Transgenic models in xenobiotic metabolism and toxicology

Toxicology

Volumn 181-182, Issue , 2002, Pages 237-239

  Gonzalez, Frank J ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Cancer susceptibility; Chemical carcinogens; Gene knockout mice; P450s; Xenobiotic metabolizing enzymes

Indexed keywords

CARCINOGEN; CYTOCHROME P450; ENZYME; EPOXIDE HYDROLASE; OXIDOREDUCTASE; QUINONE DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; TOXIN;

ANIMAL MODEL; ANIMAL TISSUE; CHEMICAL CARCINOGENESIS; CONTROLLED STUDY; DEVELOPMENT; DRUG METABOLISM; GENE; HOMEOSTASIS; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SHORT SURVEY; TOXICITY; TOXICOLOGY; XENOBIOTIC METABOLISM;

ANIMALIA; MAMMALIA;

EID: 0037184858     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(02)00288-3     Document Type: Article

References (11)

1. Buters J.T., Sakai S., Richter T., Pineau T., Alexander D.L., Savas U., Doehmer J., Ward J.M., Jefcoate C.R., Gonzalez F.J. Cytochrome P450 CYP1B1 determines susceptibility to 7,12-dimethylbenz[a]anthracene-induced lymphomas. Proc. Natl. Acad. Sci. USA. 96:1999;1977-1982.
2. Caporaso N., Goldstein A. Cancer genes: single and susceptibility: exposing the difference. Pharmacogenetics. 5:1995;59-63.
3. Dalton T.P., Dieter M.Z., Matlib R.S., Childs N.L., Shertzer H.G., Genter M.B., Nebert D.W. Targeted knockout of CYP1A1 gene does not alter hepatic constitutive expression of other genes in the mouse [Ah] battery. Biochem. Biophys. Res. Commun. 267:2000;184-189.
4. Gonzalez F.J., Idle J.R. Pharmacogenetic phenotyping and genotyping present status and future potential. Clin. Pharmacokinet. 26:1994;59-70.
5. Henderson C.J., Smith A.G., Ure J., Brown K., Bacon E.J., Wolf C.R. Increased skin tumorigenesis in mice lacking pi class glutathione S-transferases. Proc. Natl. Acad. Sci. USA. 95:1998;5275-5280.
6. Lee S.S., Buters J.T., Pineau T., Fernandez-Salguero P., Gonzalez F.J. Role of CYP2E1 in the hepatotoxicity of acetaminophen. J. Biol. Chem. 271:1996;12063-12067.
7. Miyata M., Kudo G., Lee Y.H., Yang T.J., Gelboin H.V., Fernandez-Salguero P., Kimura S., Gonzalez F.J. Targeted disruption of the microsomal epoxide hydrolase gene. Microsomal epoxide hydrolase is required for the carcinogenic activity of 7,12-dimethylbenz[a]anthracene. J. Biol. Chem. 274:1999;23963-23968.
8. Pineau T., Fernandez-Salguero P., Lee S.S., McPhail T., Ward J.M., Gonzalez F.J. Neonatal lethality associated with respiratory distress in mice lacking cytochrome P450 1A2. Proc. Natl. Acad. Sci. USA. 92:1995;5134-5138.
9. Radjendirane V., Joseph P., Lee Y.H., Kimura S., Klein-Szanto A.J., Gonzalez F.J., Jaiswal A.K. Disruption of the DT diaphorase (NQO1) gene in mice leads to increased menadione toxicity. J. Biol. Chem. 273:1998;7382-7389.
10. Sinal C.J., Miyata M., Tohkin M., Nagata K., Bend J.R., Gonzalez F.J. Targeted disruption of soluble epoxide hydrolase reveals a role in blood pressure regulation. J. Biol. Chem. 275:2000;40504-40510.
11. Zaher H., Buters J.T., Ward J.M., Bruno M.K., Lucas A.M., Stern S.T., Cohen S.D., Gonzalez F.J. Protection against acetaminophen toxicity in CYP1A2 and CYP2E1 double-null mice. Toxicol. Appl. Pharmacol. 152:1998;193-199.