Molecular characterization of Osh6p, an oxysterol binding protein homolog in the yeast Saccharomyces cerevisiae

FEBS Journal

Volumn 272, Issue 18, 2005, Pages 4703-4715

  Wang, Penghua ^a   Duan, Wei ^a   Munn, Alan L ^b,c   Yang, Hongyuan ^a,d  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Singapore)

^c UNIVERSITY OF QUEENSLAND   (Australia)

^d NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

OSBP; OSH; Osh6p; Oxysterol binding protein; Sterol homeostasis

Indexed keywords

BINDING PROTEIN; CARBOXYPEPTIDASE C; ERGOSTEROL; GREEN FLUORESCENT PROTEIN; NYSTATIN; OLEIC ACID; OXYSTEROL; PHOSPHATIDIC ACID; PHOSPHATIDYLINOSITIDE; PROTEIN OXYSTEROL BINDING PROTEIN; STEROL; UNCLASSIFIED DRUG;

ARTICLE; CELL MEMBRANE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOSOL; GENE OVEREXPRESSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN TRANSPORT; PROTEIN VARIANT; SACCHAROMYCES CEREVISIAE; STEROL METABOLISM;

BIOLOGICAL TRANSPORT; CARBOXYPEPTIDASE C; CARRIER PROTEINS; CELL MEMBRANE; CYTOSOL; ERGOSTEROL; GREEN FLUORESCENT PROTEINS; PHOSPHATIDIC ACIDS; PHOSPHATIDYLINOSITOLS; RECEPTORS, STEROID; SACCHAROMYCES CEREVISIAE PROTEINS; STEROLS;

SACCHAROMYCES CEREVISIAE;

EID: 25444460845     PISSN: 1742464X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2005.04886.x     Document Type: Article

References (35)

