메뉴 건너뛰기




Volumn 65, Issue 4, 2000, Pages 171-179

Aromatase inhibitors and their application in breast cancer treatment

Author keywords

Aromatase; Breast cancer; Inhibitors

Indexed keywords

ANASTROZOLE; ANTIESTROGEN; AROMATASE; AROMATASE INHIBITOR; EXEMESTANE; FORMESTANE; LETROZOLE; MEGESTROL ACETATE; TAMOXIFEN;

EID: 0034106931     PISSN: 0039128X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0039-128X(99)00104-X     Document Type: Review
Times cited : (114)

References (72)
  • 1
    • 0001429361 scopus 로고
    • An update on estrogen and progesterone receptors in prognosis for primary and advanced breast cancer
    • S. et al. Iacobelli. New York: Raven Press
    • McGuire W.L. An update on estrogen and progesterone receptors in prognosis for primary and advanced breast cancer. Iacobelli S., et al. Hormones and Cancer. 1980;337-344 Raven Press, New York.
    • (1980) Hormones and Cancer , pp. 337-344
    • McGuire, W.L.1
  • 2
    • 0015984830 scopus 로고
    • Plasma precursors of estrogen: II. Correlation of the extent of conversion of plasma androstenedione to estrone with age
    • Hemsell D.L., Gordon J., Breuner P.F., Siiteri P.K. Plasma precursors of estrogen II. Correlation of the extent of conversion of plasma androstenedione to estrone with age . J Clin Endocr Metab. 38:1974;476-479.
    • (1974) J Clin Endocr Metab , vol.38 , pp. 476-479
    • Hemsell, D.L.1    Gordon, J.2    Breuner, P.F.3    Siiteri, P.K.4
  • 3
    • 0015594143 scopus 로고
    • Studies on the mechanism of estrogen biosynthesis. VII. The development of inhibitors of the enzyme system in the human placenta
    • Schwarzel W.C., Kruggel W., Brodie H.J. Studies on the mechanism of estrogen biosynthesis. VII. The development of inhibitors of the enzyme system in the human placenta. Endocrinology. 92:1973;866-880.
    • (1973) Endocrinology , vol.92 , pp. 866-880
    • Schwarzel, W.C.1    Kruggel, W.2    Brodie, H.J.3
  • 4
    • 0017755181 scopus 로고
    • The effect of an aromatase inhibitor, 4-hydroxy-4-androstene-3,17-dione, on estrogen dependent processes in reproduction and breast cancer
    • Brodie A.M.H., Schwarzel W.C., Shaikh A.A., Brodie H.J. The effect of an aromatase inhibitor, 4-hydroxy-4-androstene-3,17-dione, on estrogen dependent processes in reproduction and breast cancer. Endocrinology. 100:1977;1684-1694.
    • (1977) Endocrinology , vol.100 , pp. 1684-1694
    • Brodie, A.M.H.1    Schwarzel, W.C.2    Shaikh, A.A.3    Brodie, H.J.4
  • 5
    • 0015069359 scopus 로고
    • A new antiestrogenic agent in late breast cancer: An early appraisal of ICI 46,474
    • Cole M.P., Jones C.T.A., Todd I.D.H. A new antiestrogenic agent in late breast cancer an early appraisal of ICI 46,474 . Br J Cancer. 25:1971;270-275.
    • (1971) Br J Cancer , vol.25 , pp. 270-275
    • Cole, M.P.1    Jones, C.T.A.2    Todd, I.D.H.3
  • 6
    • 0003193675 scopus 로고
    • Systemic treatment of early breast cancer by hormonal, cytotoxic, or immune therapy
    • Early Breast Cancer Trialists' Collaborative Group
    • Early Breast Cancer Trialists' Collaborative Group. Systemic treatment of early breast cancer by hormonal, cytotoxic, or immune therapy. Lancet 1992;339:1-15.
    • (1992) Lancet , vol.339 , pp. 1-15
  • 7
    • 0028987866 scopus 로고
    • Tamoxifen: Toxicities and drug resistance during the treatment and prevention of breast cancer
    • Jordan V.C. Tamoxifen toxicities and drug resistance during the treatment and prevention of breast cancer . Ann Rev Pharmacol Toxicol. 35:1995;195-211.
