Immunological research using RNA interference technology

Immunology

Volumn 121, Issue 3, 2007, Pages 295-307

  Mao, Chih Ping ^a   Lin, Yen Yu ^a   Hung, Chien Fu ^a   Wu, T C ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Immune regulation; Immunotherapy; RNA interference; Small interfering RNA

Indexed keywords

ABC TRANSPORTER; ANTIGEN; APOLIPOPROTEIN B MESSENGER RNA EDITING ENZYME CATALYTIC POLYPEPTIDE 3G; BRUTON TYROSINE KINASE; CANCER VACCINE; CD40 LIGAND; CD40 LIGAND MONOCLONAL ANTIBODY; CYCLIN DEPENDENT KINASE INHIBITOR A1; DENDRITIC CELL VACCINE; DISACCHARIDE; DNA VACCINE; FAS ANTIGEN; FLICE INHIBITORY PROTEIN; GALACTOSYLTRANSFERASE; GUANINE NUCLEOTIDE EXCHANGE FACTOR; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; INTERLEUKIN 12; MACROPHAGE INFLAMMATORY PROTEIN 2; ORNITHINE DECARBOXYLASE; OSTEOCLAST DIFFERENTIATION FACTOR; PROTEIN BAK; PROTEIN BAX; PROTEIN E7; PROTEIN P21; SMALL INTERFERING RNA; SUPPRESSOR OF CYTOKINE SIGNALING 1; TRANSCRIPTION FACTOR GATA 3; TRANSCRIPTION FACTOR T BET; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; UNCLASSIFIED DRUG; VIRUS VECTOR;

ACUTE LUNG INJURY; ADAPTIVE IMMUNITY; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ATHEROSCLEROSIS; AUTOIMMUNE DISEASE; BONE METASTASIS; CANCER IMMUNIZATION; CLINICAL IMMUNOLOGY; COMPLEMENT SYSTEM; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DENDRITIC CELL; DNA VECTOR; DRUG EFFECT; DRUG POTENCY; DRUG TARGETING; ELECTROPORATION; GENE DELIVERY SYSTEM; GENE EXPRESSION REGULATION; GENE GUN; GENE SILENCING; GENETIC TRANSFECTION; GRAFT REJECTION; HELICOBACTER INFECTION; HELICOBACTER PYLORI; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN PAPILLOMAVIRUS TYPE 16; IMMUNE RESPONSE; IMMUNE SYSTEM; IMMUNITY; IMMUNOCOMPETENT CELL; IMMUNOMODULATION; IMMUNOTHERAPY; INNATE IMMUNITY; KIDNEY INJURY; KIDNEY ISCHEMIA; LYMPHOCYTE; LYMPHOCYTE FUNCTION; MACROPHAGE; MACROPHAGE ACTIVATION; MAST CELL; MEDICAL RESEARCH; MOLECULAR BIOLOGY; NATURAL KILLER CELL; NEUTROPHIL; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; OSTEOPOROSIS; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN TARGETING; REPERFUSION INJURY; REVIEW; RNA DEGRADATION; RNA INTERFERENCE; RNA STABILITY; SIGNAL TRANSDUCTION; SWINE; T LYMPHOCYTE; TH1 CELL; TH2 CELL; TUMOR; TUMOR IMMUNITY; VACCINATION; VIRAL GENE DELIVERY SYSTEM; VIRUS INHIBITION; VIRUS REPLICATION; XENOTRANSPLANTATION;

GENE THERAPY; GENE TRANSFER TECHNIQUES; HUMANS; IMMUNITY, CELLULAR; IMMUNOTHERAPY; RNA INTERFERENCE;

EID: 34249291606     PISSN: 00192805     EISSN: 13652567     Source Type: Journal    
DOI: 10.1111/j.1365-2567.2007.02599.x     Document Type: Review

References (87)