1. Lehto M & Olkkonen VM (2003) The OSBP-related proteins: a novel protein family involved in vesicle transport, cellular lipid metabolism, and cell signaling. Biochim Biophys Acta 1631, 1-11.
2. Olkkonen VM & Levine TP (2004) Oxysterol binding proteins: in more than one place at one time? Biochem Cell Biol 82, 87-98.
3. Lagace TA, Byers DM, Cook HW & Ridgway ND (1997) Altered regulation of cholesterol and cholesteryl ester synthesis in Chinese-hamster ovary cells overexpressing the oxysterol-binding protein is dependent on the pleckstrin homology domain. Biochem J 326, 205-213.
4. Ridgway ND, Dawson PA, Ho YK, Brown MS & Goldstein JL (1992) Translocation of oxysterol binding protein to Golgi apparatus triggered by ligand binding. J Cell Biol 116, 301-319.
5. Ridgway ND, Lagace TA, Cook HW & Byers DM (1998) Differential effects of sphingomyelin hydrolysis and cholesterol transport on oxysterol-binding protein phosphorylation and Golgi localization. J Biol Chem 273, 31621-31628.
6. Storey MK, Byers DM, Cook HW & Ridgway ND (1998) Cholesterol regulates oxysterol binding protein (OSBP) phosphorylation and Golgi localization in Chinese hamster ovary cells: correlation with stimulation of sphingomyelin synthesis by 25-hydroxycholesterol. Biochem J 336, 247-256.
7. Wyles JP, McMaster CR & Ridgway ND (2002) Vesicle-associated membrane protein-associated protein-A (VAP-A) interacts with the oxysterol-binding protein to modify export from the endoplasmic reticulum. J Biol Chem 277, 29908-29918.
8. Laitinen S, Lehto M, Lehtonen S, Hyvarinen K, Heino S, Lehtonen E, Ehnholm C, Ikonen E & Olkkonen VM (2002) ORP2, a homolog of oxysterol binding protein, regulates cellular cholesterol metabolism. J Lipid Res 43, 245-255.
9. Wang C, JeBailey L & Ridgway ND (2002) Oxysterol-binding-protein (OSBP)-related protein 4 binds 25-hydroxycholesterol and interacts with vimentin intermediate filaments. Biochem J 361, 461-472.
10. Beh CT, Cool L, Phillips J & Rine J (2001) Overlapping functions of the yeast oxysterol-binding protein homologs. Genetics 157, 1117-1140.
11. Beh CT & Rine J (2004) A role for yeast oxysterol-binding protein homologs in endocytosis and in the maintenance of intracellular sterol-lipid distribution. J Cell Sci 111, 2983-2996.
12. Wang PY, Weng J & Anderson RG (2005) OSBP is a cholesterol-regulated scaffolding protein in control of ERK 1/2 activation. Science 307, 1472-1476.
13. Xu Y, Liu Y, Ridgway ND & McMaster CR (2001) Novel members of the human oxysterol-binding protein family bind phospholipids and regulate vesicle transport. J Biol Chem 276, 18407-18414.
14. Fang M, Kearns BG, Gedvilaite A, Kagiwada S, Kearns M, Fung MK & Bankaitis VA (1996) Kes1p shares homology with human oxysterol binding protein and participates in a novel regulatory pathway for yeast Golgi-derived transport vesicle biogenesis. EMBO J 15, 6447-6459.
15. Li X, Rivas MP, Fang M, Marchena J, Mehrotra B, Chaudhary A, Feng L, Prestwich GD & Bankaitis VA (2002) Analysis of oxysterol binding protein homolog Kes1p function in regulation of Sec14p-dependent protein transport from the yeast Golgi complex. J Cell Biol 157, 63-77.
16. Alphey L, Jimenez J & Glover DA (1998) Drosophila homolog of oxysterol binding protein (OSBP) - implications for the role of OSBP. Biochim Biophys Acta 1395, 159-164.
17. Park YU, Hwang O & Kim J (2002) Two-hybrid cloning and characterization of OSH3, a yeast oxysterol-binding protein homolog. Biochem Biophys Res Commun 293, 733-740.
18. Fournier MV, Guimaraes da Costa F, Paschoal ME, Ronco LV, Carvalho MG & Pardee AB (1999) Identification of a gene encoding a human oxysterol-binding protein-homolog: a potential general molecular marker for blood dissemination of solid tumors. Cancer Res 59, 3748-3753.
19. Gaullier JM, Ronning E, Gillooly DJ & Stenmark H (2000) Interaction of the EEA1 FYVE finger with phosphatidylinositol 3-phosphate and early endosomes. Role of conserved residues. J Biol Chem 275, 24595-24600.
20. Rameh LE, Tolias KF, Duckworth BC & Cantley LC (1997) A new pathway for phosphatidylinositol-4,5-bisphosphate synthesis. Nature 390, 192-196.
21. Vida TA & Emr SD (1995) A new vital stain for visualizing vacuolar membrane dynamics and endocytosis in yeast. J Cell Biol 128, 779-792.
22. Dawson PA, Van der Westhuyzen DR, Goldstein JL & Brown MS (1989) Purification of oxysterol binding protein from hamster liver cytosol. J Biol Chem 264, 9046-9052.
23. Levine TP & Munro S (1998) The pleckstrin homology domain of oxysterol-binding protein recognises a determinant specific to Golgi membranes. Curr Biol 8, 729-739.
24. Levine TP & Munro S (2002) Targeting of Golgi-specific pleckstrin homology domains involves both PtdIns 4-kinase-dependent and -independent components. Curr Biol 12, 695-704.
25. Sreenivas A, Patton-Vogt JL, Bruno V, Griac P & Henry SA (1998) A role for phospholipase D (Pld1p) in growth, secretion, and regulation of membrane lipid synthesis in yeast. J Biol Chem 273, 16635-16638.
26. Xie Z, Fang M, Rivas MP, Faulkner AJ, Sternweis PC, Engebrecht JA & Bankaitis VA (1998) Phospholipase D activity is required for suppression of yeast phosphatidylinositol transfer protein defects. Proc Natl Acad Sci USA 95, 12346-12351.
27. Yang H, Bard M, Bruner DA, Gleeson A, Deckelbaum RJ, Aljinovic G, Pohl TM, Rothstein R & Sturley SL (1996) Sterol esterification in yeast: a two-gene process. Science 272, 1353-1356.
28. Loewen CJ, Roy A & Levine TP (2003) A conserved ER targeting motif in three families of lipid binding proteins and in Opi1p binds VAP. EMBO J 22, 2025-2035.
29. Sambrook J, Fritsch EF & Maniatis T (1989) Molecular Cloning: a Laboratory Manual, Vol. 3, 2nd edn. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York.
30. Dowler S, Currie RA, Campbell DG, Deak M, Kular G, Downes CP & Alessi DR (2000) Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities. Biochem J 351, 19-31.
31. Yeo SC, Xu L, Ren J, Boulton VJ, Wagle MD, Liu C, Ren G, Wong P, Zahn R, Sasajala P, Yang H, Piper RC & Munn AL (2003) Vps20p and Vta1p interact with Vps4p and function in multivesicular body sorting and endosomal transport in Saccharomyces cerevisiae. J Cell Sci 116, 3957-3970.
32. Tinkelenberg AH, Liu Y, Alcantara F, Khan S, Guo Z, Bard M & Sturley SL (2000) Mutations in yeast ARV1 alter intracellular sterol distribution and are complemented by human ARVl. J Biol Chem 275, 40667-40670.
33. Paltauf F, Kohlwein S & Henry SA (1992) Regulation and compartmentalization of lipid synthesis in yeast. In Molecular and Cellular Biology of the Yeast Saccharomyces (Jones EW, Pringle JR & Broach JR, eds), pp. 415-500, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York.
34. Wang P, Zhang Y, Li H, Chieu HK, Munn AL & Yang H (2005) AAA ATPases regulate membrane association of yeast oxysterol binding proteins and sterol metabolism. EMBO J doi:10.1038.
35. Levine TP & Munro S (2001) Dual targeting of Osh1p, a yeast homolog of oxysterol-binding protein, to both the Golgi and the nucleus-vacuole junction. Mol Biol Cell 12, 1633-1644.