    • (1995) Ann Rev Pharmacol Toxicol , vol.35 , pp. 195-211
    • Jordan, V.C.1
  • 8
    • 0032537990 scopus 로고    scopus 로고
    • Tamoxifen for prevention of breast cancer: Report of the National Surgical Adjuvant Breast and Bowel Project P-1 study
    • other National Surgical Adjuvant Breast and Bowel Project Investigators
    • Fisher B, Constantino JP, Wickerham DL, et al., other National Surgical Adjuvant Breast and Bowel Project Investigators. Tamoxifen for prevention of breast cancer: report of the National Surgical Adjuvant Breast and Bowel Project P-1 study. J Natl Cancer Inst 1998;90:1371-88.
    • (1998) J Natl Cancer Inst , vol.90 , pp. 1371-1388
    • Fisher, B.1    Constantino, J.P.2    Wickerham, D.L.3
  • 9
    • 0027362482 scopus 로고
    • Descriptive clinicopathologic study of 17 patients with endometrial cancer during or after adjuvant tamoxifen in early breast cancer
    • Fornander T., Hellstrom A.C., Moberger B. Descriptive clinicopathologic study of 17 patients with endometrial cancer during or after adjuvant tamoxifen in early breast cancer. J Natl Cancer Inst. 815:1993;1850-1855.
    • (1993) J Natl Cancer Inst , vol.815 , pp. 1850-1855
    • Fornander, T.1    Hellstrom, A.C.2    Moberger, B.3
  • 10
    • 0014053604 scopus 로고
    • A new derivative of triphenylethylene: Effect on implantation and mode of action in rats
    • Harper M.J.K., Wapole A.L. A new derivative of triphenylethylene effect on implantation and mode of action in rats . J Reprod Fertil. 13:1967;101-119.
    • (1967) J Reprod Fertil , vol.13 , pp. 101-119
    • Harper, M.J.K.1    Wapole, A.L.2
  • 11
    • 0022348964 scopus 로고
    • Distribution and regulation of aromatase activity in the rat hypothalamus and limbic systems
    • Roselli C.E., Horton L.E., Resko J.A. Distribution and regulation of aromatase activity in the rat hypothalamus and limbic systems. Endocrinology. 117:1985;2471-2477.
    • (1985) Endocrinology , vol.117 , pp. 2471-2477
    • Roselli, C.E.1    Horton, L.E.2    Resko, J.A.3
  • 12
    • 0023468452 scopus 로고
    • Intratesticular site of aromatase activity and possible function of testicular estradiol
    • Payne A.H., Perkins L.M., Georgiou M., Quinn P.G. Intratesticular site of aromatase activity and possible function of testicular estradiol. Steroids. 50:1987;435-448.
    • (1987) Steroids , vol.50 , pp. 435-448
    • Payne, A.H.1    Perkins, L.M.2    Georgiou, M.3    Quinn, P.G.4
  • 16
    • 0027141308 scopus 로고
    • Use of tissue specific promoters in the regulation of aromatase cytochrome P450 gene expression in human testicular and ovarian sex cord tumors, as well as in normal fetal and adult gonads
    • Bulun SE, Rosenthal IM, Brodie AMH, et al. Use of tissue specific promoters in the regulation of aromatase cytochrome P450 gene expression in human testicular and ovarian sex cord tumors, as well as in normal fetal and adult gonads. J Clin Endocriol Metab 1993a;77:1616-21.
    • (1993) J Clin Endocriol Metab , vol.77 , pp. 1616-1621
    • Bulun, S.E.1    Rosenthal, I.M.2    Brodie, A.M.H.3
  • 17
    • 0018547573 scopus 로고
    • The production of progesterone, androgens, and estrogens by granulosa cells, thecal tissue, and stromal tissue from human ovaries in vitro
    • McNatty K.P., Makris A., De Grazia C., Osathanondh R., Ryan K.J. The production of progesterone, androgens, and estrogens by granulosa cells, thecal tissue, and stromal tissue from human ovaries in vitro. J Clin Endocrinol Metab. 49:1979;687-699.
    • (1979) J Clin Endocrinol Metab , vol.49 , pp. 687-699
    • McNatty, K.P.1    Makris, A.2    De Grazia, C.3    Osathanondh, R.4    Ryan, K.J.5
  • 18
    • 0025939110 scopus 로고
    • Expression of aromatase cytochrome P-450 in premenopausal and postmenopausal human ovaries: An immunocytochemical study
    • Inkster S.E., Brodie A.M.H. Expression of aromatase cytochrome P-450 in premenopausal and postmenopausal human ovaries an immunocytochemical study . J Clin Endocrinol Metab. 73:1991;717-726.
    • (1991) J Clin Endocrinol Metab , vol.73 , pp. 717-726
    • Inkster, S.E.1    Brodie, A.M.H.2
  • 19
    • 0016590015 scopus 로고
    • The formation of estrogen by central neuroendocrine tissues
    • Naftolin F., Ryan K.J., Davis I.J., et al. The formation of estrogen by central neuroendocrine tissues. Recent Prog Horm Res. 31:1975;295-319.
