AAA ATPases regulate membrane association of yeast oxysterol binding proteins and sterol metabolism

EMBO Journal

Volumn 24, Issue 17, 2005, Pages 2989-2999

  Wang, Penghua ^a   Zhang, Yong ^a   Li, Hongzhe ^a   Hai, Kee Chieu ^a   Munn, Alan L ^b,c   Yang, Hongyuan ^a,d  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Singapore)

^c UNIVERSITY OF QUEENSLAND   (Australia)

^d NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

AAA ATPase; Lipid transport; Oxysterol binding protein (OSBP)

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ATPASE ASSOCIATED WITH A VARIETY OF CELLULAR ACTIVITIES PROTEIN; BINDING PROTEIN; ERGOSTEROL; OSH1P PROTEIN; OSH2P PROTEIN; OSH3P PROTEIN; OSH4P PROTEIN; OSH5P PROTEIN; OSH6P PROTEIN; OSH7P PROTEIN; OXYSTEROL; OXYSTEROL BINDING PROTEIN; PROTEIN; PROTEIN DERIVATIVE; STEROL; UNCLASSIFIED DRUG; VPS4P PROTEIN; CARRIER PROTEIN; ESTER; OXYSTEROL RECEPTOR; SACCHAROMYCES CEREVISIAE PROTEIN; STEROID RECEPTOR; VPS4 PROTEIN, S CEREVISIAE;

ARTICLE; ESTERIFICATION; GENE DELETION; GENE OVEREXPRESSION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN PROTEIN INTERACTION; STEROL METABOLISM; CELL MEMBRANE; GENETICS; METABOLISM; MUTATION; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; SACCHAROMYCES CEREVISIAE; TWO HYBRID SYSTEM;

ADENOSINE TRIPHOSPHATASES; CARRIER PROTEINS; CELL MEMBRANE; ESTERS; MUTATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, STEROID; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; STEROLS; TWO-HYBRID SYSTEM TECHNIQUES;

EID: 25444529050     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/sj.emboj.7600764     Document Type: Article

References (49)

