-
1
-
-
0029161458
-
Liarozole potentiates the cancer chemopreventive activity of and the up-regulation of gap junctional communication and connexin43 expression by retinoic acid and β-carotene in 10T1/2 cells
-
Acevedo P and Bertram JS (1995) Liarozole potentiates the cancer chemopreventive activity of and the up-regulation of gap junctional communication and connexin43 expression by retinoic acid and β-carotene in 10T1/2 cells. Carcinogenesis 16: 2215-2222
-
(1995)
Carcinogenesis
, vol.16
, pp. 2215-2222
-
-
Acevedo, P.1
Bertram, J.S.2
-
2
-
-
0028243129
-
Differences in the pharmacokinetic properties of orally administered all-transretinoic acid and 9-cis-retinoic acid in the plasma of nude mice
-
Achkar CC, Bentel JM, Boylan JF, Scher HI, Gudas LJ and Miller WH Jr (1994) Differences in the pharmacokinetic properties of orally administered all-transretinoic acid and 9-cis-retinoic acid in the plasma of nude mice. Drug Metab Dis 22: 451-458
-
(1994)
Drug Metab Dis
, vol.22
, pp. 451-458
-
-
Achkar, C.C.1
Bentel, J.M.2
Boylan, J.F.3
Scher, H.I.4
Gudas, L.J.5
Miller Jr., W.H.6
-
4
-
-
0026668041
-
Experimental studies with liarozole (R 75251): An antitumoral agent which inhibits retinoic acid breakdown
-
De Coster R, Wouters W, Van Ginckel R, End D, Krekels M, Coene M-C and Bowden C (1992) Experimental studies with liarozole (R 75251): an antitumoral agent which inhibits retinoic acid breakdown. J Steroid Biochem Mol Biol 43: 197-201
-
(1992)
J Steroid Biochem Mol Biol
, vol.43
, pp. 197-201
-
-
De Coster, R.1
Wouters, W.2
Van Ginckel, R.3
End, D.4
Krekels, M.5
Coene, M.-C.6
Bowden, C.7
-
5
-
-
0028082398
-
Antitumoral effects of liarozole in androgen-dependent and -independent R3327-Dunning prostate adenocarcinomas
-
Dijkman GA, Van Moortselaar RJA, Van Ginckel R, Van Stratum P, Wouters L, Debruyne FMJ, Schalken JA and De Coster R (1994) Antitumoral effects of liarozole in androgen-dependent and -independent R3327-Dunning prostate adenocarcinomas. J Urol 151: 217-222
-
(1994)
J Urol
, vol.151
, pp. 217-222
-
-
Dijkman, G.A.1
Van Moortselaar, R.J.A.2
Van Ginckel, R.3
Van Stratum, P.4
Wouters, L.5
Debruyne, F.M.J.6
Schalken, J.A.7
De Coster, R.8
-
6
-
-
0029044970
-
Bromodeoxyuridine: A diagnostic tool in biology and medicine. Part I: Historical perspectives, histochemical methods and cell kinetics
-
Dolbeare F (1995) Bromodeoxyuridine: a diagnostic tool in biology and medicine. Part I: Historical perspectives, histochemical methods and cell kinetics. Histochem J 27: 339-369
-
(1995)
Histochem J
, vol.27
, pp. 339-369
-
-
Dolbeare, F.1
-
7
-
-
0030003842
-
Retinoic acid isomers applied to human skin in vivo each induce a 4-hydroxylase that inactivates only trans retinoic acid
-
Duell EA, Kang S and Voorhees JJ (1996) Retinoic acid isomers applied to human skin in vivo each induce a 4-hydroxylase that inactivates only trans retinoic acid. J Invest Dermatol 106: 316-320
