Sterol transport in yeast and the oxysterol binding protein homologue (OSH) family

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

Volumn 1771, Issue 6, 2007, Pages 769-780

  Schulz, Timothy A ^a   Prinz, William A ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

Lipid; Lipid binding protein; Membrane transport; Oxysterol binding protein; Sterol; Yeast

Indexed keywords

BINDING PROTEIN; ERGOSTEROL; LIPID BINDING PROTEIN; OXYSTEROL; OXYSTEROL BINDING PROTEIN; STEROL; UNCLASSIFIED DRUG;

CELL MEMBRANE; CELL ORGANELLE; CELL POLARITY; CHOLESTEROL TRANSPORT; ENDOCYTOSIS; EUKARYOTIC CELL; GOLGI COMPLEX; MEMBRANE TRANSPORT; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN STRUCTURE; REVIEW; SEQUENCE HOMOLOGY; TRANSPORT KINETICS; YEAST;

BIOLOGICAL TRANSPORT, ACTIVE; CARRIER PROTEINS; CELL MEMBRANE; ENDOPLASMIC RETICULUM; ERGOSTEROL; GOLGI APPARATUS; INTRACELLULAR MEMBRANES; PROTEIN TRANSPORT; SACCHAROMYCES CEREVISIAE PROTEINS; STEROLS; VESICULAR TRANSPORT PROTEINS;

EUKARYOTA;

EID: 34249863339     PISSN: 13881981     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbalip.2007.03.003     Document Type: Review

References (128)

1. Liscum L., and Munn N.J. Intracellular cholesterol transport. Biochim. Biophys. Acta 1438 (1999) 19-37
2. Maxfield F.R., and Wustner D. Intracellular cholesterol transport. J. Clin. Invest. 110 (2002) 891-898
3. Yeagle P.L. The Membrane of Cells (1993), Academic Press, Inc., New York
4. Incardona J.P., and Eaton S. Cholesterol in signal transduction. Curr. Opin. Cell Biol. 12 (2000) 193-203
5. McIntosh T.J., and Simon S.A. Roles of bilayer material properties in function and distribution of membrane proteins. Annu. Rev. Biophys. Biomol. Struct. 35 (2006) 177-198
6. Sturley S.L., Patterson M.C., Balch W., and Liscum L. The pathophysiology and mechanisms of NP-C disease. Biochim. Biophys. Acta 1685 (2004) 83-87
7. Nofer J.R., and Remaley A.T. Tangier disease: still more questions than answers. Cell. Mol. Life Sci. 62 (2005) 2150-2160
8. Orci L., Montesano R., Meda P., Malaisse-Lagae F., Brown D., Perrelet A., and Vassalli P. Heterogeneous distribution of filipin-cholesterol complexes across the cisternae of the Golgi apparatus. Proc. Natl. Acad. Sci. U. S. A. 78 (1981) 293-297
9. Bretscher M.S., and Munro S. Cholesterol and the Golgi apparatus. Science 261 (1993) 1280-1281
10. Coxey R.A., Pentchev P.G., Campbell G., and Blanchette-Mackie E.J. Differential accumulation of cholesterol in Golgi compartments of normal and Niemann-Pick type C fibroblasts incubated with LDL: a cytochemical freeze-fracture study. J. Lipid Res. 34 (1993) 1165-1176
11. Holthuis J.C., van Meer G., and Huitema K. Lipid microdomains, lipid translocation and the organization of intracellular membrane transport (Review). Mol. Membr. Biol. 20 (2003) 231-241
12. Brugger B., Sandhoff R., Wegehingel S., Gorgas K., Malsam J., Helms J.B., Lehmann W.D., Nickel W., and Wieland F.T. Evidence for segregation of sphingomyelin and cholesterol during formation of COPI-coated vesicles. J. Cell Biol. 151 (2000) 507-518
13. Maxfield F.R., and Menon A.K. Intracellular sterol transport and distribution. Curr. Opin. Cell Biol. 18 (2006) 379-385