1. Babst M, Katzmann DJ, Estepa-Sabal EJ, Meerloo T, Emr SD (2002a) Escrt-III: an endosome-associated heterooligomeric protein complex required for mvb sorting. Dev Cell 3: 271-282
2. Babst M, Katzmann DJ, Snyder WB, Wendland B, Emr SD (2002b) Endosome-associated complex, ESCRT-II, recruits transport machinery for protein sorting at the multivesicular body. Dev Cell 3: 283-289
3. Babst M, Sato TK, Banta LM, Emr SD (1997) Endosomal transport function in yeast requires a novel AAA-type ATPase, Vps4p. EMBO J 16: 1820-1831
4. Babst M, Wendland B, Estepa EJ, Emr SD (1998) The Vps4p AAA ATPase regulates membrane association of a Vps protein complex required for normal endosome function. EMBO J 17: 2982-2993
5. Baudin A, Ozier-Kalogeropoulos O, Denouel A, Lacroute F, Cullin C (1993) A simple and efficient method for direct gene deletion in Saccharomyces cerevisiae. Nucleic Acids Res 21: 3329-3330
6. Beh CT, Cool L, Phillips J, Rine J (2001) Overlapping functions of the yeast oxysterol-binding protein homologues. Genetics 157: 1117-1140
7. Beh CT, Rine J (2004) A role for yeast oxysterol-binding protein homologs in endocytosis and in the maintenance of intracellular sterol-lipid distribution. J Cell Sci 117: 2983-2996
8. Bishop N, Woodman P (2000) ATPase-defective mammalian VPS4 localizes to aberrant endosomes and impairs cholesterol trafficking. Mol Biol Cell 11: 227-239
9. Coe JGS, Lim ACB, Xu J, Hong W (1999) A role for Tlg1p in the transport of proteins within the Golgi apparatus of Saccharomyces cerevisiae. Mol Biol Cell 7: 2407-2423
10. Dawson PA, Ridgway ND, Slaughter CA, Brown MS, Goldstein JL (1989a) cDNA cloning and expression of oxysterol-binding protein, an oligomer with a potential leucine zipper. J Biol Chem 264: 16798-16803
11. Dawson PA, Van der Westhuyzen DR, Goldstein JL, Brown MS (1989b) Purification of oxysterol binding protein from hamster liver cytosol. J Biol Chem 264: 9046-9052
12. Fang M, Kearns BG, Gedvilaite A, Kagiwada S, Kearns M, Fung MK, Bankaitis VA (1996) Kes1p shares homology with human oxysterol binding protein and participates in a novel regulatory pathway for yeast Golgi-derived transport vesicle biogenesis. EMBO J 15: 6447-6459
13. Funato K, Riezman H (2001) Vesicular and nonvesicular transport of ceramide from ER to the Golgi apparatus in yeast. J Cell Biol 155: 949-959
14. Gavin AC, Bosche M, Krause R, Grandi P, Marzioch M, Bauer A, Schultz J, Rick JM, Michon AM, Cruciat CM, Remor M, Hofert C, Schelder M, Brajenovic M, Ruffner H, Merino A, Klein K, Hudak M, Dickson D, Rudi T, Gnau V, Bauch A, Bastuck S, Huhse B, Leutwein C, Heurtier MA, Copley RR, Edelmann A, Querfurth E, Rybin V, Drewes G, Raida M, Bouwmeester T, Bork P, Seraphin B, Kuster B, Neubauer G, Superti-Furga G (2002) Functional organization of the yeast proteome by systematic analysis of protein complexes. Nature 415: 141-147
15. Gaynor EC, te Heesen S, Graham TR, Aebi M, Emr SD (1994) Signal-mediated retrieval of a membrane protein from the Golgi to the ER in yeast. J Cell Biol 127: 653-665
16. Gietz RD, Woods RA (2002) Transformation of yeast by lithium acetate/single-stranded carrier DNA/polyethylene glycol method. Methods Enzymol 350: 87-96
17. Hanada K, Kumagai K, Yasuda S, Miura Y, Kawano M, Fukasawa M, Nishijima M (2003) Molecular machinery for non-vesicular trafficking of ceramide. Nature 426: 803-809
18. Horazdovsky BF, Emr SD (1993) The VPS16 gene product associates with a sedimentable protein complex and is essential for vacuolar protein sorting in yeast. J Biol Chem 268: 4953-4962
19. James P, Halladay J, Craig EA (1996) Genomic libraries and a host strain designed for highly efficient two-hybrid selection in yeast. Genetics 144: 1425-1436
20. Kandutsch AA, Taylor FR, Shown EP (1984) Different forms of the oxysterol-binding protein. Binding kinetics and stability. J Biol Chem 259: 12388-12397
21. Katzmann DJ, Babst M, Emr SD (2001) Ubiquitin-dependent sorting into the multivesicular body pathway requires the function of a conserved endosomal protein sorting complex, ESCRT-I. Cell 106: 145-155
22. Katzmann DJ, Odorizzi G, Emr SD (2002) Receptor downregulation and multivesicular-body sorting. Nat Rev Mol Cell Biol 3: 893-905
23. Kolling R, Hollenberg CP (1994) The ABC-transporter Ste6 accumulates in the plasma membrane in a ubiquitinated form in endocytosis mutants. EMBO J 13: 3261-3271
24. Lagace TA, Byers DM, Cook HW, Ridgway ND (1997) Altered regulation of cholesterol and cholesteryl ester synthesis in Chinese-hamster ovary cells overexpressing the oxysterol-binding protein is dependent on the pleckstrin homology domain. Biochem J 326: 205-213
