Noncalcemic, antiproliferative, transcriptionally active, 24-fluorinated hybrid analogues of the hormone 1α,25-dihydroxyvitamin D3. Synthesis and preliminary biological evaluation

Journal of Medicinal Chemistry

Volumn 41, Issue 16, 1998, Pages 3008-3014

  Posner, Gary H ^a   Lee, Jae Kyoo ^a   Wang, Qiang ^a   Peleg, Sara ^b   Burke, Martin ^c   Brem, Henry ^c   Dolan, Patrick ^d   Kensler, Thomas W ^d  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b UNIVERSITY OF TEXAS   (United States)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d The Johns Hopkins University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCITRIOL DERIVATIVE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; LIPOPHILICITY; NONHUMAN; STEREOCHEMISTRY;

ADMINISTRATION, ORAL; ANIMALS; ANTINEOPLASTIC AGENTS; CALCITRIOL; CALCIUM; CELL DIVISION; CIRCULAR DICHROISM; CYTOCHROME P-450 ENZYME SYSTEM; DRUG SCREENING ASSAYS, ANTITUMOR; KERATINOCYTES; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MICE; RATS; RATS, INBRED F344; STEREOISOMERISM; STEROID HYDROXYLASES; TRANSCRIPTION, GENETIC; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 15144345623     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm980031t     Document Type: Article

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