Potent, selective and low-calcemic inhibitors of CYP24 Hydroxylase: 24-Sulfoximine analogues of the hormone 1α,25-dihydroxyvitamin D 3

Journal of Medicinal Chemistry

Volumn 47, Issue 27, 2004, Pages 6854-6863

  Kahraman, Mehmet ^a   Sinishtaj, Sandra ^a   Dolan, Patrick M ^b   Kensler, Thomas W ^b   Peleg, Sara ^c   Saha, Uttam ^d   Chuang, Samuel S ^d   Bernstein, Galina ^d   Korczak, Bozena ^d   Posner, Gary H ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b The Johns Hopkins University   (United States)

^c UNIVERSITY OF TEXAS   (United States)

^d Cytochroma Inc   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

24 AMINOPHENYLSULFOXIMINE; 24 SULFOXIMINE DERIVATIVE; 4 FLUOROPHENYLMETHYLSULFOXIMINE; CALCITRIOL; CYCLOPROPYLPHENYLSULFOXIMINE; CYTOCHROME P450; CYTOCHROME P450 27A1; CYTOCHROME P450 27B; CYTOCHROME P450 HYDROXYLASE; ENZYME INHIBITOR; METHYLPHENYLSULFOXIMINE; OXYGENASE; SULFONE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG DESIGN; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; IC 50; STEREOCHEMISTRY;

ANIMALS; CALCITRIOL; CALCIUM; CYTOCHROME P-450 ENZYME SYSTEM; MALE; RATS; RATS, INBRED F344; STEROID HYDROXYLASES; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONES;

EID: 19944427528     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm040129+     Document Type: Article

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