P.A.1    Modzelewski, R.A.2    Shurin, Z.R.3    Rueger, R.M.4    Trump, D.L.5    Johnson, C.S.6
  • 18
    • 0033564697 scopus 로고    scopus 로고
    • CDK inhibitors: Positive and negative regulators of G1-phase progression
    • Sherr CJ, Roberts JM: CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev 1999;13:1501-1512.
    • (1999) Genes Dev , vol.13 , pp. 1501-1512
    • Sherr, C.J.1    Roberts, J.M.2
  • 19
    • 0029849620 scopus 로고    scopus 로고
    • Cancer cell cycles
    • Sherr CJ: Cancer cell cycles. Science 1996;274:1672-1677.
    • (1996) Science , vol.274 , pp. 1672-1677
    • Sherr, C.J.1
  • 20
    • 0030200377 scopus 로고    scopus 로고
    • 1,25-Dihydroxyvitamin D3 induces morphological and biochemical markers of apoptosis in MCF-7 breast cancer cells
    • Simboli-Campbell M, Narvaez CJ, Tenniswood M, Welsh J: 1,25-Dihydroxyvitamin D3 induces morphological and biochemical markers of apoptosis in MCF-7 breast cancer cells. J Steroid Biochem Mol Biol 1996;58:367-376.
    • (1996) J Steroid Biochem Mol Biol , vol.58 , pp. 367-376
    • Simboli-Campbell, M.1    Narvaez, C.J.2    Tenniswood, M.3    Welsh, J.4
  • 21
    • 0032233813 scopus 로고    scopus 로고
    • The role of vitamin D3 and antiestrogens in modulating apoptosis of breast cancer cells and tumors
    • Welsh J, VanWeelden K, Flanagan L, Byrne I, Nolan E, Narvaez CJ: The role of vitamin D3 and antiestrogens in modulating apoptosis of breast cancer cells and tumors. Subcell Biochem 1998;30:245-270.
    • (1998) Subcell Biochem , vol.30 , pp. 245-270
    • Welsh, J.1    VanWeelden, K.2    Flanagan, L.3    Byrne, I.4    Nolan, E.5    Narvaez, C.J.6
  • 22
    • 0342803660 scopus 로고    scopus 로고
    • Apoptosis is induced by the active metabolite of vitamin D3 and its analogue EB1089 in colorectal adenoma and carcinoma cells: Possible implications for prevention and therapy
    • Diaz GD, Paraskeva C, Thomas MG, Binderup L, Hague A: Apoptosis is induced by the active metabolite of vitamin D3 and its analogue EB1089 in colorectal adenoma and carcinoma cells: possible implications for prevention and therapy. Cancer Res 2000;60:2304-2312.
    • (2000) Cancer Res , vol.60 , pp. 2304-2312
    • Diaz, G.D.1    Paraskeva, C.2    Thomas, M.G.3    Binderup, L.4    Hague, A.5
  • 23
    • 0001404630 scopus 로고    scopus 로고
    • Apoptotic effects of paclitaxel and calcitriol in rat Dunning MLL and human PC-3 prostate tumor cells in vitro
    • Modzelewski R, Hershberger P, Johnson C, Trump D: Apoptotic effects of paclitaxel and calcitriol in rat Dunning MLL and human PC-3 prostate tumor cells in vitro. Proc Am Assoc Cancer Res 1999;40:580a.
    • (1999) Proc Am Assoc Cancer Res , vol.40
    • Modzelewski, R.1    Hershberger, P.2    Johnson, C.3    Trump, D.4
  • 24
    • 0035854680 scopus 로고    scopus 로고
    • Vitamin D(3)-induced apoptosis of murine squamous cell carcinoma cells. Selective induction of caspase-dependent MEK cleavage and up-regulation of MEKK-1
    • McGuire TF, Trump DL, Johnson CS: Vitamin D(3)-induced apoptosis of murine squamous cell carcinoma cells. Selective induction of caspase-dependent MEK cleavage and up-regulation of MEKK-1. J Biol Chem 2001;276:26365-26373.