-
(1996)
J Invest Dermatol
, vol.106
, pp. 316-320
-
-
Duell, E.A.1
Kang, S.2
Voorhees, J.J.3
-
8
-
-
0018418459
-
Isolation and identification of 4-hydroxy- and 4-oxoretinoic acid. In vitro metabolites of all-trans-retinoic acid in hamster trachea and liver
-
Frolik CA, Roberts AB, Tavela TE, Roller PP, Newton DL and Sporn MB (1979) Isolation and identification of 4-hydroxy- and 4-oxoretinoic acid. In vitro metabolites of all-trans-retinoic acid in hamster trachea and liver. Biochemistry 18: 2092-2097
-
(1979)
Biochemistry
, vol.18
, pp. 2092-2097
-
-
Frolik, C.A.1
Roberts, A.B.2
Tavela, T.E.3
Roller, P.P.4
Newton, D.L.5
Sporn, M.B.6
-
9
-
-
0025696355
-
Metabolism of retinoic acid and retinol by intact cells and cell extracts
-
Gubler ML and Sherman MI (1990) Metabolism of retinoic acid and retinol by intact cells and cell extracts. Methods Enzymol 189: 525-530
-
(1990)
Methods Enzymol
, vol.189
, pp. 525-530
-
-
Gubler, M.L.1
Sherman, M.I.2
-
10
-
-
0029891109
-
Liarozole amplifies retinoid-induced apoptosis in human prostate cancer cells
-
Hall AK (1996) Liarozole amplifies retinoid-induced apoptosis in human prostate cancer cells. Anti-Cancer Drugs 7: 312-320
-
(1996)
Anti-Cancer Drugs
, vol.7
, pp. 312-320
-
-
Hall, A.K.1
-
11
-
-
0001319804
-
Retinoids and human cancer
-
Sporn MB, Roberts AB and Goodman DS (eds). Raven Press: New York
-
Hong WK and Itri LM (1994) Retinoids and human cancer. In The retinoids: Biology, Chemistry and Medicine, Sporn MB, Roberts AB and Goodman DS (eds). pp. 597-630. Raven Press: New York
-
(1994)
The Retinoids: Biology, Chemistry and Medicine
, pp. 597-630
-
-
Hong, W.K.1
Itri, L.M.2
-
12
-
-
0018138071
-
Estrogen control of progesterone receptor in human breast cancer
-
Horwitz KB and McGuire WL (1978) Estrogen control of progesterone receptor in human breast cancer. J Biol Chem 253: 2223-2228
-
(1978)
J Biol Chem
, vol.253
, pp. 2223-2228
-
-
Horwitz, K.B.1
McGuire, W.L.2
-
13
-
-
13344295088
-
Mechanisms of retinoid resistance in leukemic cells: Possible role of cytochrome P450 and P-glycoprotein
-
Kizaki M, Ueno H, Yamazoe Y, Shimada M, Takayama N, Muto A, Matsushita H, Nakajima H, Morikawa M, Koeffler HP and Ikeda Y (1996) Mechanisms of retinoid resistance in leukemic cells: possible role of cytochrome P450 and P-glycoprotein. Blood 87: 725-733
-
(1996)
Blood
, vol.87
, pp. 725-733
-
-
Kizaki, M.1
Ueno, H.2
Yamazoe, Y.3
Shimada, M.4
Takayama, N.5
Muto, A.6
Matsushita, H.7
Nakajima, H.8
Morikawa, M.9
Koeffler, H.P.10
Ikeda, Y.11
-
14
-
-
0029942117
-
Analysis of the oxidative catabolism of retinoic acid in rat Dunning R3327G prostate tumors
-
Krekels MDWG, Zimmerman J, Janssens B, Van Ginckel R, Cools W, Van Hove C, Coene M-C and Wouters W (1996) Analysis of the oxidative catabolism of retinoic acid in rat Dunning R3327G prostate tumors. Prostate 29: 36-41