14. Chang T.Y., Chang C.C., Ohgami N., and Yamauchi Y. Cholesterol sensing, trafficking, and esterification. Annu. Rev. Cell Dev. Biol. 22 (2006) 129-157
15. Soccio R.E., and Breslow J.L. Intracellular Cholesterol Transport. Arterioscler. Thromb. Vasc. Biol. 4 (2004) 1150-1160
16. Strauss III J.F., Liu P., Christenson L.K., and Watari H. Sterols and intracellular vesicular trafficking: lessons from the study of NPC1. Steroids 67 (2002) 947-951
17. Mukherjee S., and Maxfield F.R. Lipid and cholesterol trafficking in NPC. Biochim. Biophys. Acta 1685 (2004) 28-37
18. Sturley S.L. Conservation of eukaryotic sterol homeostasis: new insights from studies in budding yeast. Biochim. Biophys. Acta 1529 (2000) 155-163
19. Henneberry A.L., and Sturley S.L. Sterol homeostasis in the budding yeast, Saccharomyces cerevisiae. Semin. Cell Dev. Biol. 16 (2005) 155-161
20. Daum G., Lees N.D., Bard M., and Dickson R. Biochemistry, cell biology and molecular biology of lipids of Saccharomyces cerevisiae. Yeast 14 (1998) 1471-1510
21. Daum G., Lees N.D., Bard M., and Dickson R. Biochemistry, cell biology and molecular biology of lipids of Saccharomyces cerevisiae. Yeast 14 (1998) 1471-1510
22. Edqvist J., and Blomqvist K. Fusion and fission, the evolution of sterol carrier protein-2. J. Mol. Evol. 62 (2006) 292-306
23. Bagnat M., Keranen S., Shevchenko A., Shevchenko A., and Simons K. Lipid rafts function in biosynthetic delivery of proteins to the cell surface in yeast. Proc. Natl. Acad. Sci. U. S. A. 97 (2000) 3254-3259
24. Xu X., Bittman R., Duportail G., Heissler D., Vilcheze C., and London E. Effect of the structure of natural sterols and sphingolipids on the formation of ordered sphingolipid/sterol domains (rafts). Comparison of cholesterol to plant, fungal, and disease-associated sterols and comparison of sphingomyelin, cerebrosides, and ceramide. J. Biol. Chem. 276 (2001) 33540-33546
25. Bard M., Woods R.A., Barton D.H., Corrie J.E., and Widdowson D.A. Sterol mutants of Saccharomyces cerevisiae: chromatographic analyses. Lipids 12 (1977) 645-654
26. Gaber R.F., Copple D.M., Kennedy B.K., Vidal M., and Bard M. The yeast gene ERG6 is required for normal membrane function but is not essential for biosynthesis of the cell-cycle-sparking sterol. Mol. Cell. Biol. 9 (1989) 3447-3456
27. Lees N.D., Bard M., Kemple M.D., Haak R.A., and Kleinhans F.W. ESR determination of membrane order parameter in yeast sterol mutants. Biochim. Biophys. Acta 553 (1979) 469-475
28. Emter R., Heese-Peck A., and Kralli A. ERG6 and PDR5 regulate small lipophilic drug accumulation in yeast cells via distinct mechanisms. FEBS Lett. 521 (2002) 57-61
29. Kleinhans F.W., Lees N.D., Bard M., Haak R.A., and Woods R.A. ESR determinations of membrane permeability in a yeast sterol mutant. Chem. Phys. Lipids 23 (1979) 143-154
30. Heese-Peck A., Pichler H., Zanolari B., Watanabe R., Daum G., and Riezman H. Multiple functions of sterols in yeast endocytosis. Mol. Biol. Cell 13 (2002) 2664-2680
31. Grossmann G., Opekarova M., Novakova L., Stolz J., and Tanner W. Lipid raft-based membrane compartmentation of a plant transport protein expressed in Saccharomyces cerevisiae. Eukaryot. Cell 5 (2006) 945-953
32. Munn A.L., Heese-Peck A., Stevenson B.J., Pichler H., and Riezman H. Specific sterols required for the internalization step of endocytosis in yeast. Mol. Biol. Cell 10 (1999) 3943-3957