    • (2001) J Biol Chem , vol.276 , pp. 26365-26373
    • McGuire, T.F.1    Trump, D.L.2    Johnson, C.S.3
  • 25
    • 0035875881 scopus 로고    scopus 로고
    • A phase I trial of pulse calcitriol in patients with refractory malignancies: Pulse dosing permits substantial dose escalation
    • Beer TM, Munar M, Henner WD: A phase I trial of pulse calcitriol in patients with refractory malignancies: pulse dosing permits substantial dose escalation. Cancer 2001;91:2431-2439.
    • (2001) Cancer , vol.91 , pp. 2431-2439
    • Beer, T.M.1    Munar, M.2    Henner, W.D.3
  • 28
    • 0028048717 scopus 로고
    • Remission of cutaneous T-cell lymphoma with combined calcitriol and acitretin
    • French LE, Ramelet AA, Saurat JH: Remission of cutaneous T-cell lymphoma with combined calcitriol and acitretin. Lancet 1994;344:686-687.
    • (1994) Lancet , vol.344 , pp. 686-687
    • French, L.E.1    Ramelet, A.A.2    Saurat, J.H.3
  • 29
    • 0001013226 scopus 로고
    • Phase II trial of oral 1,25-dihydroxyvitamin D (calcitriol) in hormone refractory prostate cancer
    • Osborne JL, Schwartz GG, Smith DC, Bahnson R, Day RS, Trump DL: Phase II trial of oral 1,25-dihydroxyvitamin D (calcitriol) in hormone refractory prostate cancer. Urol Oncol 1995;1:195-198.
    • (1995) Urol Oncol , vol.1 , pp. 195-198
    • Osborne, J.L.1    Schwartz, G.G.2    Smith, D.C.3    Bahnson, R.4    Day, R.S.5    Trump, D.L.6
  • 30
    • 0032439651 scopus 로고    scopus 로고
    • Treatment of early recurrent prostate cancer with 1,25-dihydroxyvitamin D3 (calcitriol)
    • Gross C, Stamey T, Hancock S, Feldman D: Treatment of early recurrent prostate cancer with 1,25-dihydroxyvitamin D3 (calcitriol). J Urol 1998;159:2035-2040.
    • (1998) J Urol , vol.159 , pp. 2035-2040
    • Gross, C.1    Stamey, T.2    Hancock, S.3    Feldman, D.4
  • 31
    • 33646339673 scopus 로고    scopus 로고
    • Phase II trial of high-dose, intermittent calcitriol (1,25 dihydroxyvitamin D3) and dexamethasone in androgen-independent prostate cancer
    • Trump DL, Potter DM, Muindi J, Brufsky A, Johnson CS: Phase II trial of high-dose, intermittent calcitriol (1,25 dihydroxyvitamin D3) and dexamethasone in androgen-independent prostate cancer. Cancer 2006;106:2136-2142.
    • (2006) Cancer , vol.106 , pp. 2136-2142
    • Trump, D.L.1    Potter, D.M.2    Muindi, J.3    Brufsky, A.4    Johnson, C.S.5
  • 32
    • 22544442722 scopus 로고    scopus 로고
    • ASCENT Investigators: Interim results from ASCENT: a double-blinded randomized study of DN-101 (high-dose calcitriol) plus docetaxel vs. placebo plus docetaxel in androgen-independent prostate cancer (AIPC)
    • June
    • Beer TM, Ryan CW, Venner PM, Petrylak DP, Chatta G, Ruether JD, Henner WMD, Chi KN, Cruickshank S; ASCENT Investigators: Interim results from ASCENT: a double-blinded randomized study of DN-101 (high-dose calcitriol) plus docetaxel vs. placebo plus docetaxel in androgen-independent prostate cancer (AIPC). Int J Clin Oncol, June 2005, p 4516.
    • (2005) Int J Clin Oncol , pp. 4516
    • Beer, T.M.1    Ryan, C.W.2    Venner, P.M.3    Petrylak, D.P.4    Chatta, G.5    Ruether, J.D.6    Henner, W.M.D.7    Chi, K.N.8    Cruickshank, S.9
  • 33
    • 0037372282 scopus 로고    scopus 로고
    • High-dose weekly oral calcitriol in patients with a rising PSA after prostatectomy or radiation for prostate carcinoma
    • Beer TM, Lemmon D, Lowe BA, Henner WD: High-dose weekly oral calcitriol in patients with a rising PSA after prostatectomy or radiation for prostate carcinoma. Cancer 2003;97:1217-1224.