1. Caplen NJ. Gene therapy progress and prospects. Downregulating gene expression. the impact of RNA interference. Gene Ther 2004 11 : 1241 8.
2. Leung RK, Whittaker PA. RNA interference: from gene silencing to gene-specific therapeutics. Pharmacol Ther 2005 107 : 222 39.
3. Shankar P, Manjunath N, Lieberman J. The prospect of silencing disease using RNA interference. JAMA 2005 293 : 1367 73.
4. Vivier E, Malissen B. Innate and adaptive immunity. Specificities and signaling hierarchies revisited. Nat Immunol 2005 6 : 17 21.
5. Hoebe K, Janssen E, Beutler B. The interface between innate and adaptive immunity. Nat Immunol 2004 5 : 971 4.
6. Fu J, Naren AP, Gao X, Ahmmed GU, Malik AB. Protease-activated receptor-1 activation of endothelial cells induces protein kinase Cα-dependent phosphorylation of syntaxin 4 and Munc18c: role in signaling p-selectin expression. J Biol Chem 2005 280 : 3178 84.
7. Cao HB, Wang A, Martin B, Koehler DR, Zeitlin PL, Tanawell AK, Hu J. Down-regulation of IL-8 expression in human airway epithelial cells through helper-dependent adenoviral-mediated RNA interference. Cell Res 2005 15 : 111 19.
8. Schmeck B, Zahlten J, Moog K et al. Streptococcus pneumoniae-induced p38 MAPK-dependent phosphorylation of RelA at the interleukin-8 promotor. J Biol Chem 2004 279 : 53241 7.
9. Wang Q, Yerukhimovich M, Gaarde WA, Popoff IJ, Doerschuk CM. MKK3 and -6-dependent activation of p38alpha MAP kinase is required for cytoskeletal changes in pulmonary microvascular endothelial cells induced by ICAM-1 ligation. Am J Physiol Lung Cell Mol Physiol 2005 288 : L359 69.
10. Lomas-Neira JL, Chung CS, Wesche DE, Perl M, Ayala A. In vivo gene silencing (with siRNA) of pulmonary expression of MIP-2 versus KC results in divergent effects on hemorrhage-induced, neutrophil-mediated septic acute lung injury. J Leukoc Biol 2005 77 : 846 53.
11. Perl M, Chung CS, Lomas-Neira J, Rachel TM, Biffl WL, Cioffi WG, Ayala A. Silencing of Fas, but not caspase-8, in lung epithelial cells ameliorates pulmonary apoptosis, inflammation, and neutrophil influx after hemorrhagic shock and sepsis. Am J Pathol 2005 167 : 1545 59.
12. Soloski MJ. Recognition of tumor cells by the innate immune system. Curr Opin Immunol 2001 13 : 154 62.
13. Hamerman JA, Ogasawara K, Lanier LL. NK cells in innate immunity. Curr Opin Immunol 2005 17 : 29 35.
14. Lanier LL. NK cell receptors. Annu Rev Immunol 1998 16 : 359 93.
15. Fernandez NC, Lozier A, Flament C et al. Dendritic cells directly trigger NK cell functions: cross-talk relevant in innate anti-tumor immune responses in vivo. Nat Med 1999 5 : 405 11.
16. Borg C, Jalil A, Laderach D et al. NK cell activation by dendritic cells (DCs) requires the formation of a synapse leading to IL-12 polarization in DCs. Blood 2004 104 : 3267 75.
17. Marusina AI, Kim DK, Lieto LD, Borrego F, Coligan JE. GATA-3 is an important transcription factor for regulating human NKG2A gene expression. J Immunol 2005 174 : 2152 9.
18. Ma LL, Wang CL, Neely GG, Epelman S, Krensky AM, Mody CH. NK cells use perforin rather than granulysin for anticryptococcal activity. J Immunol 2004 173 : 3357 65.
19. Mirandola P, Ponti C, Gobbi G et al. Activated human NK and CD8+ T cells express both TNF-related apoptosis-inducing ligand (TRAIL) and TRAIL receptors but are resistant to TRAIL-mediated cytotoxicity. Blood 2004 104 : 2418 24.
20. Heinonen JE, Smith CI, Nore BF. Silencing of Bruton's tyrosine kinase (Btk) using short interfering RNA duplexes (siRNA). FEBS Lett 2002 527 : 274 8.
21. Li L, Yang Y, Stevens RL. RasGRP4 regulates the expression of prostaglandin D2 in human and rat mast cell lines. J Biol Chem 2003 278 : 4725 9.
22. Yu L, Miao H, Guo L. Effect of RNA interference on Gal α 1,3 Gal expression in PIEC cells. DNA Cell Biol 2005 24 : 235 43.
23. Zhu M, Wang SS, Xia ZX et al. Inhibition of xenogeneic response in porcine endothelium using RNA interference. Transplantation 2005 79 : 289 96.