    • (1975) Recent Prog Horm Res , vol.31 , pp. 295-319
    • Naftolin, F.1    Ryan, K.J.2    Davis, I.J.3
  • 20
    • 0024828449 scopus 로고
    • Immunocytochemical studies of aromatase in early and full term human placental tissues: Comparison with biochemical assays
    • Inkster S.E., Brodie A.M.H. Immunocytochemical studies of aromatase in early and full term human placental tissues comparison with biochemical assays . Biol Reprod. 41:1989;889-898.
    • (1989) Biol Reprod , vol.41 , pp. 889-898
    • Inkster, S.E.1    Brodie, A.M.H.2
  • 21
    • 0023485907 scopus 로고
    • Peripheral aromatization: Studies on controlling factors
    • Longcope C. Peripheral aromatization studies on controlling factors . Steroids. 50:1987;253-267.
    • (1987) Steroids , vol.50 , pp. 253-267
    • Longcope, C.1
  • 23
    • 0021931084 scopus 로고
    • Endogenous concentration and subcellular distribution of estrogens in normal and malignant human breast tissue
    • van Landegham A.A.J., Portman J., Nabauurs M. Endogenous concentration and subcellular distribution of estrogens in normal and malignant human breast tissue. Cancer Res. 45:1985;2900-2906.
    • (1985) Cancer Res , vol.45 , pp. 2900-2906
    • Van Landegham, A.A.J.1    Portman, J.2    Nabauurs, M.3
  • 25
    • 0029941512 scopus 로고    scopus 로고
    • Expression of aromatase protein and messenger ribonucleic acid in tumor epithelial cells and evidence of functional significance of locally produced estrogen in human breast cancers
    • Lu Q., Nakmura J., Savinov A., et al. Expression of aromatase protein and messenger ribonucleic acid in tumor epithelial cells and evidence of functional significance of locally produced estrogen in human breast cancers. Endocrinology. 137:1996;3061-3068.
    • (1996) Endocrinology , vol.137 , pp. 3061-3068
    • Lu, Q.1    Nakmura, J.2    Savinov, A.3
  • 26
    • 0028076949 scopus 로고
    • Regulation of aromatase expression in human tissues
    • Bulun S.E., Simpson E. Regulation of aromatase expression in human tissues. Breast Cancer Res Treat. 30:1994;19-29.
    • (1994) Breast Cancer Res Treat , vol.30 , pp. 19-29
    • Bulun, S.E.1    Simpson, E.2
  • 27
    • 0027261356 scopus 로고
    • Tissue-specific and hormonally controlled alternative promoters regulate aromatase cytochrome P-450 gene expression in human adipose tissue
    • Mahendroo M.S., Mendelson C.R., Simpson E.R. Tissue-specific and hormonally controlled alternative promoters regulate aromatase cytochrome P-450 gene expression in human adipose tissue. J Biol Chem. 268:1993;19463-19470.
    • (1993) J Biol Chem , vol.268 , pp. 19463-19470
    • Mahendroo, M.S.1    Mendelson, C.R.2    Simpson, E.R.3
  • 28
    • 0027362649 scopus 로고
    • Tissue-specific expression of the human aromatase cytochrome P-450 gene by alternative use of multiple exons 1 and promoters, and switching of tissue-specific exons 1 in carcinogenesis
    • Harada N., Utsumi T., Takagi Y. Tissue-specific expression of the human aromatase cytochrome P-450 gene by alternative use of multiple exons 1 and promoters, and switching of tissue-specific exons 1 in carcinogenesis. Proc Natl Acad Sci USA. 90:1993;11313-11316.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 11313-11316
    • Harada, N.1    Utsumi, T.2    Takagi, Y.3
  • 29
    • 0028225088 scopus 로고
    • Novel exon 1 of the aromatase gene specific for transcripts in human brain
    • Honda S., Harada N., Takagi Y. Novel exon 1 of the aromatase gene specific for transcripts in human brain. Biochem Biophys Res Comm. 198:1994;1153-1160.
    • (1994) Biochem Biophys Res Comm , vol.198 , pp. 1153-1160
    • Honda, S.1    Harada, N.2    Takagi, Y.3
  • 30
    • 0028032138 scopus 로고
    • Expression of the gene encoding aromatase cytochrome P-450 (CYP19) in fetal tissues
    • Toda K., Simpson E.R., Mendelson C.R., Shizuta Y., Kilgore M.W. Expression of the gene encoding aromatase cytochrome P-450 (CYP19) in fetal tissues. Mol Endocrinol. 8:1994;210-217.