-
(1996)
Prostate
, vol.29
, pp. 36-41
-
-
Krekels, M.D.W.G.1
Zimmerman, J.2
Janssens, B.3
Van Ginckel, R.4
Cools, W.5
Van Hove, C.6
Coene, M.-C.7
Wouters, W.8
-
15
-
-
8044225936
-
Induction of the oxidative catabolism of retinoic acid in MCF-7 cells
-
Krekels MDWG, Verhoeven A, van Dun J, Cools W, Van Hove C, Dillen L, Coene M-C and Wouters W (1997) Induction of the oxidative catabolism of retinoic acid in MCF-7 cells. Br J Cancer 75: 1098-1104
-
(1997)
Br J Cancer
, vol.75
, pp. 1098-1104
-
-
Krekels, M.D.W.G.1
Verhoeven, A.2
Van Dun, J.3
Cools, W.4
Van Hove, C.5
Dillen, L.6
Coene, M.-C.7
Wouters, W.8
-
16
-
-
0019223520
-
Effects of vitamin A and its analogs (retinoids) on normal and neoplastic cells
-
Lotan R (1980) Effects of vitamin A and its analogs (retinoids) on normal and neoplastic cells. Biochim Biophys Acta 605: 33-91
-
(1980)
Biochim Biophys Acta
, vol.605
, pp. 33-91
-
-
Lotan, R.1
-
17
-
-
0018088123
-
Isolation and identification of 5,6-epoxy-retinoic acid: A biologically active metabolite of retinoic acid
-
McCormick AM, Napoli JL, Schnoes HK and DeLuca HF (1978) Isolation and identification of 5,6-epoxy-retinoic acid: A biologically active metabolite of retinoic acid. Biochemistry 17: 4085-4090
-
(1978)
Biochemistry
, vol.17
, pp. 4085-4090
-
-
McCormick, A.M.1
Napoli, J.L.2
Schnoes, H.K.3
DeLuca, H.F.4
-
18
-
-
0027468908
-
Ketoconazole and liarozole in the treatment of advanced prostatic cancer
-
Mahler C, Verhelst J and Denis L (1993) Ketoconazole and liarozole in the treatment of advanced prostatic cancer. Cancer 71 (suppl.): 1068-1073
-
(1993)
Cancer
, vol.71
, Issue.SUPPL.
, pp. 1068-1073
-
-
Mahler, C.1
Verhelst, J.2
Denis, L.3
-
19
-
-
0003060912
-
Retinoids and cancer in experimental animals
-
Sporn MB, Roberts AB and Goodman DS (eds). Raven Press: New York
-
Moon RC, Mehta RG and Rao KVN (1994) Retinoids and cancer in experimental animals. In The Retinoids: Biology. Chemistry and Medicine, Sporn MB, Roberts AB and Goodman DS (eds). pp. 573-595. Raven Press: New York
-
(1994)
The Retinoids: Biology. Chemistry and Medicine
, pp. 573-595
-
-
Moon, R.C.1
Mehta, R.G.2
Rao, K.V.N.3
-
20
-
-
0026536835
-
Continuous treatment with all-trans-retinoic acid causes a progressive reduction in plasma drug concentrations: Implications for relapse and retinoid 'resistance' in patients with acute promyelocytic leukemia
-
Muindi JRF, Frankel SR, Miller WHJr, Jakubowski A, Scheinberg DA, Young CW, Dmitrovsky E and Warrell RPJ (1992) Continuous treatment with all-trans-retinoic acid causes a progressive reduction in plasma drug concentrations: implications for relapse and retinoid 'resistance' in patients with acute promyelocytic leukemia. Blood 79: 299-303
-
(1992)
Blood
, vol.79
, pp. 299-303