33. Proszynski T.J., Klemm R.W., Gravert M., Hsu P.P., Gloor Y., Wagner J., Kozak K., Grabner H., Walzer K., Bagnat M., Simons K., and Walch-Solimena C. A genome-wide visual screen reveals a role for sphingolipids and ergosterol in cell surface delivery in yeast. Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 17981-17986
34. Kato M., and Wickner W. Ergosterol is required for the Sec18/ATP-dependent priming step of homotypic vacuole fusion. EMBO J. 20 (2001) 4035-4040
35. Lange Y., and Matthies H.J. Transfer of cholesterol from its site of synthesis to the plasma membrane. J. Biol. Chem. 259 (1984) 14624-14630
36. Kaplan M.R., and Simoni R.D. Transport of cholesterol from the endoplasmic reticulum to the plasma membrane. J. Cell Biol. 101 (1985) 446-453
37. Urbani L., and Simoni R.D. Cholesterol and vesicular stomatitis virus G protein take separate routes from the endoplasmic reticulum to the plasma membrane. J. Biol. Chem. 265 (1990) 1919-1923
38. Field F.J., Born E., Murthy S., and Mathur S.N. Transport of cholesterol from the endoplasmic reticulum to the plasma membrane is constitutive in CaCo-2 cells and differs from the transport of plasma membrane cholesterol to the endoplasmic reticulum. J. Lipid Res. 39 (1998) 333-343
39. Baumann N.A., Sullivan D.P., Ohvo-Rekila H., Simonot C., Pottekat A., Klaassen Z., Beh C.T., and Menon A.K. Transport of newly synthesized sterol to the sterol-enriched plasma membrane occurs via nonvesicular equilibration. Biochemistry 44 (2005) 5816-5826
40. Schnabl M., Daum G., and Pichler H. Multiple lipid transport pathways to the plasma membrane in yeast. Biochim. Biophys. Acta 1687 (2005) 130-140
41. Juschke C., Wachter A., Schwappach B., and Seedorf M. SEC18/NSF-independent, protein-sorting pathway from the yeast cortical ER to the plasma membrane. J. Cell Biol. 169 (2005) 613-622
42. Athenstaedt K., and Daum G. The life cycle of neutral lipids: synthesis, storage and degradation. Cell. Mol. Life Sci. 63 (2006) 1355-1369
43. Zinser E., Paltauf F., and Daum G. Sterol composition of yeast organelle membranes and subcellular distribution of enzymes involved in sterol metabolism. J. Bacteriol. 175 (1993) 2853-2858
44. Milla P., Athenstaedt K., Viola F., Oliaro-Bosso S., Kohlwein S.D., Daum G., and Balliano G. Yeast oxidosqualene cyclase (Erg7p) is a major component of lipid particles. J. Biol. Chem. 277 (2002) 2406-2412
45. Mullner H., Zweytick D., Leber R., Turnowsky F., and Daum G. Targeting of proteins involved in sterol biosynthesis to lipid particles of the yeast Saccharomyces cerevisiae. Biochim. Biophys. Acta 1663 (2004) 9-13
46. Leber R., Landl K., Zinser E., Ahorn H., Spok A., Kohlwein S.D., Turnowsky F., and Daum G. Dual localization of squalene epoxidase, Erg1p, in yeast reflects a relationship between the endoplasmic reticulum and lipid particles. Mol. Biol. Cell 9 (1998) 375-386
47. Mo C., Milla P., Athenstaedt K., Ott R., Balliano G., Daum G., and Bard M. In yeast sterol biosynthesis the 3-keto reductase protein (Erg27p) is required for oxidosqualene cyclase (Erg7p) activity. Biochim. Biophys. Acta 1633 (2003) 68-74