    • (1994) Mol Endocrinol , vol.8 , pp. 210-217
    • Toda, K.1    Simpson, E.R.2    Mendelson, C.R.3    Shizuta, Y.4    Kilgore, M.W.5
  • 32
    • 0001246894 scopus 로고
    • Estrogen formation in stromal cells of adipose tissue of women: Induction of glucocorticosteroids
    • Simpson E.R., Ackerman G.E., Smith M.E., Mendelson C.R. Estrogen formation in stromal cells of adipose tissue of women induction of glucocorticosteroids . Proc Natl Acad Sci USA. 78:1981;5690-5694.
    • (1981) Proc Natl Acad Sci USA , vol.78 , pp. 5690-5694
    • Simpson, E.R.1    Ackerman, G.E.2    Smith, M.E.3    Mendelson, C.R.4
  • 33
    • 0020202030 scopus 로고
    • Regulation of aromatase activity of stromal cells derived from human adipose tissue
    • Mendelson C.R., Cleland W.H., Smith M.E., Simpson E.R. Regulation of aromatase activity of stromal cells derived from human adipose tissue. Endocrinology. 111:1982;1077-1085.
    • (1982) Endocrinology , vol.111 , pp. 1077-1085
    • Mendelson, C.R.1    Cleland, W.H.2    Smith, M.E.3    Simpson, E.R.4
  • 34
    • 0016293443 scopus 로고
    • Utilization of oxygen and reduced nicotinamide adenine dinucleotide phosphate by human placental microsomes during aromatization of androstenedione
    • Thompson E.A., Sitteri P.K. Utilization of oxygen and reduced nicotinamide adenine dinucleotide phosphate by human placental microsomes during aromatization of androstenedione. J Biol Chem. 249:1974;5364-5367.
    • (1974) J Biol Chem , vol.249 , pp. 5364-5367
    • Thompson, E.A.1    Sitteri, P.K.2
  • 35
    • 0016272566 scopus 로고
    • The involvement of human placental microsomal cytochrome P-450 in aromataization
    • Thompson E.A., Sitteri P.K. The involvement of human placental microsomal cytochrome P-450 in aromataization. J Biol Chem. 249:1974;5373-5378.
    • (1974) J Biol Chem , vol.249 , pp. 5373-5378
    • Thompson, E.A.1    Sitteri, P.K.2
  • 36
    • 0027315887 scopus 로고
    • Mechanistic studies on aromatase and related C-C bond cleaving P-450 enzymes
    • Akhtar M., Njar V.C.O., Wright J.N. Mechanistic studies on aromatase and related C-C bond cleaving P-450 enzymes. J Steroid Biochem Mol Biol. 44:1993;375-387.
    • (1993) J Steroid Biochem Mol Biol , vol.44 , pp. 375-387
    • Akhtar, M.1    Njar, V.C.O.2    Wright, J.N.3
  • 37
    • 0025187459 scopus 로고
    • Mechanism and inhibition of cytochrome P-450 aromatase
    • Cole P.A., Robinson C.H. Mechanism and inhibition of cytochrome P-450 aromatase. J Med Chem. 33:1990;2933-2944.
    • (1990) J Med Chem , vol.33 , pp. 2933-2944
    • Cole, P.A.1    Robinson, C.H.2
  • 38
    • 0006656956 scopus 로고
    • Isolation of a full-length cDNA insert encoding human aromatase system cytochrome P-450 and its expression in nonsteroidogenic cells
    • Corbin C., Graham-Lorence S., McPhaul M., Mason J., Mendelson C., Simpson E. Isolation of a full-length cDNA insert encoding human aromatase system cytochrome P-450 and its expression in nonsteroidogenic cells. Proc Natl Acad Sci USA. 85:1988;8948-8952.
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 8948-8952
    • Corbin, C.1    Graham-Lorence, S.2    McPhaul, M.3    Mason, J.4    Mendelson, C.5    Simpson, E.6
  • 39
    • 0025765126 scopus 로고
    • The P-450 superfamily: Update on new sequences, gene mapping and recommended nomenclature
    • Nebert DW, Nelson DR, Coon MJ, et al. The P-450 superfamily: update on new sequences, gene mapping and recommended nomenclature. DNA Mol Biol 1991;10:1-14.