    • (2003) Cancer , vol.97 , pp. 1217-1224
    • Beer, T.M.1    Lemmon, D.2    Lowe, B.A.3    Henner, W.D.4
  • 34
    • 0242612058 scopus 로고    scopus 로고
    • Vitamin D and prostate cancer prevention and treatment
    • Chen TC, Holick MF: Vitamin D and prostate cancer prevention and treatment. Trends Endocrinol Metab 2003;14:423-430.
    • (2003) Trends Endocrinol Metab , vol.14 , pp. 423-430
    • Chen, T.C.1    Holick, M.F.2
  • 35
    • 0345403572 scopus 로고    scopus 로고
    • 19-Nor-1-alpha-25-dihydroxyvitamin D2 (paricalcitol) safely and effectively reduces the levels of intact parathyroid hormone in patients on hemodialysis
    • Martin KJ, Gonzalez EA, Gellens M, Hamm LL, Abboud H, Lindberg J: 19-Nor-1-alpha-25-dihydroxyvitamin D2 (paricalcitol) safely and effectively reduces the levels of intact parathyroid hormone in patients on hemodialysis. J Am Soc Nephrol 1998;9:1427-1432.
    • (1998) J Am Soc Nephrol , vol.9 , pp. 1427-1432
    • Martin, K.J.1    Gonzalez, E.A.2    Gellens, M.3    Hamm, L.L.4    Abboud, H.5    Lindberg, J.6
  • 37
    • 0037704213 scopus 로고    scopus 로고
    • Vitamin D2 analog 19-nor-1,25-dihydroxyvitamin D2: Antitumor activity against leukemia, myeloma, and colon cancer cells
    • Kumagai T, O'Kelly J, Said JW, Koeffler HP: Vitamin D2 analog 19-nor-1,25-dihydroxyvitamin D2: antitumor activity against leukemia, myeloma, and colon cancer cells. J Natl Cancer Inst 2003;95:896-905.
    • (2003) J Natl Cancer Inst , vol.95 , pp. 896-905
    • Kumagai, T.1    O'Kelly, J.2    Said, J.W.3    Koeffler, H.P.4
  • 38
    • 3042647149 scopus 로고    scopus 로고
    • 19-Nor-1alpha,25- dihydroxyvitamin D2 (paricalcitol) exerts anticancer activity against HL-60 cells in vitro at clinically achievable concentrations
    • Molnar I, Kute T, Willingham MC, Schwartz GG: 19-Nor-1alpha,25- dihydroxyvitamin D2 (paricalcitol) exerts anticancer activity against HL-60 cells in vitro at clinically achievable concentrations. J Steroid Biochem Mol Biol 2004;89-90:539-543.
    • (2004) J Steroid Biochem Mol Biol
    • Molnar, I.1    Kute, T.2    Willingham, M.C.3    Schwartz, G.G.4
  • 39
    • 0043236062 scopus 로고    scopus 로고
    • 1alpha,25-dihydroxyvitamin D(3) (calcitriol) and its analogue, 19-nor-1alpha,25(OH)(2)D(2) potentiate the effects of ionising radiation on human prostate cancer cells
    • Dunlap N, Schwartz GG, Eads D, Cramer SD, Sherk AB, John V, Koumenis C: 1alpha,25-dihydroxyvitamin D(3) (calcitriol) and its analogue, 19-nor-1alpha,25(OH)(2)D(2) potentiate the effects of ionising radiation on human prostate cancer cells. Br J Cancer 2003;89:746-753.
    • (2003) Br J Cancer , vol.89 , pp. 746-753
    • Dunlap, N.1    Schwartz, G.G.2    Eads, D.3    Cramer, S.D.4    Sherk, A.B.5    John, V.6    Koumenis, C.7
  • 40
    • 15144345623 scopus 로고    scopus 로고
    • Noncalcemic, antiproliferative, transcriptionally active, 24-fluorinated hybrid analogues of the hormone 1alpha,25-dihydroxyvitamin D3. Synthesis and preliminary biological evaluation
    • Posner G, Lee J, Wang Q, Peleg S, Burke M, Brem H, Dolan P, Kensler T: Noncalcemic, antiproliferative, transcriptionally active, 24-fluorinated hybrid analogues of the hormone 1alpha,25-dihydroxyvitamin D3. Synthesis and preliminary biological evaluation. J Med Chem 1998;41:3008-3014.