48. Ott R.G., Athenstaedt K., Hrastnik C., Leitner E., Bergler H., and Daum G. Flux of sterol intermediates in a yeast strain deleted of the lanosterol C-14 demethylase Erg11p. Biochim. Biophys. Acta 1735 (2005) 111-118
49. Ness F., Achstetter T., Duport C., Karst F., Spagnoli R., and Degryse E. Sterol uptake in Saccharomyces cerevisiae heme auxotrophic mutants is affected by ergosterol and oleate but not by palmitoleate or by sterol esterification. J. Bacteriol. 180 (1998) 1913-1919
50. Lewis L., Keesler G.A., Fenner G.P., and Parks L.W. Pleiotropic mutations in Saccharomyces cerevisiae affecting sterol uptake and metabolism. Yeast 4 (1988) 93-106
51. Arthington-Skaggs B.A., Crowell D.N., Yang H., Sturley S.L., and Bard M. Positive and negative regulation of a sterol biosynthetic gene (ERG3) in the post-squalene portion of the yeast ergosterol pathway. FEBS Lett. 392 (1996) 161-165
52. Wilcox L.J., Balderes D.A., Wharton B., Tinkelenberg A.H., Rao G., and Sturley S.L. Transcriptional profiling identifies two members of the ATP-binding cassette transporter superfamily required for sterol uptake in yeast. J. Biol. Chem. 277 (2002) 32466-32472
53. Bourot S., and Karst F. Isolation and characterization of the Saccharomyces cerevisiae SUT1 gene involved in sterol uptake. Gene 165 (1995) 97-102
54. Alimardani P., Regnacq M., Moreau-Vauzelle C., Ferreira T., Rossignol T., Blondin B., and Berges T. SUT1-promoted sterol uptake involves the ABC transporter Aus1 and the mannoprotein Dan1 whose synergistic action is sufficient for this process. Biochem. J. 381 (2004) 195-202
55. Li Y., and Prinz W.A. ABC-transporters mediate nonvesicular, raft-modulated sterol movement from the plasma membrane to the ER. J. Biol. Chem. 279 (2004) 45226-45234
56. Kaminski W.E., Piehler A., and Wenzel J.J. ABC A-subfamily transporters: structure, function and disease. Biochim. Biophys. Acta 1762 (2006) 510-524
57. Reiner S., Micolod D., Zellnig G., and Schneiter R. A genomewide screen reveals a role of mitochondria in anaerobic uptake of sterols in yeast. Mol. Biol. Cell 17 (2006) 90-103
58. Sesaki H., and Jensen R.E. Ugo1p links the Fzo1p and Mgm1p GTPases for mitochondrial fusion. J. Biol. Chem. 279 (2004) 28298-28303
59. Kishimoto T., Yamamoto T., and Tanaka K. Defects in structural integrity of ergosterol and the Cdc50p-Drs2p putative phospholipid translocase cause accumulation of endocytic membranes, onto which actin patches are assembled in yeast. Mol. Biol. Cell 16 (2005) 5592-5609
60. Heiniger H.J., Kandutsch A.A., and Chen H.W. Depletion of L-cell sterol depresses endocytosis. Nature 263 (1976) 515-517
61. Blanchette-Mackie E.J., Dwyer N.K., Amende L.M., Kruth H.S., Butler J.D., Sokol J., Comly M.E., Vanier M.T., August J.T., Brady R.O., et al. Type-C Niemann-Pick disease: low density lipoprotein uptake is associated with premature cholesterol accumulation in the Golgi complex and excessive cholesterol storage in lysosomes. Proc. Natl. Acad. Sci. U. S. A. 85 (1988) 8022-8026
62. Sleat D.E., Wiseman J.A., El-Banna M., Price S.M., Verot L., Shen M.M., Tint G.S., Vanier M.T., Walkley S.U., and Lobel P. Genetic evidence for nonredundant functional cooperativity between NPC1 and NPC2 in lipid transport. Proc. Natl. Acad. Sci. U. S. A. 101 (2004) 5886-5891