-
-
Muindi, J.R.F.1
Frankel, S.R.2
Miller Jr., W.H.3
Jakubowski, A.4
Scheinberg, D.A.5
Young, C.W.6
Dmitrovsky, E.7
Warrell, R.P.J.8
-
21
-
-
0018876924
-
Metabolism of all-trans-retinoic acid in hamster liver microsomes: Oxidation of 4-hydroxy-to 4-keto-retinoic acid
-
Roberts AB, Lamb LC and Sporn MB (1980) Metabolism of all-trans-retinoic acid in hamster liver microsomes: oxidation of 4-hydroxy-to 4-keto-retinoic acid. Arch Biochem Biophys 199: 374-383
-
(1980)
Arch Biochem Biophys
, vol.199
, pp. 374-383
-
-
Roberts, A.B.1
Lamb, L.C.2
Sporn, M.B.3
-
22
-
-
0029046483
-
Liarozole, an antitumor drug, modulates cytokeratin expression in the Dunning AT-6sq prostatic carcinoma through in situ accumulation of all-trans-retinoic acid
-
Smets G, Van Ginckel R, Daneels G, Moeremans M, Van Wauwe J, Coene M-C, Ramaekers FCS, Schalken JA, Borgers M and De Coster R (1995) Liarozole, an antitumor drug, modulates cytokeratin expression in the Dunning AT-6sq prostatic carcinoma through in situ accumulation of all-trans-retinoic acid. Prostate 27: 129-140
-
(1995)
Prostate
, vol.27
, pp. 129-140
-
-
Smets, G.1
Van Ginckel, R.2
Daneels, G.3
Moeremans, M.4
Van Wauwe, J.5
Coene, M.-C.6
Ramaekers, F.C.S.7
Schalken, J.A.8
Borgers, M.9
De Coster, R.10
-
23
-
-
0027081810
-
Phase I and pharmacokinetic evaluation of all-trans-retinoic acid in pediatric patients with cancer
-
Smith MA, Adamson PC, Balis FM, Feusner J, Aronson L, Murphy RF, Horowitz ME, Reaman G, Hammond GD, Connaghan GD, Hittelman WN and Poplack DG (1992) Phase I and pharmacokinetic evaluation of all-trans-retinoic acid in pediatric patients with cancer. J Clin Oncol 10: 1666-1673
-
(1992)
J Clin Oncol
, vol.10
, pp. 1666-1673
-
-
Smith, M.A.1
Adamson, P.C.2
Balis, F.M.3
Feusner, J.4
Aronson, L.5
Murphy, R.F.6
Horowitz, M.E.7
Reaman, G.8
Hammond, G.D.9
Connaghan, G.D.10
Hittelman, W.N.11
Poplack, D.G.12
-
24
-
-
0027220644
-
Liarozole and 13-cis-retinoic acid antiprostatic tumor activity
-
Stearns ME, Wang M and Fudge K (1993) Liarozole and 13-cis-retinoic acid antiprostatic tumor activity. Cancer Res 53: 3073-3077
-
(1993)
Cancer Res
, vol.53
, pp. 3073-3077
-
-
Stearns, M.E.1
Wang, M.2
Fudge, K.3
-
25
-
-
0028207149
-
Isomerization of all-trans-retinoic acid to 9-cis-retinoic acid
-
Urbach J and Rando RR (1994) Isomerization of all-trans-retinoic acid to 9-cis-retinoic acid. Biochem J 299: 459-465
-
(1994)
Biochem J
, vol.299
, pp. 459-465
-
-
Urbach, J.1
Rando, R.R.2
-
26
-
-
0025118507
-
Antitumoral effects of R 75251 on the growth of transplantable R3327 prostatic adenocarcinoma in rats
-
Van Ginckel R, De Coster R, Wouters W, Vanherck W, van der Veer R, Goeminne N, Jagers E, Van Cauteren H, Wouters L. Distelmans W and Janssen PAJ (1990) Antitumoral effects of R 75251 on the growth of transplantable R3327 prostatic adenocarcinoma in rats. Prostate 16: 313-323