24. Zhou W, Farrar CA, Abe K, Pratt JR, Marsh JE, Wang Y, Stahl GL, Sacks SH. Predominant role for C5b-9 in renal ischemia/reperfusion injury. J Clin Invest 2000 105 : 1363 71.
25. Zheng X, Feng B, Chen G et al. Preventing renal ischemia-reperfusion injury using small interfering RNA by targeting complement 3 gene. Am J Transplant 2006 6 : 2009 108.
26. Wesemann DR, Qin H, Kokorina N, Benveniste EN. TRADD interacts with STAT1-alpha and influences interferon-gamma signaling. Nat Immunol 2004 5 : 199 207.
27. Hatsuzawa K, Tamura T, Hashimoto H, Hashimoto H, Yokoya S, Miura M, Nagaya H, Wada I. Involvement of syntaxin 18, an endoplasmic reticulum (ER) -localized SNARE protein, in ER-mediated phagocytosis. Mol Biol Cell 2006 17 : 3964 77.
28. Bussiere FI, Chaturvedi R, Cheng Y et al. Spermine causes loss of innate immune response to Helicobacter pylori by inhibition of inducible nitric-oxide synthase translation. J Biol Chem 2005 280 : 2409 12.
29. Wahl SM, Greenwell-Wild T, Peng G, Ma G, Orenstein JM, Vazquez N. Viral and host cofactors facilitate HIV-1 replication in macrophages. J Leukoc Biol 2003 74 : 726 35.
30. Vazquez N, Greenwell-Wild T, Marinos NJ et al. Human immunodeficiency virus type 1-induced macrophage gene expression includes the p21 gene, a target for viral regulation. J Virol 2005 79 : 4479 91.
31. Wang N, Lan D, Chen W, Matsuura F, Tall AR. ATP-binding cassette transporters G1 and G4 mediate cellular cholesterol efflux to high-density lipoproteins. Proc Natl Acad Sci USA 2004 101 : 9774 9.
32. Teitelbaum SL. Bone resorption by osteoclasts. Science 2000 289 (5484 1504 8.
33. Kukita T, Wada N, Kukita A et al. RANKL-induced DC-STAMP is essential for osteoclastogenesis. J Exp Med 2004 200 : 941 6.
34. Seifert U, Maranon C, Shmueli A et al. An essential role for tripeptidyl peptidase in the generation of an MHC class I epitope. Nat Immunol 2003 4 : 375 9.
35. Kwon DS, Gregorio G, Bitton N, Hendrickson WA, Littman DR. DC-SIGN-mediated internalization of HIV is required for trans-enhancement of T cell infection. Immunity 2002 16 : 135 44.
36. Arrighi JF, Pion M, Wiznerowicz M et al. Lentivirus-mediated RNA interference of DC-SIGN expression inhibits human immunodeficiency virus transmission from dendritic cells to T cells. J Virol 2004 78 : 10848 55.
37. Schotte R, Nagasawa M, Weijer K, Spits H, Blom B. The ETS transcription factor Spi-B is required for human plasmacytoid dendritic cell development. J Exp Med 2004 200 : 1503 9.
38. Kim TW, Lee JH, He L, Boyd DA, Hardwick JM, Hung CF, Wu TC. Modification of professional antigen-presenting cells with small interfering RNA in vivo to enhance cancer vaccine potency. Cancer Res 2005 65 : 309 16.
39. Peng S, Kim TW, Lee JH, Yang M, He L, Hung CF, Wu TC. Vaccination with dendritic cells transfected with BAK and BAX siRNA enhances antigen-specific immune responses by prolonging dendritic cell life. Hum Gene Ther 2005 16 : 584 93.
40. Kang TH, Lee JH, Bae HC et al. Enhancement of dendritic cell-based vaccine potency by targeting antigen to endosomal/lysosomal compartments. Immunol Lett 2006 106 : 126 34.
41. Evel-Kabler K, Song XT, Aldrich M, Huang XF, Chen SY. SOCS1 restricts dendritic cells' ability to break self tolerance and induce antitumor immunity by regulating IL-12 production and signaling. J Clin Invest 2006 116 : 90 100.
42. Song XT, Evel-Kabler K, Rollins L, Aldrich M, Gao F, Huang XF, Chen SY. An alternative and effective HIV vaccination approach based on inhibition of antigen presentation attenuators in dendritic cells. PLoS Med 2006 3 : e11.
43. Shen L, Evel-Kabler K, Strube R, Chen SY. Silencing of SOCS1 enhances antigen presentation by dendritic cells and antigen-specific anti-tumor immunity. Nat Biotechnol 2004 22 : 1546 53.
44. Liu G, Ng H, Akasaki Y, Yuan X, Ehtesham M, Yin D, Black KL, Yu JS. Small interference RNA modulation of IL-10 in human monocyte-derived dendritic cells enhances the Th1 response. Eur J Immunol 2004 34 : 1680 7.