63. Malathi K., Higaki K., Tinkelenberg A.H., Balderes D.A., Almanzar-Paramio D., Wilcox L.J., Erdeniz N., Redican F., Padamsee M., Liu Y., Khan S., Alcantara F., Carstea E.D., Morris J.A., and Sturley S.L. Mutagenesis of the putative sterol-sensing domain of yeast Niemann Pick C-related protein reveals a primordial role in subcellular sphingolipid distribution. J. Cell Biol. 164 (2004) 547-556
64. Berger A.C., Vanderford T.H., Gernert K.M., Nichols J.W., Faundez V., and Corbett A.H. Saccharomyces cerevisiae Npc2p is a functionally conserved homologue of the human Niemann-Pick disease type C 2 protein, hNPC2. Eukaryot Cell 4 (2005) 1851-1862
65. Berger A.C., Hanson P.K., Wylie Nichols J., and Corbett A.H. A yeast model system for functional analysis of the Niemann-Pick type C protein 1 homolog, Ncr1p. Traffic 6 (2005) 907-917
66. Cheruku S.R., Xu Z., Dutia R., Lobel P., and Storch J. Mechanism of cholesterol transfer from the Niemann-Pick type C2 protein to model membranes supports a role in lysosomal cholesterol transport. J. Biol. Chem. 281 (2006) 31594-31604
67. Ko D.C., Binkley J., Sidow A., and Scott M.P. The integrity of a cholesterol-binding pocket in Niemann-Pick C2 protein is necessary to control lysosome cholesterol levels. Proc. Natl. Acad. Sci. U. S. A. 100 (2003) 2518-2525
68. Alpy F., Stoeckel M.E., Dierich A., Escola J.M., Wendling C., Chenard M.P., Vanier M.T., Gruenberg J., Tomasetto C., and Rio M.C. The steroidogenic acute regulatory protein homolog MLN64, a late endosomal cholesterol-binding protein. J. Biol. Chem. 276 (2001) 4261-4269
69. Alpy F., and Tomasetto C. Give lipids a START: the StAR-related lipid transfer (START) domain in mammals. J. Cell Sci. 118 (2005) 2791-2801
70. Tsujishita Y., and Hurley J.H. Structure and lipid transport mechanism of a StAR-related domain. Nat. Struct. Biol. 7 (2000) 408-414
71. Kishida T., Kostetskii I., Zhang Z., Martinez F., Liu P., Walkley S.U., Dwyer N.K., Blanchette-Mackie E.J., Radice G.L., and Strauss III J.F. Targeted mutation of the MLN64 START domain causes only modest alterations in cellular sterol metabolism. J. Biol. Chem. 279 (2004) 19276-19285
72. Hanada K., Kumagai K., Yasuda S., Miura Y., Kawano M., Fukasawa M., and Nishijima M. Molecular machinery for non-vesicular trafficking of ceramide. Nature 426 (2003) 803-809
73. Jiang B., Brown J.L., Sheraton J., Fortin N., and Bussey H. A new family of yeast genes implicated in ergosterol synthesis is related to the human oxysterol binding protein. Yeast 10 (1994) 341-353
74. Beh C.T., Cool L., Phillips J., and Rine J. Overlapping functions of the yeast oxysterol-binding protein homologues. Genetics 157 (2001) 1117-1140
75. Olkkonen V.M., and Lehto M. Oxysterols and oxysterol binding proteins: role in lipid metabolism and atherosclerosis. Ann. Med. 36 (2004) 562-572
76. Olkkonen V.M., Johansson M., Suchanek M., Yan D., Hynynen R., Ehnholm C., Jauhiainen M., Thiele C., and Lehto M. The OSBP-related proteins (ORPs): global sterol sensors for co-ordination of cellular lipid metabolism, membrane trafficking and signalling processes?. Biochem. Soc. Trans. 34 (2006) 389-391
77. Wang P.Y., Weng J., and Anderson R.G.W. OSBP Is a Cholesterol-Regulated Scaffolding Protein in Control of ERK1/2 Activation. Science 307 (2005) 1472-1476