    • (1991) DNA Mol Biol , vol.10 , pp. 1-14
    • Nebert, D.W.1    Nelson, D.R.2    Coon, M.J.3
  • 40
    • 0017755181 scopus 로고
    • The effect of an aromatase inhibitor, 4-hydroxy-4-androstene-3,17-dione, on estrogen dependent processes in reproduction and breast cancer
    • Brodie A.M.H., Schwarzel W.C., Shaikh A.A., Brodie H.J. The effect of an aromatase inhibitor, 4-hydroxy-4-androstene-3,17-dione, on estrogen dependent processes in reproduction and breast cancer. Endocrinology. 100:1974;1684-1694.
    • (1974) Endocrinology , vol.100 , pp. 1684-1694
    • Brodie, A.M.H.1    Schwarzel, W.C.2    Shaikh, A.A.3    Brodie, H.J.4
  • 41
    • 0017132777 scopus 로고
    • Studies on the mechanism of estrogen biosynthesis in the rat ovary-1
    • Brodie A.M.H., Schwarzel W.C., Brodie H.J. Studies on the mechanism of estrogen biosynthesis in the rat ovary-1. J Steroid Biochem. 7:1976;787-793.
    • (1976) J Steroid Biochem , vol.7 , pp. 787-793
    • Brodie, A.M.H.1    Schwarzel, W.C.2    Brodie, H.J.3
  • 42
    • 0020326595 scopus 로고
    • Effects of 4-hydroxyandrostenedione and other compounds in the DMBA breast carcinoma model
    • Brodie A.M.H., Garrett W.M., Hendrickson J.R., Tsai-Morris C.H. Effects of 4-hydroxyandrostenedione and other compounds in the DMBA breast carcinoma model. Cancer Res. 42:1982;3360s-3364s.
    • (1982) Cancer Res , vol.42
    • Brodie, A.M.H.1    Garrett, W.M.2    Hendrickson, J.R.3    Tsai-Morris, C.H.4
  • 43
    • 0019800997 scopus 로고
    • Inactivation of aromatase activity in placental and ovarian microsomes by 4-hydroxyandrostene-3,17-dione and 4-acetoxyandrostene-3,17-dione
    • Brodie AMH, Garrett WM, Hendrickson JR, Marcotte PA., Robinson CH. Inactivation of aromatase activity in placental and ovarian microsomes by 4-hydroxyandrostene-3,17-dione and 4-acetoxyandrostene-3,17-dione. Steroids 1981;38:693-702.
    • (1981) Steroids , vol.38 , pp. 693-702
    • Brodie, A.M.H.1    Garrett, W.M.2    Hendrickson, J.R.3    Marcotte, P.A.4    Robinson, C.H.5
  • 44
    • 0018914490 scopus 로고
    • Inhibition of peripheral aromatization by aromatase inhibitors, 4-hydroxy-and 4-acetoxy-androstene-3,17-dione
    • Brodie A.M.H., Longcope C. Inhibition of peripheral aromatization by aromatase inhibitors, 4-hydroxy-and 4-acetoxy-androstene-3,17-dione. Clin Endocrin. 106:1980;19-21.
    • (1980) Clin Endocrin , vol.106 , pp. 19-21
    • Brodie, A.M.H.1    Longcope, C.2
  • 45
    • 0026639780 scopus 로고
    • The influence of intramuscular (i.m.) 4-hydroxyandrostenedione on peripheral aromatization in breast cancer patients
    • Jones AL, MacNeill F, Jacobs S, Lønning PE, Doesett M, Powles TJ. The influence of intramuscular (i.m.) 4-hydroxyandrostenedione on peripheral aromatization in breast cancer patients. Eur J Cancer 1992;28A:1712-6.
    • (1992) Eur J Cancer , vol.28 A , pp. 1712-1716
    • Jones, A.L.1    MacNeill, F.2    Jacobs, S.3    Lønning, P.E.4    Doesett, M.5    Powles, T.J.6
  • 47
    • 0021712326 scopus 로고
    • 4-Hydroxyandrostenedione treatment of postmenopausal patients with advanced breast cancer
    • Coombes R.C., Goss P., Dowsett M., Gazet J.C., Brodie A.M.H. 4-Hydroxyandrostenedione treatment of postmenopausal patients with advanced breast cancer. Lancet. 2:1984;1237-1239.
    • (1984) Lancet , vol.2 , pp. 1237-1239
    • Coombes, R.C.1    Goss, P.2    Dowsett, M.3    Gazet, J.C.4    Brodie, A.M.H.5
  • 48
    • 0022471541 scopus 로고
    • Treatment of advanced post-menopausal breast cancer with aromatase inhibitor, 4-hydroxyandrostenedione-Phase 2 report
    • Goss P.E., Coombes R.L., Powles T.J., Brodie A.M.H. Treatment of advanced post-menopausal breast cancer with aromatase inhibitor, 4-hydroxyandrostenedione-Phase 2 report. Cancer Res. 46:1986;4823-4826.