45. Hill JA, Ichim TE, Kusznieruk KP et al. Immune modulation by silencing IL-12 production in dendritic cells using small interfering RNA. J Immunol 2003 171 : 691 6.
46. Hernandez-Hoyos G, Anderson MK, Wang C, Rothenberg EV, Alberola-Ila J. GATA-3 expression is controlled by TCR signals and regulates CD4/CD8 differentiation. Immunity 2003 19 : 83 94.
47. Skapenko A, Leipe J, Niesner U et al. GATA-3 in human T cell helper type 2 development. J Exp Med 2004 199 : 423 8.
48. Lovett-Racke AE, Rocchini AE, Choy J, Northrop SC, Hussain RZ, Ratts RB, Sikder D, Racke MK. Silencing T-bet defines a critical role in the differentiation of autoreactive T lymphocytes. Immunity 2004 21 : 719 31.
49. Launay P, Cheng H, Srivatsan S, Penner R, Fleig A, Kinet JP. TRPM4 regulates calcium oscillations after T cell activation. Science 2004 306 (5700 1374 7.
50. Fan Z, Beresford PJ, Zhang D, Xu Z, Novina CD, Yoshida A, Pommier Y, Lieberman J. Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A. Nat Immunol 2003 4 : 145 53.
51. Chiu YL, Soros VB, Kreisberg JF, Stopak K, Yonemoto W, Greene WC. Cellular APOBEC3G restricts HIV-1 infection in resting CD4+ T cells. Nature 2005 435 (7038 108 14.
52. Ganesh L, Burstein E, Guha-Niyogi A et al. The gene product Murr1 restricts HIV-1 replication in resting CD4+ lymphocytes. Nature 2003 426 (6968 853 7.
53. Dotti G, Savoldo B, Pule M et al. Human cytotoxic T lymphocytes with reduced sensitivity to Fas-induced apoptosis. Blood 2005 105 : 4677 84.
54. Pluvinet R, Petriz J, Torras J, Herrero-Fresneda I, Cruzado JM, Grinyo JM, Aran JM. RNAi-mediated silencing of CD40 prevents leukocyte adhesion on CD154-activated endothelial cells. Blood 2004 104 : 3642 6.
55. Qin XF, An DS, Chen IS, Baltimore D. Inhibiting HIV-1 infection in human T cells by lentiviral-mediated delivery of small interfering RNA against CCR5. Proc Natl Acad Sci U S A 2003 100 : 183 8.
56. Martinez MA, Gutierrez A, Armand-Ugon M, Blanco J, Parera M, Gomez J, Clotet B, Este JA. Suppression of chemokine receptor expression by RNA interference allows for inhibition of HIV-1 replication. Aids 2002 16 : 2385 90.
57. Lin YL, Mettling C, Portales P, Reant B, Robert-Hebmann V, Reynes J, Clot J, Corbeau P. The efficiency of R5 HIV-1 infection is determined by CD4 T-cell surface CCR5 density through Gαi-protein signalling. Aids 2006 20 : 1369 77.
58. Ryther RC, Flynt AS, Phillips JA 3rd, Patton JG. siRNA therapeutics: big potential from small RNAs. Gene Ther 2005 12 : 5 11.
59. Morrissey DV, Lockridge JA, Shaw L et al. Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs. Nat Biotechnol 2005 23 : 1002 7.
60. Chiu YL, Rana TM. siRNA function in RNAi: a chemical modification analysis. Rna 2003 9 : 1034 48.
61. Oliveira S, van Rooy I, Kranenburg O, Storm G, Schiffelers RM. Fusogenic peptides enhance endosomal escape improving siRNA-induced silencing of oncogenes. Int J Pharm 2006 331 : 211 14.
62. Song E, Lee SK, Wang J et al. RNA interference targeting Fas protects mice from fulminant hepatitis. Nat Med 2003 9 : 347 51.
63. Song J, Pang S, Lu Y, Chiu R. Poly(U) and polyadenylation termination signals are interchangeable for terminating the expression of shRNA from a pol II promoter. Biochem Biophys Res Commun 2004 323 : 573 8.
64. Schiffelers RM, Ansari A, Xu J et al. Cancer siRNA therapy by tumor selective delivery with ligand-targeted sterically stabilized nanoparticle. Nucl Acids Res 2004 32 : e149.
65. Oberdoerffer P, Kanellopoulou C, Heissmeyer V, Paeper C, Borowski C, Aifantis I, Rao A, Rajewsky K. Efficiency of RNA interference in the mouse hematopoietic system varies between cell types and developmental stages. Mol Cell Biol 2005 25 : 3896 905.
66. Vang T, Abrahamsen H, Myklebust S, Enserink J, Prydz H, Mustelin T, Amarzguioui M, Tasken K. Knockdown of C-terminal Src kinase by siRNA-mediated RNA interference augments T cell receptor signaling in mature T cells. Eur J Immunol 2004 34 : 2191 9.