78. Im Y., Raychaudhuri S., Prinz W.A., and Hurley J.H. Structural mechanism for sterol sensing and transport by OSBP-related proteins. Nature 437 (2005) 154-158
79. Raychaudhuri S., Im Y.J., Hurley J.H., and Prinz W.A. Nonvesicular sterol movement from plasma membrane to ER requires oxysterol-binding protein-related proteins and phosphoinositides. J. Cell Biol. 173 (2006) 107-119
80. Sullivan D.P., Ohvo-Rekila H., Baumann N.A., Beh C.T., and Menon A.K. Sterol trafficking between the endoplasmic reticulum and plasma membrane in yeast. Biochem. Soc. Trans. 34 (2006) 356-358
81. Beh C.T., and Rine J. A role for yeast oxysterol-binding protein homologs in endocytosis and in the maintenance of intracellular sterol-lipid distribution. J. Cell Sci. 117 (2004) 2983-2996
82. Voelker D.R. Bridging gaps in phospholipid transport. Trends Biochem. Sci. 30 (2005) 396-404
83. Audhya A., and Emr S.D. Stt4 PI 4-kinase localizes to the plasma membrane and functions in the Pkc1-mediated MAP kinase cascade. Dev. Cell 2 (2002) 593-605
84. Li X., Rivas M.P., Fang M., Marchena J., Mehrotra B., Chaudhary A., Feng L., Prestwich G.D., and Bankaitis V.A. Analysis of oxysterol binding protein homologue Kes1p function in regulation of Sec14p-dependent protein transport from the yeast Golgi complex. J. Cell Biol. 157 (2002) 63-77
85. Perry R.J., and Ridgway N.D. Oxysterol-binding protein and vesicle-associated membrane protein-associated protein are required for sterol-dependent activation of the ceramide transport protein. Mol. Biol. Cell 17 (2006) 2604-2616
86. Bankaitis V.A., Phillips S., Yanagisawa L., Li X., Routt S., and Xie Z. Phosphatidylinositol transfer protein function in the yeast Saccharomyces cerevisiae. Adv. Enzyme Regul. 45 (2005) 155-170
87. Park Y.U., Hwang O., and Kim J. Two-hybrid cloning and characterization of OSH3, a yeast oxysterol-binding protein homolog. Biochem. Biophys. Res. Commun. 293 (2002) 733-740
88. Tinkelenberg A.H., Liu Y., Alcantara F., Khan S., Guo Z., Bard M., and Sturley S.L. Mutations in yeast ARV1 alter intracellular sterol distribution and are complemented by human ARV1. J. Biol. Chem. 275 (2000) 40667-40670
89. Swain E., Baudry K., Stukey J., McDonough V., Germann M., and Nickels Jr. J.T. Sterol-dependent regulation of sphingolipid metabolism in Saccharomyces cerevisiae. J. Biol. Chem. 277 (2002) 26177-26184
90. Daum G., Tuller G., Nemec T., Hrastnik C., Balliano G., Cattel L., Milla P., Rocco F., Conzelmann A., Vionnet C., Kelly D.E., Kelly S., Schweizer E., Schuller H.J., Hojad U., Greiner E., and Finger K. Systematic analysis of yeast strains with possible defects in lipid metabolism. Yeast 15 (1999) 601-614
91. Yano T., Inukai M., and Isono F. Deletion of OSH3 gene confers resistance against ISP-1 in Saccharomyces cerevisiae. Biochem. Biophys. Res. Commun. 315 (2004) 228-234
92. Sano T., Kihara A., Kurotsu F., Iwaki S., and Igarashi Y. Regulation of the sphingoid long-chain base kinase Lcb4p by ergosterol and heme: studies in phytosphingosine-resistant mutants. J. Biol. Chem. 280 (2005) 36674-36682
93. T.P. Levine, S. Munro, Dual targeting of Osh1p, a yeast homologue of oxysterol-binding protein, to both the Golgi and the nucleus-vacuole junction., 12(6):1633-44. 6 (2001), pp. 1633-1644.