    • (1986) Cancer Res , vol.46 , pp. 4823-4826
    • Goss, P.E.1    Coombes, R.L.2    Powles, T.J.3    Brodie, A.M.H.4
  • 49
  • 50
    • 0027971584 scopus 로고
    • Formestane in the treatment of advanced postmenopausal breast cancer
    • Possinger K, Jonat W, Hoffken K. Formestane in the treatment of advanced postmenopausal breast cancer. Ann Oncol 1994;5:S7-S10.
    • (1994) Ann Oncol , vol.5
    • Possinger, K.1    Jonat, W.2    Hoffken, K.3
  • 52
    • 0023637445 scopus 로고
    • Oral 4-hydroxyandrostenedione, a new endocrine treatment for disseminated breast cancer
    • Cunningham D., Powles T.J., Dowsett M., et al. Oral 4-hydroxyandrostenedione, a new endocrine treatment for disseminated breast cancer. Cancer Chemother Pharmacol. 20:1987;253-255.
    • (1987) Cancer Chemother Pharmacol , vol.20 , pp. 253-255
    • Cunningham, D.1    Powles, T.J.2    Dowsett, M.3
  • 53
    • 0028131860 scopus 로고
    • Comparison of the selective aromatase inhibitor formestane with tamoxifen as first-line hormonal therapy in postmenopausal women with advanced breast cancer
    • Carrion R.P., Candel V.A., Calabresi F., et al. Comparison of the selective aromatase inhibitor formestane with tamoxifen as first-line hormonal therapy in postmenopausal women with advanced breast cancer. Ann Oncol. 7:1994;S19-S24.
    • (1994) Ann Oncol , vol.7
    • Carrion, R.P.1    Candel, V.A.2    Calabresi, F.3
  • 54
    • 0023518823 scopus 로고
    • 7α-Substituted androstenediones as effective in vitro and in vivo inhibitors of aromatase
    • Brueggermeier R.W., Li P.K., Snider C.E., Darby M.V., Katlic N.E. 7α-Substituted androstenediones as effective in vitro and in vivo inhibitors of aromatase. Steroids. 50:1987;163-178.
    • (1987) Steroids , vol.50 , pp. 163-178
    • Brueggermeier, R.W.1    Li, P.K.2    Snider, C.E.3    Darby, M.V.4    Katlic, N.E.5
  • 55
    • 0030748661 scopus 로고    scopus 로고
    • Endocrine and clinical effects of exemestane (PNU 155971), a novel steroidal aromatase inhibitor, in postmenopausal breast cancer patients: A phase I study
    • Johannessen D.C., Engan T., di Salle E., et al. Endocrine and clinical effects of exemestane (PNU 155971), a novel steroidal aromatase inhibitor, in postmenopausal breast cancer patients a phase I study . Clin Cancer Res. 1997;1101-1108.
    • (1997) Clin Cancer Res , pp. 1101-1108
    • Johannessen, D.C.1    Engan, T.2    Di Salle, E.3
  • 56
    • 0022550064 scopus 로고
    • 1-Methly-1,4-androstadiene-3,17-dione (SH489) characterization of an irreversible inhibitor of estrogen biosynthesis
    • Henderson D., Norbisrath G., Kerb U. 1-Methly-1,4-androstadiene-3,17-dione (SH489) characterization of an irreversible inhibitor of estrogen biosynthesis . J Steroid Biochem. 24:1986;303-306.
    • (1986) J Steroid Biochem , vol.24 , pp. 303-306
    • Henderson, D.1    Norbisrath, G.2    Kerb, U.3
  • 57
    • 0000106947 scopus 로고
    • Substrate-induced inactivation of aromatase by allenic and acetylenic steroids
    • Metcalf B.W., Wright C.L., Burkhart J.P., Johnston J.O. Substrate-induced inactivation of aromatase by allenic and acetylenic steroids. J Amer Chem Soc. 103:1981;3221-3222.
    • (1981) J Amer Chem Soc , vol.103 , pp. 3221-3222
    • Metcalf, B.W.1    Wright, C.L.2    Burkhart, J.P.3    Johnston, J.O.4
  • 58
    • 0031663593 scopus 로고    scopus 로고
    • In vivo inhibition of aromatization by exemestane, a novel irreversible aromatase inhibitor, in postmenopausal breast cancer patients
    • Geisler J, King N, Anker G, et al. In vivo inhibition of aromatization by exemestane, a novel irreversible aromatase inhibitor, in postmenopausal breast cancer patients. Clin Cancer Res 1998: 4:2089-93.