25. Lagace TA, Byers DM, Cook HW, Ridgway ND (1999) Chinese hamster ovary cells overexpressing the oxysterol binding protein (OSBP) display enhanced synthesis of sphingomyelin in response to 25-hydroxycholesterol. J Lipid Res 40: 109-116
26. Lehto M, Laitinen S, Chinetti G, Johansson M, Ehnholm C, Staels B, Ikonen E, Olkkonen VM (2001) The OSBP-related protein family in humans. J Lipid Res 42: 1203-1213
27. Levine TP (2004) Short-range intracellular trafficking of small molecules across endoplasmic reticulum junctions. Trends Cell Biol 14: 483-490
28. Levine TP, Munro S (1998) The pleckstrin homology domain of oxysterol-binding protein recognises a determinant specific to Golgi membranes. Curr Biol 8: 729-739
29. Levine TP, Munro S (2001) Dual targeting of Osh1p, a yeast homologue of oxysterol-binding protein, to both the Golgi and the nucleus-vacuole junction. Mol Biol Cell 12: 1633-1644
30. Li X, Rivas MP, Fang M, Marchena J, Mehrotra B, Chaudhary A, Feng L, Prestwich GD, Bankaitis VA (2002) Analysis of oxysterol binding protein homologue Kes1p function in regulation of Sec14p-dependent protein transport from the yeast Golgi complex. J Cell Biol 157: 63-77
31. Loewen CJ, Roy A, Levine TP (2003) A conserved ER targeting motif in three families of lipid binding proteins and in Opi1p binds VAP. EMBO J 22: 2025-2035
32. Lupas AN, Martin J (2002) AAA proteins. Curr Opin Struct Biol 12: 746-753
33. Munro S (2003) Cell biology: earthworms and lipid couriers. Nature 426: 775-776
34. Odorizzi G, Babst M, Emr SD (1998) Fab1p PtdIns(3)P 5-kinase function essential for protein sorting in the multivesicular body. Cell 95: 847-858
35. Olkkonen VM, Levine TP (2004) Oxysterol binding proteins: in more than one place at one time? Biochem Cell Biol 82: 87-98
36. Patel S, Latterich M (1998) The AAA team: related ATPases with diverse functions. Trends Cell Biol 8: 65-71
37. Reggiori F, Pelham HR (2001) Sorting of proteins into multivesicular bodies: ubiquitin-dependent and -independent targeting. EMBO J 20: 5176-5186
38. Ridgway ND, Dawson PA, Ho YK, Brown MS, Goldstein JL (1992) Translocation of oxysterol binding protein to Golgi apparatus triggered by ligand binding. J Cell Biol 116: 307-319
39. Sambrook J, Fritsch EF, Maniatis T (1989) Molecular Cloning: A Laboratory Manual. Cold Spring Harbor, NY, USA: Cold Spring Harbor Press
40. Shiflett SL, Ward DM, Huynh D, Vaughn MB, Simmons JC, Kaplan J (2004) Characterization of Vta1p, a class E Vps protein in Saccharomyces cerevisiae. J Biol Chem 279: 10982-10990
41. Storey MK, Byers DM, Cook HW, Ridgway ND (1998) Cholesterol regulates oxysterol binding protein (OSBP) phosphorylation and Golgi localization in Chinese hamster ovary cells: correlation with stimulation of sphingomyelin synthesis by 25-hydroxycholesterol. Biochem J 336: 247-256
42. Taylor FR, Saucier SE, Shown EP, Parish EJ, Kandutsch AA (1984) Correlation between oxysterol binding to a cytosolic binding protein and potency in the repression of hydroxymethylglutaryl coenzyme A reductase. J Biol Chem 259: 12382-12387
43. Vida TA, Emr SD (1995) A new vital stain for visualizing vacuolar membrane dynamics and endocytosis in yeast. J Cell Biol 128: 779-792
44. Walworth NC, Goud B, Ruohola H, Novick PJ (1989) Fractionation of yeast organelles. Methods Cell Biol 31: 335-356
45. Wang PY, Weng J, Anderson RG (2005) OSBP is a cholesterol-regulated scaffolding protein in control of ERK1/2 activation. Science 307: 1472-1476
46. Wyles JP, McMaster CR, Ridgway ND (2002) Vesicle-associated membrane protein-associated protein-A (VAP-A) interacts with the oxysterol-binding protein to modify export from the endoplasmic reticulum. J Biol Chem 277: 29908-29918
47. Yang H, Bard M, Bruner DA, Gleeson A, Deckelbaum RJ, Aljinovic G, Pohl TM, Rothstein R, Sturley SL (1996) Sterol esterification in yeast: a two-gene process. Science 272: 1353-1356
48. Yeo SC, Xu L, Ren J, Boulton VJ, Wagle MD, Liu C, Ren G, Wong P, Zahn R, Sasajala P, Yang H, Piper RC, Munn AL (2003) Vps20p and Vta1p interact with Vps4p and function in multivesicular body sorting and endosomal transport in Saccharomyces cerevisiae. J Cell Sci 116: 3957-3970
49. Zahn R, Stevenson BJ, Schroder-Kohne S, Zanolari B, Riezman H, Munn AL (2001) End13p/Vps4p is required for efficient transport from early to late endosomes in Saccharomyces cerevisiae. J Cell Sci 114: 1935-1947