94. Wang P., Duan W., Munn A.L., and Yang H. Molecular characterization of Osh6p, an oxysterol binding protein homolog in the yeast Saccharomyces cerevisiae. FEBS J. 272 (2005) 4703-4715
95. Levine T.P., and Munro S. The pleckstrin homology domain of oxysterol-binding protein recognises a determinant specific to Golgi membranes. Curr. Biol. 8 (1998) 729-739
96. Loewen C.J., Roy A., and Levine T.P. A conserved ER targeting motif in three families of lipid binding proteins and in Opi1p binds VAP. EMBO 22 (2003) 2025-2035
97. Lehto M., and Olkkonen V.M. The OSBP-related proteins: a novel protein family involved in vesicle transport, cellular lipid metabolism, and cell signalling. Biochim. Biophys. Acta 1631 (2003) 1-11
98. Schmalix W.A., and Bandlow W. SWH1 from yeast encodes a candidate nuclear factor containing ankyrin repeats and showing homology to mammalian oxysterol-binding protein. Biochim. Biophys. Acta 1219 (1994) 205-210
99. Anantharaman V., and Aravind L. The GOLD domain, a novel protein module involved in Golgi function and secretion. Genome Biol. 3 (2002) research23.1-reseach23.7
100. Ridgway N.D., Dawson P.A., Ho Y.K., Brown M.S., and Goldstein J.L. Translocation of oxysterol binding protein to Golgi apparatus triggered by ligand binding. J. Cell Biol. 116 (1992) 307-319
101. Levine T., and Loewen C. Inter-organelle membrane contact sites: through a glass, darkly. Curr. Opin. Cell Biol. 18 (2006) 371-378
102. Voeltz G.K., Rolls M.M., and Rapoport T.A. Structural organization of the endoplasmic reticulum. EMBO Rep. 3 (2002) 944-950
103. Gaigg B., Simbeni R., Hrastnik C., Paltauf F., and Daum G. Characterization of a microsomal subfraction associated with mitochondria of the yeast, Saccharomyces cerevisiae. Involvement in synthesis and import of phospholipids into mitochondria. Biochim. Biophys. Acta 1234 (1995) 214-220
104. Pichler H., Gaigg B., Hrastnik C., Achleitner G., Kohlwein S.D., Zellnig G., Perktold A., and Daum G. A subfraction of the yeast endoplasmic reticulum associates with the plasma membrane and has a high capacity to synthesize lipids. Eur. J. Biochem. 268 (2001) 2351-2361
105. Achleitner G., Gaigg B., Krasser A., Kainersdorfer E., Kohlwein S.D., Perktold A., Zellnig G., and Daum G. Association between the endoplasmic reticulum and mitochondria of yeast facilitates interorganelle transport of phospholipids through membrane contact. Eur. J. Biochem. 264 (1999) 545-553
106. Roberts P., Moshitch-Moshkovitz S., Kvam E., O'Toole E., Winey M., and Goldfarb D.S. Piecemeal microautophagy of nucleus in Saccharomyces cerevisiae. Mol. Biol. Cell 14 (2003) 129-141
107. Pan X., Roberts P., Chen Y., Kvam E., Shulga N., Huang K., Lemmon S., and Goldfarb D.S. Nucleus-vacuole junctions in Saccharomyces cerevisiae are formed through the direct interaction of Vac8p with Nvj1p. Mol. Biol. Cell 11 (2000) 2445-2457
108. Kvam E., and Goldfarb D.S. Nvj1p is the outer-nuclear-membrane receptor for oxysterol-binding protein homolog Osh1p in Saccharomyces cerevisiae. J. Cell Sci. 117 (2004) 4959-4968
109. Kvam E., and Goldfarb D.S. Structure and function of nucleus-vacuole junctions: outer-nuclear-membrane targeting of Nvj1p and a role in tryptophan uptake. J. Cell Sci. 119 (2006) 3622-3633
110. Umebayashi K., and Nakano A. Ergosterol is required for targeting of tryptophan permease to the yeast plasma membrane. J. Cell Biol. 161 (2003) 1117-1131