    • (1998) Clin Cancer Res , vol.4 , pp. 2089-2093
    • Geisler, J.1    King, N.2    Anker, G.3
  • 59
    • 0020078292 scopus 로고
    • Aminoglutethimide as treatment of postmenopausal women with advanced breast carcinoma: Correlation of clinical and hormonal responses
    • Santen R.J., Worgul T.J., Lipton A., et al. Aminoglutethimide as treatment of postmenopausal women with advanced breast carcinoma correlation of clinical and hormonal responses . Ann Intern Med. 96:1982;94-101.
    • (1982) Ann Intern Med , vol.96 , pp. 94-101
    • Santen, R.J.1    Worgul, T.J.2    Lipton, A.3
  • 60
    • 0028170545 scopus 로고
    • Arimidex: A potent and selective fourth-generation aromatase inhibitor
    • Plourde P.V., Dyroff M., Dukes M. Arimidex a potent and selective fourth-generation aromatase inhibitor . Breast Cancer Res Treat. 30:1994;103-111.
    • (1994) Breast Cancer Res Treat , vol.30 , pp. 103-111
    • Plourde, P.V.1    Dyroff, M.2    Dukes, M.3
  • 61
    • 0025697212 scopus 로고
    • Highly selective inhibition of estrogen biosynthesis by CGS 20267, a new non-steroidal aromatase inhibitor
    • Bhatnagar A.S., Hausler A., Trunet P., Schieweck K., Lang M., Bowman P. Highly selective inhibition of estrogen biosynthesis by CGS 20267, a new non-steroidal aromatase inhibitor. J Steroid Biochem Mol Biol. 37:1990;1021-1027.
    • (1990) J Steroid Biochem Mol Biol , vol.37 , pp. 1021-1027
    • Bhatnagar, A.S.1    Hausler, A.2    Trunet, P.3    Schieweck, K.4    Lang, M.5    Bowman, P.6
  • 62
    • 9244245282 scopus 로고    scopus 로고
    • A randomized trial comparing two doses of the new selective aromatase inhibitor anastrozole ('ARIMIDEX') with megestrol acetate in postmenopausal patients with advanced breast cancer
    • Jonat W, Howell A, Blomqvist C, et al. A randomized trial comparing two doses of the new selective aromatase inhibitor anastrozole ('ARIMIDEX') with megestrol acetate in postmenopausal patients with advanced breast cancer. Eur J Cancer 1996;32A:404-12.
    • (1996) Eur J Cancer , vol.32 A , pp. 404-412
    • Jonat, W.1    Howell, A.2    Blomqvist, C.3
  • 63
    • 0001043073 scopus 로고    scopus 로고
    • Significant improved survival with Arimidex (anastrozole) versus megestrol acetate in postmenopausal advanced breast cancer: Updated results of two randomized trials
    • The Arimidex International study Group, Houston, TX, Kiel, Germany, Manchester, UK, Wilmington, DE, Macclesfield, UK, (Arimidex is a trademark, property of Zeneca Limited)
    • Buzdar A, Jonat W, Howell A, Yin H, Lee D. Significant improved survival with Arimidex (anastrozole) versus megestrol acetate in postmenopausal advanced breast cancer: updated results of two randomized trials. The Arimidex International study Group, Houston, TX, Kiel, Germany, Manchester, UK, Wilmington, DE, Macclesfield, UK, (Arimidex is a trademark, property of Zeneca Limited). Proceedings of American Society of Clinical Oncology 1997;16:156a.
    • (1997) Proceedings of American Society of Clinical Oncology , vol.16
    • Buzdar, A.1    Jonat, W.2    Howell, A.3    Yin, H.4    Lee, D.5
  • 64
    • 0000707927 scopus 로고    scopus 로고
    • Letrozole, a new potent, selective aromatase inhibitor (AI) superior to aminoglutethimide (AG) in postmenopausal women with advanced breast cancer (ABC) previously treated with anti-estrogens
    • The Letrozole International Trial group (AR/BC3)
    • Marty M, Gershanovich M, Campos B, et al. Letrozole, a new potent, selective aromatase inhibitor (AI) superior to aminoglutethimide (AG) in postmenopausal women with advanced breast cancer (ABC) previously treated with anti-estrogens. The Letrozole International Trial group (AR/BC3). Proceedings of ASCO 1997;16:156a.