67. Lewis DL, Hagstrom JE, Loomis AG, Wolff JA, Herweijer H. Efficient delivery of siRNA for inhibition of gene expression in postnatal mice. Nat Genet 2002 32 : 107 8.
68. Golzio M, Mazzolini L, Moller P, Rols MP, Teissie J. Inhibition of gene expression in mice muscle by in vivo electrically mediated siRNA delivery. Gene Ther 2005 12 : 246 51.
69. Rubinson DA, Dillon CP, Kwiatkowski AV et al. A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference. Nat Genet 2003 33 : 401 6.
70. Sumimoto H, Miyagishi M, Miyoshi H, Yamagata S, Shimizu A, Taira K, Kawakami Y. Inhibition of growth and invasive ability of melanoma by inactivation of mutated BRAF with lentivirus-mediated RNA interference. Oncogene 2004 23 : 6031 9.
71. Sumimoto H, Yamagata S, Shimizu A et al. Gene therapy for human small-cell lung carcinoma by inactivation of Skp-2 with virally mediated RNA interference. Gene Ther 2005 12 : 95 100.
72. Duxbury MS, Ito H, Benoit E, Zinner MJ, Ashley SW, Whang EE. Retrovirally mediated RNA interference targeting the M2 subunit of ribonucleotide reductase: a novel therapeutic strategy in pancreatic cancer. Surgery 2004 136 : 261 9.
73. Chen LM, Le HY, Qin RY, Du Kumar MZY, Xia RJ, Deng J. Reversal of the phenotype by K-rasval12 silencing mediated by adenovirus-delivered siRNA in human pancreatic cancer cell line Panc-1. World J Gastroenterol 2005 11 : 831 8.
74. Uchida H, Tanaka T, Sasaki K et al. Adenovirus-mediated transfer of siRNA against survivin induced apoptosis and attenuated tumor cell growth in vitro and in vivo. Mol Ther 2004 10 : 162 71.
75. Brummelkamp TR, Bernards R, Agami R. Stable suppression of tumorigenicity by virus-mediated RNA interference. Cancer Cell 2002 2 : 243 7.
76. Chen X, He J, Chang LJ. Alteration of T cell immunity by lentiviral transduction of human monocyte-derived dendritic cells. Retrovirology 2004 1 : 37.
77. Xu D, McCarty D, Fernandes A, Fisher M, Samulski RJ, Juliano RL. Delivery of MDR1 small interfering RNA by self-complementary recombinant adeno-associated virus vector. Mol Ther 2005 11 : 523 30.
78. Sledz CA, Holko M, de Veer MJ, Silverman RH, Williams BR. Activation of the interferon system by short-interfering RNAs. Nat Cell Biol 2003 5 : 834 9.
79. Kariko K, Bhuyan P, Capodici J, Weissman D. Small interfering RNAs mediate sequence-independent gene suppression and induce immune activation by signaling through toll-like receptor 3. J Immunol 2004 172 : 6545 9.
80. Hornung V, Guenthner-Biller M, Bourquin C et al. Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7. Nat Med 2005 11 : 263 70.
81. Sioud M. Induction of inflammatory cytokines and interferon responses by double-stranded and single-stranded siRNAs is sequence-dependent and requires endosomal localization. J Mol Biol 2005 348 : 1079 90.
82. Jackson AL, Linsley PS. Noise amidst the silence. Off-target effects of siRNAs? Trends Genet 2004 20 : 521 4.
83. Saxena S, Jonsson ZO, Dutta A. Small RNAs with imperfect match to endogenous mRNA repress translation. Implications for off-target activity of small inhibitory RNA in mammalian cells. J Biol Chem 2003 278 (45 44312 19.
84. Scacheri PC, Rozenblatt-Rosen O, Caplen NJ et al. Short interfering RNAs can induce unexpected and divergent changes in the levels of untargeted proteins in mammalian cells. Proc Natl Acad Sci USA 2004 101 : 1892 7.
85. Elmen J, Thonberg H, Ljungberg K et al. Locked nucleic acid (LNA) mediated improvements in siRNA stability and functionality. Nucl Acids Res 2005 33 : 439 47.
86. Boese Q, Leake D, Reynolds A, Read S, Scaringe SA, Marshall WS, Khvorova A. Mechanistic insights aid computational short interfering RNA design. Meth Enzymol 2005 392 : 73 96.
87. Yamada T, Morishita S. Accelerated off-target search algorithm for siRNA. Bioinformatics 2005 21 : 1316 24.