111. Fang M., Kearns B.G., Gedvilaite A., Kagiwada S., Kearns M., Fung M.K., and Bankaitis V.A. Kes1p shares homology with human oxysterol binding protein and participates in a novel regulatory pathway for yeast Golgi-derived transport vesicle biogenesis. EMBO 15 (1996) 6447-6459
112. Kearns B.G., Alb J.G.J., and Bankaitis V. Phosphatidylinositol transfer proteins: the long and winding road to physiological function. Trends Cell Biol. 8 (1998) 276-282
113. Routt S.M., and Bankaitis V.A. Biological functions of phosphatidylinositol transfer proteins. Biochem. Cell. Biol. 82 (2004) 254-262
114. Xie Z., Fang M., Rivas M.P., Faulkner A.J., Sternweis P.C., Engebrecht J.A., and Bankaitis V.A. Phospholipase D activity is required for suppression of yeast phosphatidylinositol transfer protein defects. Proc. Natl. Acad. Sci. U. S. A. 95 (1989) 12346-12351
115. Sreenivas A., Patton-Vogt J.L., Bruno V., Griac P., and Henry S.A. A role for phospholipase D (Pld1p) in growth, secretion, and regulation of membrane lipid synthesis in yeast. J. Biol. Chem. 273 (1998) 16635-16638
116. Liscovitch M., Chalifa V., Pertile P., Chen C.S., and Cantley L.C. Novel function of phosphatidylinositol 4,5-bisphosphate as a cofactor for brain membrane phospholipase D. J. Biol. Chem. 269 (1994) 21403-21406
117. Rose K., Rudge S.A., Frohman M.A., Morris A.J., and Engebrecht J. Phospholipase D signaling is essential for meiosis. Proc. Natl. Acad. Sci. U. S. A. 92 (1995) 12151-12155
118. Sciorra V.A., Rudge S.A., Wang J., McLaughlin S., Engebrecht J., and Morris A.J. Dual role for phosphoinositides in regulation of yeast and mammalian phospholipase D enzymes. J. Cell Biol. 159 (2002) 1039-1049
119. Coluccio A., Malzone M., and Neiman A.M. Genetic evidence of a role for membrane lipid composition in the regulation of soluble NEM-sensitive factor receptor function in Saccharomyces cerevisiae. Genetics 166 (2004) 89-97
120. Fairn G.D., and McMaster C.R. The roles of the human lipid-binding proteins ORP9S and ORP10S in vesicular transport. Biochem. Cell. Biol. 83 (2005) 631-636
121. Fairn G.D., and McMaster C.R. Identification and assessment of the role of a nominal phospholipid binding region of ORP1S (oxysterol-binding-protein-related protein 1 short) in the regulation of vesicular transport. Biochem. J. 387 (2005) 889-896
122. Kozminski K.G., Alfaro G., Dighe S., and Beh C.T. Homologues of oxysterol-binding proteins affect Cdc42p- and Rho1p-mediated cell polarization in Saccharomyces cerevisiae. Traffic 7 (2006) 1224-1242
123. Pruyne D., and Bretscher A. Polarization of cell growth in yeast. J. Cell Sci. 113 Pt 4 (2000) 571-585
124. Wang P., Zhang Y., Li H., Chieu H.K., Munn A.L., and Yang H. AAA ATPases regulate membrane association of yeast oxysterol binding proteins and sterol metabolism. EMBO 24 (2005) 2989-2999
125. Babst M., Katzmann D.J., Snyder W.B., Wendland B., and Emr S.D. Endosome-associated complex, ESCRT-II, recruits transport machinery for protein sorting at the multivesicular body. Dev. Cell 3 (2002) 283-289
126. Yang H. Nonvesicular sterol transport: two protein families and a sterol sensor?. Trends Cell Biol. 16 (2006) 427-432
127. Zhang S., Ren J., Li H., Zhang Q., Armstrong J.S., Munn A.L., and Yang H. Ncr1p, the yeast ortholog of mammalian Niemann Pick C1 protein, is dispensable for endocytic transport. Traffic 5 (2004) 1017-1030
128. Ohsaki Y., Sugimoto Y., Suzuki M., Hosokawa H., Yoshimori T., Davies J.P., Ioannou Y.A., Vanier M.T., Ohno K., and Ninomiya H. Cholesterol depletion facilitates ubiquitilation of NPC1 and its association with SKD1/Vps4. J. Cell Sci. 119 (2006) 2643-2653