-
(1990)
Prostate
, vol.16
, pp. 313-323
-
-
Van Ginckel, R.1
De Coster, R.2
Wouters, W.3
Vanherck, W.4
Van Der Veer, R.5
Goeminne, N.6
Jagers, E.7
Van Cauteren, H.8
Wouters, L.9
Distelmans, W.10
Janssen, P.A.J.11
-
27
-
-
0029794534
-
Liarozole potentiates the all-trans-retinoic acid-induced structural remodelling in human breast carcinoma MCF-7 cells in vitro
-
Van heusden J, Borgers M, Ramaekers F, Xhonneux B, Wouters W, De Coster R and Smets G (1996) Liarozole potentiates the all-trans-retinoic acid-induced structural remodelling in human breast carcinoma MCF-7 cells in vitro. Eur J Cell Biol 71: 89-98
-
(1996)
Eur J Cell Biol
, vol.71
, pp. 89-98
-
-
Van Heusden, J.1
Borgers, M.2
Ramaekers, F.3
Xhonneux, B.4
Wouters, W.5
De Coster, R.6
Smets, G.7
-
28
-
-
0031042044
-
Fluorescein-labeled tyramide strongly enhances the detection of low bromodeoxyuridine-incorporation levels
-
Van heusden J, de Jong P, Ramaekers F, Bruwiere H, Borgers M and Smets G (1997) Fluorescein-labeled tyramide strongly enhances the detection of low bromodeoxyuridine-incorporation levels. J Histochem Cytochem 45: 315-319
-
(1997)
J Histochem Cytochem
, vol.45
, pp. 315-319
-
-
Van Heusden, J.1
De Jong, P.2
Ramaekers, F.3
Bruwiere, H.4
Borgers, M.5
Smets, G.6
-
29
-
-
0031964550
-
All-trans-retinoic acid metabolites significantly inhibit the proliferation of MCF-7 human breast cancer cells in vitro
-
Van heusden J, Wouters W, Ramaekers FCS, Krekels MDWG, Dillen L, Borgers M and Smets G (1998) All-trans-retinoic acid metabolites significantly inhibit the proliferation of MCF-7 human breast cancer cells in vitro. Br J Cancer 77: 26-32
-
(1998)
Br J Cancer
, vol.77
, pp. 26-32
-
-
Van Heusden, J.1
Wouters, W.2
Ramaekers, F.C.S.3
Krekels, M.D.W.G.4
Dillen, L.5
Borgers, M.6
Smets, G.7
-
30
-
-
0025089911
-
Effects of cytochrome P-450 inhibitors on the in vivo metabolism of all-trans-retinoic acid in rats
-
Van Wauwe JP, Coene M-C, Goosens J, Cools W and Monbaliu J (1990) Effects of cytochrome P-450 inhibitors on the in vivo metabolism of all-trans-retinoic acid in rats. J Pharmacol Exp Ther 252: 365-369
-
(1990)
J Pharmacol Exp Ther
, vol.252
, pp. 365-369
-
-
Van Wauwe, J.P.1
Coene, M.-C.2
Goosens, J.3
Cools, W.4
Monbaliu, J.5
-
31
-
-
0026659954
-
Liarozole, an inhibitor of retinoic acid metabolism, exerts retinoid-mimetic effects in vivo
-
Van Wauwe J, Van Nyen G, Coene M-C, Stoppie P, Cools W, Goossens J, Borghgraef P and Janssen P (1991) Liarozole, an inhibitor of retinoic acid metabolism, exerts retinoid-mimetic effects in vivo. J Pharmacol Exp Ther 261: 773-779
-
(1991)
J Pharmacol Exp Ther
, vol.261
, pp. 773-779
-
-
Van Wauwe, J.1
Van Nyen, G.2
Coene, M.-C.3
Stoppie, P.4
Cools, W.5
Goossens, J.6
Borghgraef, P.7
Janssen, P.8
-
32
-
-
0028295727
-
Liarozole-fumarate inhibits the metabolism of 4-keto-all-trans-retinoic acid
