Metabolism and growth inhibition of four retinoids in head and neck squamous normal and malignant cells

British Journal of Cancer

Volumn 85, Issue 4, 2001, Pages 630-635

  Klaassen, I ^a   Brakenhoff, R H ^a   Smeets, S J ^a   Snow, G B ^a   Braakhuis, B J M ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Head and neck cancer; Isotretinoin; Keratinocytes; Metabolism; Retinoid; Squamous

Indexed keywords

4 OXOISOTRETINOIN; ISOTRETINOIN; RETINOIC ACID; RETINOID DERIVATIVE; RETINOL;

ARTICLE; CANCER CELL; CANCER INHIBITION; CANCER PREVENTION; CELL DIFFERENTIATION; CONTROLLED STUDY; DRUG METABOLISM; GENE EXPRESSION REGULATION; GROWTH INHIBITION; HEAD AND NECK CANCER; HUMAN; HUMAN CELL; HUMAN TISSUE; KERATINOCYTE; PRIORITY JOURNAL;

CARCINOMA, SQUAMOUS CELL; CELL DIVISION; HEAD AND NECK NEOPLASMS; HUMANS; KERATINOCYTES; RECEPTORS, RETINOIC ACID; RETINOIDS; TUMOR CELLS, CULTURED;

EID: 0035902840     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1054/bjoc.2001.1952     Document Type: Article

References (39)

1. Retinoic acid receptors and retinoid X receptors: Interactions with endogenous retinoic acids
2. Chemoprevention of head and neck cancer
3. Retinoic acid and synthetic analogs differentially activate retinoic acid receptor dependent transcription
4. Retinoid metabolism in spontaneously transformed mouse fibroblasts (Balb/c 3T12-3 cells): Enzymatic conversion of retinol to anhydroretinol
5. Retinoids in cancer prevention and therapy
6. Importance of pharmacodynamics in the in vitro antiproliferative activity of the antifolates methotrexate and 10-ethyl- 10-deazaaminopterin against human head and neck squamous cell carcinoma
7. Retinoid metabolism and all-trans retinoic acid-induced growth inhibition in head and neck squamous cell carcinoma cell lines
8. Cell surface antigen expression and prognosis
9. A HPLC method for the determination of 9-cis retinoic acid (ALRT 1057) and its 4-oxo metabolite in human plasma
10. Identification and quantitation of all-trans-and 13-cis-retinoic acid and 13-cis-4-oxoretinoic acid in human plasma
11. Cellular biology and biochemistry of the retinoids
12. Metabolism of all-trans-retinol in normal human cell strains and squamous cell carcinoma (SCC) lines from the oral cavity and skin: Reduced esterification of retinol in SCC lines
13. 9-cis retinoic acid is a high affinity ligand for the retinoid X receptor
14. 13-cis-retinoic acid in the treatment of oral leukoplakia
15. Prevention of second primary tumors with isotretinoin in squamous-cell carcinoma of the head and neck
16. Retinoids and human cancer
17. Considerations for in vitro retinoid experiments: Importance of protein interaction
18. Enhanced turnover of all-trans-retinoic acid and increased formation of polar metabolites in head and neck squamous cell carcinoma cells compared to normal oral keratinocytes
19. The expression of retinoic acid receptor γ correlates with retinoic acid sensitivity and metabolism in head and neck squamous cell carcinoma cell lines
20. Biochemical treatment of precancerous oral lesions: The effectiveness of various analogues of retinoic acid
21. Autoregulation of retinoic acid biosynthesis through regulation of retinol esterification in human keratinocytes
22. Modulation of retinoic acid receptor function alters the growth inhibitory response of oral SCC cells to retinoids
23. New pathway for retinol metabolism in liver microsomes
24. Treatment of advanced squamous cell carcinoma of the head and neck with isotretinoin: A phase II randomized trial
25. Effects of vitamin A and its analogs (retinoids) on normal and neoplastic cells
26. Vitamin A receptors
27. Clinical pharmacology of all-trans retinoic acid
28. Implication of retinoic acid receptor gamma in squamous differentiation and response to retinoic acid in head and neck SqCC/Y1 squamous carcinoma cells
29. Phase I trial of all-trans retinoic acid in patients with treated head and neck squamous carcinoma
30. Metabolism of all-trans, 9-cis, and 13-cis isomers of retinal by purified isozymes of microsomal cytochrome P450 and mechanism-based inhibition of retinoid oxidation by citral
31. CYP26, a novel mammalian cytochrome P450, is induced by retinoic acid and defines a new family
32. A simple and reliable technique for culturing of human oral keratinocytes and fibroblasts
33. Metabolism of all-trans-retinoic acid in hamster liver microsomes: Oxidation of 4-hydroxy- to 4-keto-retinoic acid
34. Identification of a decarboxylation product of retinoic acid
35. Glucuronidation and isomerization of all-trans- and 13-cis-retinoic acid by liver microsomes of phenobarbital-or 3-methylcholanthrene-treated rats
36. Human retinoic acid (RA) 4-hydroxylase (CYP26) is highly specific for all-trans-RA and can be induced through RA receptors in human breast and colon carcinoma cells
37. Differential effects of synthetic nuclear retinoid receptor-selective retinoids on the growth of human non-small cell lung carcinoma cells
38. Simultaneous analysis of retinol, all-trans-and 13-cis-retinoic acid and 13-cis-4-oxoretinoic acid in plasma by liquid chromatography using on-column concentration after single-phase fluid extraction
39. Cdna cloning of human retinoic acid-metabolizing enzyme (hP450RAI) identifies a novel family of cytochromes P450