    • (1998) J Med Chem , vol.41 , pp. 3008-3014
    • Posner, G.1    Lee, J.2    Wang, Q.3    Peleg, S.4    Burke, M.5    Brem, H.6    Dolan, P.7    Kensler, T.8
  • 41
    • 0033938195 scopus 로고    scopus 로고
    • Conceptually new deltanoids (vitamin D analogs) inhibit multistage skin tumorigenesis
    • Kensler T, Dolan P, Gange S, Lee J, Wang Q, Posner G: Conceptually new deltanoids (vitamin D analogs) inhibit multistage skin tumorigenesis. Carcinogenesis 2000;21:1341-1345.
    • (2000) Carcinogenesis , vol.21 , pp. 1341-1345
    • Kensler, T.1    Dolan, P.2    Gange, S.3    Lee, J.4    Wang, Q.5    Posner, G.6
  • 44
    • 0034896572 scopus 로고    scopus 로고
    • Calcitriol (1,25-dihydroxycholecalciferol) enhances paclitaxel antitumor activity in vitro and in vivo and accelerates paclitaxel-induced apoptosis
    • Hershberger PA, Yu WD, Modzelewski RA, Rueger RM, Johnson CS, Trump DL: Calcitriol (1,25-dihydroxycholecalciferol) enhances paclitaxel antitumor activity in vitro and in vivo and accelerates paclitaxel-induced apoptosis. Clin Cancer Res 2001;7:1043-1051.
    • (2001) Clin Cancer Res , vol.7 , pp. 1043-1051
    • Hershberger, P.A.1    Yu, W.D.2    Modzelewski, R.A.3    Rueger, R.M.4    Johnson, C.S.5    Trump, D.L.6
  • 45
    • 0022402049 scopus 로고
    • Pentobarbital anesthesia and the response of tumor and normal tissue in the C3Hf/sed mouse to radiation
    • Suit HD, Sedlacek RS, Silver G, Dosoretz D: Pentobarbital anesthesia and the response of tumor and normal tissue in the C3Hf/sed mouse to radiation. Radiat Res 1985;104:47-65.
    • (1985) Radiat Res , vol.104 , pp. 47-65
    • Suit, H.D.1    Sedlacek, R.S.2    Silver, G.3    Dosoretz, D.4
  • 46
    • 0020823261 scopus 로고
    • Flow cytometric measurement of total DNA content and incorporated bromodeoxyuridine
    • Dolbeare F, Gratzner H, Pallavicini MG, Gray JW: Flow cytometric measurement of total DNA content and incorporated bromodeoxyuridine. Proc Natl Acad Sci USA 1983;80:5573-5577.
    • (1983) Proc Natl Acad Sci USA , vol.80 , pp. 5573-5577
    • Dolbeare, F.1    Gratzner, H.2    Pallavicini, M.G.3    Gray, J.W.4
  • 48
    • 0033604585 scopus 로고    scopus 로고
    • The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB
    • Kandel ES, Hay N: The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB. Exp Cell Res 1999;253:210-229.
    • (1999) Exp Cell Res , vol.253 , pp. 210-229
    • Kandel, E.S.1    Hay, N.2
  • 49
    • 0031900740 scopus 로고    scopus 로고
    • Signal transduction through MAP kinase cascades
    • Lewis TS, Shaprio PS, Ahn NG: Signal transduction through MAP kinase cascades. Adv Cancer Res 1998;74:49-139.
    • (1998) Adv Cancer Res , vol.74 , pp. 49-139
    • Lewis, T.S.1    Shaprio, P.S.2    Ahn, N.G.3
  • 51
    • 0037378444 scopus 로고    scopus 로고
    • Paricalcitol versus calcitriol in the treatment of secondary hyperparathyroidism
    • Sprague SM, Llach F, Amdahl M, Taccetta C, Batlle D: Paricalcitol versus calcitriol in the treatment of secondary hyperparathyroidism. Kidney Int 2003;63:1483-1490.
    • (2003) Kidney Int , vol.63 , pp. 1483-1490
    • Sprague, S.M.1    Llach, F.2    Amdahl, M.3    Taccetta, C.4    Batlle, D.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.