-
Van Wauwe J, Coene M-C, Cools W, Goosens J, Lauwers W, Le Jeune L. Van Hove C and Van Nyen G (1994) Liarozole-fumarate inhibits the metabolism of 4-keto-all-trans-retinoic acid. Biochem Pharmcol 47: 737-741
-
(1994)
Biochem Pharmcol
, vol.47
, pp. 737-741
-
-
Van Wauwe, J.1
Coene, M.-C.2
Cools, W.3
Goosens, J.4
Lauwers, W.5
Le Jeune, L.6
Van Hove, C.7
Van Nyen, G.8
-
33
-
-
0027448677
-
Retinoid resistance in acute promyelocytic leukemia: New mechanisms, strategies, and implications
-
Warrell RPJr (1993) Retinoid resistance in acute promyelocytic leukemia: new mechanisms, strategies, and implications. Blood 82: 1949-1953
-
(1993)
Blood
, vol.82
, pp. 1949-1953
-
-
Warrell Jr., R.P.1
-
35
-
-
6844238791
-
Effect of six retinoids and retinoic acid catabolic inhibitor liarozole on two glioblastoma cell lines, and in vivo experience in malignant brain tumor patients
-
Banzet P. Holland JF, Khayat D and Weil M (eds). Springer: Paris
-
Westarp ME, Westarp MP, Bollag W, Bruynseels J, Biesalski H, Grossmann N and Kornhuber H-H (1994) Effect of six retinoids and retinoic acid catabolic inhibitor liarozole on two glioblastoma cell lines, and in vivo experience in malignant brain tumor patients. In Cancer Treatment - an Update. Banzet P. Holland JF, Khayat D and Weil M (eds). pp.590-598. Springer: Paris
-
(1994)
Cancer Treatment - An Update
, pp. 590-598
-
-
Westarp, M.E.1
Westarp, M.P.2
Bollag, W.3
Bruynseels, J.4
Biesalski, H.5
Grossmann, N.6
Kornhuber, H.-H.7
-
36
-
-
0029861003
-
Identification of the retinoic acid-inducible all-trans-retinoic acid 4-hydroxylase
-
White JA, Guo Y-D, Baetz K, Beckett-Jones B, Bonasoro J, Hsu KE, Dilworth FJ, Jones G and Petkovich M (1996) Identification of the retinoic acid-inducible all-trans-retinoic acid 4-hydroxylase. J Biol Chem 271: 29922-29927
-
(1996)
J Biol Chem
, vol.271
, pp. 29922-29927
-
-
White, J.A.1
Guo, Y.-D.2
Baetz, K.3
Beckett-Jones, B.4
Bonasoro, J.5
Hsu, K.E.6
Dilworth, F.J.7
Jones, G.8
Petkovich, M.9
-
37
-
-
4244079154
-
Retinoid metabolism and its inhibition by liarozole-fumarate
-
Wouters W (1994) Retinoid metabolism and its inhibition by liarozole-fumarate. Ann Oncology 5: S45-S47
-
(1994)
Ann Oncology
, vol.5
-
-
Wouters, W.1
-
38
-
-
0026742178
-
Effects of liarozole, a new antitumor compound, on retinoic acid-induced inhibition of cell growth and on retinoic acid metabolism in MCF-7 human breast cancer cells
-
Wouters W, van Dun J, Dillen A, Coene M-C, Cools W and De Coster R (1992) Effects of liarozole, a new antitumor compound, on retinoic acid-induced inhibition of cell growth and on retinoic acid metabolism in MCF-7 human breast cancer cells. Cancer Res 52: 2841-2846
-
(1992)
Cancer Res
, vol.52
, pp. 2841-2846
-
-
Wouters, W.1
Van Dun, J.2
Dillen, A.3
Coene, M.-C.4
Cools, W.5
De Coster, R.6
|