Analysis of oxysterol binding protein homologue Kes1p function in regulation of Sec14p-dependent protein transport from the yeast Golgi complex

Journal of Cell Biology

Volumn 157, Issue 1, 2002, Pages 63-77

  Li, Xinmin ^a   Rivas, Marcos P ^a   Fang, Min ^a   Marchena, Jennifer ^b   Mehrotra, Bharat ^c   Chaudhary, Anu ^c   Li, Feng ^c   Prestwich, Glenn D ^c   Bankaitis, Vytas A ^b  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

^c UNIVERSITY OF UTAH   (United States)

Author keywords

ARF; Kes1p; Phosphoinositides; Sec14p; Yeast Golgi

Indexed keywords

ADENOSINE DIPHOSPHATE RIBOSYLATION FACTOR; BINDING PROTEIN; CARRIER PROTEIN; MEMBRANE PROTEIN; OXYSTEROL BINDING PROTEIN; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLINOSITOL; PROTEIN KES1P; PROTEIN SEC14P; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; GOLGI COMPLEX; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; REGULATORY MECHANISM; YEAST;

1-PHOSPHATIDYLINOSITOL 4-KINASE; ADP-RIBOSYLATION FACTOR 1; ADP-RIBOSYLATION FACTORS; BINDING SITES; CARRIER PROTEINS; DNA-BINDING PROTEINS; FUNGAL PROTEINS; GENE EXPRESSION REGULATION, FUNGAL; GOLGI APPARATUS; GTPASE-ACTIVATING PROTEINS; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; MUTAGENESIS; PHOSPHATIDYLINOSITOLS; PHOSPHOLIPID TRANSFER PROTEINS; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, STEROID; SACCHAROMYCES CEREVISIAE PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; YEASTS;

EUKARYOTA;

EID: 0036544518     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200201037     Document Type: Article

References (49)

1. A Drosophila homologue of oxysterol binding protein (OSBP) - Implications for the role of OSBP
2. The Saccharomyces cerevisiae SEC14 gene encodes a cytosolic factor that is required for transport of secretory proteins from the yeast Golgi complex
3. An essential role for a phospholipid transfer protein in yeast Golgi function
4. Overlapping functions of the yeast oxysterol binding protein homologues
5. A proteolytic pathway that controls the cholesterol content of membranes, cells and blood
6. Genome sequence of the nematode C. elegans: A platform for investigating biology
7. Probing the phosphoinositide 4,5-bisphosphate binding site of human profilin I
8. Specific interaction of Golgi coatomer α-COP with phosphatidylinositol 3,4,5-trisphosphate
9. Mutations in the SAC1 gene suppress defects in yeast Golgi and yeast actin function
10. Phospholipid transfer proteins: A biological debut
11. Mutations in the CDP-choline pathway for phospholipid biosynthesis bypass the requirement for an essential phospholipid transfer protein
12. The yeast and mammalian isoforms of phosphatidylinositol transfer protein can all restore phospholipase C-mediated inositol lipid signaling in cytosol-depleted RBL-2H3 and HL-60 cells
13. Purification of oxysterol binding protein from hamster liver cytosol
14. Benzophenone photo-probes in biochemistry
15. Kes1p shares homology with human oxysterol binding protein and participates in a novel regulatory pathway for yeast Golgi-derived transport vesicle biogenesis
16. Full-contact domain labeling: Identification of a novel phosphoinositide binding site on gelsolin that requires the complete protein
17. Sac1 lipid phosphates and Stt4 phospharidylinositol 4-kinase regulate a pool of phosphatidylinositol 4-phosphate that functions in the control of the actin cytoskeleton and vacuole morphology
18. Identification of a gene encoding a human oxysterol-binding protein-homologue: A potential genetic molecular marker for blood dissemination of solid tumors
19. SAC1-like domains of yeast SAC1, INP52 and INP53, and human synaptojanin encode polyPIP phosphatases
20. Direct involvement of phosphatidylinositol-4-phosphate in secretion in the yeast Saccharomyces cerevisiae
21. 2-activated secretion
22. Lipid metabolism and membrane dynamics
23. Transformation of intact yeast cells treated with alkaline cations
24. A new family of yeast genes implicated in ergosterol synthesis is related to the human oxysterol binding protein
25. A phosphatidylinositol 3-kinase and phosphatidylinositol transfer protein act synergistically in formation of constitutive transport vesicles from the trans-Golgi network
26. Phosphatidylinositol transfer proteins: The long and winding road to function
27. Novel developmentally regulated PIP binding proteins from soybean whose expression bypasses the requirement for an essential phosphatidylinositol transfer protein in yeast
28. Altered regulation of cholesterol and cholesteroyl ester synthesis in Chinese hamster ovary cells overexpressing the oxysterol binding protein is dependent on the pleckstrin homology domain
29. Structural basis for high-affinity PIP binding by pleckstrin homology domains
30. The pleckstrin homology domain of oxysterol-binding protein recognizes a determinant specific to Golgi membranes
31. Identification of a novel family of nonclassical yeast PITPs whose function modulates activation of phospholipase D and Sec14p-independent cell growth
32. Phosphatidylinositol/phosphatidylcholine transfer proteins in yeast
33. A phosphatidylinositol transfer protein controls the phosphatidylcholine content of yeast Golgi membranes
34. Functional characterization of a mammalian Sac1 and mutants exhibiting substrate specific defects in phosphoinositide phosphatase activity
35. Identification of 23 complementation groups required for post-translational events in the yeast secretory pathway
36. Yeast Sec14p deficient in phospharidylinositol transfer activity is functional in vivo
37. Touching all the bases: Inositol polyphosphate and phosphoinositide affinity probes from glucose
38. Benzophenone photo-probes for PIPs, peptides and drugs
39. Relationship between altered phospholipid metabolism, diacylglycerol, 'bypass Sec14p', and the inositol auxotrophy of yeast sac1 mutants
40. DNA sequencing with chain terminating inhibitors
41. SEC14-dependent secretion in Saccharomyces cerevisiae: Non-dependence on sphingolipid-coupled diacylglycerol synthesis
42. PIP binding specificity among phospholipase C isozymes as determined by photo-crosslinking to novel substrate and product analogs
43. Correlation between oxysterol binding to a cytosolic binding protein and potency in the repression of hydroxymethylglutaryl coenzyme A reductase
44. The yeast phospharidylinositol-4-OH kinase pik1 regulates secretion at the Golgi
45. SAC1p is an integral membrane protein that influences the cellular requirement for phospholipid transfer protein function and inositol in yeast
46. Evidence for an intrinsic toxicity of phosphatidylcholine to Sec14p-dependent protein transport from the yeast Golgi complex
47. Phospholipase D activity is required for suppression of yeast phosphatidylinositol transfer protein defects
48. A family of ARF effectors defined as suppressors of the loss of Arf function in the yeast Saccharomyces cerevisiae