    • (1997) Proceedings of ASCO , vol.16
    • Marty, M.1    Gershanovich, M.2    Campos, B.3
  • 65
    • 0027985528 scopus 로고
    • A new nude mouse model for postmenopausal breast cancer using MCF-7 cells transfected with the human aromatase gene
    • Yue W., Zhou D., Chen S., Brodie A. A new nude mouse model for postmenopausal breast cancer using MCF-7 cells transfected with the human aromatase gene. Cancer Res. 54:1994;5092-5095.
    • (1994) Cancer Res , vol.54 , pp. 5092-5095
    • Yue, W.1    Zhou, D.2    Chen, S.3    Brodie, A.4
  • 66
    • 0029032231 scopus 로고
    • Effect of aromatase inhibitors on growth of mammary tumors in a nude mouse model
    • Yue W., Wang J., Savinov A., Brodie A. Effect of aromatase inhibitors on growth of mammary tumors in a nude mouse model. Cancer Res. 55:1995;3073-3077.
    • (1995) Cancer Res , vol.55 , pp. 3073-3077
    • Yue, W.1    Wang, J.2    Savinov, A.3    Brodie, A.4
  • 67
    • 0032031754 scopus 로고    scopus 로고
    • In situ aromatization enhances breast tumor estradiol levels and cellular proliferation
    • Yue W., Wang J., Hamilton C.J., Demers L.M., Santen R.J. In situ aromatization enhances breast tumor estradiol levels and cellular proliferation. Cancer Res. 58:1998;927-932.
    • (1998) Cancer Res , vol.58 , pp. 927-932
    • Yue, W.1    Wang, J.2    Hamilton, C.J.3    Demers, L.M.4    Santen, R.J.5
  • 68
    • 0031726080 scopus 로고    scopus 로고
    • The effects of aromatase inhibitors and antiestrogens in the nude mouse model
    • Lu Q., Yue W., Wang J., Lui Y., Long B., Brodie A. The effects of aromatase inhibitors and antiestrogens in the nude mouse model. Breast Cancer Res Treat. 50:1998;63-71.
    • (1998) Breast Cancer Res Treat , vol.50 , pp. 63-71
    • Lu, Q.1    Yue, W.2    Wang, J.3    Lui, Y.4    Long, B.5    Brodie, A.6
  • 69
    • 0000047030 scopus 로고    scopus 로고
    • Preclinical studies using the intratumoral aromatase model for postmenopausal breast cancer
    • Brodie A., Lu Q., Liu Y., Long B., Wang J.P., Yue W. Preclinical studies using the intratumoral aromatase model for postmenopausal breast cancer. Oncology. 12:1998;29-33.
    • (1998) Oncology , vol.12 , pp. 29-33
    • Brodie, A.1    Lu, Q.2    Liu, Y.3    Long, B.4    Wang, J.P.5    Yue, W.6
  • 70
    • 0032711815 scopus 로고    scopus 로고
    • The effect of combining aromatase inhibitors with antiestrogens on tumor growth in a nude mouse model for breast cancer
    • Lu Q, Liu Y, Long BJ, Grigoryev D, Gimbel M, Brodie A. The effect of combining aromatase inhibitors with antiestrogens on tumor growth in a nude mouse model for breast cancer. Breast Cancer Res Treat 1999;57:183-92.
    • (1999) Breast Cancer Res Treat , vol.57 , pp. 183-192
    • Lu, Q.1    Liu, Y.2    Long, B.J.3    Grigoryev, D.4    Gimbel, M.5    Brodie, A.6
  • 71
    • 0030007732 scopus 로고    scopus 로고
    • Treatment with formestane alone and in combination with aminoglutethimide in heavily pretreated cancer patients: Clinical and endocrine effects
    • Geisler J., Johannessen D.C., Anker G., Lønning P.E. Treatment with formestane alone and in combination with aminoglutethimide in heavily pretreated cancer patients clinical and endocrine effects . Eur J Cancer. 32:1996;789-792.
    • (1996) Eur J Cancer , vol.32 , pp. 789-792
    • Geisler, J.1    Johannessen, D.C.2    Anker, G.3    Lønning, P.E.4
  • 72
    • 0029031797 scopus 로고
    • Aromatase inhibition with 4-OH androtenedione after prior aromatase inhibition with aminoglutethimide in women with advanced breast cancer
    • Murray R., Pitt P. Aromatase inhibition with 4-OH androtenedione after prior aromatase inhibition with aminoglutethimide in women with advanced breast cancer. Breast Cancer Res Treat. 35:1995;249-253.
    • (1995) Breast Cancer Res Treat , vol.35 , pp. 249-253
    • Murray, R.1    Pitt, P.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.