Activation of the antitumor agent aminoflavone (NSC 686288) is mediated by induction of tumor cell cytochrome P450 1A1/1A2

Molecular Pharmacology

Volumn 62, Issue 1, 2002, Pages 143-153

  Kuffel, Mary J ^a   Schroeder, Jennifer C ^a   Pobst, Lori J ^a   Naylor, Stephen ^a   Reid, Joel M ^a   Kaufmann, Scott H ^a   Ames, Matthew M ^a,b  

^a Departments of Oncology   (United States)

^b MAYO GRADUATE SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

(5 AMINO 2,3 FLUOROPHENYL) 6,8 DIFLUORO 7 METHYL 4H 1 BENZOPYRAN 4 ONE; 3 METHYLCHOLANTHRENE; 5 AMINO 6,8 DIFLUORO 2 (3 FLUOROPHENYL) 7 METHYL 4H 1 BENZOPYRAN 4 ONE; ALPHA NAPHTHOFLAVONE; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; FLAVONE DERIVATIVE; PROTEIN P21; PROTEIN P53; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CANCER INHIBITION; CONTROLLED STUDY; COVALENT BOND; CYTOTOXICITY; DNA DAMAGE; DRUG ACTIVATION; DRUG METABOLISM; ENZYME INDUCTION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; ISOTOPE LABELING; KIDNEY CANCER; NONHUMAN; NUCLEOTIDE SEQUENCE; OVARY CANCER; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; BINDING SITES; CELL DIVISION; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 CYP1A2; DNA; DNA DAMAGE; ENZYME INDUCTION; FLAVONOIDS; HT29 CELLS; HUMANS; MICROSOMES, LIVER; RATS; RATS, INBRED F344; TUMOR CELLS, CULTURED;

EID: 0036085571     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.62.1.143     Document Type: Article

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